Cloned (Comment) | Organism |
---|---|
tagged overexpression of MRPP1, MRPP2 and MRPP3 in human cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | mitochondrial RNase P requires divalent metal ions, preferably Mg2+, for cleavage | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
26000 | - |
MRPP2 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
MRPP1, affinity purified | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pre-tRNA + H2O | removes 5' extensions from genuine mitochondrial tRNA precursors | Homo sapiens | tRNA + 5'-oligoribonucleotide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mitochondrial RNase P protein 1 | - |
Homo sapiens |
MRPP1 | - |
Homo sapiens |
MRPP2 | - |
Homo sapiens |
MRPP3 | - |
Homo sapiens |
ribonuclease P | - |
Homo sapiens |
RNase P | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the mitochondrial RNase P is devoid of any RNA, mitochondria make their RNase P of three proteins only. MRPP1 is involved in the methylation of G9 in mitochondria in addition to its role in mitochondrial RNase P. MRRP2 may contribute RNA binding activity to mitochondrial RNase P via its conserved NAD+-binding domain. In its C-terminal half MRPP3 displays a handful of amino acid residues strictly conserved in their identity and spacing and reminiscent of a metallonuclease's active site: three aspartates and a histidine, the latter proposed to be directly involved in catalysis | Homo sapiens |