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Literature summary for 2.3.3.14 extracted from
- Insensitivity of homocitrate synthase in extracts of Penicillium chrysogenum to feedback inhibition by lysine (1974), Appl. Microbiol., 28, 265-270.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ATP | required | Penicillium chrysogenum |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| benzylpenicillin | 20 mM, partial inhibition is enhanced by lysine | Penicillium chrysogenum | |
| casein hydrolysate | about 50% inhibition | Penicillium chrysogenum | |
| L-Lys | no inhibition | Penicillium chrysogenum | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 5.5 | - |
2-oxoglutarate | - |
Penicillium chrysogenum | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Penicillium chrysogenum | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Penicillium chrysogenum | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mycelium | - |
Penicillium chrysogenum | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + H2O + 2-oxoglutarate | - |
Penicillium chrysogenum | 2-hydroxybutane-1,2,4-tricarboxylate + CoA | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.9 | - |
- |
Penicillium chrysogenum |
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