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EC 1.14.13.100 Details
show Brenda entryEC number
1.14.13.100
Accepted name
25/26-hydroxycholesterol 7α-hydroxylase
Reaction
(1) cholest-5-ene-3β,25-diol + NADPH + H+ + O2 = cholest-5-ene-3β,7α,25-triol + NADP+ + H2O;;(2) (25R)-cholest-5-ene-3β,26-diol + NADPH + H+ + O2 = (25R)-cholest-5-ene-3β,7α,26-triol + NADP+ + H2O
Other name(s)
25-hydroxycholesterol 7α-monooxygenase,
CYP7B1,
CYP7B1 oxysterol 7α-hydroxylase,
27-hydroxycholesterol 7-monooxygenase,
27-hydroxycholesterol 7α-hydroxylase,
cholest-5-ene-3β,25-diol,NADPH:oxygen oxidoreductase (7α-hydroxylating),
25-hydroxycholesterol 7α-hydroxylase
Systematic name
cholest-5-ene-3β,25/26-diol,NADPH:oxygen oxidoreductase (7α-hydroxylating)
CAS registry number
149316-80-3
Comment
A heme-thiolate protein (P-450). Unlike EC 1.14.13.99, 24-hydroxycholesterol 7α-monooxygenase, which is specific for its oxysterol substrate, this enzyme can also metabolize the oxysterols 24,25-epoxycholesterol, 22-hydroxycholesterol and 24-hydroxycholesterol, but to a lesser extent [2].
History
created 2005, modified 2013 (EC 1.14.13.60 created 1999, incorporated 2013), deleted 2016
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.4.1 created 1961, deleted 2002 1.6.4.2 created 1961, modified 1989, deleted 2002 1.6.4.3 created 1961, modified 1976, deleted 1983 1.6.4.4 created 1965, deleted 2002 1.6.4.5 created 1972, deleted 2002 1.6.4.6 created 1972, deleted 2002 1.6.4.7 created 1978, deleted 2002 1.6.4.8 created 1989, deleted 2002 1.6.4.9 created 1992, deleted 2002 1.6.4.10 created 1992, deleted 2002 1.14.13.45 created 1992, deleted 2003
