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2.3.1.26: sterol O-acyltransferase

This is an abbreviated version!
For detailed information about sterol O-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.26

Reaction

a long-chain acyl-CoA
+
a sterol
=
CoA
 +
a long-chain 3-hydroxysterol ester

Synonyms

A2, ACAT, ACAT-1, ACAT-2, ACAT1, ACAT2, acyl coenzyme A-cholesterol-O-acyltransferase, acyl coenzyme A: cholesteryl acyltransferase, acyl-CoA cholesterol acyltransferase, acyl-CoA cholesterol O-acyltransferase, acyl-CoA: cholesterol acyltransferase, acyl-CoA:cholesterol acyltransferase, acyl-CoA:cholesterol acyltransferase 1, acyl-CoA:cholesterol acyltransferase 2, acyl-coA:cholesterol o-acyl transferase 2, acyl-coenzyme A: cholesterol acyltransferase, acyl-coenzyme A:cholesterol acyltransferase, acyl-coenzyme A:cholesterol acyltransferase 1, acyl-coenzyme A:cholesterol acyltransferase 2, acyl-coenzyme A:cholesterol acyltransferase-1, acyl-coenzyme A:cholesterol O-acyltransferase, acyl-coenzymeA cholesterol acyltransferase, acyl-coenzymeA:cholesterol acyl-transferase, acylcoenzyme A:cholesterol O-acyltransferase, acyltransferase, cholesterol, AsAT, cholesterol acyltransferase, cholesterol acyltransferase 2, cholesterol ester synthase, cholesterol ester synthetase, cholesteryl ester synthetase, hACAT, hACAT-1, hACAT-2, hACAT1, SOAT, SOAT!, Soat1, Soat2, sterol O-acyltransferase 2, sterol-ester synthase, sterol-ester synthetase, steroyl O-acyltransferase 1, steroyl O-acyltransferase 2

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.26 sterol O-acyltransferase

IC50 Value

IC50 Value on EC 2.3.1.26 - sterol O-acyltransferase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0138 - 0.0251
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 3-methylbutanoate
0.0537 - 0.0562
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl benzoate
0.0496 - 0.0776
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl butanoate
0.0307 - 0.0714
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl pent-4-enoate
0.0845 - 0.0948
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl pentanoate
0.0224 - 0.0287
(1R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl propanoate
0.025 - 0.102
(24R)-ethylcholest-5-ene-3,7-diol
0.0000368 - 0.071
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-2-(2-methoxyphenyl)-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
0.00011 - 0.00178
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-chlorobenzoate
0.00032 - 0.00079
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-cyanobenzoate
0.00005 - 0.0027
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-fluorobenzoate
0.00032 - 0.0034
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-methoxybenzoate
0.00003 - 0.0043
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-bromobenzoate
0.000019 - 0.0027
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-chlorobenzoate
0.00003 - 0.0022
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-cyanobenzoate
0.000013 - 0.003
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-fluorobenzoate
0.00007 - 0.0043
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-methoxybenzoate
0.00001 - 0.0069
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-bromobenzoate
0.000009 - 0.0058
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-chlorobenzoate
0.000006 - 0.0028
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
0.000007 - 0.0062
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
0.00003 - 0.0055
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-formylbenzoate
0.000014 - 0.0069
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-methoxybenzoate
0.00006 - 0.0139
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-nitrobenzoate
0.0000118 - 0.0728
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(2-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
0.000023 - 0.0139
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(2-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
0.0000078 - 0.00373
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(3-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
0.0000476 - 0.00951
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(3-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
