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2.3.3.14: homocitrate synthase

This is an abbreviated version!
For detailed information about homocitrate synthase, go to the full flat file.

Word Map on EC 2.3.3.14

Reaction

acetyl-CoA
+
H2O
 +
2-oxoglutarate
=
(2R)-2-hydroxybutane-1,2,4-tricarboxylate
 +
CoA

Synonyms

2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating), acetyl-coenzyme A: 2-ketoglutarate C-transferase, acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase, EC 4.1.3.21, HCS, HcsA, homocitrate synthase, homocitrate synthetase, homocitrate-condensing enzyme, homocondensing enzyme, LYS20, LYS21, Lys21p, LYS22, Lys22p, nifV, nifV2, saci_1304, SpHCS, synthase, homocitrate, TtHCS

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.14 homocitrate synthase

Inhibitors

Inhibitors on EC 2.3.3.14 - homocitrate synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
0.01 mM, 91% inhibition
2,2'-dipyridyl
-
0.01 mM, 82% inhibition
2-aminoethyl-L-cysteine
-
-
2-methylcitrate
89.6% residual activity at 5 mM
2-oxoglutarate
-
-
2-Oxomalonate
-
-
acetyl-CoA
-
-
AMP
-
1 mM, 13-15% inhibition
benzylpenicillin
-
20 mM, partial inhibition is enhanced by lysine
Ca2+
96.3% residual activity at 1 mM
casein hydrolysate
-
about 50% inhibition
-
citrate
desulfo-CoA
-
uncompetitive
dipicolinic acid
Saccharomycopsis lipolytica
-
non-competitive inhibitor of 2-oxoglutarate fixation
dipyridyl
95% residual activity at 0.1 mM
DL-4,5-transdehydrolysine
Saccharomycopsis lipolytica
-
5 mM, 90% inhibition
DL-5-hydroxylysine
-
-
DL-allo-5-Hydroxylysine
Saccharomycopsis lipolytica
-
5 mM, 75% inhibition
DL-alpha-aminoadipate
-
-
DL-alpha-Difluoromethyllysine
-
strong inhibitor of isoform Lys22p, but not Lys21p
DL-Homolysine
-
inhibition of enzyme from wild-type strain, enzyme from S-(beta-aminoethyl)-L-cysteine resistant mutant strain is not inhibited
glyoxylate
-
competitive, analysis of pH-dependence of inhibition
hydroxylysine
iodoacetic acid
-
0.01 mM, 71% inhibition
K+
91.7% residual activity at 0.1 mM
L-Arg
L-lysine
L-norleucine
-
-
LL-Diaminopimelic acid
Saccharomycopsis lipolytica
-
5 mM, 90% inhibition
lysine
Mg2+
-
10 mM MgSO4, 30% inhibition
Na2HAsO4
-
0.01 mM, 67% inhibition
Na2SO4
90.9% residual activity at 0.2 mM
NaF
-
0.01 mM, 73% inhibition
NEM
-
0.1 mM, 90% inhibition
oxalglycine
-
competitive inhibition versus 2-oxoglutarate
oxaloacetate
-
-
oxalylglycine
-
-
p-hydroxymercuribenzoate
-
0.0001 mM, complete inhibition
pipecolic acid
Saccharomycopsis lipolytica
-
non-competitive inhibition on the fixation of both substrates
pyridine-2,3-dicarboxylate
-
-
Pyridine-2,4-dicarboxylate
-
-
Pyridine-2,5-dicarboxylate
-
-
pyridine-2,6-dicarboxylate
-
-
pyridine-2-carboxylate
-
-
S-(2-aminoethyl)-L-cysteine
-
-
S-(beta-aminoethyl)-L-cysteine
-
1.1 mM required for half-maximal inhibition of enzyme from wild-type strain, enzyme from S-(beta-aminoethyl)-L-cysteine resistant mutant strain is not inhibited
Selenalysine
-
7.5 mM, 90% inhibition, half-maximal inhibition at 1.9 mM, competitive inhibition against both acetyl-CoA and 2-oxoglutarate
succinyl phosphonate
-
-
thialysine
additional information
-