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Literature summary for 2.3.3.14 extracted from

  • Scott, E.M.; Pillus, L.
    Homocitrate synthase connects amino acid metabolism to chromatin functions through Esa1 and DNA damage (2010), Genes Dev., 24, 1903-1913.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.3.14

Activating Compound

Activating Compound Comment Organism Structure
L-lysine stimulates activity on histone H4 Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli B834 DE3 cells Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Saccharomyces cerevisiae 5634
-

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + H2O + 2-oxoglutarate
-
 Saccharomyces cerevisiae 2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?
additional information the enzyme has no activity with core histone substrates or calf thymus histones. However, when histone H4 purified from yeast is used as substrate, histone acetyltransferases activity is observed Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
HCS
-
 Saccharomyces cerevisiae
LYS20
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction deletion of the homocitrate synthase gene suppresses htz1D DNA damage sensitivity Saccharomyces cerevisiae
physiological function the enzyme is linked to the key process of DNA damage repair through the essential MYST family histone acetyltransferase Esa1 and the H2A.Z. The enzyme has a role in addition to amino acid synthesis, and functions in nuclear activities involving chromatin regulation that are distinct from its previously established role in lysine biosynthesis Saccharomyces cerevisiae