0.0000097 - 0.00811
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(4-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
0.0000151 - 0.00554
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(4-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
0.0000232 - 0.0691
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(naphthalen-2-yl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
0.0000066 - 0.01
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2,4-dimethylphenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
0.0000072 - 0.0712
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2,6-dimethylphenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
0.0000068 - 0.00033
(2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2-fluorophenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
0.000077
(2S)-2-[(5aR,6R,8R,9aR,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]propane-1,2-diyl diacetate
Homo sapiens
NBD22-steryl ester fluorescence assay, pH not specified in the publication, temperature not specified in the publication
0.0000056 - 0.00276
(3S,4aR,6S,6aS,12R,12aS,12bS)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-3-(propanoyloxy)-4-[(propanoyloxy)methyl]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
0.0000065 - 0.0049
(3S,4aR,6S,6aS,12R,12aS,12bS)-12-hydroxy-4,6a,12b-trimethyl-3-[(2-methylpropanoyl)oxy]-4-[[(2-methylpropanoyl)oxy]methyl]-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
0.00101 - 0.00364
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-4-(propylcarbamoyl)-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
0.0000144 - 0.00666
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-4-[(propanoyloxy)methyl]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
0.000619 - 0.00092
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-4-[[(3-phenylpropanoyl)oxy]methyl]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
0.000042 - 0.00915
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-4-[[(2-methylpropanoyl)oxy]methyl]-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
0.00341 - 0.014
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-12-hydroxy-4-[(2-methoxy-2-oxoethyl)carbamoyl]-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
0.00309 - 0.0138
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(2-ethoxy-2-oxoethyl)carbamoyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
0.0000081 - 0.00143
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2,3,4-trifluorobenzoate
0.00006 - 0.001
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-chlorobenzoate
0.00029 - 0.00162
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-cyanobenzoate
0.00003 - 0.001
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-fluorobenzoate
0.000005 - 0.00019
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-iodobenzoate
0.00023 - 0.00269
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-methoxybenzoate
0.00001 - 0.00042
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2-methylbenzoate
0.000009 - 0.00011
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-(methylsulfanyl)benzoate
0.0000012 - 0.00012
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-bromobenzoate
0.000007 - 0.00021
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-chlorobenzoate
0.00001 - 0.00223
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-cyanobenzoate
0.000011 - 0.00015
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-ethenylbenzoate
0.0000061 - 0.00096
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluoro-4-methoxybenzoate
0.0000063 - 0.00043
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluoro-4-methylbenzoate
0.000006 - 0.00414
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluoro-4-nitrobenzoate
0.0000009 - 0.00023
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-fluorobenzoate
0.000005 - 0.00025
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-iodobenzoate
0.000015 - 0.00015
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-methoxybenzoate
0.000005 - 0.00065
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 3-methylbenzoate
0.000005 - 0.00066
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-(2lambda~5~-triaza-1,2-dien-2-yl)benzoate
