BRENDA - Enzyme Database
show all sequences of 1.5.1.5

Formyl-methenyl-methylenetetrahydrofolate synthetase (combined); correlation of enzymic activities with limited proteolytic degradation of the protein from yeast

Paukert, J.L.; Williams, G.R.; Rabinowitz, J.C.; Biochem. Biophys. Res. Commun. 77, 147-154 (1977)

Data extracted from this reference:

Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
104500
-
2 * 104500, SDS-PAGE
Saccharomyces cerevisiae
201000
-
formyltetrahydrofolate synthetase, methenyltetrahydrofolate cyclohydrolase and methylenetetrahydrofolate dehydrogenase combined, gel filtration
Saccharomyces cerevisiae
Organism
Organism
UniProt
Commentary
Textmining
Saccharomyces cerevisiae
-
-
-
Purification (Commentary)
Purification (Commentary)
Organism
formyltetrahydrofolate synthetase, methenyltetrahydrofolate cyclohydrolase and methylenetetrahydrofolate dehydrogenase combined
Saccharomyces cerevisiae
Subunits
Subunits
Commentary
Organism
dimer
2 * 104500, SDS-PAGE
Saccharomyces cerevisiae
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
104500
-
2 * 104500, SDS-PAGE
Saccharomyces cerevisiae
201000
-
formyltetrahydrofolate synthetase, methenyltetrahydrofolate cyclohydrolase and methylenetetrahydrofolate dehydrogenase combined, gel filtration
Saccharomyces cerevisiae
Purification (Commentary) (protein specific)
Commentary
Organism
formyltetrahydrofolate synthetase, methenyltetrahydrofolate cyclohydrolase and methylenetetrahydrofolate dehydrogenase combined
Saccharomyces cerevisiae
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
2 * 104500, SDS-PAGE
Saccharomyces cerevisiae
Other publictions for EC 1.5.1.5
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
755732
Bueno
An assessment of three human ...
Homo sapiens
Acta Crystallogr. Sect. F
75
148-152
2019
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757625
Sah
Utilisation of 10-formyldihyd ...
Escherichia coli, Escherichia coli K12
Microbiology
164
982-991
2018
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1
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757773
Hitzel
Oxidized phospholipids regula ...
Homo sapiens
Nat. Commun.
9
2292
2018
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1
1
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756334
Shin
Human mitochondrial MTHFD2 is ...
Homo sapiens
Cancer Metab.
5
11
2017
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2
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4
2
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2
2
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2
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2
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10
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4
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2
4
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2
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2
2
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2
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3
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10
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4
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2
2
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4
4
743250
Aluri
Physiological role of FolD (m ...
Clostridium perfringens
Microbiology
162
145-155
2016
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2
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5
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2
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3
3
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744335
Sah
Impact of mutating the key re ...
Escherichia coli, Escherichia coli K12
Biochemistry
54
3504-3513
2015
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7
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8
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8
8
742856
Shin
Mitochondrial MTHFD2L is a du ...
Mus musculus, Rattus norvegicus, Mus musculus C57BL/6
J. Biol. Chem.
289
15507-15517
2014
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2
-
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2
8
2
6
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9
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5
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1
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11
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1
14
1
10
2
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6
2
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10
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2
10
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2
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8
2
6
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9
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1
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11
-
1
14
1
2
-
-
6
2
-
-
-
-
6
6
-
6
6
720406
Eadsforth
The crystal structure of Leish ...
Leishmania major, Leishmania major Fridlin
Mol. Biochem. Parasitol.
181
178-185
2012
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1
1
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1
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2
2
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2
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1
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2
1
2
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1
1
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1
1
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1
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1
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718743
Lee
Crystal structure of bifunctio ...
Thermoplasma acidophilum
Biochem. Biophys. Res. Commun.
406
459-463
2011
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1
1
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1
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1
1
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725456
Bolusani
Mammalian MTHFD2L encodes a mi ...
Homo sapiens, Rattus norvegicus
J. Biol. Chem.
286
5166-5174
2011
-
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2
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2
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2
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10
-
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12
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2
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4
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2
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2
2
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12
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2
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712807
Bi
Association analysis of CbetaS ...
