Reference on EC 3.1.4.1 - phosphodiesterase I
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Futai, M.; Mizuno, D.
A new phosphodiesterase forming nucleoside 5'-monophosphate from rat liver. Its partial purification and substrate specificity for nicotinamide adenine dinucleotide and oligonucleotides
J. Biol. Chem.
242
5301-5307
1967
Rattus norvegicus
Sakura, H.; Nagashima, S.; Nakashima, A.; Maeda, M.
Characterization of fetal serum 5'-nucleotide phosphodiesterase: A novel function as a platelet aggregation inhibitor in fetal circulation
Thromb. Res.
91
83-89
1998
Homo sapiens
Kanno, C.; Ohmura, Y.; Yanagisawa, H.
Comparative study of the enzymatic properties of phosphodiesterases I from the plasma membrane of lactating bovine mammary gland and bovine milk fat globule membrane
Agric. Biol. Chem.
53
607-613
1989
Bos taurus
-
Fukazawa, H.; Nishimura, T.; Tanaka, N.; Suzuki, H.
5'-Nucleotide phosphodiesterase and alkaline phosphatase in tumor cells: evidence for existence of novel species in the cytosol
Biochim. Biophys. Acta
966
99-106
1988
Bos taurus, Homo sapiens, Mus musculus
Fukazawa, H.; Suzuki, H.; Tanaka, N.
A novel tumor-associated molecular species of 5'-nucleotide phosphodiesterase
Biochem. Biophys. Res. Commun.
130
1072-1077
1985
Mus musculus
Ito, K.; Yamamoto, T.; Minamiura, N.
Phosphodiesterase I in human urine: purification and characterization of the enzyme
J. Biochem.
102
359-367
1987
Homo sapiens
Keller, R.; Schlingmann, M.; Woernle, R.
Production of 5'-ribonucleotides using immobilized 5'-phosphodiesterase
Methods Enzymol.
136
517-522
1987
Penicillium sp.
-
Robinson, A.K.; Barnes, L.D.
Three diadenosine 5',5'''-P1,P4-tetraphosphate hydrolytic enzymes from Physarum polycephalum with differential effects by calcium: a specific dinucleoside polyphosphate pyrophosphohydrolase, a nucleotide pyrophosphatase, and a phosphodiesterase
Arch. Biochem. Biophys.
248
502-515
1986
Physarum polycephalum
Jakubowski, H.; Guranowski, A.
Enzymes hydrolyzing ApppA and/or AppppA in higher plants. Purification and some properties of diadenosine triphosphatase, diadenosine tetraphosphatase, and phosphodiesterase from yellow lupin (Lupinus luteus) seeds
J. Biol. Chem.
258
9982-9989
1983
Lupinus luteus
Fitt, P.S.; Baddoo, P.
Separation and purification of the alkaline phosphatase and a phosphodiesterase from Halobacterium cutirubrum
Biochem. J.
181
347-353
1979
Halobacterium salinarum
Fujimoto, M.; Fujiyama, K.; Midorikawa, Y.; Fujishima, T.; Kuninaka, A.; Yoshino, H.
Properties of 5'-phosphodiesterase from Aspergillus niger
Agric. Biol. Chem.
41
737-744
1977
Aspergillus awamori, Aspergillus batatae, Aspergillus carbonarius, Aspergillus fuscus, Aspergillus inuii, Aspergillus niger, Aspergillus phoenicis, Aspergillus usamii
-
Felicioli, R.A.; Ipata, P.L.; Senesi, S.; Falcone, G.
Characterization of the specificity of intracellular phosphodiesterases in Bacillus subtilis
Biochim. Biophys. Acta
276
584-587
1972
Bacillus subtilis
Lerch, B.; Wolf, G.
Isolation of phosphodiesterase from sugar beet leaves
Biochim. Biophys. Acta
258
206-218
1972
Beta vulgaris
Harvey, C.L.; Olson, K.C.; Wright, R.
Further purification and properties of phosphodiesterase from the carrot
Biochemistry
9
921-925
1970
Daucus carota
Razzell, W.E.
Tissue and intracellular distribution of two phophodiesterases
J. Biol. Chem.
236
3028-3030
1961
Homo sapiens, Rattus norvegicus, Sus scrofa
Razzell, W.E.
