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Literature summary for 2.3.3.14 extracted from

  • Gray, G.S.; Bhattacharjee, J.K.
    Biosynthesis of lysine in Saccharomyces cerevisiae: properties and spectrophotometric determination of homocitrate synthase activity (1976), Can. J. Microbiol., 22, 1664-1667.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline 0.01 mM, 91% inhibition Saccharomyces cerevisiae
2,2'-dipyridyl 0.01 mM, 82% inhibition Saccharomyces cerevisiae
Cu2+ 0.0001 mM CuSO4, complete inhibition Saccharomyces cerevisiae
Hg2+ 0.01 mM HgCl2, complete inhibition Saccharomyces cerevisiae
iodoacetic acid 0.01 mM, 71% inhibition Saccharomyces cerevisiae
L-Lys 10 mM, 80% inhibition. No inhibition by 10 mM D-Lys Saccharomyces cerevisiae
Na2HAsO4 0.01 mM, 67% inhibition Saccharomyces cerevisiae
NaF 0.01 mM, 73% inhibition Saccharomyces cerevisiae
p-hydroxymercuribenzoate 0.0001 mM, complete inhibition Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 0.002 mM MgCl2 has no effect Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + H2O + 2-oxoglutarate
-
 Saccharomyces cerevisiae 2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
32
-
-
 Saccharomyces cerevisiae

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
25 40 25°C: about 60% of maximal activity, 40°C: about 50% of maximal activity Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8
-
 Saccharomyces cerevisiae