Homo sapiens
J. Neural Transm.
117
499-503
2010
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1
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698187
Christensen
The MTHFD1 p.Arg653Gln variant ...
Homo sapiens
Hum. Mutat.
30
212-220
2009
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1
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1
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2
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1
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2
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700281
Murta
Methylene tetrahydrofolate deh ...
Leishmania major
Mol. Microbiol.
71
1386-1401
2009
-
1
2
-
1
-
7
4
2
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3
-
1
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2
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2
1
3
-
5
1
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4
1
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2
2
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14
-
1
2
2
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1
-
14
7
2
4
2
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3
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2
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2
1
3
-
1
-
-
4
1
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1
1
-
2
2
688323
Kim
Crystallization and preliminar ...
Thermoplasma acidophilum
J. Microbiol. Biotechnol.
18
283-286
2008
-
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1
1
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1
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1
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1
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1
1
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1
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1
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701402
Christensen
Mitochondrial methylenetetrahy ...
Saccharomyces cerevisiae, Homo sapiens
Vitam. Horm.
79
393-410
2008
-
-
2
-
7
-
1
1
4
4
1
7
-
3
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3
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7
-
11
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6
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2
6
-
7
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1
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1
4
4
1
7
-
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3
-
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7
-
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2
2
-
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654937
Casaite
-
Elucidation of enzymatic funct ...
Arthrobacter globiformis
Biologia (Bratisl. )
2
1-4
2004
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392334
Goenrich
Purification and characterizat ...
Hyphomicrobium zavarzinii, no activity in Methylobacterium extorquens, Hyphomicrobium zavarzinii ZV580
Arch. Microbiol.
177
299-303
2002
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2
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4
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2
1
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1
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392333
Pawelek
Methenyltetrahydrofolate cyclo ...
Homo sapiens, Photobacterium phosphoreum
Biochemistry
37
1109-1115
1998
-
-
-
-
-
-
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7
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1
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2
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2
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4
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7
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2
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4
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209738
Pawelek
Methylenetetrahydrofolate dehy ...
Photobacterium phosphoreum
Biochim. Biophys. Acta
1296
47-54
1996
1
-
1
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2
4
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1
1
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1
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1
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1
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1
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2
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209737
Kirk
-
A 5,10-methylenetetrahydrofola ...
Pisum sativum
Phytochemistry
39
1309-1317
1995
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4
3
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2
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1
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1
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2
1
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1
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1
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1
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3
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1
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3
3
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1
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392331
Pelletier J.N.; MacKenzie
Binding and interconversion of ...
Homo sapiens
Biochemistry
34
12673-12680
1995
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1518
Cossins
Enzymes for synthesis of 10-fo ...
Pisum sativum
Adv. Exp. Med. Biol.
338
707-710
1993
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2
1
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2
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1
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1
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1
1
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1
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1
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1
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1
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2
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1
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1
1
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1
1
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1
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392079
Mackenzie
Methylenetetrahydrofolate dehy ...
Homo sapiens, Mus musculus
Adv. Enzyme Regul.
27
31-39
1988
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1
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2
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5
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2
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1
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5
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392315
Hum
Primary structure of a human t ...
Homo sapiens
J. Biol. Chem.
263
15946-15950
1988
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1
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1
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1
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1
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392323
Gardam
The NADP-dependent trifunction ...
Mus musculus
Biochem. Cell Biol.
66
66-70
1988
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2
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1
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8
-
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1
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5
1
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1
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1
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1
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5
1
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1
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1532
Villar
C1-Tetrahydrofolate synthase f ...
Oryctolagus cuniculus
J. Biol. Chem.
260
2245-2252
1985
-
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2
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392321
Ross
Studies on the polyglutamate s ...
Sus scrofa
Biochemistry
23
1796-1801
1984
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1
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6
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1505
Paukert
Formyl-methenyl-methylenetetra ...
Saccharomyces cerevisiae, Ovis aries, Sus scrofa
Methods Enzymol.
66
616-626
1980
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-
-
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2
6
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1
4
3
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3
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3
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2
1
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3
1
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6
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3
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2
1
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3
1
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392309
Ljungdahl
Methylenetetrahydrofolate dehy ...
Moorella thermoacetica
Methods Enzymol.
