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Information on EC 2.3.3.14 - homocitrate synthase

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.14 homocitrate synthase
IUBMB Comments
Belongs in the alpha-aminoadipate pathway of lysine synthesis, along with EC 4.2.1.36, homoaconitate hydratase. The enzyme also acts with oxaloacetate as substrate, but more slowly [2,3].
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Word Map
  • 2.3.3.14
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  • prefrontal
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  • visuospatial
  • unmedicated
  • parahippocampal
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  • fasciculus
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  • peripapillary
  • euthymic
  • stroop
  • biotechnology
  • synthesis
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
hcs, homocitrate synthase, lys22, nifv2, sphcs, tthcs, lys21p, homocitrate synthetase, saci_1304, lys22p, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + H2O + 2-oxoglutarate = (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA
show the reaction diagram
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