Literature summary for 2.3.3.14 extracted from

Quezada, H.; Aranda, C.; DeLuna, A.; Hernandez, H.; Calcagno, M.L.; Marin-Hernandez, A.; Gonzalez, A.
Specialization of the paralogue LYS21 determines lysine biosynthesis under respiratory metabolism in Saccharomyces cerevisiae (2008), Microbiology, 154, 1656-1667.

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Inhibitors

Inhibitors	Comment	Organism	Structure
lysine	strong allosteric inhibitor of Lys21p. Induces positive cooperativity for alpha-ketoglutarate binding	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetyl-CoA + H2O + 2-oxoglutarate	Saccharomyces cerevisiae	in the yeast Saccharomyces cerevisiae, the first committed step of the lysine biosynthetic pathway is catalysed by two homocitrate synthases encoded by LYS20 and LYS21. During growth on ethanol, homocitrate is mainly synthesized through Lys21p, while under fermentative metabolism, Lys20p and Lys21p play redundant roles	2-hydroxybutane-1,2,4-tricarboxylate + CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P48570	-	-
Saccharomyces cerevisiae	Q12122	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + H2O + 2-oxoglutarate	in the yeast Saccharomyces cerevisiae, the first committed step of the lysine biosynthetic pathway is catalysed by two homocitrate synthases encoded by LYS20 and LYS21. During growth on ethanol, homocitrate is mainly synthesized through Lys21p, while under fermentative metabolism, Lys20p and Lys21p play redundant roles	Saccharomyces cerevisiae	2-hydroxybutane-1,2,4-tricarboxylate + CoA	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.053	-	lysine	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)