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Literature summary for 1.5.1.5 extracted from
- The prognostic significance of immune-related metabolic enzyme MTHFD2 in head and neck squamous cell carcinoma (2020), Diagnostics (Basel), 10, 689 .
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | prognostic significance of MTHFD1 in head and neck squamous cell carcinoma (HNSCC) as well as the association between MTHFD1 and immune cell infiltration. MTHFD1 overexpression is closely correlated with unfavorable prognosis of HNSCC, and it might play an important role in modulating the tumor immune microenvironment | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + NADP+ | Homo sapiens | - |
5,10-methenyltetrahydrofolate + NADPH + H+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P11586 | MTHFD1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| head and neck squamous cell carcinoma cell | HNSCC cell carcinoma, a total of 121 significantly altered IRMEs are identified between HNSCC and normal tissues, and 21 IRMEs are found to be strongly associated with overall survival of HNSCC. THe expression level of MTHFD1 is significantly overexpressed in tumor tissues compared to the normal controls in both GSE6631 and TCGA HNSCC cohort | Homo sapiens | - |
| additional information | MTHFD1 is positively correlated with NK cells resting, mast cells activated, and eosinophils, while negatively associated with NK cells activated, mast cells resting, and dendritic cells resting | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + NADP+ | - |
Homo sapiens | 5,10-methenyltetrahydrofolate + NADPH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| methylenetetrahydrofolate dehydrogenase (NADP+ dependent) | - |
Homo sapiens |
| MTHFD1 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Homo sapiens | |
| NADPH | - |
Homo sapiens | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | the expression level of MTHFD1 is significantly overexpressed in tumor tissues compared to the normal controls in both GSE6631 and TCGA HNSCC cohort. A total of 121 significantly altered IRMEs are identified between head and neck squamous cell carcinoma (HNSCC) and normal tissues, and 21 IRMEs are found to be strongly associated with overall survival of HNSCC. Upregulation of MTHFD1 is positively correlated with adverse clinicopathological factors in TCGA HNSCC cohort. Increased MTHFD1 expression is negatively associated with NK cells activation, while positively correlated with mast cells activation | up |
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Release 2023.1 (January 2023)
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