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Literature summary for 1.5.1.5 extracted from
- Methylenetetrahydrofolate dehydrogenases in normal and transformed mammalian cells (1988), Adv. Enzyme Regul., 27, 31-39.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | for binding NAD+ | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
MCF-7, M4, LS-180, CCRF-CEM, MG-63 | - |
| Mus musculus | - |
P9, BN/2, P8115, EL4,YAC, 3T3 | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.4 | 6.9 | bifunctional NAD+-dependent enzyme, in various cell lines | Mus musculus |
| 2.7 | 12.9 | bifunctional NAD+-dependent enzyme, in various cell lines | Homo sapiens |
| 8 | 17.9 | trifuncional NADP+-dependent enzyme, in various cell lines | Homo sapiens |
| 8.1 | - |
trifunctional enzyme, human liver | Homo sapiens |
| 12.7 | 42 | trifunctional NADP+-dependent enzyme, in various cell lines | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Mus musculus | |
| NADP+ | - |
Homo sapiens | |
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