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EC 1.14.13.104 Details
show Brenda entryEC number
1.14.13.104
Accepted name
(+)-menthofuran synthase
Reaction
(+)-pulegone + NADPH + H+ + O2 = (+)-menthofuran + NADP+ + H2O
Other name(s)
menthofuran synthase,
(+)-pulegone 9-hydroxylase,
(+)-MFS,
cytochrome P450 menthofuran synthase
Systematic name
(+)-pulegone,NADPH:oxygen oxidoreductase (9-hydroxylating)
Comment
A heme-thiolate protein (P-450). The conversion of substrate into product involves the hydroxylation of the syn-methyl (C9), intramolecular cyclization to the hemiketal and dehydration to the furan [1]. This is the second cytochrome P-450-mediated step of monoterpene metabolism in peppermint, with the other step being catalysed by EC 1.14.13.47, (S)-limonene 3-monooxygenase [1].
History
created 2008, deleted 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.4.1 created 1961, deleted 2002 1.6.4.2 created 1961, modified 1989, deleted 2002 1.6.4.3 created 1961, modified 1976, deleted 1983 1.6.4.4 created 1965, deleted 2002 1.6.4.5 created 1972, deleted 2002 1.6.4.6 created 1972, deleted 2002 1.6.4.7 created 1978, deleted 2002 1.6.4.8 created 1989, deleted 2002 1.6.4.9 created 1992, deleted 2002 1.6.4.10 created 1992, deleted 2002 1.14.13.45 created 1992, deleted 2003
