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EC 1.14.13.79 Details
show Brenda entryEC number
1.14.13.79
Accepted name
ent-kaurenoic acid oxidase
Reaction
ent-kaur-16-en-19-oate + 3 NADPH + 3 H+ + 3 O2 = gibberellin A12 + 3 NADP+ + 4 H2O (overall reaction);;(1a) ent-kaur-16-en-19-oate + NADPH + H+ + O2 = ent-7α-hydroxykaur-16-en-19-oate + NADP+ + H2O;;(1b) ent-7α-hydroxykaur-16-en-19-oate + NADPH + H+ + O2 = gibberellin A12 aldehyde + NADP+ + 2 H2O;;(1c) gibberellin A12 aldehyde + NADPH + H+ + O2 = gibberellin A12 + NADP+ + H2O
Systematic name
ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating)
CAS registry number
337507-95-6
Comment
Requires cytochrome P-450. Catalyses three sucessive oxidations of ent-kaurenoic acid. The second step includes a ring-B contraction giving the gibbane skeleton. In pumpkin (Cucurbita maxima) ent-6α,7α-dihydroxykaur-16-en-19-oate is also formed.
History
created 2002, deleted 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.4.1 created 1961, deleted 2002 1.6.4.2 created 1961, modified 1989, deleted 2002 1.6.4.3 created 1961, modified 1976, deleted 1983 1.6.4.4 created 1965, deleted 2002 1.6.4.5 created 1972, deleted 2002 1.6.4.6 created 1972, deleted 2002 1.6.4.7 created 1978, deleted 2002 1.6.4.8 created 1989, deleted 2002 1.6.4.9 created 1992, deleted 2002 1.6.4.10 created 1992, deleted 2002 1.14.13.45 created 1992, deleted 2003