Partial purification and properties of phosphodiesterase I from hog kidney
J. Biol. Chem.
236
3031-3036
1961
Sus scrofa
Hawley, D.M.; Crisp, M.; Hodes, M.E.
The synthesis of 4-methylumbelliferyl phenylphosphonate and its use in an improved method for the zymogram analysis of phosphodiesterase I
Anal. Biochem.
129
522-528
1983
Bos taurus
Hawley, D.M.; Schulz, A.R.; Hodes, M.E.
A comparative kinetic analysis of six substrates widely used for the detection and quantitation of phosphodiesterase I
Enzyme
32
105-109
1984
Bos taurus
Wang, A.Y.; Juang, R.H.; Chang, C.T.; Sung, H.Y.
Purification and characterization of 5'-phosphodiesterase from barley rootlets
Biochem. Mol. Biol. Int.
29
1095-1102
1993
Hordeum vulgare
Maruyama, E.; Iwamatsu, A.; Takashima, S.
Purification and amino acid microsequencing of alkaline phosphodiesterase I from calf kidney
Biochem. Mol. Biol. Int.
29
579-586
1993
Bos taurus
Maruyama, E.; Takashima, S.
Characterization of over-expressed alkaline phosphodiesterase I in tumor-derived fibroblasts from patients with neurofibromatosis
Cell Biochem. Funct.
11
271-277
1993
Homo sapiens
Chohnan, S.; Nagata, T.; Midorikawa, Y.
Purification and characterization of a novel bifunctional enzyme, cyclic-ribonucleotide phosphomutase-5'-phosphodiesterase, from Aspergillus niger
Biosci. Biotechnol. Biochem.
58
250-255
1994
Aspergillus niger
-
Belli, S.I.; van Driel, I.R.; Goding, J.W.
Identification and characterization of a soluble form of the plasma cell membrane glycoprotein PC-1 (5'-nucleotide phosphodiesterase)
Eur. J. Biochem.
217
421-428
1993
Mus musculus
Belli, S.I.; Goding, J.W.
Biochemical characterization of human PC-1, an enzyme possessing alkaline phosphodiesterase I and nucleotide pyrophosphatase activities
Eur. J. Biochem.
226
433-443
1994
Homo sapiens, Mus musculus
Lopez-Gomez, J.; Costas, M.J.; Meireles Ribeiro, J.; Fernandez, A.; Romero, A.; Avalos, M.; Cameselle, J.C.
Glycine-enhanced inhibition of rat liver nucleotide pyrophosphatase/phosphodiesterase-I by EDTA: a full account of the reported inhibition by commercial preparations of acidic fibroblast growth factor (FGF-1)
FEBS Lett.
421
77-79
1998
Rattus norvegicus
Uriarte, M.; Stalmans, W.; Hickman, S.; Bollen, M.
Regulation of purified hepatic PC-1 (phosphodiesterase-I/nucleotide pyrophosphatase) by threonine auto(de)phosphorylation and by binding of acidic fibroblast growth factor
Biochem. J.
306
271-277
1995
Rattus norvegicus
Stefanovic, V.; Vlahovic, P.; Ardaillou, R.
Characterization and control of expression of cell surface alkaline phosphodiesterase I activity in rat mesangial glomerular cells
Renal Physiol. Biochem.
18
12-20
1995
Rattus norvegicus
Rebbe, N.F.; Tong, B.D.; Finley, E.M.; Hickman, S.
Identification of nucleotide pyrophosphatase/alkaline phosphodiesterase I activity associated with the mouse plasma cell differentiation antigen PC-1
Proc. Natl. Acad. Sci. USA
88
5192-5196
1991
Mus musculus, Mus musculus BALB/c
Luthje, J.; Ogilvie, A.
Catabolism of Ap3A and Ap4A in human plasma. Purification and characterization of a glycoprotein complex with 5'-nucleotide phosphodiesterase activity
Eur. J. Biochem.
149
119-127
1985
Homo sapiens
Culp, J.S.; Blytt, H.J.; Hermodson, M.; Butler, L.G.
