2.3.3.14: homocitrate synthase
This is an abbreviated version!
For detailed information about homocitrate synthase, go to the full flat file.
Word Map on EC 2.3.3.14
-
2.3.3.14
-
gyrus
-
resting-state
-
frontal
-
deficit
-
sclerosis
-
cingulate
-
schizophrenia
-
hair
-
emotional
-
prefrontal
-
inferior
-
anxiety
-
bipolar
-
neuropsychological
-
auditory
-
parietal
-
insula
-
neuroimaging
-
occipital
-
default
-
precuneus
-
high-content
-
verbal
-
cochlea
-
putamen
-
whole-brain
-
tensor
-
voxel-based
-
precentral
-
nervosa
-
first-episode
-
relapsing-remitting
-
obsessive-compulsive
-
salience
-
hemichannels
-
t1-weighted
-
orbitofrontal
-
dlpfc
-
visuospatial
-
unmedicated
-
parahippocampal
-
impulsivity
-
event-related
-
fluency
-
fasciculus
-
connectome
-
tractography
-
peripapillary
-
euthymic
-
stroop
-
biotechnology
-
synthesis
-
medicine
- 2.3.3.14
- gyrus
-
resting-state
-
frontal
- deficit
- sclerosis
-
cingulate
-
schizophrenia
- hair
-
emotional
-
prefrontal
-
inferior
-
anxiety
-
bipolar
-
neuropsychological
-
auditory
-
parietal
-
insula
-
neuroimaging
-
occipital
-
default
-
precuneus
-
high-content
-
verbal
- cochlea
-
putamen
-
whole-brain
-
tensor
-
voxel-based
-
precentral
-
nervosa
-
first-episode
-
relapsing-remitting
-
obsessive-compulsive
-
salience
-
hemichannels
-
t1-weighted
-
orbitofrontal
-
dlpfc
-
visuospatial
-
unmedicated
-
parahippocampal
-
impulsivity
-
event-related
-
fluency
-
fasciculus
-
connectome
-
tractography
-
peripapillary
-
euthymic
-
stroop
- biotechnology
- synthesis
- medicine
Reaction
Synonyms
2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating), acetyl-coenzyme A: 2-ketoglutarate C-transferase, acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase, EC 4.1.3.21, HCS, HcsA, homocitrate synthase, homocitrate synthetase, homocitrate-condensing enzyme, homocondensing enzyme, LYS20, LYS21, Lys21p, LYS22, Lys22p, nifV, nifV2, saci_1304, SpHCS, synthase, homocitrate, TtHCS
ECTree
Advanced search results
General Information
General Information on EC 2.3.3.14 - homocitrate synthase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
malfunction
metabolism
physiological function
-
the enzyme is linked to the key process of DNA damage repair through the essential MYST family histone acetyltransferase Esa1 and the H2A.Z. The enzyme has a role in addition to amino acid synthesis, and functions in nuclear activities involving chromatin regulation that are distinct from its previously established role in lysine biosynthesis
an hcsA deletion mutant is lysine auxotrophic and unable to germinate on unhydrolyzed proteins given as a sole nutrient source. The mutant grows on blood and serum, indicating the existence of high-affinity lysine uptake systems. The virulence of the mutant is strongly attenuated in murine models of bronchopulmonary aspergillosis. The mutant retains full virulence when injected intravenously
malfunction
-
deletion of the homocitrate synthase gene suppresses htz1D DNA damage sensitivity
malfunction
nifV-disruption (DELTAnifV) mutant of Bradyrhizobium DOA9 shows significantly less nitrogenase activity in a free-living state than the respective wild-type strain
malfunction
-
nifV-disruption (DELTAnifV) mutant of Bradyrhizobium SUTN9-2 shows significantly less nitrogenase activity in a free-living state than the respective wild-type strain
malfunction
-
an hcsA deletion mutant is lysine auxotrophic and unable to germinate on unhydrolyzed proteins given as a sole nutrient source. The mutant grows on blood and serum, indicating the existence of high-affinity lysine uptake systems. The virulence of the mutant is strongly attenuated in murine models of bronchopulmonary aspergillosis. The mutant retains full virulence when injected intravenously
-
-
reaction is the first step in the lysine biosynthetic pathway through alpha-aminoadipate
metabolism
-
reaction is the first step in the lysine biosynthetic pathway through alpha-aminoadipate
metabolism
-
the first committed step in the lysine biosynthetic pathway is catalyzed by the Lys20 and Lys21 homocitrate synthase isoforms. The Lys20 isoform exerts high control over L-lysine flux, while isoform Lys21 exerts low control over the alpha-aminoadipate-pathway flux
metabolism
nifV of DOA9 is involved in acetylene reduction activity under free-living conditions, but not in symbiosis with Aeschynomene americana
metabolism
the enzyme catalyzes the first and committed step of the alpha-aminoadipate pathway
metabolism
the enzyme catalyzes the formation of homocitrate, which is essential for arranging the FeMo-cofactor in the catalytic center of nitrogenase. Bradyrhizobium ORS285, a symbiont of Aeschynomene cross-inoculation groups 2 and 3, requires nifV for symbiosis with Aeschynomene species that belong to CI group 3, and some species belonging to CI group 2
metabolism
the enzyme is required for free-living and symbiotic dinitrogen fixation with Nod factorF-independent Aeschynomene species
metabolism
-
the symbiotic phenotypes of SUTN9-2 and its DELTAnifV mutant are examined with four legumes, Aeschynomene americana, Stylosanthes hamata, Indigofera tinctoria, and Desmodium tortuosum. nifV is required for the efficient symbiosis of SUTN9-2 establishes symbiosis with all four legumes. nifV is required for symbiosis with Indigofera tinctoria and Desmodium tortuosum
metabolism
-
the first committed step in the lysine biosynthetic pathway is catalyzed by the Lys20 and Lys21 homocitrate synthase isoforms. The Lys20 isoform exerts high control over L-lysine flux, while isoform Lys21 exerts low control over the alpha-aminoadipate-pathway flux
-
metabolism
-
the enzyme catalyzes the first and committed step of the alpha-aminoadipate pathway
-