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2.3.3.14: homocitrate synthase

This is an abbreviated version!
For detailed information about homocitrate synthase, go to the full flat file.

Word Map on EC 2.3.3.14

Reaction

acetyl-CoA
+
H2O
+
2-oxoglutarate
=
(2R)-2-hydroxybutane-1,2,4-tricarboxylate
+
CoA

Synonyms

2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating), acetyl-coenzyme A: 2-ketoglutarate C-transferase, acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase, EC 4.1.3.21, HCS, HcsA, homocitrate synthase, homocitrate synthetase, homocitrate-condensing enzyme, homocondensing enzyme, LYS20, LYS21, Lys21p, LYS22, Lys22p, nifV, nifV2, saci_1304, SpHCS, synthase, homocitrate, TtHCS

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.14 homocitrate synthase

Molecular Weight

Molecular Weight on EC 2.3.3.14 - homocitrate synthase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
148000
different bands are detected at 66 kDa (monomer), 148 kDa (dimer), 226 kDa (trimer), and 280 kDa (tetramer), and the dimeric and tetrameric compositions are most abundant, gel filtration
155000
-
gel filtration
200700
-
isoform Lys22p, gel filtration
210300
-
isoform Lys21p, gel filtration
226000
different bands are detected at 66 kDa (monomer), 148 kDa (dimer), 226 kDa (trimer), and 280 kDa (tetramer), and the dimeric and tetrameric compositions are most abundant, gel filtration
280000
different bands are detected at 66 kDa (monomer), 148 kDa (dimer), 226 kDa (trimer), and 280 kDa (tetramer), and the dimeric and tetrameric compositions are most abundant, gel filtration
47087
-
4 * 47087, isoform Lys22p, calculated from amino acid sequence
48300
-
4 * 48300, isoform Lys21p, SDS-PAGE
48314
-
4 * 48314, isoform Lys21p, calculated from amino acid sequence
48442
-
x * 48442, calculation from nucleotide sequence
49400
-
4 * 49400, isoform Lys22p, SDS-PAGE
50600
x * 50600, deduced from amino acid sequence
50700
x * 50700, calculated from amino acid sequence
51000
x * 51000, SDS-PAGE
58600
theoretical
60000
-
gel filtration
66000
different bands are detected at 66 kDa (monomer), 148 kDa (dimer), 226 kDa (trimer), and 280 kDa (tetramer), and the dimeric and tetrameric compositions are most abundant, gel filtration
89000
-
gel filtration