Information on EC 1.14.13.100 - 25/26-hydroxycholesterol 7alpha-hydroxylase

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EC Tree 1 Oxidoreductases 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor 1.14.13.100 25/26-hydroxycholesterol 7alpha-hydroxylase

IUBMB Comments

A heme-thiolate protein (P-450). Unlike EC 1.14.13.99, 24-hydroxycholesterol 7α-monooxygenase, which is specific for its oxysterol substrate, this enzyme can also metabolize the oxysterols 24,25-epoxycholesterol, 22-hydroxycholesterol and 24-hydroxycholesterol, but to a lesser extent .

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Release 2023.1 (January 2023)