Amino acid sequence of the active site peptide of bovine intestinal 5'-nucleotide phosphodiesterase and identification of the active site residue as threonine
J. Biol. Chem.
260
8320-8324
1985
Bos taurus
Kelly, S.J.; Dardinger, D.E.; Butler, L.G.
Hydrolysis of phosphonate esters catalyzed by 5'nucleotide phosphodiesterase
Biochemistry
14
4983-4988
1975
Bos taurus
Kelly, S.J.; Butler, L.G.
Enzymic hydrolysis of phosphonate esters. Reaction mechanism of intestinal 5'-nucleotide phosphodiesterase
Biochemistry
16
1102-1104
1977
Bos taurus
Udvardy, J.; Marre, E.; Farkas, G.L.
Purification and properties of a phosphodiesterase from Avena leaf tissues
Biochim. Biophys. Acta
206
392-403
1970
Avena sativa
Sabatini, Z.J.; Hotchkiss, R.D.
Preparation of an exonuclease from Lactobacillus which releases 5'-mononucleotides from polynucleotides
Biochemistry
8
4831-4837
1969
Lactobacillus acidophilus, Lactobacillus acidophilus R26
Yano, T.; Funakoshi, I.; Yamashina, I.
Purification and properties of nucleotide pyrophosphatase from human placenta
J. Biochem.
98
1097-1107
1985
Rattus norvegicus
Wilson, C.M.
Plant nucleases
Annu. Rev. Plant Physiol.
26
187-208
1975
Avena sativa, Beta vulgaris, Daucus carota, Hordeum vulgare, Nicotiana tabacum
-
Kurosawa, S.i.; Hayashi, M.; Ishizawa, H.
Purification and properties of alkaline phosphodiesterase from the fruit body of Flammulina velutipes
Agric. Biol. Chem.
48
299-305
1984
Flammulina velutipes
-
Cameselle, J.C.; Costas, M.J.; Sillero, M.A.G.; Sillero, A.
Two low Km hydrolytic activities on dinucleoside 5',5'''-P1,P4-tetraphosphates in rat liver. Characterization as the specific dinucleoside tetraphosphatase and a phosphodiesterase-I-like enzyme
J. Biol. Chem.
259
2879-2885
1984
Rattus norvegicus
Picher, M.; Boucher, R.C.
Biochemical evidence for an ecto alkaline phosphodiesterase I in human airways
Am. J. Respir. Cell Mol. Biol.
23
255-261
2000
Homo sapiens
Rosemeyer, H.; Ramzaeva, N.; Becker, E.M.; Feiling, E.; Seela, F.
Oligonucleotides incorporating 7-(aminoalkynyl)-7-deaza-2'-deoxyguanosines: duplex stability and phosphodiester hydrolysis by exonucleases
Bioconjug. Chem.
13
1274-1285
2002
Bos taurus, Crotalus atrox
Deoda, A.J.; Singhal, R.S.
5'-Phosphodiesterase (5'-PDE) from germinated barley for hydrolysis of RNA to produce flavour nucleotides
Biores. Technol.
88
245-250
2003
Hordeum vulgare
Takebayashi, S.; Ikeda, M.; Takeuchi, M.; Shinkai, S.
Metal ion induced allosteric transition in the catalytic activity of an artificial phosphodiesterase
Chem. Commun. (Camb.)
2004
420-421
2004
synthetic construct
-
Bollen, M.; Gijsbers, R.; Ceulemans, H.; Stalmans, W.; Stefan, C.
Nucleotide pyrophosphatases/phosphodiesterases on the move
Crit. Rev. Biochem. Mol. Biol.
35
393-432
2000
Mammalia
Garcia-Nieto, R.M.; Jose, E.S.; Martin-Nieto, J.; Villalobo, A.
Characterization of a new plasma membrane-associated ecto-5'-phosphodiesterase/nucleotide-pyrophosphatase from rat hepatocarcinoma AS-30D cells
J. Physiol. Biochem.
57
31-40
2001
Rattus norvegicus
Bowman, K.J.; Pla, R.L.; Guichard, Y.; Farmer, P.B.; Jones, G.D.