0.0000027 - 0.00054
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-(methylsulfanyl)benzoate
0.0002 - 0.0051
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-aminobenzoate
0.000007 - 0.00115
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-bromo-2-fluorobenzoate
0.000005 - 0.00049
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-bromo-3-fluorobenzoate
0.000002 - 0.00083
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-bromobenzoate
0.000039 - 0.00089
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-chloro-2-iodobenzoate
0.000001 - 0.00069
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-chlorobenzoate
0.0000078 - 0.00065
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyano-3-fluorobenzoate
0.0000009 - 0.00416
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
0.000005 - 0.00071
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-ethenylbenzoate
0.000001 - 0.00019
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-ethylbenzoate
0.0000017 - 0.00079
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-fluorobenzoate
0.00027 - 0.0028
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-hydroxybenzoate
0.000004 - 0.00117
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-iodobenzoate
0.0000008 - 0.00051
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-methoxybenzoate
0.000005 - 0.00741
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-nitrobenzoate
0.00014 - 0.1263
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[[(2,4-dimethoxyphenyl)methyl]carbamoyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
0.0152
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-6-[(4-cyanobenzoyl)oxy]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-carboxylic acid
0.00076 - 0.063
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(benzoyloxy)-4-[(benzoyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
0.00067 - 0.0639
(3S,4aR,6S,6aS,12R,12aS,12bS)-3-(hexanoyloxy)-4-[(hexanoyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
0.00001 - 0.00206
(3S,4aR,6S,6aS,12R,12aS,12bS)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-3-(propanoyloxy)-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
0.0000096 - 0.00039
(3S,4aR,6S,6aS,12R,12aS,12bS)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-3-[(phenylacetyl)oxy]-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
0.000015 - 0.00199
(3S,4aR,6S,6aS,12R,12aS,12bS)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-3-[(2-methylpropanoyl)oxy]-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
0.00122 - 0.0136
(3S,4aR,6S,6aS,12R,12aS,12bS)-6-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-3-yl 2-methylpropanoate
0.0005 - 0.00286
(3S,4aR,6S,6aS,12R,12aS,12bS)-6-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-3-yl 3-phenylpropanoate
0.000897 - 0.0273
(3S,4aR,6S,6aS,12R,12aS,12bS)-6-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-3-yl propanoate
0.000025 - 0.000062
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-12,12b-dihydroxy-4,6a-dimethyl-4-[[(methylsulfonyl)oxy]methyl]-11-oxo-6-(pentanoyloxy)-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-3-yl benzoate
0.00001 - 0.00007
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-12,12b-dihydroxy-4,6a-dimethyl-4-[[(methylsulfonyl)oxy]methyl]-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diyl dipentanoate
0.000006 - 0.0035
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12,12b-dihydroxy-4,6a-dimethyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-6-yl 3-methylbutanoate
0.00007 - 0.08
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-4-[(acetyloxy)methyl]-12,12b-dihydroxy-4,6a-dimethyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diyl diacetate
0.000012 - 0.0028
(3S,4R,4aS,6S,6aS,12R,12aR,12bR)-4-[(acetyloxy)methyl]-3-(butanoyloxy)-12,12b-dihydroxy-4,6a-dimethyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-6-yl hexanoate
0.00001 - 0.0042
(3S,4S,4aR,6S,6aS,12R,12aR,12bR)-3-(acetyloxy)-4-[(acetyloxy)methyl]-4,12,12b-trihydroxy-6a-methyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-6-yl (2E)-pent-2-enoate
0.00001 - 0.0007
