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Information on EC 1.5.1.5 - methylenetetrahydrofolate dehydrogenase (NADP+)

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IUBMB Comments
In eukaryotes, occurs as a trifunctional enzyme also having methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) and formate---tetrahydrofolate ligase (EC 6.3.4.3) activity. In some prokaryotes occurs as a bifunctional enzyme also having methenyltetrahydrofolate cyclohydrolase activity (EC 3.5.4.9).
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
5,10-methylenetetrahydrofolate dehydrogenase, mthfd2 protein, mthfd1 protein, mitochondrial methylenetetrahydrofolate dehydrogenase, n5,n10-methylenetetrahydrofolate dehydrogenase, 5,10-ch2-thf dehydrogenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH + H+
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