Evaluation of phosphodiesterase I-based protocols for the detection of multiply damaged sites in DNA: the detection of abasic, oxidative and alkylative tandem damage in DNA oligonucleotides
Nucleic Acids Res.
29
E101
2001
Crotalus atrox
Kuznetsova, E.; Proudfoot, M.; Sanders, S.A.; Reinking, J.; Savchenko, A.; Arrowsmith, C.H.; Edwards, A.M.; Yakunin, A.F.
Enzyme genomics: Application of general enzymatic screens to discover new enzymes
FEMS Microbiol. Rev.
29
263-279
2005
Escherichia coli (P37049), Escherichia coli (P39300), Escherichia coli (P67095)
Chen, S.; Yakunin, A.F.; Kuznetsova, E.; Busso, D.; Pufan, R.; Proudfoot, M.; Kim, R.; Kim, S.H.
Structural and Functional Characterization of a Novel Phosphodiesterase from Methanococcus jannaschii
J. Biol. Chem.
279
31854-31862
2004
Methanocaldococcus jannaschii (Q58346)
Fuerstenau, C.R.; Trentin, D.d.S.; Barreto-Chaves, M.L.; Sarkis, J.J.
Ecto-nucleotide pyrophosphatase/phosphodiesterase as part of a multiple system for nucleotide hydrolysis by platelets from rats: kinetic characterization and biochemical properties
Platelets
17
84-91
2006
Rattus norvegicus
Akamatsu, K.
A novel methodology for characterizing strand-break termini and damaged bases in plasmid DNA exposed to ionizing radiation
Anal. Biochem.
362
229-235
2007
Crotalus adamanteus
Henz, S.L.; Fuerstenau, C.R.; Chiarelli, R.A.; Sarkis, J.J.
Kinetic and biochemical characterization of an ecto-nucleotide pyrophosphatase/phosphodiesterase (EC 3.1.4.1) in cells cultured from submandibular salivary glands of rats
Arch. Oral Biol.
52
916-923
2007
Rattus norvegicus
Spaeth, B.; Settele, F.; Schilling, O.; DAngelo, I.; Vogel, A.; Feldmann, I.; Meyer-Klaucke, W.; Marchfelder, A.
Metal requirements and phosphodiesterase activity of tRNase Z enzymes
Biochemistry
46
14742-14750
2007
Arabidopsis thaliana
Aoyagi, H.; Akimoto-Tomiyama, C.; Tanaka, H.
Preparation of mixed alginate elicitors with high activity for the efficient production of 5-phosphodiesterase by Catharanthus roseus cells
Biotechnol. Lett.
28
1567-1571
2006
Catharanthus roseus
Acosta Maldonado, P.; de Carvalho Correa, M.; Vargas Becker, L.; Flores, C.; Beatriz Moretto, M.; Morsch, V.; Chitolina Schetinger, M.R.
Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine Ddaminase (ADA) activities in patients with uterine cervix neoplasia
Clin. Biochem.
46
400-406
2008
Homo sapiens
Jackson, E.K.; Ren, J.; Zacharia, L.C.; Mi, Z.
Characterization of renal ecto-phosphodiesterase
J. Pharmacol. Exp. Ther.
321
810-815
2007
Rattus norvegicus
Ruecker, B.; Almeida, M.E.; Libermann, T.A.; Zerbini, L.F.; Wink, M.R.; Sarkis, J.J.
Biochemical characterization of ecto-nucleotide pyrophosphatase/phosphodiesterase (E-NPP, E.C. 3.1.4.1) from rat heart left ventricle
Mol. Cell. Biochem.
306
247-254
2007
Rattus norvegicus
Asensio, A.C.; Rodriguez-Ferrer, C.R.; Castaneyra-Perdomo, A.; Oaknin, S.; Rotllan, P.
Biochemical analysis of ecto-nucleotide pyrophosphatase phosphodiesterase activity in brain membranes indicates involvement of NPP1 isoenzyme in extracellular hydrolysis of diadenosine polyphosphates in central nervous system
Neurochem. Int.
50
581-590
2007
Rattus norvegicus
Keppetipola, N.; Shuman, S.
Characterization of the 2,3 cyclic phosphodiesterase activities of Clostridium thermocellum polynucleotide kinase-phosphatase and bacteriophage lambda phosphatase
Nucleic Acids Res.
