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3.1.4.1: phosphodiesterase I

This is an abbreviated version!
For detailed information about phosphodiesterase I, go to the full flat file.

Word Map on EC 3.1.4.1

Reaction

[nucleotide]n
+
H2O
=
[nucleotide]m
 +
Nucleotide

Synonyms

5' nucleotide phosphodiesterase/alkaline phosphodiesterase I, 5'-exonuclease, 5'-NPDase, 5'-nucleotide phosphodiesterase, 5'-PDase, 5'-PDE, 5'-phosphodiesterase, 5'NPDE, alkaline phosphodiesterase, Ap3A (Ap4A) hydrolase, autotaxin, B10, calcium-dependent phosphodiesterase 1C, cleavage/polyadenylation specificity factor, CPSF-73, cRNPMase-5'-PDase, cyclic nucleotide phosphodiesterase 1, cyclic-ribonucleotide phosphomutase-5'-phosphodiesterase I, ecto-NPPase, ecto-nucleotide pyrophosphatase/phosphodiesterase 1, ectonucleotide pyrophosphatase phosphodiesterase 1, ectonucleotide pyrophosphatase/phosphodiesterase 1, ectonucleotide pyrophosphate/phosphodiesterase-1, ENPP-1, ENPP1, exonuclease I, exophosphodiesterase, gp130RB13-6, liver alkaline phosphodiesterase 1, liver nucleotide phosphodiesterase, More, NPP, NPP-1, NPP/PDE, NPP1, NPP2, NPP3, nucleotide phosphodiesterase, nucleotide phosphodiesterase/pyrophosphatase, nucleotide pyrophosphatase/alkaline phosphodiesterase I, nucleotide pyrophosphatase/phosphodiesterase 1, nucleotide pyrophosphatase/phosphodiesterase I, nucleotide pyrophosphatase/phosphodiesterase-1, nucleotide pyrophosphatase/phosphodiesterase-2, nucleotide pyrophosphatase/phosphodiesterase-3, orthophosphoric diester phosphohydrolase, PC-1, PDase, PDE, PDE 1A, PDE I, PDE1, PDE1A, PDE1C, PDE4A, PDEase, phosphodiesterase, phosphodiesterase 1, phosphodiesterase 1A, phosphodiesterase 1C, phosphonate monoester hydrolase/phosphodiesterase, phosphoric diester hydrolase, plant exonuclease I, plasma cell antigen 1, plasma cell membrane glycoprotein, plasma cell membrane protein-1, PMH, RNase J1, SMPDL3A, sphingomyelin phosphodiesterase, acid-like 3A, SVPD, Tdp 1, TDP1, tRNase Z, tyrosyl DNA phosphodiesterase 1, tyrosyl-DNA phosphodiesterase 1, tyrosyl-DNA phosphodiesterase I, tyrosyl-DNA-phosphodiesterase I, yfcE

