Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.1.4.1: phosphodiesterase I

This is an abbreviated version!
For detailed information about phosphodiesterase I, go to the full flat file.

Word Map on EC 3.1.4.1

Reaction

[nucleotide]n
+
H2O
=
[nucleotide]m
 +
Nucleotide

Synonyms

5' nucleotide phosphodiesterase/alkaline phosphodiesterase I, 5'-exonuclease, 5'-NPDase, 5'-nucleotide phosphodiesterase, 5'-PDase, 5'-PDE, 5'-phosphodiesterase, 5'NPDE, alkaline phosphodiesterase, Ap3A (Ap4A) hydrolase, autotaxin, B10, calcium-dependent phosphodiesterase 1C, cleavage/polyadenylation specificity factor, CPSF-73, cRNPMase-5'-PDase, cyclic nucleotide phosphodiesterase 1, cyclic-ribonucleotide phosphomutase-5'-phosphodiesterase I, ecto-NPPase, ecto-nucleotide pyrophosphatase/phosphodiesterase 1, ectonucleotide pyrophosphatase phosphodiesterase 1, ectonucleotide pyrophosphatase/phosphodiesterase 1, ectonucleotide pyrophosphate/phosphodiesterase-1, ENPP-1, ENPP1, exonuclease I, exophosphodiesterase, gp130RB13-6, liver alkaline phosphodiesterase 1, liver nucleotide phosphodiesterase, More, NPP, NPP-1, NPP/PDE, NPP1, NPP2, NPP3, nucleotide phosphodiesterase, nucleotide phosphodiesterase/pyrophosphatase, nucleotide pyrophosphatase/alkaline phosphodiesterase I, nucleotide pyrophosphatase/phosphodiesterase 1, nucleotide pyrophosphatase/phosphodiesterase I, nucleotide pyrophosphatase/phosphodiesterase-1, nucleotide pyrophosphatase/phosphodiesterase-2, nucleotide pyrophosphatase/phosphodiesterase-3, orthophosphoric diester phosphohydrolase, PC-1, PDase, PDE, PDE 1A, PDE I, PDE1, PDE1A, PDE1C, PDE4A, PDEase, phosphodiesterase, phosphodiesterase 1, phosphodiesterase 1A, phosphodiesterase 1C, phosphonate monoester hydrolase/phosphodiesterase, phosphoric diester hydrolase, plant exonuclease I, plasma cell antigen 1, plasma cell membrane glycoprotein, plasma cell membrane protein-1, PMH, RNase J1, SMPDL3A, sphingomyelin phosphodiesterase, acid-like 3A, SVPD, Tdp 1, TDP1, tRNase Z, tyrosyl DNA phosphodiesterase 1, tyrosyl-DNA phosphodiesterase 1, tyrosyl-DNA phosphodiesterase I, tyrosyl-DNA-phosphodiesterase I, yfcE

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.1 phosphodiesterase I

Expression

Expression on EC 3.1.4.1 - phosphodiesterase I

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
angiotensin II upregulates phosphodiesterase 1A expression
cAMP-dependent inhibition of NPP1 expression not involving the the activator protein-1 motif present in the promoter of the rat NPP1 gene. (R,S)-Isoproterenol decreases the amount of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 protein by 75% and 81%, respectively. Contrary to downregulation of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 , an upregulation of glial fibrillary acidic protein, a differentiation marker for astrocytic cells is observed. Ca2+, PKA, PI 3-K/PKB/GSK-3, Epac/Rap1/PP2A and MAP kinase modules are not involved in the inhibition of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 gene expression
fibroblast growth factor-2, FGF2, specifically induces PC-1 expression in calvarial pre-osteoblasts, which occurs via a transcriptional mechanism involving Runx2. FGF2 promotes Msx2-stimulated PC-1 expression via Frs2/MAPK signaling, Msx2 promotes transcription of the PC-1 gene downstream of FGF2, overview. both Msx2 and Runx2 are recruited to a conserved core Msx2 binding site within the PC-1 gene promoter upon FGF2 stimulation, and that Msx2 and Runx2 function together to induce PC-1 gene expression in osteoblastic cells
-
generation of single Tdp1-knock-out Gallus gallus DT40 cells and of dual Tdp1-CtIP-deficient DT40 cells
-
genomic instability and cellular senescence in vascular smooth muscle cells increase enzyme expression
-
PDE1 mRNA expression is investigated
-
the enzyme encoding gene is upregulated in bladder tumor versus healthy urothelium tissue. The enzyme is induced by cAMP, the up-regulation of enzyme secretion by raised cAMP levels are mediated by a PKA-independent pathway. The enzyme is strongly upregulated by cholesterol loading, increase in SMPDL3A mRNA expression due to cholesterol accumulation and by and synthetic LXR ligands