35
7721-7732
2007
Acetivibrio thermocellus
Dhule, S.S.; Shetty, P.R.; Iyer, J.L.; Singhal, R.S.
Purification and characterization of 5-phosphodiesterase from germinated barley
Process Biochem.
41
1899-1902
2006
Hordeum vulgare
-
Miller, D.J.; Shuvalova, L.; Evdokimova, E.; Savchenko, A.; Yakunin, A.F.; Anderson, W.F.
Structural and biochemical characterization of a novel Mn2+-dependent phosphodiesterase encoded by the yfcE gene
Protein Sci.
16
1338-1348
2007
Escherichia coli
Singh, S.K.; Singh, S.S.; Pandey, V.D.; Mishra, A.K.
Factors modulating alkaline phosphatase activity in the diazotrophic rice-field cyanobacterium, Anabaena oryzae
World J. Microbiol. Biotechnol.
22
927-935
2006
Nostoc oryzae
-
Lassila, J.K.; Herschlag, D.
Promiscuous sulfatase activity and thio-effects in a phosphodiesterase of the alkaline phosphatase superfamily
Biochemistry
47
12853-12859
2008
Xanthomonas axonopodis
Hatch, N.E.; Franceschi, R.T.
Osteoblast differentiation stage-specific expression of the pyrophosphate-generating enzyme PC-1
Cells Tissues Organs
189
65-69
2009
Mus musculus (P06802)
Keene, K.L.; Mychaleckyj, J.C.; Smith, S.G.; Leak, T.S.; Perlegas, P.S.; Langefeld, C.D.; Freedman, B.I.; Rich, S.S.; Bowden, D.W.; Sale, M.M.
Association of the distal region of the ectonucleotide pyrophosphatase/phosphodiesterase 1 gene with type 2 diabetes in an African-American population enriched for nephropathy
Diabetes
57
1057-1062
2008
Homo sapiens
Goldfine, I.D.; Maddux, B.A.; Youngren, J.F.; Reaven, G.; Accili, D.; Trischitta, V.; Vigneri, R.; Frittitta, L.
The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities
Endocr. Rev.
29
62-75
2008
Homo sapiens
Deikus, G.; Condon, C.; Bechhofer, D.H.
Role of Bacillus subtilis RNase J1 endonuclease and 5'-exonuclease activities in trp leader RNA turnover
J. Biol. Chem.
283
17158-17167
2008
Bacillus subtilis, Bacillus subtilis BG581
Santoro, N.; Cirillo, G.; Lepore, M.G.; Palma, A.; Amato, A.; Savarese, P.; Marzuillo, P.; Grandone, A.; Perrone, L.; Del Giudice, E.M.
Effect of the rs997509 polymorphism on the association between ectonucleotide pyrophosphatase phosphodiesterase 1 and metabolic syndrome and impaired glucose tolerance in childhood obesity
J. Clin. Endocrinol. Metab.
94
300-305
2009
Homo sapiens
Takahama, Y.; Uto, H.; Kanmura, S.; Oketani, M.; Ido, A.; Kusumoto, K.; Hasuike, S.; Nagata, K.; Hayashi, K.; Stuver, S.; Okayama, A.; Tsubouchi, H.
Association of a genetic polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase 1 with hepatitis C virus infection and hepatitis C virus core antigen levels in subjects in a hyperendemic area of Japan
J. Gastroenterol.
43
942-950
2008
Homo sapiens
Jonas, S.; van Loo, B.; Hyvoenen, M.; Hollfelder, F.
A new member of the alkaline phosphatase superfamily with a formylglycine nucleophile: structural and kinetic characterisation of a phosphonate monoester hydrolase/phosphodiesterase from Rhizobium leguminosarum
J. Mol. Biol.
384
120-136
2008
Rhizobium leguminosarum
Yang, X.C.; Sullivan, K.D.; Marzluff, W.F.; Dominski, Z.
Studies of the 5' exonuclease and endonuclease activities of CPSF-73 in histone pre-mRNA processing
Mol. Cell. Biol.
