Reference on EC 3.1.26.5 - ribonuclease P
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Altman, S.
Ribonuclease P: an enzyme with a catalytic RNA subunit
Adv. Enzymol. Relat. Areas Mol. Biol.
62
1-36
1989
Bos taurus, Escherichia coli, Haloferax volcanii, Homo sapiens
Cech, T.R.; Bass, B.L.
Biological catalysis by RNA
Annu. Rev. Biochem.
55
599-629
1986
Bacillus subtilis, Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Pace, N.R.; Smith, D.
Ribonuclease P: function and variation
J. Biol. Chem.
265
3587-3590
1990
Bacillus subtilis, Saccharomyces cerevisiae, Homo sapiens, Schizosaccharomyces pombe, Xenopus laevis
Altman, S.; Baer, M.F.; Bartkiewicz, M.; Gold, H.; Guerrier-Takada, C.; Kirsebom, L.A.; Lumelsky, N.; Peck, K.
Catalysis by the RNA subunit of RNase P - a minireview
Gene
82
63-64
1989
Escherichia coli
Vioque, A.; Arnez, J.; Altman, S.
Protein-RNA interactions in the RNase P holoenzyme from Escherichia coli
J. Mol. Biol.
202
835-848
1988
Escherichia coli
James, B.D.; Olsen, G.J.; Liu, J.; Pace, N.R.
The secondary structure of ribonuclease P RNA, the catalytic element of a ribonucleoprotein enzyme
Cell
52
19-26
1988
Geobacillus stearothermophilus, Brevibacillus brevis, Priestia megaterium, Bacillus subtilis, Escherichia coli, Pseudomonas fluorescens
Guerrier-Takada, C.; van Belkum, A.; Pleij, C.W.A.; Altman, S.
Novel reactions of RNAase P with a tRNA-like structure in turnip yellow mosaic virus RNA
Cell
53
267-272
1988
Escherichia coli
Reich, C.; Gardiner, K.J.; Olsen, G.J.; Pace, B.; Marsh, T.L.; Pace, N.P.
The RNA component of the Bacillus subtilis RNase P. Sequence, activity, and partial secondary structure
J. Biol. Chem.
261
7888-7893
1986
Bacillus subtilis
Gold, H.A.; Altman, S.
Reconstitution of RNAase P activity using inactive subunits from E. coli and HeLa cells
Cell
44
243-249
1986
Escherichia coli, Homo sapiens
Guerrier-Takada, C.; Haydock, K.; Allen, L.; Altman, S.
Metal ion requirements and other aspects of the reaction catalyzed by M1 RNA, the RNA subunit of ribonuclease P from Escherichia coli
Biochemistry
25
1509-1515
1986
Escherichia coli
Gardiner, K.J.; Marsh, T.L.; Pace, N.R.
Ion dependence of the Bacillus subtilis RNase P reaction
J. Biol. Chem.
260
5415-5419
1985
Bacillus subtilis
Guerrier-Takada, C.; Gardiner, K.; Marsh, T.; Pace, N.; Altman, S.
The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
Cell
35
849-857
1983
Bacillus subtilis, Escherichia coli
Sakamoto, H.; Kimura, N.; Nagawa, F.; Shimura, Y.
Nucleotide sequence and stability of the RNA component of RNase P from a temperature-sensitive mutant of E. coli
Nucleic Acids Res.
11
8237-8251
1983
Escherichia coli
Kole, R.; Altman, S.
Properties of purified ribonuclease P from Escherichia coli
Biochemistry
20
1902-1906
1981
Escherichia coli
Bothwell, A.L.M.; Stark, B.C.; Altman, S.
Ribonuclease P substrate specificity: cleavage of a bacteriophage phi80-induced RNA
Proc. Natl. Acad. Sci. USA
73
1912-1916
1976
Escherichia coli
Gardiner, K.; Pace, N.R.
RNase P of Bacillus subtilis has a RNA component
J. Biol. Chem.
255
7507-7509
1980
Bacillus subtilis
Kole, R.; Baer, M.F.; Stark, B.C.; Altman, S.
E. coli RNAase P has a required RNA component in vivo
Cell
19
881-887
1980
Escherichia coli
Stark, B.C.; Kole, R.; Bowman, E.J.; Altman, S.
Ribonuclease P: an enzyme with an essential RNA component
Proc. Natl. Acad. Sci. USA
75
3717-3721
1978
Escherichia coli
Brown, J.W.; Haas, E.S.; Pace, N.R.
Characterization of ribonuclease P RNAs from thermophilic bacteria
Nucleic Acids Res.
21
671-679
1993
Deinococcus radiodurans, Escherichia coli, Thermotoga maritima, Thermotoga neapolitana, Thermus aquaticus
Schmidt, F.J.; Seidman, J.G.; Bock, R.M.
Transfer ribonucleic acid biosynthesis. Substrate specificity of ribonuclease P
J. Biol. Chem.
251
2440-2445
1976
Escherichia coli, Escherichia coli MRE 600
Robertson, H.D.; Altman, S.; Smith, J.D.
Purification and properties of a specific Escherichia coli ribonuclease which cleaves a tyrosine transfer ribonucleic acid precursor
J. Biol. Chem.
247
5243-5251
1972
Escherichia coli, Escherichia coli MRE 600
Carter, B.J.; Vold, B.S.; Hecht, S.M.
Control of the position of RNase P-mediated transfer RNA precursor processing
J. Biol. Chem.
265
7100-7103
1990
Escherichia coli
Koski, R.A.; Bothwell, A.L.M.; Altman, S.
Identification of a ribonuclease P-like activity from human KB cells
Cell
9
101-116
1976
Escherichia coli, Homo sapiens
Leontis, N.; DaLio, A.; Strobel, M.; Engelke, D.
Effects of tRNA-intron structure on cleavage of precursor tRNAs by RNase P from Saccharomyces cerevisiae
Nucleic Acids Res.
16
2537-2552
1988
Saccharomyces cerevisiae
Hollingsworth, M.J.; Martin, N.C.
RNase P activity in the mitochondria of Saccharomyces cerevisiae depends on both mitochondrion and nucleus-encoded components
Mol. Cell. Biol.
6
1058-1064
1986
Saccharomyces cerevisiae
Lee, J.Y.; Engelke, D.R.
Partial characterization of an RNA component that copurifies with Saccharomyces cerevisiae RNase P
Mol. Cell. Biol.
9
2536-2543
1989
Saccharomyces cerevisiae
Kilani, A.F.; Jo, S.; Kim, J.; Nepomuceno, E.; Trang, P.; Liu, F.
Characterization of a RNase P ribozyme variant that efficiently cleaves the mRNA sequences of human herpes simplex virus 1
Nucleic Acids Symp. Ser.
41
21-23
1999
Escherichia coli
-
Kirsebom, L.
Inhibition and other aspects of RNase P cleavage
Nucleic Acids Symp. Ser.
41
17-20
1999
Escherichia coli
-
Kline, L.; Nishikawa, S.; Soel, D.
Partial purification of RNase P from Schizosaccharomyces pombe
J. Biol. Chem.
256
5058-5063
1981
Schizosaccharomyces pombe
Drainas, D.; Zimmerly, S.; Willis, I.; Soell, D.
Substrate structural requirements of Schizosaccharomyces pombe RNase P
FEBS Lett.
251
84-88
1989
Schizosaccharomyces pombe
Doersen, C.J.; Guerrier-Takada, C.; Altman, S.; Attardi, G.
Characterization of an RNase P activity from HeLa cell mitochondria. Comparison with the cytosol RNase P activity
J. Biol. Chem.
260
5942-5949
1985
Homo sapiens
Akaboshi, E.; Guerrier-Takada, C.; Altman, S.
Veal heart ribonuclease P has an essential RNA component
Biochem. Biophys. Res. Commun.
96
831-837
1980
Bos taurus
Bowman, E.J.; Altman, S.
Identification of ribonuclease P activity from chick embryos
Biochim. Biophys. Acta
613
439-447
1980
Gallus gallus
Lawrence, N.; Wesolowski, D.; Gold, H.; Bartkiewicz, M.; Guerrier-Takada, C.; McClain, W.H.; Altman, S.