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.1 phosphodiesterase I

IC50 Value

IC50 Value on EC 3.1.4.1 - phosphodiesterase I

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.015
(2R,4R,4aR,7R,8aS)-4,7-dimethyl-2-(5-aminothiophen-2-yl)octahydro-2H-chromen-4-ol
Homo sapiens
at pH 8.0 and 26°C
0.015
(2R,4S,4aR,7R,8aS)-4,7-dimethyl-2-(5-aminothiophen-2-yl)octahydro-2H-chromen-4-ol
Homo sapiens
at pH 8.0 and 26°C
0.0006
(RP)-adenosine 5'-(alpha-thio-beta,gamma-dichloromethylene)triphosphate
Homo sapiens
-
pH 8.5, 37°C, enzyme NPP1
0.0163
(RP)-adenosine 5'-(alpha-thio-beta,gamma-methylene)triphosphate
Homo sapiens
-
pH 8.5, 37°C, enzyme NPP1
0.0312
(SP)-adenosine 5'-(alpha-thio-beta,gamma-dichloromethylene)triphosphate
Homo sapiens
-
pH 8.5, 37°C, enzyme NPP1
0.0187
(SP)-adenosine 5'-(alpha-thio-beta,gamma-methylene)triphosphate
Homo sapiens
-
pH 8.5, 37°C, enzyme NPP1
0.23
1,2,3,4-tetrahydro-9H-[1]benzothieno[2',3':4,5]pyrimido[6,1-b]quinazolin-9-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.3
1,2-dimethyl-7H-thieno[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.08
1,3-bis(4-nitrophenyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.1
1-(4-chlorophenyl)-3-(4-methylphenyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.12
1-(4-chlorophenyl)-7H-thieno[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.07
1-(4-methoxyphenyl)-3-phenyl-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.07
1-(4-methoxyphenyl)-7H-thieno[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.09
1-(4-methylphenyl)-3-phenyl-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.23
1-(4-methylphenyl)-7H-thieno[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.06
1-(furan-2-ylmethyl)-3-(4-methylphenyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.07
10,12-dibromo-1,3-bis(4-nitrophenyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.06
10,12-dibromo-1-(4-chlorophenyl)-3-(4-methylphenyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.03
10,12-dibromo-1-(4-methoxyphenyl)-3-phenyl-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.05
10,12-dibromo-1-(4-methylphenyl)-3-phenyl-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.07
10,12-dibromo-1-(furan-2-ylmethyl)-3-(4-methylphenyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.08
10,12-dibromo-3-(4-chlorophenyl)-1-phenyl-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.07
10,12-dibromo-3-(4-methoxyphenyl)-1-(3-nitrophenyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.1
10-bromo-1,3-bis(4-nitrophenyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.07
10-bromo-1-(4-chlorophenyl)-3-(4-methylphenyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.08
10-bromo-1-(4-methoxyphenyl)-3-phenyl-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.08
10-bromo-1-(4-methylphenyl)-3-phenyl-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.07
10-bromo-1-(furan-2-ylmethyl)-3-(4-methylphenyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.1
10-bromo-3-(4-chlorophenyl)-1-phenyl-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.1
10-bromo-3-(4-methoxyphenyl)-1-(3-nitrophenyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.1
11,13-dibromo-1,2,3,4-tetrahydro-9H-[1]benzothieno[2',3':4,5]pyrimido[6,1-b]quinazolin-9-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.13
11-bromo-1,2,3,4-tetrahydro-9H-[1]benzothieno[2',3':4,5]pyrimido[6,1-b]quinazolin-9-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.004
2,2,2-trifluoro-N-(5-((2R,4R,4aR,7R,8aR)-4-hydroxy-4,7-dimethyloctahydro-2H-chromen-2-yl)thiophen-2-yl)acetamide
Homo sapiens
at pH 8.0 and 26°C
