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EC 1.14.13.197 Details
show Brenda entryEC number
1.14.13.197
Accepted name
dihydromonacolin L hydroxylase
Reaction
dihydromonacolin L acid + O2 + NADPH + H+ = monacolin L acid + NADP+ + 2 H2O (overall reaction);;(1a) dihydromonacolin L acid + O2 + NADPH + H+ = 3α-hydroxy-3,5-dihydromonacolin L acid + NADP+ + H2O;;(1b) 3α-hydroxy-3,5-dihydromonacolin L acid = monacolin L acid + H2O (spontaneous)
Other name(s)
LovA (ambiguous)
Systematic name
dihydromonacolin L acid,NADPH:oxygen oxidoreductase (3-hydroxylating)
Comment
A heme-thiolate protein (cytochrome P-450). The dehydration of 3α-hydroxy-3,5-dihydromonacolin L acid is believed to be spontaneous [1,2]. The enzyme from fungi also catalyses the reaction of EC 1.14.13.198, monacolin L hydroxylase [3].
History
created 2014, deleted 2018
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.4.1 created 1961, deleted 2002 1.6.4.2 created 1961, modified 1989, deleted 2002 1.6.4.3 created 1961, modified 1976, deleted 1983 1.6.4.4 created 1965, deleted 2002 1.6.4.5 created 1972, deleted 2002 1.6.4.6 created 1972, deleted 2002 1.6.4.7 created 1978, deleted 2002 1.6.4.8 created 1989, deleted 2002 1.6.4.9 created 1992, deleted 2002 1.6.4.10 created 1992, deleted 2002 1.14.13.45 created 1992, deleted 2003
