2.3.3.14: homocitrate synthase
This is an abbreviated version!
For detailed information about homocitrate synthase, go to the full flat file.
Word Map on EC 2.3.3.14
-
2.3.3.14
-
gyrus
-
resting-state
-
frontal
-
deficit
-
sclerosis
-
cingulate
-
schizophrenia
-
hair
-
emotional
-
prefrontal
-
inferior
-
anxiety
-
bipolar
-
neuropsychological
-
auditory
-
parietal
-
insula
-
neuroimaging
-
occipital
-
default
-
precuneus
-
high-content
-
verbal
-
cochlea
-
putamen
-
whole-brain
-
tensor
-
voxel-based
-
precentral
-
nervosa
-
first-episode
-
relapsing-remitting
-
obsessive-compulsive
-
salience
-
hemichannels
-
t1-weighted
-
orbitofrontal
-
dlpfc
-
visuospatial
-
unmedicated
-
parahippocampal
-
impulsivity
-
event-related
-
fluency
-
fasciculus
-
connectome
-
tractography
-
peripapillary
-
euthymic
-
stroop
-
biotechnology
-
synthesis
-
medicine
- 2.3.3.14
- gyrus
-
resting-state
-
frontal
- deficit
- sclerosis
-
cingulate
-
schizophrenia
- hair
-
emotional
-
prefrontal
-
inferior
-
anxiety
-
bipolar
-
neuropsychological
-
auditory
-
parietal
-
insula
-
neuroimaging
-
occipital
-
default
-
precuneus
-
high-content
-
verbal
- cochlea
-
putamen
-
whole-brain
-
tensor
-
voxel-based
-
precentral
-
nervosa
-
first-episode
-
relapsing-remitting
-
obsessive-compulsive
-
salience
-
hemichannels
-
t1-weighted
-
orbitofrontal
-
dlpfc
-
visuospatial
-
unmedicated
-
parahippocampal
-
impulsivity
-
event-related
-
fluency
-
fasciculus
-
connectome
-
tractography
-
peripapillary
-
euthymic
-
stroop
- biotechnology
- synthesis
- medicine
Reaction
Synonyms
2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating), acetyl-coenzyme A: 2-ketoglutarate C-transferase, acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase, EC 4.1.3.21, HCS, HcsA, homocitrate synthase, homocitrate synthetase, homocitrate-condensing enzyme, homocondensing enzyme, LYS20, LYS21, Lys21p, LYS22, Lys22p, nifV, nifV2, saci_1304, SpHCS, synthase, homocitrate, TtHCS
ECTree
2.3.3.14 homocitrate synthaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.3.3.14 - homocitrate synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + H2O + 2-oxoadipate
2-hydroxyhexane-1,2,6-tricarboxylate
-
-
-
-
?
acetyl-CoA + H2O + oxaloacetate
?
-
oxaloacetate is a slow alternative substrate
-
-
?
acetyl-CoA + H2O + oxaloacetate
? + CoA
-
oxaloacetate is a substrate with lower affinity than 2-oxoglutarate
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
(2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
(2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
(2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
(2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
(2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
(2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
(2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
the enzyme catalyzes the first and committed step of the alpha-aminoadipate pathway
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
(2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
(2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
the enzyme catalyzes the first and committed step of the alpha-aminoadipate pathway
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
(R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
(R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
(R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
(R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
specific substrates
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
specific substrates
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
enzymatic formation of homocitric acid, an intermediate in lysine biosynthesis
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
expression of lys1 is partially repressed by high concentrations of lysine in the culture medium, but lysine repression seems to be a weak mechanism of control of the lysine pathway as compared to lysine inhibition of homocitrate synthase
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
the enzyme catalyzes the first step of the lysine and penicillin pathway and is highly sensitive to feedback regulation by L-lysine
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
the enzyme may play a regulatory function, in addition to its catalytic function, in Saccharomyces cerevisiae but not in Penicillium chrysogenum
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
first enzyme of the lysine biosynthetic pathway, feedback regulated by L-lysine. Maximum homocitrate synthase activity in cultures is found at 48 h, coinciding with the phase of high rate of penicillin biosynthesis
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
the enzyme may play a regulatory function, in addition to its catalytic function, in Saccharomyces cerevisiae but not in Penicillium chrysogenum
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
first enzyme of the 2-aminoadipic acid pathway for biosynthesis of lysine
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
sequential ordered kinetic mechanism for the histidine-tagged enzyme with 2-oxoglutarate binding before acetyl-CoA and CoA released before homocitrate
-
-
ir
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
in the yeast Saccharomyces cerevisiae, the first committed step of the lysine biosynthetic pathway is catalysed by two homocitrate synthases encoded by LYS20 and LYS21. During growth on ethanol, homocitrate is mainly synthesized through Lys21p, while under fermentative metabolism, Lys20p and Lys21p play redundant roles
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
a catalytic dyad comprising Glu155 and His309 acts to deprotonate the methyl group of acetyl-CoA, while Tyr320 is likely not directly involved in catalysis, but may aid in orienting the reactant and/or the catalytic dyad
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
Saccharomycopsis lipolytica
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
first enzyme of the lysine biosynthetic pathway
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
first enzyme of the lysine biosynthetic pathway
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + 2-oxoglutarate
2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
-
-
?
acetyl-CoA + H2O + oxaloacetate
2-hydroxypropane-1,2,3-tricarboxylate + CoA
-
-
-
-
?
acetyl-CoA + H2O + oxaloacetate
2-hydroxypropane-1,2,3-tricarboxylate + CoA
-
-
-
-
?
additional information
?
-
-
isoforms Lys21p and Lys22p are not able to catalyze the condensation of oxaloacetate with acetyl-CoA to give citrate
-
-
?
additional information
?
-
-
the enzyme has no activity with core histone substrates or calf thymus histones. However, when histone H4 purified from yeast is used as substrate, histone acetyltransferases activity is observed
-
-
?
additional information
?
-
-
homocitrate synthase is a labile target for oxidative stress caused by CuZn-superoxide dismutase depletion
-
-
?