Characteristics of ribonuclease P from various organisms
Cold Spring Harbor Symp. Quant. Biol.
52
233-238
1987
Escherichia coli, Haloferax volcanii
Puttaraju, M.; Beebe, J.A.; Niranjanakumari, S.; Been, M.D.; Fierke, C.A.
Generation and characterization of circular Bacillus subtilis RNase P RNA; activation by RNase P protein
Nucleic Acids Symp. Ser.
33
92-94
1995
Bacillus subtilis
Tranguch, A.J.; Kindelberger, D.W.; Rohlman, C.E.; Lee, J.Y.; Engelke, D.R.
Structure-sensitive RNA footprinting of yeast nuclear ribonuclease P
Biochemistry
33
1778-1787
1994
Saccharomyces cerevisiae
LaGrandeur, T.E.; Darr, S.C.; Haas, E.S.; Pace, N.R.
Characterization of the RNase P RNA of Sulfolobus acidocaldarius
J. Bacteriol.
175
5043-5048
1993
Sulfolobus acidocaldarius
Baer, M.F.; Arnez, J.G.; Guerrier-Takada, C.; Vioque, A.; Altman, S.
Preparation and characterization of RNase P from Escherichia coli
Methods Enzymol.
181
569-582
1990
Escherichia coli
Jayanthi, G.P.; van Tuyle, G.C.
Characterization of ribonuclease P isolated from rat liver cytosol
Arch. Biochem. Biophys.
296
264-270
1992
Rattus norvegicus
Roselli, D.M.; Marsh, T.L.
Purification and characterization of RNase P from Clostridium sporogenes
Mol. Microbiol.
4
1393-1400
1990
Clostridium sporogenes
Kilani, A.F.; Trang, P.; Jo, S.; Hsu, A.; Kim, J.; Nepomuceno, E.; Liou, K.; Liu, F.
RNase P ribozymes selected in vitro to cleave a viral mRNA effectively inhibit its expression in cell culture
J. Biol. Chem.
275
10611-10622
2000
Escherichia coli
Niranjanakumari, S.; Kurz, J.C.; Fierke, C.A.
Expression, purification and characterization of the recombinant ribonuclease P protein component from Bacillus subtilis
Nucleic Acids Res.
26
3090-3096
1998
Bacillus subtilis
Cordier, A.; Schoen, A.
Cyanelle RNase P: RNA structure analysis and holoenzyme properties of an organellar ribonucleoprotein enzyme
J. Mol. Biol.
289
9-20
1999
Cyanophora paradoxa
Lee, Y.C.; Lee, B.J.; Hwang, D.S.; Kang, H.S.
Purification and characterization of mitochondrial ribonuclease P from Aspergillus nidulans
Eur. J. Biochem.
235
289-296
1996
Aspergillus nidulans
Han, S.J.; Lee, B.J.; Kang, H.S.
Purification and characterization of the nuclear ribonuclease P of Aspergillus nidulans
Eur. J. Biochem.
251
244-251
1998
Aspergillus nidulans
Stathopoulos, C.; Kalpaxis, D.L.; Drainas, D.
Partial purification and characterization of RNase P from Dictyostelium discoideum
Eur. J. Biochem.
228
976-980
1995
Dictyostelium discoideum
Andrews, A.J.; Brown, J.W.
The partial purification of Methanococcus jannaschii RNase P holoenzyme
Nucleic Acids Symp. Ser.
41
60-62
1999
Methanothermobacter thermautotrophicus, Methanocaldococcus jannaschii
-
Pascual, A.; Vioque, A.
Cloning, purification and characterization of the protein subunit of ribonuclease P from the cyanobacterium Synechocystis sp. PCC 6803
Eur. J. Biochem.
241
17-24
1996
Synechocystis sp., Escherichia coli
Jarrous, N.; Eder, P.S.; Guerrier-Takada, C.; Hoog, C.; Altman,S.
Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P
RNA
4
407-417
1998
Homo sapiens
Rossmanith, W.; Karwan, R.M.
Characterization of human mitochondrial RNase P: novel aspects in tRNA processing
Biochem. Biophys. Res. Commun.
247
234-241
1998
Homo sapiens
Baer, M.F.; Reilly, R.M.; McCorkle, G.M.; Hai, T.Y.; Altman, S.; RajBhandary, U.L.
The recognition by RNaseP of precursor tRNAs
J. Biol. Chem.
263
2344-2351
1988
Escherichia coli
Fingerhut, C.; Schoen, A.
Sequence and functional characterization of RNase P RNA from the chl alb containing cyanobacterium Prochlorothrix hollandica
FEBS Lett.
428
161-164
1998
Prochlorothrix hollandica
Xiao, S.; Scott, F.; Fierke, C.A.; Engelke, D.R.
Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes
Annu. Rev. Biochem.
71
165-189
2002
Bacillus subtilis, Cyanophora paradoxa, Escherichia coli, Homo sapiens, Methanothermobacter thermautotrophicus, Nicotiana tabacum, Saccharomyces cerevisiae, Spinacia oleracea
Takagi, H.; Watanabe, M.; Kakuta, Y.; Kamachi, R.; Numata, T.; Tanaka, I.; Kimura, M.
Crystal structure of the ribonuclease P protein Ph1877p from hyperthermophilic archaeon Pyrococcus horikoshii OT3
Biochem. Biophys. Res. Commun.
319
787-794
2004
Pyrococcus horikoshii (O59543), Pyrococcus horikoshii OT-3 (O59543)
Andrews, A.J.; Hall, T.A.; Brown, J.W.
Characterization of RNase P holoenzymes from Methanococcus jannaschii and Methanothermobacter thermoautotrophicus
Biol. Chem.
382
1171-1177
2001
Methanocaldococcus jannaschii, Methanothermobacter thermautotrophicus
Ando, T.; Tanaka, T.; Hori, Y.; Kikuchi, Y.
Kinetics of hyperprocessing reaction of human tyrosine tRNA by ribonuclease P ribozyme from Escherichia coli
Biosci. Biotechnol. Biochem.
66
1967-1971
2002
Escherichia coli
Ando, T.; Tanaka, T.; Kikuchi, Y.
Comparative analyses of hairpin substrate recognition by Escherichia coli and Bacillus subtilis ribonuclease P ribozymes
Biosci. Biotechnol. Biochem.
67
1825-1827
2003
Bacillus subtilis, Escherichia coli
Kurz, J.C.; Fierke, C.A.
Ribonuclease P: a ribonucleoprotein enzyme
Curr. Opin. Chem. Biol.
4
553-558
2000
Bacillus subtilis, Escherichia coli, Staphylococcus aureus
Harris, M.E.; Christian, E.L.
Recent insights into the structure and function of the ribonucleoprotein enzyme ribonuclease P
Curr. Opin. Struct. Biol.
13
325-333
2003
Bacillus subtilis, Escherichia coli
Christian, E.L.; Kaye, N.M.; Harris, M.E.
Evidence for a polynuclear metal ion binding site in the catalytic domain of ribonuclease P RNA
EMBO J.
21
2253-2262
2002
Escherichia coli
Gopalan, V.; Vioque, A.; Altman, S.
RNase P: variations and uses
J. Biol. Chem.
277
6759-6762
2002
Aspergillus nidulans, Bacillus subtilis, Cyanophora paradoxa, Escherichia coli, Homo sapiens, Leishmania sp., Mus musculus, Saccharomyces cerevisiae, Trypanosoma sp.
Xiao, S.; Houser-Scott, F.; Engelke, D.R.
Eukaryotic ribonuclease P: increased complexity to cope with the nuclear pre-tRNA pathway
J. Cell. Physiol.
187
11-20
2001
Bacillus subtilis, Bacteria, Saccharomyces cerevisiae, Cyanophora paradoxa, Homo sapiens, Spinacia oleracea
Christian, E.L.; Zahler, N.H.; Kaye, N.M.; Harris, M.E.