29
31-42
2009
Mus musculus
Patel, S.D.; Habeski, W.M.; Cheng, A.C.; de la Cruz, E.; Loh, C.; Kablaoui, N.M.
Quinazolin-4-piperidin-4-methyl sulfamide PC-1 inhibitors: alleviating hERG interactions through structure based design
Bioorg. Med. Chem. Lett.
19
3339-3343
2009
Homo sapiens
Laddha, S.S.; Bhatnagar, S.P.
A new therapeutic approach in Parkinsons disease: some novel quinazoline derivatives as dual selective phosphodiesterase 1 inhibitors and anti-inflammatory agents
Bioorg. Med. Chem.
17
6796-6802
2009
Bos taurus, Rattus norvegicus
Li, Y.; Liu, J.; Hudson, M.; Kim, S.; Hatch, N.E.
FGF2 promotes Msx2 stimulated PC-1 expression via Frs2/MAPK signaling
J. Cell. Biochem.
111
1346-1358
2010
Homo sapiens
Ortiz-Capisano, M.C.; Liao, T.D.; Ortiz, P.A.; Beierwaltes, W.H.
Calcium-dependent phosphodiesterase 1C inhibits renin release from isolated juxtaglomerular cells
Am. J. Physiol. Regul. Integr. Comp. Physiol.
297
R1469-R1476
2009
Mus musculus
Shimizu, K.; Murata, T.; Watanabe, Y.; Sato, C.; Morita, H.; Tagawa, T.
Characterization of phosphodiesterase 1 in human malignant melanoma cell lines
Anticancer Res.
29
1119-1122
2009
Homo sapiens
Khan, K.M.; Fatima, N.; Rasheed, M.; Jalil, S.; Ambreen, N.; Perveen, S.; Choudhary, M.I.
1,3,4-Oxadiazole-2(3H)-thione and its analogues: a new class of non-competitive nucleotide pyrophosphatases/phosphodiesterases 1 inhibitors
Bioorg. Med. Chem.
17
7816-7822
2009
Bothrops atrox, Homo sapiens
Cygnar, K.D.; Zhao, H.
Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons
Nat. Neurosci.
12
454-462
2009
Mus musculus
Cai, Y.; Miller, C.L.; Nagel, D.J.; Jeon, K.I.; Lim, S.; Gao, P.; Knight, P.A.; Yan, C.
Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells
Arterioscler. Thromb. Vasc. Biol.
31
616-623
2011
Rattus norvegicus
Interthal, H.; Champoux, J.J.
Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1
Biochem. J.
436
559-566
2011
Homo sapiens
Perego, P.; Cossa, G.; Tinelli, S.; Corna, E.; Carenini, N.; Gatti, L.; De Cesare, M.; Ciusani, E.; Zunino, F.; Luison, E.; Canevari, S.; Zaffaroni, N.; Beretta, G.L.
Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition
Biochem. Pharmacol.
83
27-36
2011
Homo sapiens
Aerts, I.; Grobben, B.; Van Ostade, X.; Slegers, H.
Cyclic AMP-dependent down regulation of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) in rat C6 glioma
Eur. J. Pharmacol.
654
1-9
2011
Rattus norvegicus (Q924C3), Rattus norvegicus Wistar (Q924C3)
Lebedeva, N.A.; Rechkunova, N.I.; Lavrik, O.I.
AP-site cleavage activity of tyrosyl-DNA phosphodiesterase 1
FEBS Lett.
585
683-686
2011
Homo sapiens
Giachini, F.R.; Lima, V.V.; Carneiro, F.S.; Tostes, R.C.; Webb, R.C.
Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1
Hypertension
57
655-663
2011
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Banerjee, B.; Roy, A.; Sen, N.; Majumder, H.K.
A tyrosyl DNA phosphodiesterase 1 from kinetoplastid parasite Leishmania donovani (LdTdp1) capable of removing topo I-DNA covalent complexes
Mol. Microbiol.
78
119-137
2010
Leishmania donovani (C8CT07), Leishmania donovani
Fehr, M.; Baechler, S.; Kropat, C.; Mielke, C.; Boege, F.; Pahlke, G.; Marko, D.
