2.7.2.4: aspartate kinase This is an abbreviated version! For detailed information about aspartate kinase, go to the full flat file .
Reaction
ATP +
L-aspartate =
ADP +
4-phospho-L-aspartate
Synonyms AK, AK II, AK III, AK-HSDH, AK-HSDH I, AK-HSDH1, AK-HSDH2, AK-HseDH, AK-R7, AK-ts31d, AK1, AK2, AK3, AKbeta, AKII, AKIII, AKsyn, Ask, ASK1, ASK2, Ask_Ect, Ask_LysC, Asp kinase-homoserine dehydrogenase, aspartate kinase, aspartate kinase (phosphorylating), aspartate kinase 1, aspartate kinase 2, aspartate kinase 3, aspartate kinase beta, aspartate kinase I, aspartate kinase II, aspartate kinase III, aspartic kinase, aspartokinase, aspartokinase 1-homoserine dehydrogenase 1, aspartokinase 2, aspartokinase 3, aspartokinase I, aspartokinase II, aspartokinase III, aspartokinase-homoserine dehydrogenase, beta-aspartokinase, bifunctional aspartate kinase-homoserine dehydrogenase, BT, BTT, CgAK, dap-aspartokinase, HOM3 product, HOM3-R7 product, HOM3-ts31d product, HseDH, LT-aspartokinase, lysC, lysine-sensitive aspartokinase 3, More, MtbAKbeta, nspJ, Thr-sensitive aspartate kinase, thrA, thrA1, thrA2, TM_0547, XbAK
ECTree
Organism
Organism on EC 2.7.2.4 - aspartate kinase
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LC411
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LC411
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U32
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brenda
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-
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brenda
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brenda
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brenda
gene lysC
UniProt
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VB217, ATCC6051
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brenda
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brenda
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brenda
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ATCC 10068
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-
SwissProt
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N13
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N13
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gene lysC
SwissProt
brenda
gene lysC
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carrot
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brenda
9723 (ATCC)
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brenda
-
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brenda
strain LATR11 is derived from the wild-type strain Escherichia coli MG1655
UniProt
brenda
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UniProt
brenda
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brenda
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brenda
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UniProt
brenda
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brenda
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brenda
homozygous tobacco plants expressing bacterialAK are crossed with homozygous transgenic tobacco lines expressing F-AtCGS, T-AtCGS (lacking its N-terminus region) or D-AtCGS (lacking 90-nt of the N-terminus region)
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no activity in Edwardsiella sp.
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no activity in Providencia sp.
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no activity in Streptomyces akiyoshiensis
producer strain of 5-hydroxy-4-oxonorvaline
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rice, IAC-165 upland variety
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UniProt
brenda
i.e. Paenibacillus polymyxa
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feedback-resistent aspartate kinase
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contains HOM3-R7 allel, insensitive to threonine
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Massa 03
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UniProt
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UniProt
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UniProt
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UniProt
brenda
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AT-62
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wheat
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transgenic narbon bean
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TREMBL
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SwissProt
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gene ak-hsdh1
Uniprot
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gene ak-hsdh2
TREMBL
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gene ak1
SwissProt
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gene ak2
UniProt
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gene ak3
SwissProt
brenda
ligated into pET 23d(+) vector and Escherichia coli strain DH10B for cloning, expression in Escherichia coli BL21 (DE3) pLysS codon+
UniProt
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ligated into pET 23d(+) vector and Escherichia coli strain DH10B for cloning, expression in Escherichia coli BL21 (DE3) pLysS codon+
SwissProt
brenda
Saccharomyces cerevisiae M20-20D cells are transformed with A. thaliana cDNA, protein expressed and purified from Saccharomyces cerevisiae, all data refer to the recombinant yeast protein
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var. Bensheim, mutant RL4
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chimera composed of the chimeric alpha subunit that comprises the N-terminal catalytic region from Bacillus subtilis AK II and the C-terminal region from Thermus flavus
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chimera composed of the chimeric alpha subunit that comprises the N-terminal catalytic region from Bacillus subtilis AK II and the C-terminal region from Thermus flavus, and the beta subunit from Thermus flavus
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brenda
gene lysC
UniProt
brenda
VB217, ATCC6051
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brenda
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brenda
-
SwissProt
brenda
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brenda
ATCC 21799, nucleotide sequence encoding the beta-subunit
SwissProt
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expression in Escherichia coli BL21-CodonPlus(DE3)-RIL cells with pET-26b(+) vector
SwissProt
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gene lysC
SwissProt
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gene lysC
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UniProt
brenda
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Deinococcus radiodurans AK has a different protein structure and a different evolutionary history from Thermus thermophilus AK, the disruption mutant exhibits a similar phenotype and the functions are not different
UniProt
brenda
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brenda
Deinococcus radiodurans AK has a different protein structure and a different evolutionary history from Thermus thermophilus AK, the disruption mutant exhibits a similar phenotype and the functions are not different
UniProt
brenda
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brenda
-
UniProt
brenda
9723 (ATCC)
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gene lysC
UniProt
brenda
K12
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brenda
strain LATR11 is derived from the wild-type strain Escherichia coli MG1655
UniProt
brenda
Tir 8, derepressed strain of K 12 and mutant Gif 108
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barley
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L. cv. Jagriti
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brenda
-
UniProt
brenda
Methanococcus jannaschii has only a single, monofunctional form of AK; pET-41a vector and Rosetta (DE3) Escherichia coli cells for protein expression
UniProt
brenda
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brenda
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UniProt
brenda
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brenda
i.e. Paenibacillus polymyxa
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brenda
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brenda
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UniProt
brenda
-
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brenda
wild-type strain P-14
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brenda
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contains HOM3-R7 allel, insensitive to threonine
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feedback-resistent aspartate kinase
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brenda
wildtype strain 8723c, parental strain of SG211
SwissProt
brenda
yeast
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homologous expression in Streptomyces albulus CR1, expression with pQE30 plasmid in Escherichia coli M15 (pREP4)
TrEMBL
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homologous expression in Streptomyces albulus CR1, expression with pQE30 plasmid in Escherichia coli M15 (pREP4)
TrEMBL
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UniProt
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SwissProt
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AT-62
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chimera composed of the chimeric alpha subunit that comprises the N-terminal catalytic region from Bacillus subtilis AK II and the C-terminal region from Thermus flavus
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chimera composed of the chimeric alpha subunit that comprises the N-terminal catalytic region from Bacillus subtilis AK II and the C-terminal region from Thermus flavus, and the beta subunit from Thermus flavus
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brenda
expression in Escherichia coli BL21-CodonPlus(DE3)-RIL cells
SwissProt
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gene ask
SwissProt
brenda
-
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Black Mexican Sweet
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Cat100-1 inbred line
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expression in Saccharomyces cerevisiae sigma a3hu
TrEMBL
brenda
maize
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