Analysis of substrate recognition by the ribonucleoprotein endonuclease RNase P
Methods
28
307-322
2002
Bacillus subtilis, Escherichia coli, Staphylococcus aureus
Salavati, R.; Panigrahi, A.K.; Stuart, K.D.
Mitochondrial ribonuclease P activity of Trypanosoma brucei
Mol. Biochem. Parasitol.
115
109-117
2001
Trypanosoma brucei
Mann, H.; Ben-asouli, Y.; Schein, A.; Moussa, S.; Jarrous, N.
Eukaryotic RNase P: role of RNA and protein subunits of a primordial catalytic ribonucleoprotein in RNA-based catalysis
Mol. Cell
12
925-935
2003
Homo sapiens
Hansen, A.; Pfeiffer, T.; Zuleeg, T.; Limmer, S.; Ciesiolka, J.; Feltens, R.; Hartmann, R.K.
Exploring the minimal substrate requirements for trans-cleavage by RNase P holoenzymes from Escherichia coli and Bacillus subtilis
Mol. Microbiol.
41
131-143
2001
Bacillus subtilis, Escherichia coli
Krasilnikov, A.S.; Yang, X.; Pan, T.; Mondragon, A.
Crystal structure of the specificity domain of ribonuclease P
Nature
421
760-764
2003
Bacillus subtilis
Paul, R.; Lazarev, D.; Altman, S.
Characterization of RNase P from Thermotoga maritima
Nucleic Acids Res.
29
880-885
2001
Thermotoga maritima
Thomas, B.C.; Li, X.; Gegenheimer, P.
Chloroplast ribonuclease P does not utilize the ribozyme-type pre-tRNA cleavage mechanism
RNA
6
545-553
2000
Spinacia oleracea
Thomas, B.C.; Chamberlain, J.; Engelke, D.R.; Gegenheimer, P.
Evidence for an RNA-based catalytic mechanism in eukaryotic nuclear ribonuclease P
RNA
6
554-562
2000
Saccharomyces cerevisiae
Jarrous, N.
Human ribonuclease P: subunits, function, and intranuclear localization
RNA
8
1-7
2002
Saccharomyces cerevisiae, Homo sapiens
Guerrier-Takada, C.; Eder, P.S.; Gopalan, V.; Altman, S.
Purification and characterization of Rpp25, an RNA-binding protein subunit of human ribonuclease P
RNA
8
290-295
2002
Homo sapiens
Zahler, N.H.; Christian, E.L.; Harris, M.E.
Recognition of the 5' leader of pre-tRNA substrates by the active site of ribonuclease P
RNA
9
734-745
2003
Escherichia coli
Fukuhara, H.; Kifusa, M.; Watanabe, M.; Terada, A.; Honda, T.; Numata, T.; Kakuta, Y.; Kimura, M.
A fifth protein subunit Ph1496p elevates the optimum temperature for the ribonuclease P activity from Pyrococcus horikoshii OT3
Biochem. Biophys. Res. Commun.
343
956-964
2006
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Kakuta, Y.; Ishimatsu, I.; Numata, T.; Kimura, K.; Yao, M.; Tanaka, I.; Kimura, M.
Crystal structure of a ribonuclease P protein Ph1601p from Pyrococcus horikoshii OT3: an archaeal homologue of human nuclear ribonuclease P protein Rpp21
Biochemistry
44
12086-12093
2005
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Henkels, C.H.; Oas, T.G.
Thermodynamic characterization of the osmolyte- and ligand-folded states of Bacillus subtilis ribonuclease P protein
Biochemistry
44
13014-13026
2005
Bacillus subtilis (P25814), Bacillus subtilis
Rueda, D.; Hsieh, J.; Day-Storms, J.J.; Fierke, C.A.; Walter, N.G.
The 5' leader of precursor tRNAAsp bound to the Bacillus subtilis RNase P holoenzyme has an extended conformation
Biochemistry
44
16130-16139
2005
Bacillus subtilis
Tanaka, T.; Ando, T.; Haga, S.; Kikuchi, Y.
Examining the bases of the J3/4 domain of Escherichia coli ribonuclease P
Biosci. Biotechnol. Biochem.
68
1388-1392
2004
Escherichia coli
Tanaka, T.; Nagai, Y.; Kikuchi, Y.
Substrate shape preference of Escherichia coli ribonuclease P ribozyme and holo enzyme using bottom-half part-shifting variants of pre-tRNA
Biosci. Biotechnol. Biochem.
69
1992-1994
2005
Escherichia coli
Buck, A.H.; Dalby, A.B.; Poole, A.W.; Kazantsev, A.V.; Pace, N.R.
Protein activation of a ribozyme: the role of bacterial RNase P protein
EMBO J.
24
3360-3368
2005
Bacillus subtilis, Escherichia coli
Sabariegos, R.; Nadal, A.; Beguiristain, N.; Piron, M.; Gomez, J.
Catalytic RNase P RNA from Synechocystis sp. cleaves the hepatitis C virus RNA near the AUG start codon
FEBS Lett.
577
517-522
2004
Synechocystis sp., Escherichia coli
Zou, H.; Lee, J.; Kilani, A.F.; Kim, K.; Trang, P.; Kim, J.; Liu, F.
Engineered RNase P ribozymes increase their cleavage activities and efficacies in inhibiting viral gene expression in cells by enhancing the rate of cleavage and binding of the target mRNA
J. Biol. Chem.
279
32063-32070
2004
Escherichia coli
Kawano, S.; Nakashima, T.; Kakuta, Y.; Tanaka, I.; Kimura, M.
Crystal structure of protein Ph1481p in complex with protein Ph1877p of archaeal RNase P from Pyrococcus horikoshii OT3: implication of dimer formation of the holoenzyme
J. Mol. Biol.
357
583-591
2006
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Torres-Larios, A.; Swinger, K.K.; Krasilnikov, A.S.; Pan, T.; Mondragon, A.
Crystal structure of the RNA component of bacterial ribonuclease P
Nature
437
584-587
2005
Thermotoga maritima
Schmitz, M.
Change of RNase P RNA function by single base mutation correlates with perturbation of metal ion binding in P4 as determined by NMR spectroscopy
Nucleic Acids Res.
32
6358-6366
2004
Escherichia coli
Piccinelli, P.; Rosenblad, M.A.; Samuelsson, T.
Identification and analysis of ribonuclease P and MRP RNA in a broad range of eukaryotes
Nucleic Acids Res.
33
4485-4495
2005
Aedes aegypti, Anopheles gambiae, Antonospora locustae, Apis mellifera, Aspergillus fumigatus, Aspergillus nidulans, Babesia bovis, Branchiostoma floridae, Brugia malayi, Caenorhabditis briggsae, Caenorhabditis remanei, Candida albicans, Candida dubliniensis, Candida tropicalis, Canis lupus familiaris, Coccidioides immitis, Coprinopsis cinerea, Cryptosporidium hominis, Cryptosporidium parvum, Danio rerio, Debaryomyces hansenii, Dictyostelium discoideum, Drosophila ananassae, Drosophila erecta, Drosophila melanogaster, Drosophila mojavensis, Drosophila pseudoobscura, Drosophila simulans, Drosophila virilis, Drosophila willistoni, Drosophila yakuba, Eimeria tenella, Encephalitozoon cuniculi, Entamoeba histolytica, Eremothecium gossypii, Fusarium graminearum, Giardia intestinalis, Histoplasma capsulatum, Laccaria bicolor, Lachancea waltii, Macaca mulatta, Meyerozyma guilliermondii, Neurospora crassa, Ogataea angusta, Phanerodontia chrysosporium, Plasmodium berghei, Plasmodium falciparum, Plasmodium gallinaceum, Plasmodium knowlesi, Plasmodium reichenowi, Plasmodium vivax, Plasmodium yoelii, Podospora anserina, Saccharomyces kudriavzevii, Saccharomyces mikatae, Saccharomyces paradoxus, Strongylocentrotus purpuratus, Takifugu rubripes, Tetrahymena thermophila, Theileria annulata, Toxoplasma gondii, Tribolium castaneum, Trichoderma reesei, Trichomonas vaginalis, Uncinocarpus reesii, Yarrowia lipolytica, [Candida] glabrata
Sharin, E.; Schein, A.; Mann, H.; Ben-Asouli, Y.; Jarrous, N.