(4aR,4bS,6S,6aS,12R,12aR,12bR,14aS)-12,12b-dihydroxy-4a,6a-dimethyl-2-(1-methylethyl)-11-oxo-9-pyridin-3-yl-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-11H-pyrano[4',3':2,3]chromeno[6,5-f][1,3]benzodioxin-6-yl pentanoate
0.00001 - 0.0032
(4aR,4bS,6S,6aS,12R,12aR,12bR,14aS)-12,12b-dihydroxy-4a,6a-dimethyl-2-(2-methylphenyl)-11-oxo-9-pyridin-3-yl-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-11H-pyrano[4',3':2,3]chromeno[6,5-f][1,3]benzodioxin-6-yl pentanoate
0.00001 - 0.0038
(4aR,4bS,6S,6aS,12R,12aR,12bR,14aS)-12,12b-dihydroxy-4a,6a-dimethyl-2-(4-methylphenyl)-11-oxo-9-pyridin-3-yl-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-11H-pyrano[4',3':2,3]chromeno[6,5-f][1,3]benzodioxin-6-yl pentanoate
0.00002 - 0.00046
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 2,2-difluoro-2H-1,3-benzodioxole-5-carboxylate
0.00004 - 0.0038
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-(1-benzothiophen-2-yl)benzoate
0.0000009 - 0.00027
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-methylbenzoate
0.000019 - 0.00071
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 5,8-dihydronaphthalene-2-carboxylate
0.00001 - 0.00068
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl benzoate
0.00027 - 0.0032
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl naphthalene-1-carboxylate
0.0000095 - 0.0007
(4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl [1,1'-biphenyl]-4-carboxylate
0.000113
(S)-7-dimethylamino-N-(4-hydroxy-2,3,5-trimethylphenyl)-2-isobutyryl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
Oryctolagus cuniculus
-
pH 7.4, 37°C
0.00068
1-[1-butyl-4-(3-methoxyphenyl)-2-oxo-1,2,4a,8a-tetrahydro-1,8-naphthyridin-3-yl]-3-{4-[(ethylamino)methyl]-2,6-bis(1-methylethyl)phenyl}urea
Rattus norvegicus
-
IC50: 680 nM
0.0000054
1-[2,4-bis(1-methylethyl)pyridin-3-yl]-3-[1-butyl-4-(3-methoxyphenyl)-2-oxo-1,2,4a,8a-tetrahydro-1,8-naphthyridin-3-yl]urea
Rattus norvegicus
-
IC50: 5.4 nM
0.000043
1-[3-amino-2,6-bis(1-methylethyl)phenyl]-3-{1-butyl-4-[3-(3-hydroxypropoxy)phenyl]-2-oxo-1,2,4a,8a-tetrahydro-1,8-naphthyridin-3-yl}urea
Rattus norvegicus
-
IC50: 43 nM
0.000382
1-[4-(aminomethyl)-2,6-bis(1-methylethyl)phenyl]-3-[1-butyl-4-(3-methoxyphenyl)-2-oxo-1,2,4a,8a-tetrahydro-1,8-naphthyridin-3-yl]urea
Rattus norvegicus
-
IC50: 382 nM
0.000452
1-[4-amino-2,6-bis(1-methylethyl)phenyl]-3-(1-butyl-4-{3-[3-(ethylamino)propoxy]phenyl}-2-oxo-1,2,4a,8a-tetrahydro-1,8-naphthyridin-3-yl)urea
Rattus norvegicus
-
IC50: 452 nM
0.00054
1-[4-amino-2,6-bis(1-methylethyl)phenyl]-3-{1-butyl-2-oxo-4-[3-(3-piperidin-1-ylpropoxy)phenyl]-1,2,4a,8a-tetrahydro-1,8-naphthyridin-3-yl}urea
Rattus norvegicus
-
IC50: 540 nM
0.000427
1-[4-amino-2,6-bis(1-methylethyl)phenyl]-3-{1-butyl-2-oxo-4-[3-(3-pyrrolidin-1-ylpropoxy)phenyl]-1,2,4a,8a-tetrahydro-1,8-naphthyridin-3-yl}urea
Rattus norvegicus
-
IC50: 427 nM
0.000021
1-[4-amino-2,6-bis(1-methylethyl)phenyl]-3-{1-butyl-4-[3-(3-hydroxypropoxy)phenyl]-2-oxo-1,2,4a,8a-tetrahydro-1,8-naphthyridin-3-yl}urea
Rattus norvegicus
-
i.e. SMP-797, possessing a potent ACAT inhibitory activity and significantly enhanced aqueous solubility under acidic conditions. The compound is a promising agent for oral treatment of hypercholesterolemia.IC50: 21 nM
0.000061
1-[4-amino-2,6-bis(1-methylethyl)phenyl]-3-{1-butyl-4-[3-(4-hydroxybutoxy)phenyl]-2-oxo-1,2,4a,8a-tetrahydro-1,8-naphthyridin-3-yl}urea
Rattus norvegicus
-
IC50: 61 nM
0.000018
1-[4-amino-2,6-di(propan-2-yl)phenyl]-3-({1-[2-(3-hydroxypropoxy)phenyl]-4-(3-methoxyphenyl)piperidin-4-yl}methyl)urea
Rattus norvegicus
-
pH 7.4
0.000032
1-[4-amino-2,6-di(propan-2-yl)phenyl]-3-{[1-(2-butoxyphenyl)-4-(3-methoxyphenyl)piperidin-4-yl]methyl}urea
Rattus norvegicus
-
pH 7.4
0.0281 - 0.0875
2-[(2E,6Z,8E,10E)-dodeca-2,6,8,10-tetraenoylamino]-1,1-dimethylethyl acetate
0.000077 - 0.0017
2-[(5aR,6R,8R,9aR,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
0.000416 - 0.002456
2-[(5aR,6R,8R,9aR,10S)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
0.000155
2-[(5aS,6S,8S,9aS)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
Homo sapiens
-
isozyme ACAT2, pH and temperature not specified in the publication
0.001789 - 0.003059
2-[(5aS,6S,8S,9aS,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
0.000743 - 0.001272
