1.5.1.5: methylenetetrahydrofolate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about methylenetetrahydrofolate dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.5.1.5

Reaction

5,10-methylenetetrahydrofolate
+
NADP+
=
5,10-methenyltetrahydrofolate
+
NADPH
+
H+

Synonyms

5, 10-methylenetetrahydrofolate dehydrogenase, 5,10-CH2-THF dehydrogenase, 5,10-mehtylene tetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ADE3, Cpe FolD, dehydrogenasse-cyclohydrolase-synthetase, DHCH, DHCH1, FolD, methylene tetrahydrofolate dehydrogenase/cyclohydrolase, methylenetetrahydrofolate dehydrogenase, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase, MIS1, mitochondrial methylenetetrahydrofolate dehydrogenase, MTHFD1, MTHFD1 protein, MTHFD2, MTHFD2 protein, MTHFD2L, MTHFDC, N5,N10-methylenetetrahydrofolate dehydrogenase, N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, NAD-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase, NADP-dependent 5,10-methylene-THF dehydrogenase

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP+)

Reference

Reference on EC 1.5.1.5 - methylenetetrahydrofolate dehydrogenase (NADP+)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Paukert, J.L.; Rabinowitz, J.C.
Formyl-methenyl-methylenetetrahydrofolate synthetase (combined): a multifunctional protein in eukaryotic folate metabolism
Methods Enzymol.
66
616-626
1980
Ovis aries, Saccharomyces cerevisiae, Sus scrofa
Manually annotated by BRENDA team
Cossins, E.A.; Kirk, C.D.; Imeson, H.C.; Zheng, L.l.
Enzymes for synthesis of 10-formyltetrahydrofolate in plants. Characterization of a monofunctional 10-formyltetrahydrofolate synthetase and copurification of 5,10-methylenetetrahydrofolate dehydrogenase and 5,10-methenyltetrahydrofolate cyclohydrolase activities
Adv. Exp. Med. Biol.
338
707-710
1993
Pisum sativum
Manually annotated by BRENDA team
Villar, E.; Schuster, B.; Peterson, D.; Schirch, V.
C1-Tetrahydrofolate synthase from rabbit liver. Structural and kinetic properties of the enzyme and its two domains
J. Biol. Chem.
260
2245-2252
1985
Oryctolagus cuniculus
Manually annotated by BRENDA team
Cohen, L.; MacKenzie, R.E.
Methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase from porcine liver. Interaction between the dehydrogenase and cyclohydrolase activities of the multifunctional enzyme
Biochim. Biophys. Acta
522
311-317
1978
Sus scrofa
Manually annotated by BRENDA team
Tan, L.U.L.; Drury, E.J.; MacKenzie, R.E.
Methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase. A multifunctional protein from porcine liver
J. Biol. Chem.
252
1117-1122
1977
Sus scrofa
Manually annotated by BRENDA team
Kirk, C.D.; Chen, L.; Imeson, H.C.; Cossins, E.A.
A 5,10-methylenetetrahydrofolate dehydrogenase: 5,10-methenyltetrahydrofolate cyclohydrolase protein from Pisum sativum
Phytochemistry
39
1309-1317
1995
Pisum sativum
-
Manually annotated by BRENDA team
Pawelek, P.D.; MacKenzie, R.E.
Methylenetetrahydrofolate dehydrogenase-cyclohydrolase from Photobacterium phosphoreum shares properties with a mammalian mitochondrial homologue
Biochim. Biophys. Acta
1296
47-54
1996
Photobacterium phosphoreum
Manually annotated by BRENDA team
Mackenzie, R.E.; Mejia, N.; Yang, X.M.
Methylenetetrahydrofolate dehydrogenases in normal and transformed mammalian cells
Adv. Enzyme Regul.
27
31-39
1988
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Albrecht, A.M.; Pearce, F.K.; Hutchinson, D.J.
Methylenetetrahydrofolate dehydrogenase of the amethopterin-resistant strain Streptococcus faecium var. durans A and its repressibility by serine
J. Bacteriol.
95
1779-1789
1968
Enterococcus faecium
Manually annotated by BRENDA team
Dev, I.K.; Harvey, R.J.
A complex of N5,N10-methylenetetrahydrofolate dehydrogenase and N5,N10-methenyltetrahydrofolate cyclohydrolase in Escherichia coli. Purification, subunit structure, and allosteric inhibition by N10-formyltetrahydrofolate