0.0014
2,2,2-trifluoro-N-(5-((2R,4S,4aR,7R,8aR)-4-hydroxy-4,7-dimethyloctahydro-2H-chromen-2-yl)thiophen-2-yl)acetamide
Homo sapiens
at pH 8.0 and 26°C
0.01
2,2,2-trifluoro-N-(8-(trifluoromethyl)benzo[f][1,2,3,4,5]pentathiepin-6-yl)acetamide
Homo sapiens
IC50 above 0.1 mM, at pH 8.0 and 26°C
0.00022
2-(dibutylamino)-N-(8-(trifluoromethyl)benzo[f]-[1,2,3,4,5]pentathiepin-6-yl)acetamide
Homo sapiens
at pH 8.0 and 26°C
0.00128
2-(piperidin-1-yl)-N-(8-(trifluoromethyl)benzo[f]-[1,2,3,4,5]pentathiepin-6-yl)acetamide
Homo sapiens
at pH 8.0 and 26°C
0.0037
2-(pyrrolidin-1-yl)-N-(8-(trifluoromethyl)benzo[f]-[1,2,3,4,5]pentathiepin-6-yl)acetamide
Homo sapiens
at pH 8.0 and 26°C
0.00162
2-morpholino-N-(8-(trifluoromethyl)benzo[f]-[1,2,3,4,5]pentathiepin-6-yl)acetamide
Homo sapiens
at pH 8.0 and 26°C
0.00123
3-(((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methoxy)-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one
Homo sapiens
pH and temperature not specified in the publication
0.0012
3-(((1S,5R)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methoxy)-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one
Homo sapiens
pH and temperature not specified in the publication
0.01
3-((3,4,5-trimethoxybenzyl)oxy)-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one
Homo sapiens
IC50 above 0.01 mM, pH and temperature not specified in the publication
0.00493
3-((3-methoxybenzyl)oxy)-7,8,9,10-tetrahydro-6Hbenzo[c]chromen-6-one
Homo sapiens
pH and temperature not specified in the publication
0.00145
3-(2-((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethoxy)-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one
Homo sapiens
pH and temperature not specified in the publication
0.08
3-(4-chlorophenyl)-1-phenyl-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.0399
3-(4-methoxy-phenyl)-1-(3-nitro-phenyl)-8Hpyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Rattus norvegicus
-
-
0.04
3-(4-methoxyphenyl)-1-(3-nitrophenyl)-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.00562
3-(benzyloxy)-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one
Homo sapiens
pH and temperature not specified in the publication
0.00366
3-(piperidin-1-yl)-N-(8-(trifluoromethyl)benzo[f]-[1,2,3,4,5]pentathiepin-6-yl)propanamide
Homo sapiens
at pH 8.0 and 26°C
0.00603
3-(pyrrolidin-1-yl)-N-(8-(trifluoromethyl)benzo[f]-[1,2,3,4,5]pentathiepin-6-yl)propanamide
Homo sapiens
at pH 8.0 and 26°C
0.0013
3-morpholino-N-(8-(trifluoromethyl)benzo[f]-[1,2,3,4,5]pentathiepin-6-yl)propanamide
Homo sapiens
at pH 8.0 and 26°C
0.01
4-methyl-7-((3,4,5-trimethoxybenzyl)oxy)-2H-chromen-2-one
Homo sapiens
IC50 above 0.01 mM, pH and temperature not specified in the publication
0.494
5-[3-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione
Homo sapiens
-
in 20 mM Tris-HCl, pH 8.0, 0.5 M NaCl and 1 mM CaCl2, at 37°C
1
5-[3-hydroxyphenyl]-1,3,4-oxadiazole-2(3H)-thione
Bothrops atrox
-
in Tris-HCl buffer 33 mM pH 8.8, at 37°C
0.368
5-[4-(t-butyldimethylsilyloxy)-phenyl]-1,3,4-oxadiazole-2(3H)-thione
0.06647
5-[4-(t-butyldimethylsilyloxy)-phenyl]-1,3,4-thiadiazole-2(3H)-thione
Bothrops atrox
-
in Tris-HCl buffer 33 mM pH 8.8, at 37°C
0.628 - 0.9
5-[4-benzyloxyphenyl]-1,3,4-oxadiazole-2(3H)-thione
0.96
5-[4-hydroxyphenyl]-1,3,4-oxadiazole-2(3H)-thione
Bothrops atrox
-
in Tris-HCl buffer 33 mM pH 8.8, at 37°C
0.39 - 0.9
5-[4-hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione
0.66 - 0.998
5-[4-pyridyl]-1,3,4-thiadiazole-2(3H)-thione
0.001
6,6'-[(1R,2R,3S,4S)-2,4-bis(4-hydroxyphenyl)cyclobutane-1,3-diyl]di(2H-pyran-2-one)
Homo sapiens
at pH 8.0 and 26°C
0.00152