66
599-609
1980
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1
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1
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2
1
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7
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1
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1
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1
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2
1
1
1
1
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1
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392317
MacKenzie
Methylenetetrahydrofolate dehy ...
Sus scrofa
Methods Enzymol.
66
609-615
1980
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-
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1
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2
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1
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1
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1
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1
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1
1
1
1
1
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209726
Cohen
Methylenetetrahydrofolate dehy ...
Sus scrofa
Biochim. Biophys. Acta
522
311-317
1978
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2
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4
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392307
Dev
A complex of N5,N10-methylenet ...
Escherichia coli, Escherichia coli B / ATCC 11303
J. Biol. Chem.
253
4245-4253
1978
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3
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1
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1
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1
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1
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1
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1
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209727
Tan
Methylenetetrahydrofolate dehy ...
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J. Biol. Chem.
252
1117-1122
1977
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1
3
2
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2
1
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4
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1
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2
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1
1
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1
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1
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1
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3
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2
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2
1
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1
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2
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1
1
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392314
Paukert
Formyl-methenyl-methylenetetra ...
Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
77
147-154
1977
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2
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1
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1
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1
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392324
Paukert
Formyl-methyl-methylenetetrahy ...
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J. Biol. Chem.
251
5104-5111
1976
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2
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1
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4
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1
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2
1
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1
1
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1
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1
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2
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3
1
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1
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2
1
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1
1
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392308
Harvey
Regulation in the folate pathw ...
Escherichia coli, Escherichia coli B / ATCC 11303
Adv. Enzyme Regul.
13
99-124
1975
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3
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2
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177
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2
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2
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392311
O'Brien
Purification and characterizat ...
Moorella thermoacetica
J. Biol. Chem.
248
403-408
1973
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1
2
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1
1
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3
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1
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1
2
1
1
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1
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1
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1
1
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1
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1
1
2
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1
1
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1
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1
2
1
1
1
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1
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-
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392319
MacKenzie
Co-purification of three folat ...
Sus scrofa
Biochem. Biophys. Res. Commun.
53
1088-1095
1973
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1
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1
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1
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1
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1
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1
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392328
Yoshida
Comparative study on major pat ...
Bos taurus, Elaphe quadrivirgata, Gallus gallus bankiva, Ovis aries
J. Biochem.
72
1503-1516
1972
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8
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4
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4
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4
8
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4
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8
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4
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4
8
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4
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392326
Cossins
-
Plant N5,N10-methylenetetrahyd ...
Pisum sativum
Phytochemistry
9
1463-1471
1970
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-
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1
3
3
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1
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1
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3
1
1
2
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1
1
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2
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2
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1
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3
-
3
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1
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3
1
1
2
-
-
-
-
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1
1
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392306
Albrecht
Methylenetetrahydrofolate dehy ...
Enterococcus faecium
J. Bacteriol.
95
1779-1789
1968
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1
5
2
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1
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1
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1
1
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1
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1
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1
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1
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5
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2
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1
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1
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1
1
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1
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392310
Uyeda
Enzymes of clostridial purine ...
Clostridium cylindrosporum
J. Biol. Chem.
242
4378-4385
1967
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1
1
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1
1
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1
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1
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1
1
3
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1
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1
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1
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1
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1
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4
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1
1
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1
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1
1
3
-
-
-
-
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1
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-
-
-
-
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392312
Dalal
Purification of 5,10-methylene ...
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium LT2
J. Biol. Chem.
242
3636-3640
1967
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1
3
2
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2
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45
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1
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2
1
2
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1
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1
1
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-
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1
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1
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3
1
2
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-
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2
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1
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2
1
2
-
-
-
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1
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392316
Yeh
Purification and properties of ...
Bos taurus
Biochim. Biophys. Acta
105
279-291
1965
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1
6
3
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1
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1
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1
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1
3
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1
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-
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1
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1
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-
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-
-
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1
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1
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6
-
3
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1
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1
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-
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1
-
1
3
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1
-
-
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1
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392313
Ramasastri
5,10-Methylenetetrahydrofolic ...
Saccharomyces cerevisiae
J. Biol. Chem.
237
1982-1988
1962
5
-
-
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1
5
2
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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5
-
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1
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1
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5
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2
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1
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1
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1
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1
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1
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1
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1
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1
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