2.7.2.4: aspartate kinase

This is an abbreviated version!
For detailed information about aspartate kinase, go to the full flat file.

Reaction

Synonyms

AK, AK II, AK III, AK-HSDH, AK-HSDH I, AK-HSDH1, AK-HSDH2, AK-HseDH, AK-R7, AK-ts31d, AK1, AK2, AK3, AKbeta, AKII, AKIII, AKsyn, Ask, ASK1, ASK2, Ask_Ect, Ask_LysC, Asp kinase-homoserine dehydrogenase, aspartate kinase, aspartate kinase (phosphorylating), aspartate kinase 1, aspartate kinase 2, aspartate kinase 3, aspartate kinase beta, aspartate kinase I, aspartate kinase II, aspartate kinase III, aspartic kinase, aspartokinase, aspartokinase 1-homoserine dehydrogenase 1, aspartokinase 2, aspartokinase 3, aspartokinase I, aspartokinase II, aspartokinase III, aspartokinase-homoserine dehydrogenase, beta-aspartokinase, bifunctional aspartate kinase-homoserine dehydrogenase, BT, BTT, CgAK, dap-aspartokinase, HOM3 product, HOM3-R7 product, HOM3-ts31d product, HseDH, LT-aspartokinase, lysC, lysine-sensitive aspartokinase 3, More, MtbAKbeta, nspJ, Thr-sensitive aspartate kinase, thrA, thrA1, thrA2, TM_0547, XbAK

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.2 Phosphotransferases with a carboxy group as acceptor

                2.7.2.4 aspartate kinase

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Results	in table
27	Activating Compound
56694	AA Sequence
16	Application
1	CAS Registry Number
57	Cloned(Commentary)
11	Cofactor
14	Crystallization (Commentary)
1	Expression
32	General Information
9	General Stability
15	IC50 Value
196	Inhibitors
12	kcat/KM [mM/s]
29	Ki Value [mM]
206	KM Value [mM]
7	Localization
52	Metals/Ions
142	Molecular Weight [Da]
107	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
375	Organism
23	Pathway
96	PDB ID
23	pH Optimum
7	pH Range
6	pH Stability
3	pI Value
159	Protein Variants
70	Purification (Commentary)
2	Reaction
11	Reaction Type
149	Reference
1	Renatured (Commentary)
19	Source Tissue
54	Specific Activity [micromol/min/mg]
22	Storage Stability
174	Substrates and Products (Substrate)
75	Subunits
201	Synonyms
1	Systematic Name
19	Temperature Optimum [°C]
6	Temperature Range [°C]
25	Temperature Stability [°C]
71	Turnover Number [1/s]

pH Stability

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pH Stability on EC 2.7.2.4 - aspartate kinase

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5 - 12

Thermotoga maritima

Q9WZ17

purified recombinant enzyme, 10 min, 50°C, completely stable at pH 5.5-10.5, loss of 25% activity at pH 11.0, loss of 70% activity at pH 5.0 and pH 11.5, inactivation at pH 12.0

760736

5.5 - 10

Thermus thermophilus

-

stable at slight alkali to acidic pH range, most stable at about pH 7.0, unstable at high alkali pH range, losing 90% of its original activity after 30 min at 70°C at pH 10.0

642320

5.5 - 10.5

Thermotoga maritima

Q9WZ17

the enzyme loses no activity when incubated at pH values between 5.5 and 10.5 for 10 min at 50°C

760736

6 - 9

Streptococcus mutans

-

in pH regions below 6.0 and above 9.0 the enzyme activity rapidly decreases

642322

7.5

Bacillus subtilis

-

very unstable in 10 mM tris-HCl buffer, stabilized by addition of 500 mM ammoinium sulfate

642339

8

Corynebacterium pekinense

E0AE72

purified recombinant proteins, 26°C, half-life of the wild-type enzyme is 4.5 h, and the half-life of the mutant R169Y increases to 5.5 h

738419