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Literature summary for 3.1.26.5 extracted from

  • Holzmann, J.; Rossmanith, W.
    tRNA recognition, processing, and disease: hypotheses around an unorthodox type of RNase P in human mitochondria (2009), Mitochondrion, 9, 284-288.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
tagged overexpression of MRPP1, MRPP2 and MRPP3 in human cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ mitochondrial RNase P requires divalent metal ions, preferably Mg2+, for cleavage Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
26000
-
MRPP2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
MRPP1, affinity purified Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pre-tRNA + H2O removes 5' extensions from genuine mitochondrial tRNA precursors Homo sapiens tRNA + 5'-oligoribonucleotide
-
?

Synonyms

Synonyms Comment Organism
mitochondrial RNase P protein 1
-
Homo sapiens
MRPP1
-
Homo sapiens
MRPP2
-
Homo sapiens
MRPP3
-
Homo sapiens
ribonuclease P
-
Homo sapiens
RNase P
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the mitochondrial RNase P is devoid of any RNA, mitochondria make their RNase P of three proteins only. MRPP1 is involved in the methylation of G9 in mitochondria in addition to its role in mitochondrial RNase P. MRRP2 may contribute RNA binding activity to mitochondrial RNase P via its conserved NAD+-binding domain. In its C-terminal half MRPP3 displays a handful of amino acid residues strictly conserved in their identity and spacing and reminiscent of a metallonuclease's active site: three aspartates and a histidine, the latter proposed to be directly involved in catalysis Homo sapiens