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2.7.2.4: aspartate kinase

This is an abbreviated version!
For detailed information about aspartate kinase, go to the full flat file.

Word Map on EC 2.7.2.4

Reaction

ATP
+
L-aspartate
=
ADP
 +
4-phospho-L-aspartate

Synonyms

AK, AK II, AK III, AK-HSDH, AK-HSDH I, AK-HSDH1, AK-HSDH2, AK-HseDH, AK-R7, AK-ts31d, AK1, AK2, AK3, AKbeta, AKII, AKIII, AKsyn, Ask, ASK1, ASK2, Ask_Ect, Ask_LysC, Asp kinase-homoserine dehydrogenase, aspartate kinase, aspartate kinase (phosphorylating), aspartate kinase 1, aspartate kinase 2, aspartate kinase 3, aspartate kinase beta, aspartate kinase I, aspartate kinase II, aspartate kinase III, aspartic kinase, aspartokinase, aspartokinase 1-homoserine dehydrogenase 1, aspartokinase 2, aspartokinase 3, aspartokinase I, aspartokinase II, aspartokinase III, aspartokinase-homoserine dehydrogenase, beta-aspartokinase, bifunctional aspartate kinase-homoserine dehydrogenase, BT, BTT, CgAK, dap-aspartokinase, HOM3 product, HOM3-R7 product, HOM3-ts31d product, HseDH, LT-aspartokinase, lysC, lysine-sensitive aspartokinase 3, More, MtbAKbeta, nspJ, Thr-sensitive aspartate kinase, thrA, thrA1, thrA2, TM_0547, XbAK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.2 Phosphotransferases with a carboxy group as acceptor
                2.7.2.4 aspartate kinase

Temperature Stability

Temperature Stability on EC 2.7.2.4 - aspartate kinase

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
10 - 35
-
stable in this range
25
-
the wild type enzyme has a half-life of 4.66 h at 25°C
28 - 40
-
the half-life of the wild type enzyme at 28°C and 30°C is 3.8 h and 2.5 h, respectively. The wild type enzyme is almost inactive after 4 h at 35°C and 40°C
45
-
loses 70% of its original activity after heating for 15 min
50 - 100
purified recombinant enzyme, 10 min, completely stable at 50-90°C, loss of 40% activity at 100°C
50 - 90
the enzyme remains stable (more than 90% activity) after 10 min incubation between 50 and 90°C and drops to about 50% activity after 10 min at 100°C
60
-
very rapid loss of catalytic activity above
70 - 85
-
very heat stable, not inactivated after 30 min at 70°C, 30% of the original activity is lost after 30 min at 80°C, rapid inactivation above 85°C
91.7
the melting temperature in the absence of any additive is at 91.7°C
additional information