2.3.1.26: sterol O-acyltransferase
This is an abbreviated version!
For detailed information about sterol O-acyltransferase, go to the full flat file.
Word Map on EC 2.3.1.26
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2.3.1.26
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keratinocytes
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lipoprotein
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immortalize
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tnf
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dermal
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esterification
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psoriasis
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esterify
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erk
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mapks
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chemokine
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collagen
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atopic
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uvb-induced
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nanoparticles
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atherosclerosis
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keratin
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cosmetic
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dermatitis
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caspase-3
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drug development
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radiation-induced
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photoaging
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macrophage-derived
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cox-2
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filaggrin
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7alpha-hydroxylase
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hairless
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sunscreen
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nutrition
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scratch
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pharmacology
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sunburn
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antiatherosclerotic
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phototoxicity
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hypocholesterolemic
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foam
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hmg-coa
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photoprotective
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desmogleins
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dermatology
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keratinocyte-derived
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ad-like
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suprabasal
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medicine
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cholesterol-fed
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hyperproliferation
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transdermal
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mmp-1
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analysis
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imiquimod
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uvb-irradiated
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involucrin
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cyclobutane
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re-epithelialization
- 2.3.1.26
- keratinocytes
- lipoprotein
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immortalize
- tnf
- dermal
- esterification
- psoriasis
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esterify
- erk
- mapks
- chemokine
- collagen
-
atopic
-
uvb-induced
- nanoparticles
- atherosclerosis
- keratin
-
cosmetic
- dermatitis
- caspase-3
- drug development
-
radiation-induced
-
photoaging
-
macrophage-derived
- cox-2
- filaggrin
-
7alpha-hydroxylase
- hairless
-
sunscreen
- nutrition
-
scratch
- pharmacology
- sunburn
-
antiatherosclerotic
- phototoxicity
-
hypocholesterolemic
-
foam
- hmg-coa
-
photoprotective
-
desmogleins
-
dermatology
-
keratinocyte-derived
-
ad-like
-
suprabasal
- medicine
-
cholesterol-fed
-
hyperproliferation
-
transdermal
- mmp-1
- analysis
- imiquimod
-
uvb-irradiated
- involucrin
-
cyclobutane
-
re-epithelialization
Reaction
Synonyms
A2, ACAT, ACAT-1, ACAT-2, ACAT1, ACAT2, acyl coenzyme A-cholesterol-O-acyltransferase, acyl coenzyme A: cholesteryl acyltransferase, acyl-CoA cholesterol acyltransferase, acyl-CoA cholesterol O-acyltransferase, acyl-CoA: cholesterol acyltransferase, acyl-CoA:cholesterol acyltransferase, acyl-CoA:cholesterol acyltransferase 1, acyl-CoA:cholesterol acyltransferase 2, acyl-coA:cholesterol o-acyl transferase 2, acyl-coenzyme A: cholesterol acyltransferase, acyl-coenzyme A:cholesterol acyltransferase, acyl-coenzyme A:cholesterol acyltransferase 1, acyl-coenzyme A:cholesterol acyltransferase 2, acyl-coenzyme A:cholesterol acyltransferase-1, acyl-coenzyme A:cholesterol O-acyltransferase, acyl-coenzymeA cholesterol acyltransferase, acyl-coenzymeA:cholesterol acyl-transferase, acylcoenzyme A:cholesterol O-acyltransferase, acyltransferase, cholesterol, AsAT, cholesterol acyltransferase, cholesterol acyltransferase 2, cholesterol ester synthase, cholesterol ester synthetase, cholesteryl ester synthetase, hACAT, hACAT-1, hACAT-2, hACAT1, SOAT, SOAT!, Soat1, Soat2, sterol O-acyltransferase 2, sterol-ester synthase, sterol-ester synthetase, steroyl O-acyltransferase 1, steroyl O-acyltransferase 2
ECTree
2.3.1.26 sterol O-acyltransferaseAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 2.3.1.26 - sterol O-acyltransferase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
both isoforms SOAT1 and SOAT2 express in the yolk syncytial layer, hatching gland and developing cardiovascular as well as digestive systems
