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Literature summary for 3.1.4.1 extracted from
- Comparative study of the enzymatic properties of phosphodiesterases I from the plasma membrane of lactating bovine mammary gland and bovine milk fat globule membrane (1989), Agric. Biol. Chem., 53, 607-613.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | - |
Bos taurus |  |
| Cu2+ | - |
Bos taurus | |
| EDTA | - |
Bos taurus | |
| Mn2+ | - |
Bos taurus | |
| additional information | no inhibition by anions | Bos taurus | |
| Ni2+ | - |
Bos taurus | |
| Zn2+ | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.6 | - |
p-nitrophenylthymidine 5'-phosphate | milk fat globule membrane | Bos taurus | |
| 1.7 | - |
p-nitrophenylthymidine 5'-phosphate | cytoplasmic membrane of mammary gland | Bos taurus | |
| 8 | - |
bis(p-nitrophenyl) phosphate | milk fat globule membrane | Bos taurus | |
| 14.4 | - |
bis(p-nitrophenyl) phosphate | cytoplasmic membrane of mammary gland | Bos taurus | |
| 152.2 | - |
p-Nitrophenyl phenylphosphonate | cytoplasmic membrane of mammary gland | Bos taurus | |
| 202 | - |
p-Nitrophenyl phenylphosphonate | milk fat globule membrane | Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasmic membrane | mammary gland | Bos taurus | - |
- |
| lipid particle | milk fat | Bos taurus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | slight activation | Bos taurus | |
| divalent cations | required for activity | Bos taurus | |
| Mg2+ | slight activation | Bos taurus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Bos taurus | the enzyme may be important in nucleotide metabolism on the cell surface | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial, milk fat globule membrane | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mammary gland | - |
Bos taurus | - |
| milk fat | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Bos taurus |
| 0.03 | - |
cytoplasmic membrane of mammary gland | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| bis(p-nitrophenyl) phosphate + H2O | - |
Bos taurus | ? | - |
? | |
| additional information | no activity with p-nitrophenylthymidine 3'-phosphate | Bos taurus | ? | - |
? | |
| additional information | the enzyme may be important in nucleotide metabolism on the cell surface | Bos taurus | ? | - |
? | |
| p-nitrophenyl phenylphosphonate + H2O | - |
Bos taurus | p-nitrophenol + benzenephosphonic acid | - |
? | |
| p-nitrophenylthymidine 5'-phosphate + H2O | - |
Bos taurus | 5'-TMP + p-nitrophenol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alkaline phosphodiesterase | - |
Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9.5 | 9.6 | - |
Bos taurus |
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