2.7.2.4: aspartate kinase

This is an abbreviated version!
For detailed information about aspartate kinase, go to the full flat file.

Reaction

Synonyms

AK, AK II, AK III, AK-HSDH, AK-HSDH I, AK-HSDH1, AK-HSDH2, AK-HseDH, AK-R7, AK-ts31d, AK1, AK2, AK3, AKbeta, AKII, AKIII, AKsyn, Ask, ASK1, ASK2, Ask_Ect, Ask_LysC, Asp kinase-homoserine dehydrogenase, aspartate kinase, aspartate kinase (phosphorylating), aspartate kinase 1, aspartate kinase 2, aspartate kinase 3, aspartate kinase beta, aspartate kinase I, aspartate kinase II, aspartate kinase III, aspartic kinase, aspartokinase, aspartokinase 1-homoserine dehydrogenase 1, aspartokinase 2, aspartokinase 3, aspartokinase I, aspartokinase II, aspartokinase III, aspartokinase-homoserine dehydrogenase, beta-aspartokinase, bifunctional aspartate kinase-homoserine dehydrogenase, BT, BTT, CgAK, dap-aspartokinase, HOM3 product, HOM3-R7 product, HOM3-ts31d product, HseDH, LT-aspartokinase, lysC, lysine-sensitive aspartokinase 3, More, MtbAKbeta, nspJ, Thr-sensitive aspartate kinase, thrA, thrA1, thrA2, TM_0547, XbAK

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.2 Phosphotransferases with a carboxy group as acceptor

                2.7.2.4 aspartate kinase

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Results	in table
27	Activating Compound
56694	AA Sequence
16	Application
1	CAS Registry Number
57	Cloned(Commentary)
11	Cofactor
14	Crystallization (Commentary)
1	Expression
32	General Information
9	General Stability
15	IC50 Value
196	Inhibitors
12	kcat/KM [mM/s]
29	Ki Value [mM]
206	KM Value [mM]
7	Localization
52	Metals/Ions
142	Molecular Weight [Da]
107	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
375	Organism
23	Pathway
96	PDB ID
23	pH Optimum
7	pH Range
6	pH Stability
3	pI Value
159	Protein Variants
70	Purification (Commentary)
2	Reaction
11	Reaction Type
149	Reference
1	Renatured (Commentary)
19	Source Tissue
54	Specific Activity [micromol/min/mg]
22	Storage Stability
174	Substrates and Products (Substrate)
75	Subunits
201	Synonyms
1	Systematic Name
19	Temperature Optimum [°C]
6	Temperature Range [°C]
25	Temperature Stability [°C]
71	Turnover Number [1/s]

General Stability

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of the Enzyme Summary Page.

General Stability on EC 2.7.2.4 - aspartate kinase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

aspartokinase II unstable in absence of L-lysine, both isoenzymes stablized by sulfhydryl reducing agents

Brevibacillus brevis

-

642318

feedback inhibitor can partially protect from heat inactivation up to 70°C

Geobacillus stearothermophilus

-

642309

feedback inhibitor pair protects the enzyme against heat denaturation

Streptococcus mutans

-

642322

L-lysine and L-threonine partially prevents from heat inactivation

Triticum aestivum

-

642315

L-lysine, L-threonine or L-methionine protects the enzymic activity against heat inactivation

Rhodocyclus tenuis

-

642314

nonpolar L-amino acids protect from inactivation by heat and detergent and reverse the inhibition caused by feedback inhibitors L-lysine and L-threonine

Paenibacillus polymyxa

-

642314

pure protein , quickly frozen in N2 can be stored at -80°C for several months without any loss of activity

Arabidopsis thaliana

-

662432

pure protein, quickly frozen in N2 can be stored at -80°C for several months without any loss of activity

Arabidopsis thaliana

-

662432

stable up to. In the DEAE-Sephacel stage of purification, L-lysine and L-proline protect from heat inactivation

Daucus carota

-

642324