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Literature summary for 2.7.2.4 extracted from

  • Ferreira, R.R.; Meinhardt, L.W.; Azevedo, R.A.
    Lysine and threonine biosynthesis in sorghum seeds: characterisation of aspartate kinase and homoserine dehydrogenase isoenzymes (2006), Ann. Appl. Biol., 149, 77-86.
    View publication on PubMed
Search for more literature for 2.7.2.4

Inhibitors

Inhibitors Comment Organism Structure
L-lysine partially inhibits the first isoenzyme Sorghum bicolor
L-methionine inhibits the first isoenzyme at 5 mM Sorghum bicolor
L-threonine some inhibition of the first isoenzyme, together with L-lysine total inhibition Sorghum bicolor
additional information KCl, calcium, EGTA, calmodulin, compound 48/80 and L-valine have no effect on AK activity of the first isoenzyme Sorghum bicolor
S-2-aminoethyl-L-cysteine less effective on the first isoenzyme than L-lysine alone Sorghum bicolor
S-adenosyl-L-methionine only able to inhibit AK activity of the the first isoenzyme synergistically, when present with either L-lysine or L-threonine Sorghum bicolor

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Sorghum bicolor

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
79000
-
 second AK isoenzyme, gel filtration Sorghum bicolor
167000
-
 first AK isoenzyme, gel filtration Sorghum bicolor

Organism

Organism UniProt Comment Textmining
Sorghum bicolor
-
 Massa 03
-

Purification (Commentary)

Purification (Comment) Organism
partially purified, 29.9fold, by gel filtration Sorghum bicolor

Source Tissue

Source Tissue Comment Organism Textmining
seed
-
 Sorghum bicolor
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-aspartate
-
 Sorghum bicolor ADP + 4-phospho-L-aspartate
-
 ?

Synonyms

Synonyms Comment Organism
AK
-
 Sorghum bicolor