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Literature summary for 3.1.26.5 extracted from

  • Turrini, P.C.; Loveland, J.L.; Dorit, R.L.
    By any other name: heterologous replacement of the Escherichia coli RNase P protein subunit has in vivo fitness consequences (2012), PLoS ONE, 7, e32456.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information construction of a rnpA knockout strain (MTea1), deletion of the essential endogenous rnpA copy and simultaneous replacement by a heterologous version of the gene, i.e. by eight rnpA sequences from Proteus mirabilis, Pseudomonas aeruginosa, Acinetobacter baumannii, Neisseria gonorrhoaea, Bacillus subtilis, Streptococcus oralis, Staphylococcus aureus, and Thermotoga maritima. The increasingly divergent versions of the RNase P protein all complement the loss of the endogenous rnpA gene, phylogenetic range of rnpA heterologues, overview Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
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the catalytic RNA component is encoded by the gene rnpB and the protein moiety by gene rnpA
-

Posttranslational Modification

Posttranslational Modification Comment Organism
ribonucleoprotein composed of a catalytic RNA component and an associated protein moiety Escherichia coli

Synonyms

Synonyms Comment Organism
RNase P
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Escherichia coli

General Information

General Information Comment Organism
additional information all existing bacterial versions of the rnpA sequence might retain the elements required for functional interaction with the RNase P RNA. But the similarity of the heterologue to the endogenous version does not predict the fitness costs of the replacement Escherichia coli
physiological function the enzyme is essential Escherichia coli