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EC 1.14.13.185 Details
show Brenda entryEC number
1.14.13.185
Accepted name
pikromycin synthase
Reaction
(1) narbomycin + NADPH + H+ + O2 = pikromycin + NADP+ + H2O;;(2) narbomycin + NADPH + H+ + O2 = neopikromycin + NADP+ + H2O;;(3) narbomycin + 2 NADPH + 2 H+ + 2 O2 = novapikromyin + 2 NADP+ + 2 H2O;;(4) 10-deoxymethymycin + NADPH + H+ + O2 = methymycin + NADP+ + H2O;;(5) 10-deoxymethymycin + NADPH + H+ + O2 = neomethymycin + NADP+ + H2O;;(6) 10-deoxymethymycin + 2 NADPH + 2 H+ + 2 O2 = novamethymycin + 2 NADP+ + 2 H2O
Other name(s)
PikC,
CYP107L1
Systematic name
narbomycin,reduced ferredoxin [iron-sulfur] cluster:oxygen oxidoreductase (pikromycin-forming)
Comment
A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthesis of a number of bacterial macrolide antibiotics containing a desosamine glycoside unit. With narbomycin it hydroxylates at either C-12 to give pikromycin or C-14 to give neopikromycin or both positions to give narvopikromycin. With 10-deoxymethymycin it hydroxylates at either C-10 to give methymycin or C-12 to give neomethymycin or both positions to give novamethymycin.
History
created 2014, deleted 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.4.1 created 1961, deleted 2002 1.6.4.2 created 1961, modified 1989, deleted 2002 1.6.4.3 created 1961, modified 1976, deleted 1983 1.6.4.4 created 1965, deleted 2002 1.6.4.5 created 1972, deleted 2002 1.6.4.6 created 1972, deleted 2002 1.6.4.7 created 1978, deleted 2002 1.6.4.8 created 1989, deleted 2002 1.6.4.9 created 1992, deleted 2002 1.6.4.10 created 1992, deleted 2002 1.14.13.45 created 1992, deleted 2003
