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Information on EC 3.1.4.1 - phosphodiesterase I

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.1 phosphodiesterase I
IUBMB Comments
Hydrolyses both ribonucleotides and deoxyribonucleotides. Has low activity towards polynucleotides. A 3'-phosphate terminus on the substrate inhibits hydrolysis.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
5' nucleotide phosphodiesterase/alkaline phosphodiesterase I, 5'-exonuclease, 5'-NPDase, 5'-nucleotide phosphodiesterase, 5'-PDase, 5'-PDE, 5'-phosphodiesterase, 5'NPDE, alkaline phosphodiesterase, Ap3A (Ap4A) hydrolase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides
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