1.5.1.5: methylenetetrahydrofolate dehydrogenase (NADP+)

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For detailed information about methylenetetrahydrofolate dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.5.1.5

1.5.1.5

one-carbon

cyclohydrolase

thymidylate

trifunctional

methenyltetrahydrofolate

5,10-methenyltetrahydrofolate

10-formyltetrahydrofolate

mthfd1l

folate-dependent

formyltetrahydrofolate

folate-mediated

c1-tetrahydrofolate

3.5.4.9

transcobalamin

10-formyl-thf

6.3.4.3

remethylation

5,10-methenyl-thf

1-carbon

dehydrogenase-cyclohydrolase

megaloblastic

medicine

Reaction

Synonyms

5, 10-methylenetetrahydrofolate dehydrogenase, 5,10-CH2-THF dehydrogenase, 5,10-mehtylene tetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ADE3, bmMTHFD, CH2-THF dehydrogenase, Cpe FolD, dehydrogenasse-cyclohydrolase-synthetase, DHCH, DHCH1, FolD, methylene tetrahydrofolate dehydrogenase/cyclohydrolase, methylenetetrahydrofolate dehydrogenase, methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase, methylenetetrahydrofolate dehydrogenase/cyclohydrolase, methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, MIS1, mitochondrial methylenetetrahydrofolate dehydrogenase, MTHFD, MTHFD1, MTHFD1 protein, MTHFD2, MTHFD2 protein, MTHFD2L, MTHFDC, N5,N10-methylenetetrahydrofolate dehydrogenase, N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, NAD-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase, NADP-dependent 5,10-methylene-THF dehydrogenase

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.1 With NAD⁺ or NADP⁺ as acceptor

1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP+)

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Results	in table
6	Activating Compound
45268	AA Sequence
3	Application
1	CAS Registry Number
21	Cloned(Commentary)
64	Cofactor
5	Crystallization (Commentary)
236	Disease/ Diagnostics
1	Expression
20	General Information
10	General Stability
14	IC50 Value
56	Inhibitors
20	kcat/KM [mM/s]
9	Ki Value [mM]
82	KM Value [mM]
22	Localization
14	Metals/Ions
30	Molecular Weight [Da]
58	Natural Substrates/ Products (Substrates)
421	Organism
16	Pathway
72	PDB ID
13	pH Optimum
3	pH Range
16	Protein Variants
36	Purification (Commentary)
1	Reaction
6	Reaction Type
66	Reference
57	Source Tissue
34	Specific Activity [micromol/min/mg]
13	Storage Stability
91	Substrates and Products (Substrate)
19	Subunits
73	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
28	Turnover Number [1/s]

Purification

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Purification on EC 1.5.1.5 - methylenetetrahydrofolate dehydrogenase (NADP+)

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6 entries

bifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase

2 entries

by anion-exchange chromatography

Homo sapiens

P11586

698187

co-purification of 5,10-methylenetetrahydrofolate dehydrogenase and 5,10-methenyltetrahydrofolate cyclohydrolase

Pisum sativum

1518, 209737

complex of N5,N10-methylenetetrahydrofolate dehydrogenase and N5,N10-methenyltetrahydrofolate cyclohydrolase

Escherichia coli

392307

formyltetrahydrofolate synthetase, methenyltetrahydrofolate cyclohydrolase and methylenetetrahydrofolate dehydrogenase combined

Saccharomyces cerevisiae

1505, 392314

heat treatment, Ni-affinity column chromatography, and Superdex-200 gel filtration

Thermoplasma acidophilum

Q05213

718743

His-Trap affinity column chromatography

Thermoplasma acidophilum

688323

HisTrap column chromatography and Superdex 200 gel filtration

Leishmania major

Q4Q9F9

720406

in vitro transcription-translation of cDNA clone, trifunctional enzyme: 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrase and 10-formyltetrahydrofolate synthetase

Homo sapiens

392315

metal affinity chromatography

Leishmania major

700281

methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase combined

Moorella thermoacetica

392309

partial

3 entries

recombinant DHCH1 protein is purified by metal-affinity chromatography

Leishmania major

700281

recombinant His-tagged truncated enzyme mutant rMTHFD2LDELTA1-40 from Saccharomyces cerevisiae strain MWY4.4 by nickel affinity chromatography, sodium carbonate in the extraction buffer is used to release MTHFD2L from membranes

Rattus norvegicus

D3ZUA0

742856

trifunctional enzyme: methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrase, formyltetrahydrofolate synthetase

4 entries