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Literature summary for 2.3.3.14 extracted from

  • Gaillardin, C.M.; Poirier, L.; Heslot, H.
    A kinetic study of homocitrate synthetase activity in the yeast Saccharomyces lipolytica (1976), Biochim. Biophys. Acta, 422, 390-406.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
CoA strong competitive inhibitor of acetyl-CoA fixation Saccharomycopsis lipolytica
dipicolinic acid non-competitive inhibitor of 2-oxoglutarate fixation Saccharomycopsis lipolytica
DL-4,5-transdehydrolysine 5 mM, 90% inhibition Saccharomycopsis lipolytica
DL-allo-5-Hydroxylysine 5 mM, 75% inhibition Saccharomycopsis lipolytica
EDTA 15 mM Saccharomycopsis lipolytica
L-Lys 5 mM, complete inhibition Saccharomycopsis lipolytica
LL-Diaminopimelic acid 5 mM, 90% inhibition Saccharomycopsis lipolytica
pipecolic acid non-competitive inhibition on the fixation of both substrates Saccharomycopsis lipolytica

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ about 10% stimulation, no absolute requirement Saccharomycopsis lipolytica

Organism

Organism UniProt Comment Textmining
Saccharomycopsis lipolytica
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
rapid method for estimating the activity Saccharomycopsis lipolytica

Storage Stability

Storage Stability Organism
4°C, stable for at least 1 week Saccharomycopsis lipolytica

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + H2O + 2-oxoglutarate
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Saccharomycopsis lipolytica 2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8.2
-
Saccharomycopsis lipolytica