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EC 1.14.13.213 Details
show Brenda entryEC number
1.14.13.213
Accepted name
bursehernin 5′-monooxygenase
Reaction
(–)-bursehernin + NADPH + H+ + O2 = (–)-5′-demethylyatein + NADP+ + H2O
Other name(s)
CYP71CU1 (gene name),
bursehernin 5′-hydroxylase
Systematic name
(–)-bursehernin,NADPH:oxygen oxidoreductase (5′-hydroxylating)
Comment
This cytochrome P-450 enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.
History
created 2016, deleted 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.4.1 created 1961, deleted 2002 1.6.4.2 created 1961, modified 1989, deleted 2002 1.6.4.3 created 1961, modified 1976, deleted 1983 1.6.4.4 created 1965, deleted 2002 1.6.4.5 created 1972, deleted 2002 1.6.4.6 created 1972, deleted 2002 1.6.4.7 created 1978, deleted 2002 1.6.4.8 created 1989, deleted 2002 1.6.4.9 created 1992, deleted 2002 1.6.4.10 created 1992, deleted 2002 1.14.13.45 created 1992, deleted 2003