J. Biol. Chem.
253
4245-4253
1978
Escherichia coli, Escherichia coli B / ATCC 11303
Manually annotated by BRENDA team
Harvey, R.J.; Dev, I.K.
Regulation in the folate pathway of Escherichia coli
Adv. Enzyme Regul.
13
99-124
1975
Escherichia coli, Escherichia coli B / ATCC 11303
Manually annotated by BRENDA team
Ljungdahl, L.G.; O'Brien, W.E.; Moore, M.R.; Liu, M.T.
Methylenetetrahydrofolate dehydrogenase from Clostridium formicoaceticum and methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase (combined) from Clostridium thermoaceticum
Methods Enzymol.
66
599-609
1980
Moorella thermoacetica
Manually annotated by BRENDA team
Uyeda, K.; Rabinowitz, J.C.
Enzymes of clostridial purine fermentation. Methylenetetrahydrofolate dehydrogenase
J. Biol. Chem.
242
4378-4385
1967
Clostridium cylindrosporum
Manually annotated by BRENDA team
O'Brien, W.E.; Brewer, J.M.; Ljungdahl, L.G.
Purification and characterization of thermostable 5,10-methylenetetrahydrofolate dehydrogenase from Clostridium thermoaceticum
J. Biol. Chem.
248
403-408
1973
Moorella thermoacetica
Manually annotated by BRENDA team
Dalal, F.R.; Gots, J.S.
Purification of 5,10-methylenetetrahydrofolate dehydrogenase from Salmonella typhimurium and its inhibition by purine nucleotides
J. Biol. Chem.
242
3636-3640
1967
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium LT2
Manually annotated by BRENDA team
Ramasastri, B.V.; Blakley, R.L.
5,10-Methylenetetrahydrofolic dehydrogenase from bakers'yeast
J. Biol. Chem.
237
1982-1988
1962
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Paukert, J.L.; Williams, G.R.; Rabinowitz, J.C.
Formyl-methenyl-methylenetetrahydrofolate synthetase (combined); correlation of enzymic activities with limited proteolytic degradation of the protein from yeast
Biochem. Biophys. Res. Commun.
77
147-154
1977
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Hum, D.W.; Bell, A.W.; Rozen, R.; MacKenzie, R.E.
Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase
J. Biol. Chem.
263
15946-15950
1988
Homo sapiens
Manually annotated by BRENDA team
Yeh, Y.C.; Greenberg, D.M.
Purification and properties of N5, N10-Methylenetetra-hydrofolate dehydrogenase of calf thymus
Biochim. Biophys. Acta
105
279-291
1965
Bos taurus
Manually annotated by BRENDA team
MacKenzie, R.E.; Tan, L.U.L.
Methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase: a multifunctional protein from porcine liver
Methods Enzymol.
66
609-615
1980
Sus scrofa
Manually annotated by BRENDA team
MacKenzie, R.E.
Co-purification of three folate enzymes from porcine liver
Biochem. Biophys. Res. Commun.
53
1088-1095
1973
Sus scrofa
Manually annotated by BRENDA team
Ross, J.; Green, J.; Baugh, C.M.; MacKenzie, R.E.; Matthews, R.G.
Studies on the polyglutamate specificity of methylenetetrahydrofolate dehydrogenase from pig liver
Biochemistry
23
1796-1801
1984
Sus scrofa
Manually annotated by BRENDA team
Gardam, M.A.; Mejia, N.R.; MacKenzie, R.E.
The NADP-dependent trifunctional methylenetetrahydrofolate dehydrogenase purified from mouse liver is immunologically distinct from the mouse NAD-dependent [corrected] bifunctional enzyme [published erratum appears in Biochem Cell Biol 1988 May;66(5):459]
Biochem. Cell Biol.
66
66-70
1988
Mus musculus
Manually annotated by BRENDA team
Paukert, J.L.; D'Ari Straus, L.; Rabinowitz, J.C.
Formyl-methyl-methylenetetrahydrofolate synthetase-(combined). An ovine protein with multiple catalytic activities
J. Biol. Chem.
251
5104-5111
1976
Ovis aries
Manually annotated by BRENDA team
Cossins, E.A.; Wong, K.F.; Roos, A.J.
Plant N5,N10-methylenetetrahydrofolate dehydrogenase: partial purification and some general properties of the enzyme from germinating pea seedlings
Phytochemistry
9
1463-1471
1970
Pisum sativum
-
Manually annotated by BRENDA team
Yoshida, T.; Kikuchi, G.
Comparative study on major pathways of glycine and serine catabolism in vertebrate livers
