1.5.1.5: methylenetetrahydrofolate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about methylenetetrahydrofolate dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.5.1.5

Reaction

5,10-methylenetetrahydrofolate
+
NADP+
=
5,10-methenyltetrahydrofolate
+
NADPH
+
H+

Synonyms

5, 10-methylenetetrahydrofolate dehydrogenase, 5,10-CH2-THF dehydrogenase, 5,10-mehtylene tetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ADE3, Cpe FolD, dehydrogenasse-cyclohydrolase-synthetase, DHCH, DHCH1, FolD, methylene tetrahydrofolate dehydrogenase/cyclohydrolase, methylenetetrahydrofolate dehydrogenase, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase, MIS1, mitochondrial methylenetetrahydrofolate dehydrogenase, MTHFD1, MTHFD1 protein, MTHFD2, MTHFD2 protein, MTHFD2L, MTHFDC, N5,N10-methylenetetrahydrofolate dehydrogenase, N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, NAD-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase, NADP-dependent 5,10-methylene-THF dehydrogenase

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP+)

Molecular Weight

Molecular Weight on EC 1.5.1.5 - methylenetetrahydrofolate dehydrogenase (NADP+)

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30000
-
2 * 30000, SDS-PAGE
30600
-
SDS-PAGE
31000
31900
Q4Q9F9
2 * 31900, calculated from amino acid sequence
33000
-
x * 33000, fragment has methylenetetrahydrofolate dehadrogenase and methenyltetrahydrofolate cyclohydrase activity, proteolysis, SDS-PAGE
34000
-
MTHFD2 evolves from a trifunctional dehydrogenase-cyclohydrolase-synthetase precursor with the loss of synthetase function
38500
-
? * 38500, probably not a heterodimer, SDS-PAGE
50000
-
equilibrium ultracentrifugation
55000
-
methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase combined, equilibrium ultracentrifugation
57000
-
1 * 57000, bifunctional protein: methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase, SDS-PAGE
58000
-
methylenetetrahydrofolate dehydrogenase-methyltetrahydrofolate cyclohydrolase protein, gel filtration
60000
-
methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase protein, gel filtration
65000
Q4Q9F9
gel filtration
70000
-
sucrose density gradient centrifugation
100000
101000
-
trifunctional enzyme: 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase, transcription-translation of a cDNA clone
104500
-
2 * 104500, SDS-PAGE
108000
-
2 * 108000, 1 * 218000 intramolecular cross-linked with dimethylsuberimidate, SDS-PAGE
150000
-
methylenetetrahydrofolate dehydrogenase, formyltetrahydrofolate synthetase and methenyltetrahydrofolate cyclohydrolase combined, gel filtration
201000
218000
-
2 * 108000, 1 * 218000 intramolecular cross-linked with dimethylsuberimidate, SDS-PAGE
226000
-
methylenetetrahydrofolate dehydrogenase, formyltetrahydrofolate synthetase and methenyltetrahydrofolate cyclohydrolase combined, gel filtration
228000
-
methylenetetrahydrofolate dehydrogenase, formyltetrahydrofolate synthetase and methenyltetrahydrofolate cyclohydrolase combined, gel filtration