Repair of DNA damage induced by the mycotoxin alternariol involves tyrosyl-DNA phosphodiesterase 1
Mycotoxin Res.
26
247-256
2010
Homo sapiens
Kaneko, K.; Yamada, C.; Yanagida, A.; Koshu, T.; Umezawa, Y.; Itoh, K.; Hori, H.; Mitsui, T.
Differential localizations and functions of rice nucleotide pyrophosphatase/phosphodiesterase isozymes 1 and 3
Plant Biotechnol.
28
69-76
2011
Oryza sativa (Q10Q09), Oryza sativa (Q6ZI95)
-
Lee, S.Y.; Kim, H.; Hwang, H.J.; Jeong, Y.M.; Na, S.H.; Woo, J.C.; Kim, S.G.
Identification of tyrosyl-DNA phosphodiesterase as a novel DNA damage repair enzyme in Arabidopsis
Plant Physiol.
154
1460-1469
2010
Homo sapiens, Arabidopsis thaliana (Q8H1D9)
Conda-Sheridan, M.; Reddy, P.V.; Morrell, A.; Cobb, B.T.; Marchand, C.; Agama, K.; Chergui, A.; Renaud, A.; Stephen, A.G.; Bindu, L.K.; Pommier, Y.; Cushman, M.
Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1)
J. Med. Chem.
56
182-200
2013
Homo sapiens
Lebedeva, N.A.; Rechkunova, N.I.; El-Khamisy, S.F.; Lavrik, O.I.
Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites
Biochimie
94
1749-1753
2012
Homo sapiens
Lebedeva, N.A.; Rechkunova, N.I.; Ishchenko, A.A.; Saparbaev, M.; Lavrik, O.I.
The mechanism of human tyrosyl-DNA phosphodiesterase 1 in the cleavage of AP site and its synthetic analogs
DNA Repair
12
1037-1042
2013
Homo sapiens
Comeaux, E.Q.; van Waardenburg, R.C.
Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target
Drug Metab. Rev.
46
494-507
2014
Canis lupus familiaris (E2REL5), Gallus gallus (F1NSQ5), Saccharomyces cerevisiae (P38319), Rattus norvegicus (Q4G056), Mus musculus (Q8BJ37), Homo sapiens (Q9NUW8), Drosophila melanogaster (Q9VQM4), Saccharomyces cerevisiae ATCC 204508 (P38319)
Murai, J.; Huang, S.Y.; Das, B.B.; Dexheimer, T.S.; Takeda, S.; Pommier, Y.
Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells
J. Biol. Chem.
287
12848-12857
2012
Gallus gallus, Homo sapiens
Traini, M.; Quinn, C.M.; Sandoval, C.; Johansson, E.; Schroder, K.; Kockx, M.; Meikle, P.J.; Jessup, W.; Kritharides, L.
Sphingomyelin phosphodiesterase-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages
J. Biol. Chem.
289
32895-32913
2014
Mus musculus (P70158), Homo sapiens (Q92484), Homo sapiens, Mus musculus C57 black (P70158)
Nguyen, T.X.; Morrell, A.; Conda-Sheridan, M.; Marchand, C.; Agama, K.; Bermingham, A.; Bermingam, A.; Stephen, A.G.; Chergui, A.; Naumova, A.; Fisher, R.; OKeefe, B.R.; Pommier, Y.; Cushman, M.
Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors
J. Med. Chem.
55
4457-4478
2012
Homo sapiens
Lv, P.C.; Agama, K.; Marchand, C.; Pommier, Y.; Cushman, M.
Design, synthesis, and biological evaluation of O-2-modified indenoisoquinolines as dual topoisomerase I-tyrosyl-DNA phosphodiesterase I inhibitors
J. Med. Chem.
57
4324-4336
2014
Homo sapiens
Nadel, Y.; Lecka, J.; Gilad, Y.; Ben-David, G.; Foerster, D.; Reiser, G.; Kenigsberg, S.; Camden, J.; Weisman, G.A.; Senderowitz, H.; Sevigny, J.; Fischer, B.
