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EC 1.14.13.98 Details
show Brenda entryEC number
1.14.13.98
Accepted name
cholesterol 24-hydroxylase
Reaction
cholesterol + NADPH + H+ + O2 = (24S)-24-hydroxycholesterol + NADP+ + H2O
Other name(s)
cholesterol 24-monooxygenase,
CYP46,
CYP46A1,
cholesterol 24S-hydroxylase,
cytochrome P450 46A1
Systematic name
cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating)
CAS registry number
50812-30-1, 213327-78-7
Comment
A heme-thiolate protein (P-450). The enzyme can also produce 25-hydroxycholesterol. In addition, it can further hydroxylate the product to 24,25-dihydroxycholesterol and 24,27-dihydroxycholesterol [2]. This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood—brain barrier whereas cholesterol cannot [3].
History
created 2005, deleted 2016
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.4.1 created 1961, deleted 2002 1.6.4.2 created 1961, modified 1989, deleted 2002 1.6.4.3 created 1961, modified 1976, deleted 1983 1.6.4.4 created 1965, deleted 2002 1.6.4.5 created 1972, deleted 2002 1.6.4.6 created 1972, deleted 2002 1.6.4.7 created 1978, deleted 2002 1.6.4.8 created 1989, deleted 2002 1.6.4.9 created 1992, deleted 2002 1.6.4.10 created 1992, deleted 2002 1.14.13.45 created 1992, deleted 2003