6,6'-[propane-1,3-diylbis(iminopropane-3,1-diyl)]bis(5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione)
Homo sapiens
-
pH 7.5, 25°C, recombinant enzyme
0.014
6-(10-aminodecyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione
Homo sapiens
-
pH 7.5, 25°C, recombinant enzyme
0.0128
6-(11-aminoundecyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione
Homo sapiens
-
pH 7.5, 25°C, recombinant enzyme
0.0151
6-(12-aminododecyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione
Homo sapiens
-
pH 7.5, 25°C, recombinant enzyme
0.0553
6-(2-aminoethyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione
Homo sapiens
-
pH 7.5, 25°C, recombinant enzyme
0.0295
6-(3-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione
Homo sapiens
-
pH 7.5, 25°C, recombinant enzyme
0.0223
6-(4-aminobutyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione
Homo sapiens
-
pH 7.5, 25°C, recombinant enzyme
0.0175
6-(5-aminopentyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione
Homo sapiens
-
pH 7.5, 25°C, recombinant enzyme
0.025
6-(6-aminohexyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione
Homo sapiens
-
pH 7.5, 25°C, recombinant enzyme
0.0288
6-(7-aminoheptyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione
Homo sapiens
-
pH 7.5, 25°C, recombinant enzyme
0.048
6-(8-aminooctyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione
Homo sapiens
-
pH 7.5, 25°C, recombinant enzyme
0.047
6-(9-aminononyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione
Homo sapiens
-
pH 7.5, 25°C, recombinant enzyme
0.00137
7-(((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methoxy)-2,3-dihydrocyclopenta[c]chromen-4(1H)-one
Homo sapiens
pH and temperature not specified in the publication
0.00156
7-(((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methoxy)-4-methyl-2H-chromen-2-one
Homo sapiens
pH and temperature not specified in the publication
0.000675
7-(((1S,5R)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methoxy)-2,3-dihydrocyclopenta[c]chromen-4(1H)-one
Homo sapiens
pH and temperature not specified in the publication
0.00431
7-(((1S,5R)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methoxy)-4-methyl-2H-chromen-2-one
Homo sapiens
pH and temperature not specified in the publication
0.01
7-((3,4,5-trimethoxybenzyl)oxy)-2,3-dihydrocyclopenta[c]chromen-4(1H)-one
Homo sapiens
IC50 above 0.01 mM, pH and temperature not specified in the publication
0.01
7-((3-methoxybenzyl) oxy)-4-methyl-2H-chromen-2-one
Homo sapiens
IC50 above 0.01 mM, pH and temperature not specified in the publication
0.01
7-((3-methoxybenzyl)oxy)-2,3-dihydrocyclopenta[c]chromen-4(1H)-one
Homo sapiens
IC50 above 0.01 mM, pH and temperature not specified in the publication
0.00109
7-(2-((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethoxy)-2,3-dihydrocyclopenta[c]chromen-4(1H)-one
Homo sapiens
pH and temperature not specified in the publication
0.00917
7-(benzyloxy)-2,3-dihydrocyclopenta[c]chromen-4(1H)-one
Homo sapiens
pH and temperature not specified in the publication
0.00528
7-(benzyloxy)-4-methyl-2H-chromen-2-one
Homo sapiens
pH and temperature not specified in the publication
0.0000675
7-[[(1S,5R)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl]methoxy]-2,3-dihydrobenzo[b]cyclopenta[d]pyran-4(1H)-one
Homo sapiens
at pH 8.0 and 26°C
0.1
9,11-dibromo-1,2-dimethyl-7H-thieno[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.08
9,11-dibromo-1-(4-chlorophenyl)-7H-thieno[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.337
9,11-dibromo-1-(4-methoxyphenyl)-3-phenyl-8H-pyrido[2',3':4,5]pyrimido[6,1-b]quinazolin-8-one
Rattus norvegicus