Highly potent and selective ectonucleotide pyrophosphatase/phosphodiesterase I inhibitors based on an adenosine 5-(alpha or gamma)-thio-(alpha,beta- or beta,gamma)-methylenetriphosphate scaffold
J. Med. Chem.
57
4677-4691
2014
Homo sapiens
Guo, D.; Dexheimer, T.S.; Pommier, Y.; Nash, H.A.
Neuroprotection and repair of 3-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1)
Proc. Natl. Acad. Sci. USA
111
15816-15820
2014
Drosophila melanogaster
Zakharenko, A.; Khomenko, T.; Zhukova, S.; Koval, O.; Zakharova, O.; Anarbaev, R.; Lebedeva, N.; Korchagina, D.; Komarova, N.; Vasiliev, V.; Reynisson, J.; Volcho, K.; Salakhutdinov, N.; Lavrik, O.
Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety
Bioorg. Med. Chem.
23
2044-2052
2015
Homo sapiens (Q9NKW8)
Khomenko, T.; Zakharenko, A.; Odarchenko, T.; Arabshahi, H.J.; Sannikova, V.; Zakharova, O.; Korchagina, D.; Reynisson, J.; Volcho, K.; Salakhutdinov, N.; Lavrik, O.
New inhibitors of tyrosyl-DNA phosphodiesterase I (Tdp 1) combining 7-hydroxycoumarin and monoterpenoid moieties
Bioorg. Med. Chem.
24
5573-5581
2016
Homo sapiens (Q9NUW8)
Bautista Nino, P.K.; Durik, M.; Danser, A.H.; de Vries, R.; Musterd-Bhaggoe, U.M.; Meima, M.E.; Kavousi, M.; Ghanbari, M.; Hoeijmakers, J.H.; O'Donnell, C.J.; Franceschini, N.; Janssen, G.M.; De Mey, J.G.; Liu, Y.; Shanahan, C.M.; Franco, O.H.; Dehghan, A.; Roks, A.J.
Phosphodiesterase 1 regulation is a key mechanism in vascular aging
Clin. Sci.
129
1061-1075
2015
Homo sapiens
Comeaux, E.Q.; Cuya, S.M.; Kojima, K.; Jafari, N.; Wanzeck, K.C.; Mobley, J.A.; Bjornsti, M.A.; van Waardenburg, R.C.
Tyrosyl-DNA phosphodiesterase I catalytic mutants reveal an alternative nucleophile that can catalyze substrate cleavage
J. Biol. Chem.
290
6203-6214
2015
Saccharomyces cerevisiae (P38319), Saccharomyces cerevisiae
Li-Zhulanov, N.S.; Zakharenko, A.L.; Chepanova, A.A.; Patel, J.; Zafar, A.; Volcho, K.P.; Salakhutdinov, N.F.; Reynisson, J.; Leung, I.K.H.; Lavrik, O.I.
A novel class of tyrosyl-DNA phosphodiesterase 1 inhibitors that contains the octahydro-2H-chromen-4-ol scaffold
Molecules
23
E2468
2018
Homo sapiens (Q9NUW8)
Borda, M.A.; Palmitelli, M.; Veron, G.; Gonzalez-Cid, M.; de Campos Nebel, M.
Tyrosyl-DNA-phosphodiesterase I (TDP1) participates in the removal and repair of stabilized-Top2alpha cleavage complexes in human cells
Mutat. Res.
781
37-48
2015
Homo sapiens (Q9NUW8), Homo sapiens
Cuya, S.M.; Comeaux, E.Q.; Wanzeck, K.; Yoon, K.J.; van Waardenburg, R.C.
Dysregulated human tyrosyl-DNA phosphodiesterase I acts as cellular toxin
Oncotarget
7
86660-86674
2016
Homo sapiens (Q9NUW8), Homo sapiens
Rechkunova, N.; Lebedeva, N.; Lavrik, O.
Tyrosyl-DNA phosphodiesterase 1 is a new player in repair of apurinic/apyrimidinic sites
Russ. J. Bioorg. Chem.
41
474-480
2015
Saccharomyces cerevisiae (P38319), Saccharomyces cerevisiae
Nale, S.; Jadhav, V.
Synthesis of tyrosyl-DNA phosphodiesterase I inhibitors
Tetrahedron Lett.
57
2652-2654
2016
Homo sapiens (Q9NUW8)
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