RNase P: role of distinct protein cofactors in tRNA substrate recognition and RNA-based catalysis
Nucleic Acids Res.
33
5120-5132
2005
Escherichia coli
Altman, S.; Wesolowski, D.; Guerrier-Takada, C.; Li, Y.
RNase P cleaves transient structures in some riboswitches
Proc. Natl. Acad. Sci. USA
102
11284-11289
2005
Aspergillus nidulans, Escherichia coli
Kazantsev, A.V.; Krivenko, A.A.; Harrington, D.J.; Holbrook, S.R.; Adams, P.D.; Pace, N.R.
Crystal structure of a bacterial ribonuclease P RNA
Proc. Natl. Acad. Sci. USA
102
13392-13397
2005
Geobacillus stearothermophilus
Wilson, R.C.; Bohlen, C.J.; Foster, M.P.; Bell, C.E.
Structure of Pfu Pop5, an archaeal RNase P protein
Proc. Natl. Acad. Sci. USA
103
873-878
2006
Pyrococcus furiosus (Q8U151)
Numata, T.; Ishimatsu, I.; Kakuta, Y.; Tanaka, I.; Kimura, M.
Crystal structure of archaeal ribonuclease P protein Ph1771p from Pyrococcus horikoshii OT3: an archaeal homolog of eukaryotic ribonuclease P protein Rpp29
RNA
10
1423-1432
2004
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Kachouri, R.; Stribinskis, V.; Zhu, Y.; Ramos, K.S.; Westhof, E.; Li, Y.
A surprisingly large RNase P RNA in Candida glabrata
RNA
11
1064-1072
2005
[Candida] glabrata
Lindell, M.; Brannvall, M.; Wagner, E.G.; Kirsebom, L.A.
Lead(II) cleavage analysis of RNase P RNA in vivo
RNA
11
1348-1354
2005
Escherichia coli
Xiao, S.; Day-Storms, J.J.; Srisawat, C.; Fierke, C.A.; Engelke, D.R.
Characterization of conserved sequence elements in eukaryotic RNase P RNA reveals roles in holoenzyme assembly and tRNA processing
RNA
11
885-896
2005
Saccharomyces cerevisiae
Toumpeki, C.; Vourekas, A.; Kalavrizioti, D.; Stamatopoulou, V.; Drainas, D.
Activation of Bacterial Ribonuclease P by Macrolides
Biochemistry
47
4112 - 4118
2008
Escherichia coli
Marszalkowski, M.; Willkomm, D.K.; Hartmann, R.K.
5-End maturation of tRNA in Aquifex aeolicus
Biol. Chem.
389
395 - 403
2008
Aquifex aeolicus
Goessringer, M.; Kretschmer-Kazemi Far, R.; Hartmann, R.K.
Analysis of RNase P protein (rnpA) expression in Bacillus subtilis utilizing strains with suppressible rnpA expression
J. Bacteriol.
188
6816-6823
2006
Bacillus subtilis
Darr, S.C.; Pace, B.; Pace, N.R.
Characterization of ribonuclease P from the archaebacterium Sulfolobus solfataricus.
J. Biol. Chem.
265
12927-12932
1990
Saccharolobus solfataricus
Gruegelsiepe, H.; Brandt, O.; Hartmann, R.K.
Antisense inhibition of RNase P: mechanistic aspects and application to live bacteria
J. Biol. Chem.
281
30613-30620
2006
Escherichia coli, Thermus thermophilus, Pseudomonas aeruginosa
Braennvall, M.; Kikovska, E.; Wu, S.; Kirsebom, L.A.
Evidence for induced fit in bacterial RNase P RNA-mediated cleavage
J. Mol. Biol.
372
1149-1164
2007
Escherichia coli
Stribinskis, V.; Ramos, K.S.
Rpm2p, a protein subunit of mitochondrial RNase P, physically and genetically interacts with cytoplasmic processing bodies
Nucleic Acids Res.
35
1301-1311
2007
Saccharomyces cerevisiae
Wegscheid, B.; Hartmann, R.K.
In vivo and in vitro investigation of bacterial type B RNase P interaction with tRNA 3-CCA
Nucleic Acids Res.
35
2060-2073
2007
Bacillus subtilis
Mohanty, B.K.; Kushner, S.R.
Rho-independent transcription terminators inhibit RNase P processing of the secG leuU and metT tRNA polycistronic transcripts in Escherichia coli
Nucleic Acids Res.
36
364-375
2008
Escherichia coli
Kawamoto, S.A.; Sudhahar, C.G.; Hatfield, C.L.; Sun, J.; Behrman, E.J.; Gopalan, V.
Studies on the mechanism of inhibition of bacterial ribonuclease P by aminoglycoside derivatives
Nucleic Acids Res.
36
697-704
2008
Escherichia coli, Methanothermobacter thermautotrophicus, Methanocaldococcus jannaschii, Pyrococcus furiosus
Tanaka, T.; Kikuchi, Y.
Mutational analysis on the S-domain of bacterial ribonuclease P ribozyme
Nucleic Acids Symp. Ser.
51
371-372
2007
Escherichia coli
Tsai, H.Y.; Pulukkunat, D.K.; Woznick, W.K.; Gopalan, V.
Functional reconstitution and characterization of Pyrococcus furiosus RNase P
Proc. Natl. Acad. Sci. USA
103
16147-16152
2006
Pyrococcus furiosus
Lundblad, E.W.; Xiao, G.; Ko, J.H.; Altman, S.
Rapid selection of accessible and cleavable sites in RNA by Escherichia coli RNase P and random external guide sequences
Proc. Natl. Acad. Sci. USA
105
2354-2357
2008
Escherichia coli
Xiao, S.; Hsieh, J.; Nugent, R.L.; Coughlin, D.J.; Fierke, C.A.; Engelke, D.R.
Functional characterization of the conserved amino acids in Pop1p, the largest common protein subunit of yeast RNases P and MRP
RNA
12
1023-1037
2006
Saccharomyces cerevisiae
Perederina, A.; Esakova, O.; Koc, H.; Schmitt, M.E.; Krasilnikov, A.S.
Specific binding of a Pop6/Pop7 heterodimer to the P3 stem of the yeast RNase MRP and RNase P RNAs
RNA
13
1648-1655
2007
Saccharomyces cerevisiae
Chakrabarti, K.; Pearson, M.; Grate, L.; Sterne-Weiler, T.; Deans, J.; Donohue, J.P.; Ares, M.
Structural RNAs of known and unknown function identified in malaria parasites by comparative genomics and RNA analysis
RNA
13
1923-1939
2007
Plasmodium falciparum
Niranjanakumari, S.; Day-Storms, J.J.; Ahmed, M.; Hsieh, J.; Zahler, N.H.; Venters, R.A.; Fierke, C.A.
Probing the architecture of the B. subtilis RNase P holoenzyme active site by cross-linking and affinity cleavage
RNA
13
521-535
2007
Bacillus subtilis
Yang, L.; Altman, S.
A noncoding RNA in Saccharomyces cerevisiae is an RNase P substrate
RNA
13
682-690
2007
Saccharomyces cerevisiae
Amero, C.D.; Boomershine, W.P.; Xu, Y.; Foster, M.
Solution structure of Pyrococcus furiosus RPP21, a component of the archaeal RNase P holoenzyme, and interactions with its RPP29 protein partner
Biochemistry
47
11704-11710
2008
Pyrococcus furiosus (Q8U0H6), Pyrococcus furiosus
Berchanski, A.; Lapidot, A.
Bacterial RNase P RNA is a drug target for aminoglycoside-arginine conjugates
Bioconjug. Chem.
19
1896-1906
2008
Bacillus subtilis
Kiderlen, A.F.; Radam, E.; Lewin, A.
Detection of Balamuthia mandrillaris DNA by real-time PCR targeting the RNase P gene
BMC Microbiol.
8
210
2008
Balamuthia mandrillaris
Bassett, T.; Harpur, B.; Poon, H.Y.; Kuo, K.H.; Lee, C.H.