2-[(5aS,6S,8S,9aS,10S)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate
0.000068 - 0.1028
2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide
0.0115 - 0.0339
3beta-hydroxylup-20(29)-en-28-oic acid
0.16 - 0.19
5,5'-dibutoxy-2,2'-bifuran
0.017
5-(1-butoxy-2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}propyl)-1,3-benzodioxole
Homo sapiens
IC50: 0.017 mM
0.031
5-(2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-ethoxypropyl)-1,3-benzodioxole
Homo sapiens
IC50: 0.031 mM
0.035
5-(2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-methoxypropyl)-1,3-benzodioxole
Homo sapiens
IC50: 0.035 mM
0.014
5-(2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-propoxypropyl)-1,3-benzodioxole
Homo sapiens
IC50: 0.014 mM
0.05
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(heptyloxy)propyl]-1,3-benzodioxole
Homo sapiens
IC50: 0.05 mM
0.034
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(hexyloxy)propyl]-1,3-benzodioxole
Homo sapiens
IC50: 0.034 mM
0.02
5-[2-{4-[(2S,3R,4S,5R)-5-(3,4-dimethoxyphenyl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenoxy}-1-(pentyloxy)propyl]-1,3-benzodioxole
Homo sapiens
IC50: 0.02 mM
0.0387 - 0.2
5alpha,8alpha-epidioxy-24(R)-methylcholesta-6,22-diene-3beta-ol
0.000004
9-(benzo[d]oxazol-2-ylthio)-N-(2,6-diisopropylphenyl)-nonanamide
Oryctolagus cuniculus
aortic microsomes, pH 7.4, 37°C
0.1122 - 0.1289
acetylshikonin
0.0015 - 0.006
aurasperone A
0.0015 - 0.007
aurasperone D
0.0043 - 0.0235
avasimibe
0.012 - 0.0218
averufanin
0.00013 - 0.002
beauvericin
0.0006 - 0.02
beauveriolide I
0.00041 - 0.02
beauveriolide III
0.1698 - 0.1869
beta-hydroxyisovalerylshikonin
0.012 - 0.039
beta-sanshool
0.0281 - 0.0875
beta-sanshool acetate
0.083
betulin
Homo sapiens
IC50: 0.083 mM, hACAT-1
0.0013 - 0.0096
biseokeaniamide A
0.0025 - 0.0099
biseokeaniamide B
0.011 - 0.096
biseokeaniamide C
0.0048 - 0.012
celludinone A1
0.0061 - 0.015
celludinone A2
0.000069 - 0.0029
celludinone B
0.01872 - 0.01911
CI-1011
0.00006 - 0.00012
CL-283,546
0.09
dehydropipernonaline
Rattus norvegicus
-
-
0.06
dehydroretrofractamide
Rattus norvegicus
-
-
0.00068 - 0.0099
FD-549
0.006
flavasperone
Chlorocebus aethiops
isoform ACAT2, 37°C, cell-based assay
0.0797 - 0.0826
gamma-sanshool
0.0246 - 0.026
glabrol
0.0004 - 0.012
glisoprenin A
0.0575
isobutyrylshikonin
Homo sapiens
-
-
0.1 - 1
K-604
0.0015 - 0.04
K97-0239A
0.0017 - 0.7
K97-0239B
0.048
lupeol
Homo sapiens
IC50: 0.048 mM, hACAT-1
0.00065 - 0.0148
methyl (3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-6-[(4-cyanobenzoyl)oxy]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-carboxylate
0.0000532
N-(4-amino-2,6-diisopropylphenyl)-N'-([1-(2-butoxyphenyl)-4-(3-methoxyphenyl)piperidin-4-yl]-methyl)urea
Rattus norvegicus
-
pH 7.4
0.0152
oleic acid anilide
Homo sapiens
-
inhibited ACAT activity in THP-1 macrophages
0.000312
pactimibe
Oryctolagus cuniculus
-
pH 7.4, 37°C
0.002 - 0.0049
pactimibe sulfate
0.0405
pellitorin
Rattus norvegicus
-
-
0.0006 - 0.1
phenochalasin A
0.0135
piperchabamide D
Rattus norvegicus
-
-
0.0037
pipercide
Rattus norvegicus
-
-
0.0009 - 0.0045
purpactin A
0.0022 - 0.022
purpactin B
0.0028 - 0.03
purpactin C
0.00006 - 0.08
pyripyropene A
0.0008 - 0.048
pyripyropene B
0.00035 - 0.04
pyripyropene C
0.0012 - 0.038
pyripyropene D
0.0245
retrofractamide A
Rattus norvegicus
-
-
0.043
saucemeol B
Homo sapiens
IC50: 0.043 mM
0.004 - 0.02
sespendole
0.0704 - 0.1382
shikonin
0.000011
SM-32504
Rattus norvegicus
-
IC50: 11 nM
0.000031
SMP-797
Rattus norvegicus
-
-
0.003 - 0.042
spylidone
0.0024 - 0.03
sterigmatocystin
0.0005 - 0.01
terpendole C
0.000075 - 0.028
[(3S,4aR,6S,6aS,12R,12aS,12bS)-3,6-bis(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-yl]methyl 2-methylpropanoate
0.00089 - 0.0043
[(3S,4aR,6S,6aS,12R,12aS,12bS)-3,6-bis(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-yl]methyl 3-phenylpropanoate
0.000772 - 0.052
[(3S,4aR,6S,6aS,12R,12aS,12bS)-3,6-bis(acetyloxy)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-4-yl]methyl propanoate
0.00069 - 0.0159
[7-(2,2-dimethylpropanamido)-4,6-dimethyl-1-octylindolin-5-yl]acetic acid hemisulfate
additional information
(1R,3R,7R)-1-[(1S)-1-hydroxypropyl]-3,7-diphenyl-6-[(1S)-1-phenylethyl]-2-oxa-6-azaspiro[3.3]heptan-5-one