3.1.4.1: phosphodiesterase I

This is an abbreviated version!
For detailed information about phosphodiesterase I, go to the full flat file.

Word Map on EC 3.1.4.1

3.1.4.1

camp

phosphodiesterases

calcification

arterial

topoisomerase

rolipram

monophosphate

camp-specific

infancy

osteoblast

hypophosphatemic

rickets

camptothecin

pseudoxanthoma

ectoenzyme

topotecan

5'-nucleotide

elasticum

ibmx

ankylosis

3'-phosphate

zaprinast

top1-dna

camp-pde

tcf7l2

milrinone

qq

tissue-nonspecific

cgmp-inhibited

cgmp-stimulated

pyrophosphohydrolase

cilomilast

cementum

3-isobutyl-1-methylxanthine

rolipram-sensitive

vinpocetine

cardiotonic

pharmacology

medicine

synthesis

drug development

biotechnology

analysis

Reaction

Synonyms

5' nucleotide phosphodiesterase/alkaline phosphodiesterase I, 5'-exonuclease, 5'-NPDase, 5'-nucleotide phosphodiesterase, 5'-PDase, 5'-PDE, 5'-phosphodiesterase, 5'NPDE, alkaline phosphodiesterase, Ap3A (Ap4A) hydrolase, autotaxin, B10, calcium-dependent phosphodiesterase 1C, cleavage/polyadenylation specificity factor, CPSF-73, cRNPMase-5'-PDase, cyclic nucleotide phosphodiesterase 1, cyclic-ribonucleotide phosphomutase-5'-phosphodiesterase I, ecto-NPPase, ecto-nucleotide pyrophosphatase/phosphodiesterase 1, ectonucleotide pyrophosphatase phosphodiesterase 1, ectonucleotide pyrophosphatase/phosphodiesterase 1, ectonucleotide pyrophosphate/phosphodiesterase-1, ENPP-1, ENPP1, exonuclease I, exophosphodiesterase, gp130RB13-6, liver alkaline phosphodiesterase 1, liver nucleotide phosphodiesterase, More, NPP, NPP-1, NPP/PDE, NPP1, NPP2, NPP3, nucleotide phosphodiesterase, nucleotide phosphodiesterase/pyrophosphatase, nucleotide pyrophosphatase/alkaline phosphodiesterase I, nucleotide pyrophosphatase/phosphodiesterase 1, nucleotide pyrophosphatase/phosphodiesterase I, nucleotide pyrophosphatase/phosphodiesterase-1, nucleotide pyrophosphatase/phosphodiesterase-2, nucleotide pyrophosphatase/phosphodiesterase-3, orthophosphoric diester phosphohydrolase, PC-1, PDase, PDE, PDE 1A, PDE I, PDE1, PDE1A, PDE1C, PDE4A, PDEase, phosphodiesterase, phosphodiesterase 1, phosphodiesterase 1A, phosphodiesterase 1C, phosphonate monoester hydrolase/phosphodiesterase, phosphoric diester hydrolase, plant exonuclease I, plasma cell antigen 1, plasma cell membrane glycoprotein, plasma cell membrane protein-1, PMH, RNase J1, SMPDL3A, sphingomyelin phosphodiesterase, acid-like 3A, SVPD, Tdp 1, TDP1, tRNase Z, tyrosyl DNA phosphodiesterase 1, tyrosyl-DNA phosphodiesterase 1, tyrosyl-DNA phosphodiesterase I, tyrosyl-DNA-phosphodiesterase I, yfcE

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.4 Phosphoric-diester hydrolases

3.1.4.1 phosphodiesterase I

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Results	in table
24	Activating Compound
6877	AA Sequence
17	Application
1	CAS Registry Number
30	Cloned(Commentary)
2	Crystallization (Commentary)
1512	Disease/ Diagnostics
9	Expression
70	General Information
17	General Stability
127	IC50 Value
466	Inhibitors
4	kcat/KM [mM/s]
12	Ki Value [mM]
102	KM Value [mM]
57	Localization
107	Metals/Ions
48	Molecular Weight [Da]
40	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
363	Organism
66	PDB ID
49	pH Optimum
10	pH Range
10	pH Stability
21	Posttranslational Modification
56	Protein Variants
41	Purification (Commentary)
18	Reaction
3	Reaction Type
142	Reference
1	Renatured (Commentary)
149	Source Tissue
45	Specific Activity [micromol/min/mg]
9	Storage Stability
412	Substrates and Products (Substrate)
29	Subunits
212	Synonyms
1	Systematic Name
23	Temperature Optimum [°C]
3	Temperature Range [°C]
17	Temperature Stability [°C]
61	Turnover Number [1/s]

pH Stability

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pH Stability on EC 3.1.4.1 - phosphodiesterase I

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2 - 6

Aspergillus niger

FS-44: bifunctional enzyme: cyclic-ribonucleotide phosphomutase-5'-phosphodiesterase, stable between

208374

3 - 11

Homo sapiens

stable between

208358

3.3 - 5.3

Aspergillus niger

stable between

208363

3 entries

5.1

Sus scrofa

stable above in cold, but rapidly and apparently irreversibly inactivated at pH 4.5

208390

5.5 - 6.5

Flammulina velutipes

stable between

208393

6 - 10

Sus scrofa

stable between

208368

Beta vulgaris

stable at

208365