Effective stimulation of growth in MCF-7 human breast cancer cells by inhibition of syntaxin18 by external guide sequence and ribonuclease P
Cancer Lett.
272
167-175
2008
Homo sapiens
Walker, S.C.; Engelke, D.R.
A protein-only RNase P in human mitochondria
Cell
135
412-414
2008
Homo sapiens
Holzmann, J.; Frank, P.; Loeffler, E.; Bennett, K.L.; Gerner, C.; Rossmanith, W.
RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme
Cell
135
462-474
2008
Homo sapiens
Magoulas, G.; Papaioannou, D.; Papadimou, E.; Drainas, D.
Preparation of spermine conjugates with acidic retinoids with potent ribonuclease P inhibitory activity
Eur. J. Med. Chem.
44
2689-2695
2009
Dictyostelium discoideum
Vourekas, A.; Vryzaki, E.; Toumpeki, C.; Stamatopoulou, V.; Monastirli, A.; Tsambaos, D.; Drainas, D.
Partial purification and characterization of RNase P from human peripheral lymphocytes
Exp. Dermatol.
18
130-133
2009
Homo sapiens
Kirsebom, L.A.; Trobro, S.
RNase P RNA-mediated cleavage
IUBMB Life
61
189-200
2009
Bacillus subtilis, Chlamydia sp., Homo sapiens, no activity in Nanoarchaeum equitans
Suwa, S.; Nagai, Y.; Fujimoto, A.; Kikuchi, Y.; Tanaka, T.
Analysis on substrate specificity of Escherichia coli ribonuclease P using shape variants of pre-tRNA: proposal of subsites model for substrate shape recognition
J. Biochem.
145
151-160
2009
Escherichia coli
Peters, I.R.; Helps, C.R.; McAuliffe, L.; Neimark, H.; Lappin, M.R.; Gruffydd-Jones, T.J.; Day, M.J.; Hoelzle, L.E.; Willi, B.; Meli, M.; Hofmann-Lehmann, R.; Tasker, S.
RNase P RNA gene (rnpB) phylogeny of Hemoplasmas and other Mycoplasma species
J. Clin. Microbiol.
46
1873-1877
2008
[Clostridium] innocuum, Mycoplasma arthritidis, Mycoplasmopsis fermentans, Mycoplasmopsis gallinarum, Mycoplasma gallisepticum, Mycoplasma iowae, Mycoplasma buccale, Mycoplasma salivarium, Mycoplasmopsis felis, Mycoplasmopsis primatum, Mycoplasmopsis bovis, Mycoplasma orale, Mycoplasmopsis lipophila, Mycoplasma neurolyticum, Mycoplasmopsis pullorum, Mycoplasmopsis anatis, Mycoplasma hyorhinis, Mycoplasma flocculare, Mycoplasma pirum, Mycoplasma fastidiosum, Mycoplasma wenyonii, Mycoplasma suis, Mycoplasma ovis, Mycoplasma haemofelis, Mycoplasma coccoides, Mycoplasma haemocanis, Mycoplasma capricolum (P43039), Mycoplasma genitalium (P47703), Mycoplasma pneumoniae (P75111), Mycoplasmopsis synoviae (Q4A5G4), Mycoplasma hyopneumoniae (Q4A750), Mesomycoplasma mobile (Q6KH14), Mycoplasma mycoides (Q6MRS3), Malacoplasma penetrans (Q8EU90), Mycoplasmopsis pulmonis (Q98R57), Ureaplasma parvum (Q9PPN6)
Westling, K.; Julander, I.; Ljungman, P.; Vondracek, M.; Wretlind, B.; Jalal, S.
Identification of species of viridans group streptococci in clinical blood culture isolates by sequence analysis of the RNase P RNA gene, rnpB
J. Infect.
56
204-210
2008
Streptococcus pneumoniae, Streptococcus gordonii, Streptococcus mitis, Streptococcus mutans, Streptococcus oralis, Streptococcus salivarius, Streptococcus sanguinis, Streptococcus gallolyticus, Streptococcus anginosus, Streptococcus intermedius, Streptococcus constellatus, Streptococcus parasanguinis, Streptococcus cristatus, Streptococcus infantis
Cuzic, S.; Heidemann, K.A.; Woehnert, J.; Hartmann, R.K.
Escherichia coli RNase P RNA: substrate ribose modifications at G+1, but not nucleotide -1/+73 base pairing, affect the transition state for cleavage chemistry
J. Mol. Biol.
379
1-8
2008
Escherichia coli
Honda, T.; Kakuta, Y.; Kimura, K.; Saho, J.; Kimura, M.
Structure of an archaeal homolog of the human protein complex Rpp21-Rpp29 that is a key core component for the assembly of active ribonuclease P
J. Mol. Biol.
384
652-662
2008
Pyrococcus horikoshii (O59425), Pyrococcus horikoshii
Trang, P.; Liu, F.
Mapping the regions of RNase P catalytic RNA that are potentially in close contact with its protein cofactor
Methods Mol. Biol.
488
267-277
2008
Escherichia coli
Randau, L.; Schroeder, I.; Soell, D.
Life without RNase P
Nature
453
120-123
2008
Escherichia coli, no activity in Nanoarchaeum equitans
Linden, M.H.; Hartmann, R.K.; Klostermeier, D.
The putative RNase P motif in the DEAD box helicase Hera is dispensable for efficient interaction with RNA and helicase activity
Nucleic Acids Res.
36
5800-5811
2008
Thermus thermophilus
Li, D.; Willkomm, D.K.; Hartmann, R.K.
Minor changes largely restore catalytic activity of archaeal RNase P RNA from Methanothermobacter thermoautotrophicus
Nucleic Acids Res.
37
231-242
2009
Escherichia coli, Methanothermobacter thermautotrophicus, Methanothermobacter thermautotrophicus Marburg / DSM 2133
Fujimoto, A.; Suwa, S.; Nagai, Y.; Kikuchi, Y.; Tanaka, T.
Subsites for substrate recognition by bacterial ribonuclease P
Nucleic Acids Symp. Ser.
52
207-208
2008
Escherichia coli
Reiner, R.; Krasnov-Yoeli, N.; Dehtiar, Y.; Jarrous, N.
Function and assembly of a chromatin-associated RNase P that is required for efficient transcription by RNA polymerase I
PLoS ONE
3
e4072
2008
Homo sapiens
Bai, Y.; Trang, P.; Li, H.; Kim, K.; Zhou, T.; Liu, F.
Effective inhibition in animals of viral pathogenesis by a ribozyme derived from RNase P catalytic RNA
Proc. Natl. Acad. Sci. USA
105
10919-10924
2008
Mus musculus
Coughlin, D.J.; Pleiss, J.A.; Walker, S.C.; Whitworth, G.B.; Engelke, D.R.
Genome-wide search for yeast RNase P substrates reveals role in maturation of intron-encoded box C/D small nucleolar RNAs
Proc. Natl. Acad. Sci. USA
105
12218-12223
2008
Saccharomyces cerevisiae
Seif, E.; Altman, S.
RNase P cleaves the adenine riboswitch and stabilizes pbuE mRNA in Bacillus subtilis
RNA
14
1237-1243
2008
Bacillus subtilis, Bacillus subtilis 168
Esakova, O.; Perederina, A.; Quan, C.; Schmitt, M.E.; Krasilnikov, A.S.
Footprinting analysis demonstrates extensive similarity between eukaryotic RNase P and RNase MRP holoenzymes
RNA
14
1558-1567
2008
Saccharomyces cerevisiae, Saccharomyces cerevisiae YSW1
Ko, J.H.; Izadjoo, M.; Altman, S.
Inhibition of expression of virulence genes of Yersinia pestis in Escherichia coli by external guide sequences and RNase P
RNA
14
1656-1662
2008
Escherichia coli
Hsieh, J.; Walker, S.C.; Fierke, C.A.; Engelke, D.R.
Pre-tRNA turnover catalyzed by the yeast nuclear RNase P holoenzyme is limited by product release
RNA
15
224-234
2009
Saccharomyces cerevisiae, Saccharomyces cerevisiae SCWY10
Kazantsev, A.V.; Krivenko, A.A.; Pace, N.R.