high percentage (seven of fourteen) of liver samples from patients affected with hepatocellular carcinoma exhibit elevated ACAT2 expression
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3fold induction of activity after 60 days of cholesterol feeding
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7fold induction of activity after 60 days of cholesterol feeding
additional information
ACAT1 expression is significantly increased in the adipose tissue of ob/ob mice
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1.7fold induction of activity after 60 days of cholesterol feeding
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highest activity and highest mRNA level, significant immunohistochemical reactivity
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41fold induction of activity after 60 days of cholesterol feeding
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1.6fold induction of activity after 60 days of cholesterol feeding
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6fold induction of activity after 60 days of cholesterol feeding
the CDX2 (caudal type homeobox transcription factor 2) expression is elevated, accounting for its elevated ACAT2 expression
isozyme ACAT1 is the major isozyme in human primary hepatic stellate cells, little isozyme ACAT2 expression in the cells
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two different forms of the enzyme are present, ACAT1 and ACAT2
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23fold induction of activity after 60 days of cholesterol feeding
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ACAT2: strongly present in the apical third of the mucosal cells, ACAT1: strong signal in goblet cells, Paneth cells and villus macrophages
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high activity, high mRNA level, significant immunohistochemical reactivity
in normal adult human liver, CDX2 (caudal type homeobox transcription factor 2) expression is not detectable and the ACAT2 expression is very low
hepatic ACAT2 plays a critical role in driving the production of atherogenic lipoproteins
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27fold induction of activity after 60 days of cholesterol feeding
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nonparenchymal cells contain 30fold more enzyme message than parenchymal cells
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486674, 486676, 486677, 486678, 486680, 486681, 486685, 486686, 486688, 486689, 486694, 486701, 486706, 671655, 674216, 684799, 688060, 689426, 705083
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the enzyme activity is very low in fetal livers but is largely induced shortly after birth
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high activity, extremely low mRNA level and negligible immunohistochemical reactivity
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loss of ACAT activity in macrophages, either by pharmacological inhibition or by genetic knockout of ACAT-1, results in reduced induction of apoptosis in response to 7-ketocholesterol or oxidized low density lipoproteins. The apoptotic signal generated in macrophages by ACAT may be an arachidonyl oxysterol
serotonin upregiulates ACAT-1 expression in human monocyte-macrophages
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25fold induction of activity after 60 days of cholesterol feeding
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1.8fold induction of activity after 60 days of cholesterol feeding
additional information
ACAT1 is ubiquitously expressed in essentially all tissues examined
additional information
ACAT1 is ubiquitously expressed in essentially all tissues examined
additional information
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ACAT1 is ubiquitously expressed in essentially all tissues examined
additional information
ACAT2 is mainly expressed in the intestines and hepatocytes. It is also expressed in various other tissues, but at much lower levels than ACAT1
additional information
ACAT2 is mainly expressed in the intestines and hepatocytes. It is also expressed in various other tissues, but at much lower levels than ACAT1
additional information
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ACAT2 is mainly expressed in the intestines and hepatocytes. It is also expressed in various other tissues, but at much lower levels than ACAT1
additional information
effect of an atherogenic diet upon hepatic and intestinal enzyme mRNA expression and on enzyme mRNA expression in aorta and peritoneal macrophages. Enzyme activity in the liver is regulated at least in part by enzyme mRNA abundance
additional information
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effect of an atherogenic diet upon hepatic and intestinal enzyme mRNA expression and on enzyme mRNA expression in aorta and peritoneal macrophages. Enzyme activity in the liver is regulated at least in part by enzyme mRNA abundance
additional information
ACAT1 is the major isozyme in mouse primary hepatic stellate cells, and ACAT2 is the major isozyme in mouse primary hepatocytes and Kupffer cells
additional information
ACAT1 is ubiquitously expressed in essentially all tissues examined
additional information
ACAT1 is ubiquitously expressed in essentially all tissues examined
additional information
ACAT2 is mainly expressed in the intestines and hepatocytes. It is also expressed in various other tissues, but at much lower levels than ACAT1
additional information
ACAT2 is mainly expressed in the intestines and hepatocytes. It is also expressed in various other tissues, but at much lower levels than ACAT1
additional information
tissue-specific expression and physiological function of the isozyme SOAT2
additional information
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ACAT1 is the major isozyme in mouse primary hepatic stellate cells, and ACAT2 is the major isozyme in mouse primary hepatocytes and Kupffer cells
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additional information
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overview: enzyme activity in normal and cholesterol-fed organs, identification of two distinct tissue types of the enzyme