J. Biochem.
72
1503-1516
1972
Bos taurus, Elaphe quadrivirgata, Gallus gallus bankiva, Ovis aries
Manually annotated by BRENDA team
Pelletier J.N.; MacKenzie, E.
Binding and interconversion of tetrahydrofolates at a single site in the bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase
Biochemistry
34
12673-12680
1995
Homo sapiens
Manually annotated by BRENDA team
Pawelek, P.D.; MacKenzie, R.E.
Methenyltetrahydrofolate cyclohydrolase is rate limiting for the enzymatic conversion of 10-formyltetrahydrofolate to 5,10-methylenetetrahydrofolate in bifunctional dehydrogenase-cyclohydrolase enzymes
Biochemistry
37
1109-1115
1998
Homo sapiens, Photobacterium phosphoreum
Manually annotated by BRENDA team
Goenrich, M.; Bursy, J.; Hubner, E.; Linder, D.; Schwartz, A.C.; Vorholt, J.A.
Purification and characterization of the methylene tetrahydromethanopterin dehydrogenase MtdB and the methylene tetrahydrofolate dehydrogenase FolD from Hyphomicrobium zavarzinii ZV580
Arch. Microbiol.
177
299-303
2002
Hyphomicrobium zavarzinii, Hyphomicrobium zavarzinii ZV580, no activity in Methylobacterium extorquens
Manually annotated by BRENDA team
Casaite, V.; Meskiene, R.; Meskys, R.
Elucidation of enzymatic function encoded by folD and fic genes from dimethylglycine operon
Biologia (Bratisl. )
2
1-4
2004
Arthrobacter globiformis
-
Manually annotated by BRENDA team
Kim, J.H.; Sung, M.W.; Lee, E.H.; Nam, K.H.; Hwang, K.Y.
Crystallization and preliminary X-ray diffraction analysis of 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase from Thermoplasma acidophilum DSM 1728
J. Microbiol. Biotechnol.
18
283-286
2008
Thermoplasma acidophilum
Manually annotated by BRENDA team
Christensen, K.E.; Rohlicek, C.V.; Andelfinger, G.U.; Michaud, J.; Bigras, J.L.; Richter, A.; Mackenzie, R.E.; Rozen, R.
The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects
Hum. Mutat.
30
212-220
2009
Homo sapiens (P11586)
Manually annotated by BRENDA team
Murta, S.M.; Vickers, T.J.; Scott, D.A.; Beverley, S.M.
Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major
Mol. Microbiol.
71
1386-1401
2009
Leishmania major
Manually annotated by BRENDA team
Christensen, K.E.; Mackenzie, R.E.
Mitochondrial methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase, and formyltetrahydrofolate synthetases
Vitam. Horm.
79
393-410
2008
Homo sapiens, Saccharomyces cerevisiae
Manually annotated by BRENDA team
Bi, X.H.; Zhao, H.L.; Zhang, Z.X.; Liu, Q.; Zhang, J.W.
Association analysis of CbetaS 844ins68 and MTHFD1 G1958A polymorphisms with Alzheimers disease in Chinese
J. Neural Transm.
117
499-503
2010
Homo sapiens
Manually annotated by BRENDA team
Lee, W.H.; Sung, M.W.; Kim, J.H.; Kim, Y.K.; Han, A.; Hwang, K.Y.
Crystal structure of bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase from Thermoplasma acidophilum
Biochem. Biophys. Res. Commun.
406
459-463
2011
Thermoplasma acidophilum (Q05213)
Manually annotated by BRENDA team
Eadsforth, T.C.; Cameron, S.; Hunter, W.N.
The crystal structure of Leishmania major N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target
Mol. Biochem. Parasitol.
181
178-185
2012
Leishmania major (Q4Q9F9), Leishmania major Fridlin (Q4Q9F9)
Manually annotated by BRENDA team
Bolusani, S.; Young, B.A.; Cole, N.A.; Tibbetts, A.S.; Momb, J.; Bryant, J.D.; Solmonson, A.; Appling, D.R.
Mammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissues
J. Biol. Chem.
286
5166-5174
2011
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Aluri, S.; Sah, S.; Miryala, S.; Varshney, U.
Physiological role of FolD (methylenetetrahydrofolate dehydrogenase), FchA (methenyltetrahydrofolate cyclohydrolase) and Fhs (formyltetrahydrofolate synthetase) from Clostridium perfringens in a heterologous model of Escherichia coli
Microbiology
162
145-155
2016
Clostridium perfringens
Manually annotated by BRENDA team