Mapping metal-binding sites in the catalytic domain of bacterial RNase P RNA
RNA
15
266-276
2009
Geobacillus stearothermophilus
Perederina, A.; Esakova, O.; Quan, C.; Khanova, E.; Krasilnikov, A.S.
Crystallization and preliminary X-ray diffraction analysis of the P3 RNA domain of yeast ribonuclease MRP in a complex with RNase P/MRP protein components Pop6 and Pop7
Acta Crystallogr. Sect. F
66
76-80
2010
Saccharomyces cerevisiae
Li, D.; Meyer, M.H.; Willkomm, D.K.; Keusgen, M.; Hartmann, R.K.
Analysis of bacterial RNase P RNA and protein interaction by a magnetic biosensor technique
Biochimie
92
772-778
2010
Escherichia coli
Honda, T.; Hara, T.; Nan, J.; Zhang, X.; Kimura, M.
Archaeal homologs of human RNase P protein pairs Pop5 with Rpp30 and Rpp21 with Rpp29 work on distinct functional domains of the RNA subunit
Biosci. Biotechnol. Biochem.
74
266-273
2010
Escherichia coli, Pyrococcus horikoshii
Kosaka, S.; Hada, K.; Nakashima, T.; Kimura, M.
Structural changes in ribonuclease P RNA in the hyperthermophilic archaeon Pyrococcus horikoshii OT3 induced on interaction with proteins
Biosci. Biotechnol. Biochem.
74
394-396
2010
Escherichia coli, Pyrococcus horikoshii OT3
Lai, L.B.; Vioque, A.; Kirsebom, L.A.; Gopalan, V.
Unexpected diversity of RNase P, an ancient tRNA processing enzyme: challenges and prospects
FEBS Lett.
584
287-296
2010
Saccharomyces cerevisiae, Escherichia coli, Homo sapiens, Methanothermobacter thermautotrophicus
Xu, Y.; Amero, C.D.; Pulukkunat, D.K.; Gopalan, V.; Foster, M.P.
Solution structure of an archaeal RNase P binary protein complex: formation of the 30-kDa complex between Pyrococcus furiosus RPP21 and RPP29 is accompanied by coupled protein folding and highlights critical features for protein-protein and protein-RNA in
J. Mol. Biol.
393
1043-1055
2009
Methanocaldococcus jannaschii, Pyrococcus furiosus
Koutmou, K.S.; Zahler, N.H.; Kurz, J.C.; Campbell, F.E.; Harris, M.E.; Fierke, C.A.
Protein-precursor tRNA contact leads to sequence-specific recognition of 5 leaders by bacterial ribonuclease P
J. Mol. Biol.
396
195-208
2010
Bacillus subtilis, Escherichia coli
McClain, W.H.; Lai, L.B.; Gopalan, V.
Trials, travails and triumphs: an account of RNA catalysis in RNase P
J. Mol. Biol.
397
627-646
2010
Geobacillus stearothermophilus, Bacillus subtilis, Escherichia coli, Mycoplasma genitalium, Salmonella enterica subsp. enterica serovar Typhimurium, Thermotoga maritima, no activity in Nanoarchaeum equitans
Holzmann, J.; Rossmanith, W.
tRNA recognition, processing, and disease: hypotheses around an unorthodox type of RNase P in human mitochondria
Mitochondrion
9
284-288
2009
Homo sapiens
Lundblad, E.W.; Altman, S.
Inhibition of gene expression by RNase P
New Biotechnol.
27
212-221
2010
Synechocystis sp., Escherichia coli, Homo sapiens, Spinacia oleracea, no activity in Nanoarchaeum equitans, Ignicoccus hospitalis
Cuzic-Feltens, S.; Weber, M.H.; Hartmann, R.K.
Investigation of catalysis by bacterial RNase P via LNA and other modifications at the scissile phosphodiester
Nucleic Acids Res.
37
7638-7653
2009
Bacillus subtilis, Escherichia coli
Hands-Taylor, K.L.; Martino, L.; Tata, R.; Babon, J.J.; Bui, T.T.; Drake, A.F.; Beavil, R.L.; Pruijn, G.J.; Brown, P.R.; Conte, M.R.
Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA
Nucleic Acids Res.
38
4052-4066
2010
Homo sapiens
Mohanty, B.K.; Kushner, S.R.
Processing of the Escherichia coli leuX tRNA transcript, encoding tRNA(Leu5), requires either the 3-->5 exoribonuclease polynucleotide phosphorylase or RNase P to remove the Rho-independent transcription terminator
Nucleic Acids Res.
38
597-607
2010
Escherichia coli, Escherichia coli MG1693
Fujimoto, A.; Kikuchi, Y.; Tanaka, T.
Substrate recognition of pre-tRNA by ribonuclease P-subsite model of natural ribozyme originated from Escherichia coli
Nucleic Acids Symp. Ser.
53
35-36
2009
Escherichia coli
Koutmou, K.S.; Casiano-Negroni, A.; Getz, M.M.; Pazicni, S.; Andrews, A.J.; Penner-Hahn, J.E.; Al-Hashimi, H.M.; Fierke, C.A.
NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P
Proc. Natl. Acad. Sci. USA
107
2479-2484
2010
Bacillus subtilis
Bai, Y.; Li, H.; Vu, G.P.; Gong, H.; Umamoto, S.; Zhou, T.; Lu, S.; Liu, F.
Salmonella-mediated delivery of RNase P-based ribozymes for inhibition of viral gene expression and replication in human cells
Proc. Natl. Acad. Sci. USA
107
7269-7274
2010
synthetic construct
Ellis, J.; Brown, J.
The RNase P family
RNA Biol.
6
362-369
2009
Cupriavidus necator, Bacillus subtilis, Saccharomyces cerevisiae, Chlamydia trachomatis, Chlorobium limicola, Escherichia coli, Giardia intestinalis, Homo sapiens, Methanothermobacter thermautotrophicus, Methanocaldococcus jannaschii, Mycoplasmopsis fermentans, Mycoplasma hyopneumoniae, no activity in Aquifex aeolicus, Pyrobaculum aerophilum, Thermomicrobium roseum, Porphyra purpurea, Synechococcus elongatus PCC 6301, Reclinomonas americana
Marvin, M.C.; Engelke, D.R.
RNase P: increased versatility through protein complexity?
RNA Biol.
6
40-42
2009
Saccharomyces cerevisiae, Homo sapiens
Hsieh, J.; Fierke, C.A.
Conformational change in the Bacillus subtilis RNase P holoenzyme-pre-tRNA complex enhances substrate affinity and limits cleavage rate
RNA
15
1565-1577
2009
Bacillus subtilis
Stamatopoulou, V.; Toumpeki, C.; Tzakos, A.; Vourekas, A.; Drainas, D.
Domain architecture of the DRpp29 protein and its interaction with the RNA subunit of Dictyostelium discoideum RNase P
Biochemistry
49
10714-10727
2010
Dictyostelium discoideum, Dictyostelium discoideum AX2
Hara, T.; Terada, A.; Yamaguchi, H.; Nakashima, T.; Kakuta, Y.; Kimura, M.
The contribution of peripheral stem-loops to the catalytic activity of archaeal RNase P RNA from Pyrococcus horikoshii OT3
Biosci. Biotechnol. Biochem.
75
816-819
2011
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Hsieh, J.; Koutmou, K.S.; Rueda, D.; Koutmos, M.; Walter, N.G.; Fierke, C.A.
A divalent cation stabilizes the active conformation of the B. subtilis RNase P x pre-tRNA complex: a role for an inner-sphere metal ion in RNase P
J. Mol. Biol.
400
38-51
2010
Bacillus subtilis
Cho, I.M.; Kazakov, S.A.; Gopalan, V.
Evidence for recycling of external guide sequences during cleavage of bipartite substrates in vitro by reconstituted archaeal RNase P
J. Mol. Biol.
405
1121-1127
2011
Methanothermobacter thermautotrophicus, Methanocaldococcus jannaschii, Methanococcus maripaludis, Pyrococcus furiosus
Lai, L.B.; Bernal-Bayard, P.; Mohannath, G.; Lai, S.M.; Gopalan, V.; Vioque, A.