-
-
0.06
9,11-dibromo-1-(4-methoxyphenyl)-7H-thieno[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.06
9,11-dibromo-1-(4-methylphenyl)-7H-thieno[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.15
9-bromo-1,2-dimethyl-7H-thieno[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.09
9-bromo-1-(4-chlorophenyl)-7H-thieno[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.08
9-bromo-1-(4-methoxyphenyl)-7H-thieno[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.09
9-bromo-1-(4-methylphenyl)-7H-thieno[2',3':4,5]pyrimido[6,1-b]quinazolin-7-one
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.00039
adenosine 5'-(gamma-thio-beta,gamma-methylene)triphosphate
Homo sapiens
-
pH 8.5, 37°C, enzyme NPP1
0.01
aminobenzopentathiepine
Homo sapiens
IC50 above 0.01 mM, at pH 8.0 and 26°C
0.85
bis(1,3,4-oxadiazol-2-methyl)-5-thione
Bothrops atrox
-
in Tris-HCl buffer 33 mM pH 8.8, at 37°C
0.429 - 0.467
bis(1,3,4-oxadiazol-2-propyl)-5-thione
0.839
bis(1,3,4-thiadiazole-2-methyl)-5-thione
Bothrops atrox
-
in Tris-HCl buffer 33 mM pH 8.8, at 37°C
0.274
EDTA
Bothrops atrox
-
in Tris-HCl buffer 33 mM pH 8.8, at 37°C
0.0012
furamidine
Homo sapiens
at pH 8.0 and 26°C
0.02
IBMX
Bos taurus
-
60 min at 37°C, 10 mM cAMP substrate, pH not specified in the publication
0.748
L-cysteine
Bothrops atrox
-
in Tris-HCl buffer 33 mM pH 8.8, at 37°C
0.0004
methyl-3,4-dephostatin
Homo sapiens
pH and temperature not specified in the publication
0.00245
N-(2-[1-[2-(2-methyl-1H-imidazol-1-yl)pyrimidin-4-yl]piperidin-4-yl]ethyl)sulfuric diamide
Homo sapiens
-
-
0.0006
N-(2-[1-[6-(2-methyl-1H-imidazol-1-yl)pyrimidin-4-yl]piperidin-4-yl]ethyl)sulfuric diamide
Homo sapiens
-
-
0.0035
N-(3,7-dimethyloct-6-en-1-yl)tricyclo[3.3.1.1(3,7)]decan-2-amine
Homo sapiens
at pH 8.0 and 26°C
0.0029
N-(5-((2R,4R,4aR,7R,8aR)-4-hydroxy-4,7-dimethyloctahydro-2H-chromen-2-yl)thiophen-2-yl)acetamide
Homo sapiens
at pH 8.0 and 26°C
0.0033
N-(5-((2R,4R,4aR,7R,8aR)-4-hydroxy-4,7-dimethyloctahydro-2H-chromen-2-yl)thiophen-2-yl)benzamide
Homo sapiens
at pH 8.0 and 26°C
0.0028
N-(5-((2R,4R,4aR,7R,8aS)-4-hydroxy-4,7-dimethyloctahydro-2H-chromen-2-yl)thiophen-2-yl)adamantane-1-carboxamide
Homo sapiens
at pH 8.0 and 26°C
0.0058
N-(5-((2R,4S,4aR,7R,8aR)-4-hydroxy-4,7-dimethyloctahydro-2H-chromen-2-yl)thiophen-2-yl)acetamide
Homo sapiens
at pH 8.0 and 26°C
0.005
N-(5-((2R,4S,4aR,7R,8aR)-4-hydroxy-4,7-dimethyloctahydro-2H-chromen-2-yl)thiophen-2yl)benzamide
Homo sapiens
at pH 8.0 and 26°C
0.00124
N-(5-((2R,4S,4aR,7R,8aS)-4-hydroxy-4,7-dimethyloctahydro-2H-chromen-2-yl)thiophen-2-yl)adamantane-1-carboxamide
Homo sapiens
at pH 8.0 and 26°C
0.01
N-phenyl-2-(piperidin-1-yl)acetamide
Homo sapiens
IC50 above 0.1 mM, at pH 8.0 and 26°C
0.01
N-phenyl-2-(pyrrolidin-1-yl)acetamide
Homo sapiens
IC50 above 0.1 mM, at pH 8.0 and 26°C
0.000035
N-[2-(1-[6,7-dimethoxy-2-[(E)-2-(pyridin-3-yl)ethenyl]quinazolin-4-yl]piperidin-4-yl)ethyl]sulfuric diamide
Homo sapiens
-
-
0.000214
N-[2-[1-(2-ethyl-6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]ethyl]sulfuric diamide
Homo sapiens
-
-
0.000036
N-[2-[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]ethyl]sulfuric diamide
Homo sapiens
-
-
0.00598
N-[2-[1-(6-chloroquinazolin-4-yl)piperidin-4-yl]ethyl]sulfuric diamide
Homo sapiens
-
-
0.01
N-[2-[1-(7-chloroquinazolin-4-yl)piperidin-4-yl]ethyl]sulfuric diamide
Homo sapiens
-
above
0.000187
N-[2-[1-(7-methoxyquinazolin-4-yl)piperidin-4-yl]ethyl]sulfuric diamide
Homo sapiens
-
-
0.009
NSC88915
Homo sapiens
pH and temperature not specified in the publication
additional information
indomethacin
Bos taurus
-
not tested