EC Explorer

1.14.13.8

flavin-containing monooxygenase

N,N-dimethylaniline + NADPH + H⁺ + O₂ = N,N-dimethylaniline N-oxide + NADP⁺ + H₂O

dimethylaniline oxidase, dimethylaniline N-oxidase, FAD-containing monooxygenase, N,N-dimethylaniline monooxygenase, DMA oxidase, flavin mixed function oxidase, Ziegler’s enzyme, mixed-function amine oxidase, FMO, FMO-I, FMO-II, FMO1, FMO2, FMO3, FMO4, FMO5, flavin monooxygenase, methylphenyltetrahydropyridine N-monooxygenase, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase, dimethylaniline monooxygenase (N-oxide-forming)

N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)

37256-73-8

A flavoprotein. A broad spectrum monooxygenase that accepts substrates as diverse as hydrazines, phosphines, boron-containing compounds, sulfides, selenides, iodide, as well as primary, secondary and tertiary amines [3,4]. This enzyme is distinct from other monooxygenases in that the enzyme forms a relatively stable hydroperoxy flavin intermediate [4,5]. This microsomal enzyme generally converts nucleophilic heteroatom-containing chemicals and drugs into harmless, readily excreted metabolites. For example, N-oxygenation is largely responsible for the detoxification of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) [2,6]

created 1972 (EC 1.13.12.11 created 1992, part-incorporated 2006), modified 2006