A functional RNase P protein subunit of bacterial origin in some eukaryotes
Mol. Genet. Genomics
286
359-369
2011
Ostreococcus tauri (Q00XA5), Ostreococcus tauri, Ostreococcus tauri RCC745 (Q00XA5)
Gobert, A.; Gutmann, B.; Taschner, A.; Goessringer, M.; Holzmann, J.; Hartmann, R.K.; Rossmanith, W.; Giege, P.
A single Arabidopsis organellar protein has RNase P activity
Nat. Struct. Mol. Biol.
17
740-744
2010
Arabidopsis thaliana
Jarrous, N.; Gopalan, V.
Archaeal/eukaryal RNase P: subunits, functions and RNA diversification
Nucleic Acids Res.
38
7885-7894
2010
Saccharomyces cerevisiae, [Candida] glabrata, Escherichia coli, Homo sapiens, Methanothermobacter thermautotrophicus, Mus musculus, Mycoplasmopsis fermentans, Pyrococcus furiosus, Saccharolobus solfataricus
Sinapah, S.; Wu, S.; Chen, Y.; Pettersson, B.M.; Gopalan, V.; Kirsebom, L.A.
Cleavage of model substrates by archaeal RNase P: role of protein cofactors in cleavage-site selection
Nucleic Acids Res.
39
1105-1116
2011
Pyrococcus furiosus
Reiner, R.; Alfiya-Mor, N.; Berrebi-Demma, M.; Wesolowski, D.; Altman, S.; Jarrous, N.
RNA binding properties of conserved protein subunits of human RNase P
Nucleic Acids Res.
39
5704-5714
2011
Homo sapiens
McClain, W.
Discovery of a mini-RNase P in archaea
Proc. Natl. Acad. Sci. USA
107
22371-22372
2010
Pyrobaculum sp.
Bai, Y.; Gong, H.; Li, H.; Vu, G.P.; Lu, S.; Liu, F.
Oral delivery of RNase P ribozymes by Salmonella inhibits viral infection in mice
Proc. Natl. Acad. Sci. USA
108
3222-3227
2011
Salmonella sp.
Kazantsev, A.V.; Rambo, R.P.; Karimpour, S.; Santalucia, J.; Tainer, J.A.; Pace, N.R.
Solution structure of RNase P RNA
RNA
17
1159-1171
2011
Agrobacterium tumefaciens, Geobacillus stearothermophilus, Escherichia coli
Koutmou, K.S.; Day-Storms, J.J.; Fierke, C.A.
The RNR motif of B. subtilis RNase P protein interacts with both PRNA and pre-tRNA to stabilize an active conformer
RNA
17
1225-1235
2011
Bacillus subtilis
Marvin, M.C.; Walker, S.C.; Fierke, C.A.; Engelke, D.R.
Binding and cleavage of unstructured RNA by nuclear RNase P
RNA
17
1429-1440
2011
Saccharomyces cerevisiae
Marvin, M.C.; Clauder-Muenster, S.; Walker, S.C.; Sarkeshik, A.; Yates, J.R.; Steinmetz, L.M.; Engelke, D.R.
Accumulation of noncoding RNA due to an RNase P defect in Saccharomyces cerevisiae
RNA
17
1441-1450
2011
Saccharomyces cerevisiae
Sidote, D.J.; Hoffman, D.W.
NMR structure of an archaeal homologue of ribonuclease P protein Rpp29
Biochemistry
42
13541-13550
2003
Archaeoglobus fulgidus (O28362), Archaeoglobus fulgidus
Sidote, D.J.; Heideker, J.; Hoffman, D.W.
Crystal structure of archaeal ribonuclease P protein aRpp29 from Archaeoglobus fulgidus
Biochemistry
43
14128-14138
2004
Archaeoglobus fulgidus (O28362), Archaeoglobus fulgidus
Terada, A.; Yoshida, T.; Kimura, M.
Identification of nucleotide residues essential for RNase P activity from the hyperthermophilic archaeon Pyrococcus horikoshii OT3
Biosci. Biotechnol. Biochem.
71
1940-1945
2007
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Terada, A.; Honda, T.; Fukuhara, H.; Hada, K.; Kimura, M.
Characterization of the archaeal ribonuclease P proteins from Pyrococcus horikoshii OT3
J. Biochem.
140
293-298
2006
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Hazeyama, K.; Ishihara, M.; Ueda, T.; Nishimoto, E.; Nakashima, T.; Kakuta, Y.; Kimura, M.
Extra-structural elements in the RNA recognition motif in archaeal Pop5 play a crucial role in the activation of RNase P RNA from Pyrococcus horikoshii OT3
Biochem. Biophys. Res. Commun.
440
594-598
2013
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Ueda, T.; Yamaguchi, H.; Miyanoshita, M.; Nakashima, T.; Kakuta, Y.; Kimura, M.
Characterization of the peripheral structures of archaeal RNase P RNA from Pyrococcus horikoshii OT3
J. Biochem.
155
25-33
2014
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Cho, I.M.; Lai, L.B.; Susanti, D.; Mukhopadhyay, B.; Gopalan, V.
Ribosomal protein L7Ae is a subunit of archaeal RNase P
Proc. Natl. Acad. Sci. USA
107
14573-14578
2010
Methanococcus maripaludis (P62426 and P60780 and P60781 and P60832 and P62378), Methanococcus maripaludis
Lai, L.B.; Chan, P.P.; Cozen, A.E.; Bernick, D.L.; Brown, J.W.; Gopalan, V.; Lowe, T.M.
Discovery of a minimal form of RNase P in Pyrobaculum
Proc. Natl. Acad. Sci. USA
107
22493-2298
2010
Pyrobaculum aerophilum
Ma, X.; Lai, L.B.; Lai, S.M.; Tanimoto, A.; Foster, M.P.; Wysocki, V.H.; Gopalan, V.
Uncovering the stoichiometry of Pyrococcus furiosus RNase P, a multi-subunit catalytic ribonucleoprotein complex, by surface-induced dissociation and Ion mobility mass spectrometry
Angew. Chem. Int. Ed. Engl.
53
11483-11487
2014
Pyrococcus furiosus
Ishihara, M.; Nishimoto, E.; Yamashita, S.; Kakuta, Y.; Kimura, M.
A distinct binding mode of archaeal ribonuclease P proteins to RNA
Biosci. Biotechnol. Biochem.
76
2335-2337
2012
Pyrococcus horikoshii
Taschner, A.; Weber, C.; Buzet, A.; Hartmann, R.K.; Hartig, A.; Rossmanith, W.
Nuclear RNase P of Trypanosoma brucei: a single protein in place of the multicomponent RNA-protein complex
Cell Rep.
2
19-25
2012
Trypanosoma brucei
Yandek, L.E.; Lin, H.C.; Harris, M.E.
Alternative substrate kinetics of Escherichia coli ribonuclease P: determination of relative rate constants by internal competition
J. Biol. Chem.
288
8342-8354
2013
Escherichia coli
Wu, S.; Kikovska, E.; Lindell, M.; Kirsebom, L.A.
Cleavage mediated by the catalytic domain of bacterial RNase P RNA
J. Mol. Biol.
422
204-214
2012
Escherichia coli
Singh, A.; Chand, D.; Pattanayak, D.
Purification and characterization of potato ribonuclease P
J. Plant Biochem. Biotechnol.
22
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Targeting mRNAs by engineered sequence-specific RNase P ribozymes
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Escherichia coli
Goessringer, M.; Helmecke, D.; Hartmann, R.K.
Characterization of RNase P RNA activity
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Aquifex aeolicus, Bacillus subtilis, Escherichia coli, Thermus thermophilus
Gobert, A.; Pinker, F.; Fuchsbauer, O.; Gutmann, B.; Boutin, R.; Roblin, P.; Sauter, C.; Giege, P.
Structural insights into protein-only RNase P complexed with tRNA
Nat. Commun.
