Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.1 extracted from

  • Sakura, H.; Nagashima, S.; Nakashima, A.; Maeda, M.
    Characterization of fetal serum 5'-nucleotide phosphodiesterase: A novel function as a platelet aggregation inhibitor in fetal circulation (1998), Thromb. Res., 91, 83-89.
    View publication on PubMed
Search for more literature for 3.1.4.1

Inhibitors

Inhibitors Comment Organism Structure
5'-nucleotides end-product inhibition Homo sapiens
ADP competitive Homo sapiens
AMP 5'-AMP, but 2'-AMP, 3'-AMP, 3': 5'cAMP and 2': 3'cAMP has no inhibiting effects; competitive; product inhibition Homo sapiens
ATP
-
 Homo sapiens
Citric acid slight inhibition Homo sapiens
cystine slight inhibition Homo sapiens
diphosphate slight inhibition Homo sapiens
EDTA
-
 Homo sapiens
EGTA
-
 Homo sapiens
additional information no inhibition by adenosine, inosine, phenylalanine and caffeine Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
128000
-
 fetal, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme may be involved in nucleotides metabolism in human plasma ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 fetal, origin of the fetal serum PDEase might be a soluble form of human PC-1, a plasma cell membrane glycoprotein, with a molecular weight of 130000 Da, which possesses alkaline phosphodiesterase I and nucleotide pyrophosphatase activity
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
serum umbilical cord blood serum Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.103
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + H2O ADPase activity, hydrolysis of ADP by human plasma PDEase acts as an inhibitor of platelet aggregation Homo sapiens AMP + phosphate
-
 ?
additional information enzyme may be involved in nucleotides metabolism in human plasma Homo sapiens ?
-
 ?
oligonucleotides + H2O specific for 3'-5'-direction from the 3'-hydroxyl terminal in a stepwise manner Homo sapiens oligonucleotides(n-1) + 5'-mononucleotides
-
 ?
p-nitrophenylthymidine 5'-phosphate + H2O
-
 Homo sapiens 5'-TMP + p-nitrophenol
-
 ?

Synonyms

Synonyms Comment Organism
PDEase
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.9
-
-
 Homo sapiens