3.1.4.1: phosphodiesterase I

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For detailed information about phosphodiesterase I, go to the full flat file.

Word Map on EC 3.1.4.1

3.1.4.1

camp

phosphodiesterases

calcification

arterial

topoisomerase

rolipram

monophosphate

camp-specific

infancy

osteoblast

hypophosphatemic

rickets

camptothecin

pseudoxanthoma

ectoenzyme

topotecan

5'-nucleotide

elasticum

ibmx

ankylosis

3'-phosphate

zaprinast

top1-dna

camp-pde

tcf7l2

milrinone

qq

tissue-nonspecific

cgmp-inhibited

cgmp-stimulated

pyrophosphohydrolase

cilomilast

cementum

3-isobutyl-1-methylxanthine

rolipram-sensitive

vinpocetine

cardiotonic

pharmacology

medicine

synthesis

drug development

biotechnology

analysis

Reaction

Synonyms

5' nucleotide phosphodiesterase/alkaline phosphodiesterase I, 5'-exonuclease, 5'-NPDase, 5'-nucleotide phosphodiesterase, 5'-PDase, 5'-PDE, 5'-phosphodiesterase, 5'NPDE, alkaline phosphodiesterase, Ap3A (Ap4A) hydrolase, autotaxin, B10, calcium-dependent phosphodiesterase 1C, cleavage/polyadenylation specificity factor, CPSF-73, cRNPMase-5'-PDase, cyclic nucleotide phosphodiesterase 1, cyclic-ribonucleotide phosphomutase-5'-phosphodiesterase I, ecto-NPPase, ecto-nucleotide pyrophosphatase/phosphodiesterase 1, ectonucleotide pyrophosphatase phosphodiesterase 1, ectonucleotide pyrophosphatase/phosphodiesterase 1, ectonucleotide pyrophosphate/phosphodiesterase-1, ENPP-1, ENPP1, exonuclease I, exophosphodiesterase, gp130RB13-6, liver alkaline phosphodiesterase 1, liver nucleotide phosphodiesterase, More, NPP, NPP-1, NPP/PDE, NPP1, NPP2, NPP3, nucleotide phosphodiesterase, nucleotide phosphodiesterase/pyrophosphatase, nucleotide pyrophosphatase/alkaline phosphodiesterase I, nucleotide pyrophosphatase/phosphodiesterase 1, nucleotide pyrophosphatase/phosphodiesterase I, nucleotide pyrophosphatase/phosphodiesterase-1, nucleotide pyrophosphatase/phosphodiesterase-2, nucleotide pyrophosphatase/phosphodiesterase-3, orthophosphoric diester phosphohydrolase, PC-1, PDase, PDE, PDE 1A, PDE I, PDE1, PDE1A, PDE1C, PDE4A, PDEase, phosphodiesterase, phosphodiesterase 1, phosphodiesterase 1A, phosphodiesterase 1C, phosphonate monoester hydrolase/phosphodiesterase, phosphoric diester hydrolase, plant exonuclease I, plasma cell antigen 1, plasma cell membrane glycoprotein, plasma cell membrane protein-1, PMH, RNase J1, SMPDL3A, sphingomyelin phosphodiesterase, acid-like 3A, SVPD, Tdp 1, TDP1, tRNase Z, tyrosyl DNA phosphodiesterase 1, tyrosyl-DNA phosphodiesterase 1, tyrosyl-DNA phosphodiesterase I, tyrosyl-DNA-phosphodiesterase I, yfcE

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.4 Phosphoric-diester hydrolases

3.1.4.1 phosphodiesterase I

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Results	in table
24	Activating Compound
6877	AA Sequence
17	Application
1	CAS Registry Number
30	Cloned(Commentary)
2	Crystallization (Commentary)
1512	Disease/ Diagnostics
9	Expression
70	General Information
17	General Stability
127	IC50 Value
466	Inhibitors
4	kcat/KM [mM/s]
12	Ki Value [mM]
102	KM Value [mM]
57	Localization
107	Metals/Ions
48	Molecular Weight [Da]
40	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
363	Organism
66	PDB ID
49	pH Optimum
10	pH Range
10	pH Stability
21	Posttranslational Modification
56	Protein Variants
41	Purification (Commentary)
18	Reaction
3	Reaction Type
142	Reference
1	Renatured (Commentary)
149	Source Tissue
45	Specific Activity [micromol/min/mg]
9	Storage Stability
412	Substrates and Products (Substrate)
29	Subunits
212	Synonyms
1	Systematic Name
23	Temperature Optimum [°C]
3	Temperature Range [°C]
17	Temperature Stability [°C]
61	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.1.4.1 - phosphodiesterase I

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100000

Hordeum vulgare

gel filtration and PAGE

108000

gel filtration

110000

115000

118000

x * 118000 + x * 128000, PC-1, SDS-PAGE

120000

125000

128000

130000

2 * 130000, PC-1, homodimer, SDS-PAGE

208377

140000

Mus musculus

liver, gel filtration

208357

16000

Homo sapiens

x * 66000 + x * 45000 + x * 16000, enzyme has a complex structure, which is composed of subunits of different size, stoichiometry of the complex is still uncertain, SDS-PAGE

190000

gel filtration

220000

PC-1, SDS-PAGE

230000

230000 - 260000

240000

PC-1, SDS-PAGE without reduction

208377

260000

Homo sapiens

PC-1, SDS-PAGE without reduction

430000

gel filtration

45000

45300

Physarum polycephalum

gel filtration

500000

PC-1, gel filtration

51260

x * 52000-54000, SDS-PAGE, x * 51260, sequence calculation, x * 45000, about, deglycosylated recombinant enzyme, SDS-PAGE

730060

52000

Hordeum vulgare

52000 + 34000 + 16000, PDE might be a dimer with two 52000 subunits, or a heterologous trimer composed of 52000, 34000 and 16000 subunits, in the former case, one of the subunits is nicked and produced the 34000 + 16000 subunits, SDS-PAGE

53000

gel filtration

56000

1 * 56000, SDS-PAGE

62000

65000

gel filtration

66000

x * 66000 + x * 45000 + x * 16000, enzyme has a complex structure, which is composed of subunits of different size, stoichiometry of the complex is still uncertain, SDS-PAGE

208383

67000

Mus musculus

tumor cell line, N-ethylmaleimide-sensitive, gel filtration and SDS-PAGE

208356

70000

Oryza sativa

Q10Q09, Q6ZI95

x * 70000, mature isozyme NPP1, SDS-PAGE

79400

gel filtration

80000

Western blot analysis of PDE 1A, 1B, and 1C to determine which phosphodiesterase isoform is involved in inhibition of renin release. In conclusion isoform 1C is expressed in isolated JG cells

710820

98000 - 115000

Daucus carota

gel filtration

208366

additional information

7 entries