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EC 1.14.13.126 Details
show Brenda entryEC number
1.14.13.126
Accepted name
vitamin D3 24-hydroxylase
Reaction
(1) calcitriol + NADPH + H+ + O2 = calcitetrol + NADP+ + H2O;;(2) calcidiol + NADPH + H+ + O2 = secalciferol + NADP+ + H2O
Other name(s)
CYP24A1
Systematic name
calcitriol,NADPH:oxygen oxidoreductase (24-hydroxylating)
Comment
A heme-thiolate enzyme (P-450). The second donor, NADPH, donates electrons through EC 1.18.1.2, ferredoxin--NADP+ reductase and a [2Fe-2S] ferredoxin. The enzyme can perform up to 6 rounds of hydroxylation of the substrate calcitriol leading to calcitroic acid. The human enzyme also shows 23-hydroxylating activity leading to 1,25 dihydroxyvitamin D3-26,23-lactone as end product while the mouse and rat enzymes do not.
History
created 2011, deleted 2016
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.4.1 created 1961, deleted 2002 1.6.4.2 created 1961, modified 1989, deleted 2002 1.6.4.3 created 1961, modified 1976, deleted 1983 1.6.4.4 created 1965, deleted 2002 1.6.4.5 created 1972, deleted 2002 1.6.4.6 created 1972, deleted 2002 1.6.4.7 created 1978, deleted 2002 1.6.4.8 created 1989, deleted 2002 1.6.4.9 created 1992, deleted 2002 1.6.4.10 created 1992, deleted 2002 1.14.13.45 created 1992, deleted 2003
