Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a rnpA knockout strain (MTea1), deletion of the essential endogenous rnpA copy and simultaneous replacement by a heterologous version of the gene, i.e. by eight rnpA sequences from Proteus mirabilis, Pseudomonas aeruginosa, Acinetobacter baumannii, Neisseria gonorrhoaea, Bacillus subtilis, Streptococcus oralis, Staphylococcus aureus, and Thermotoga maritima. The increasingly divergent versions of the RNase P protein all complement the loss of the endogenous rnpA gene, phylogenetic range of rnpA heterologues, overview | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
the catalytic RNA component is encoded by the gene rnpB and the protein moiety by gene rnpA | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
ribonucleoprotein | composed of a catalytic RNA component and an associated protein moiety | Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
RNase P | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
additional information | all existing bacterial versions of the rnpA sequence might retain the elements required for functional interaction with the RNase P RNA. But the similarity of the heterologue to the endogenous version does not predict the fitness costs of the replacement | Escherichia coli |
physiological function | the enzyme is essential | Escherichia coli |