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EC 1.14.13.194 Details
show Brenda entryEC number
1.14.13.194
Accepted name
phylloquinone ω-hydroxylase
Reaction
phylloquinone + NADPH + H+ + O2 = ω-hydroxyphylloquinone + NADP+ + H2O
Other name(s)
vitamin K1 ω-hydroxylase,
CYP4F2,
CYP4F11
Systematic name
phylloquinone,NADPH:oxygen oxidoreductase (ω-hydroxyphylloquinone forming)
Comment
A heme-thiolate protein (cytochrome P-450). Isolated from human tissue. The enzyme will also act on menaquinone-4. Prolonged action of CYP4F2, but not CYP4F11, on the ω hydroxyl group oxidizes it to the corresponding carboxylic acid. CYP4F2 also oxidizes leukotriene B4; see EC 1.14.13.30, leukotriene-B4 20-monooxygenase [1].
History
created 2014, deleted 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.4.1 created 1961, deleted 2002 1.6.4.2 created 1961, modified 1989, deleted 2002 1.6.4.3 created 1961, modified 1976, deleted 1983 1.6.4.4 created 1965, deleted 2002 1.6.4.5 created 1972, deleted 2002 1.6.4.6 created 1972, deleted 2002 1.6.4.7 created 1978, deleted 2002 1.6.4.8 created 1989, deleted 2002 1.6.4.9 created 1992, deleted 2002 1.6.4.10 created 1992, deleted 2002 1.14.13.45 created 1992, deleted 2003