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Arabidopsis thaliana (Q66GI4)
Chen, W.Y.; Pulukkunat, D.K.; Cho, I.M.; Tsai, H.Y.; Gopalan, V.
Dissecting functional cooperation among protein subunits in archaeal RNase P, a catalytic ribonucleoprotein complex
Nucleic Acids Res.
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Methanothermobacter thermautotrophicus, Methanocaldococcus jannaschii, Pyrococcus furiosus
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The bacterial ribonuclease P holoenzyme requires specific, conserved residues for efficient catalysis and substrate positioning
Nucleic Acids Res.
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Thermotoga maritima (Q9X1H4), Thermotoga maritima
Krehan, M.; Heubeck, C.; Menzel, N.; Seibel, P.; Schoen, A.
RNase MRP RNA and RNase P activity in plants are associated with a Pop1p containing complex
Nucleic Acids Res.
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Triticum aestivum, Arabidopsis thaliana (L0N807)
Agrawal, A.; Mohanty, B.K.; Kushner, S.R.
Processing of the seven valine tRNAs in Escherichia coli involves novel features of RNase P
Nucleic Acids Res.
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Escherichia coli, Escherichia coli MG1693
Lai, S.M.; Lai, L.B.; Foster, M.P.; Gopalan, V.
The L7Ae protein binds to two kink-turns in the Pyrococcus furiosus RNase P RNA
Nucleic Acids Res.
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Pyrococcus furiosus
Turrini, P.C.; Loveland, J.L.; Dorit, R.L.
By any other name: heterologous replacement of the Escherichia coli RNase P protein subunit has in vivo fitness consequences
PLoS ONE
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Escherichia coli
Zeng, W.; Chen, Y.C.; Bai, Y.; Trang, P.; Vu, G.P.; Lu, S.; Wu, J.; Liu, F.
Effective inhibition of human immunodeficiency virus 1 replication by engineered RNase P ribozyme
PLoS ONE
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Escherichia coli
Howard, M.J.; Liu, X.; Lim, W.H.; Klemm, B.P.; Fierke, C.A.; Koutmos, M.; Engelke, D.R.
RNase P enzymes: divergent scaffolds for a conserved biological reaction
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Arabidopsis thaliana (Q66GI4), Arabidopsis thaliana, Bacillus subtilis, Homo sapiens, Ostreococcus tauri, Saccharomyces cerevisiae, Thermotoga maritima, Trypanosoma brucei
Jiang, X.; Chen, Y.C.; Gong, H.; Trang, P.; Lu, S.; Liu, F.
Ribonuclease P-mediated inhibition of human cytomegalovirus gene expression and replication induced by engineered external guide sequences
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Homo sapiens
Khanova, E.; Esakova, O.; Perederina, A.; Berezin, I.; Krasilnikov, A.S.
Structural organizations of yeast RNase P and RNase MRP holoenzymes as revealed by UV-crosslinking studies of RNA-protein interactions
RNA
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Saccharomyces cerevisiae, Saccharomyces cerevisiae YSW1
Kouzuma, Y.; Mizoguchi, M.; Takagi, H.; Fukuhara, H.; Tsukamoto, M.; Numata, T.; Kimura, M.
Reconstitution of archaeal ribonuclease P from RNA and four protein components
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Pyrococcus horikoshii (O59425 and O59150 and O59543 and O59248 and P62009), Pyrococcus horikoshii
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Structural modeling of RNase P RNA of the hyperthermophilic archaeon Pyrococcus horikoshii OT3
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Pyrococcus horikoshii (O59425 and O59150 and O59543 and O59248 and P62009)
Gao, X.; Oshima, K.; Ueda, T.; Nakashima, T.; Kimura, M.
A three-dimensional model of RNase P in the hyperthermophilic archaeon Pyrococcus horikoshii OT3
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Pyrococcus horikoshii (O59150 AND O59248 AND O59425 AND O59543 AND P62009), Pyrococcus horikoshii (O59425 and O59150 and O59543 and O59248 and P62009), Pyrococcus horikoshii
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Escherichia coli
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Biomolecules
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Escherichia coli
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Pyrococcus horikoshii (O59150 AND O59425 AND O59248 AND O59543 AND P62009), Pyrococcus horikoshii
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Identification of the Acinetobacter baumannii ribonuclease P catalytic subunit cleavage of a target mRNA in the presence of an external guide sequence
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Acinetobacter baumannii (B0V5R2), Acinetobacter baumannii, Acinetobacter baumannii ATCC 17978 (B0V5R2)
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Insight into the role of histidine in RNR motif of protein component of RNase P of M. tuberculosis in catalysis
IUBMB Life
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Mycobacterium tuberculosis (P9WGZ3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WGZ3)
Howard, M.J.; Klemm, B.P.; Fierke, C.A.
Mechanistic Studies Reveal Similar Catalytic Strategies for Phosphodiester Bond Hydrolysis by Protein-only and RNA-dependent Ribonuclease P
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Arabidopsis thaliana (Q66GI4), Arabidopsis thaliana
Oerum, S.; Roovers, M.; Rambo, R.P.; Kopec, J.; Bailey, H.J.; Fitzpatrick, F.; Newman, J.A.; Newman, W.G.; Amberger, A.; Zschocke, J.; Droogmans, L.; Oppermann, U.; Yue, W.W.
Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and ribonuclease P complexes
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Homo sapiens (O15091), Homo sapiens
Walczyk, D.; Goessringer, M.; Rossmanith, W.; Zatsepin, T.S.; Oretskaya, T.S.; Hartmann, R.K.
Analysis of the cleavage mechanism by protein-only RNase P using precursor tRNA substrates with modifications at the cleavage site
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Arabidopsis thaliana (F4JKB6), Arabidopsis thaliana
Goessringer, M.; Lechner, M.; Brillante, N.; Weber, C.; Rossmanith, W.; Hartmann, R.K.
Protein-only RNase P function in Escherichia coli viability, processing defects and differences between PRORP isoenzymes
Nucleic Acids Res.
45
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Arabidopsis thaliana (F4JKB6), Arabidopsis thaliana (Q66GI4), Arabidopsis thaliana (Q680B9), Arabidopsis thaliana
Perederina, A.; Berezin, I.; Krasilnikov, A.S.
In vitro reconstitution and analysis of eukaryotic RNase P RNPs
Nucleic Acids Res.
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Saccharomyces cerevisiae
Bonnard, G.; Gobert, A.; Arrive, M.; Pinker, F.; Salinas-Giege, T.; Giege, P.
Transfer RNA maturation in Chlamydomonas mitochondria, chloroplast and the nucleus by a single RNase P protein
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Chlamydomonas reinhardtii, Chlamydomonas reinhardtii cw15 arg7-8 mt+
Zhou, W.; Karcher, D.; Fischer, A.; Maximova, E.; Walther, D.; Bock, R.
Multiple RNA processing defects and impaired chloroplast function in plants deficient in the organellar protein-only RNase P enzyme
PLoS ONE
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Arabidopsis thaliana (Q66GI4)
Nickel, A.I.; Waeber, N.B.; Goessringer, M.; Lechner, M.; Linne, U.; Toth, U.; Rossmanith, W.; Hartmann, R.K.
Minimal and RNA-free RNase P in Aquifex aeolicus
Proc. Natl. Acad. Sci. USA
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Aquifex aeolicus (O67035)
Walczyk, D.; Willkomm, D.K.; Hartmann, R.K.
Bacterial type B RNase P functional characterization of the L5.1-L15.1 tertiary contact and antisense inhibition
RNA
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Bacillus subtilis
Liu, J.; Shao, L.; Trang, P.; Yang, Z.; Reeves, M.; Sun, X.; Vu, G.P.; Wang, Y.; Li, H.; Zheng, C.; Lu, S.; Liu, F.
Inhibition of herpes simplex virus 1 gene expression and replication by RNase P-associated external guide sequences
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Homo sapiens (Q99575 AND O95707 AND Q969H6 AND O75817 AND O95059 AND Q9H633 AND Q9BUL9 AND P78346 AND P78345 AND O75818), Homo sapiens
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