Literature summary for 2.7.2.4 extracted from

Cahyanto, M.N.; Kawasaki, H.; Nagashio, M.; Fujiyama, K.; Seki, T.
Regulation of aspartokinase, aspartate semialdehyde dehydrogenase, dihydrodipicolinate synthase and dihydrodipicolinate reductase in Lactobacillus plantarum (2006), Microbiology, 152, 105-112.

Search for more literature for 2.7.2.4

Cloned(Commentary)

Cloned (Comment)	Organism
into vector pCR2.1-TOPO, subcloned to pUC18 for heterologous expression of thrA1 or thrA2 in Escherichia coli Gif 102	Lactiplantibacillus plantarum

Inhibitors

Inhibitors	Comment	Organism	Structure
L-isoleucine	-	Lactiplantibacillus plantarum
L-lysine	inhibits the activity of ThrA2 by 87% at 1 mM and by 96% at 10 mM, no concerted inhibition by L-lysine plus L-threonine	Lactiplantibacillus plantarum
L-methionine	-	Lactiplantibacillus plantarum
L-threonine	represses, reduces growth rate, no concerted inhibition by L-lysine plus L-threonine	Lactiplantibacillus plantarum

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Lactiplantibacillus plantarum

Organism

Organism	UniProt	Comment	Textmining
Lactiplantibacillus plantarum	-	-	-
Lactiplantibacillus plantarum NCIMB 8826	-	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.00036	-	thrA1	Lactiplantibacillus plantarum
0.00096	-	thrA2, in the presence of L-lysine	Lactiplantibacillus plantarum
0.162	-	thrA2	Lactiplantibacillus plantarum
0.196	-	thrA2, in the presence of L-threonine	Lactiplantibacillus plantarum
0.289	-	thrA2, in the presence of L-isoleucine	Lactiplantibacillus plantarum
0.29	-	thrA2, in the presence of L-methionine	Lactiplantibacillus plantarum

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-aspartate	-	Lactiplantibacillus plantarum	ADP + 4-phospho-L-aspartate	-	?
ATP + L-aspartate	-	Lactiplantibacillus plantarum NCIMB 8826	ADP + 4-phospho-L-aspartate	-	?

Synonyms

Synonyms	Comment	Organism
AK	-	Lactiplantibacillus plantarum
aspartokinase	-	Lactiplantibacillus plantarum
thrA1	-	Lactiplantibacillus plantarum
thrA2	-	Lactiplantibacillus plantarum

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)