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Disease on EC 2.3.1.26 - sterol O-acyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abscess
Increasing prevalence of hypervirulent ST5 methicillin susceptible Staphylococcus aureus subtype poses a serious clinical threat.
Acantholysis
Peptides Targeting the Desmoglein 3 Adhesive Interface Prevent Autoantibody-induced Acantholysis in Pemphigus.
acetyl-coa c-acyltransferase deficiency
A Novel Mutation in ACAT1 Causing Beta-Ketothiolase Deficiency in a 4-Year-Old Sri Lankan Boy with Metabolic Ketoacidosis.
Beta-Ketothiolase Deficiency Presenting with Metabolic Stroke After a Normal Newborn Screen in Two Individuals.
C4OH is a potential newborn screening marker-a multicenter retrospective study of patients with beta-ketothiolase deficiency in China.
Clinical and Mutational Characterizations of Ten Indian Patients with Beta-Ketothiolase Deficiency.
NMR-based urinalysis for beta-ketothiolase deficiency.
Three Japanese Patients with Beta-Ketothiolase Deficiency Who Share a Mutation, c.431A>C (H144P) in ACAT1 : Subtle Abnormality in Urinary Organic Acid Analysis and Blood Acylcarnitine Analysis Using Tandem Mass Spectrometry.
[Analysis of clinical phenotype and ACAT1 gene mutation in a family affected with beta-ketothiolase deficiency].
Acidosis
Reveal genes functionally associated with ACADS by a network study.
Acne Vulgaris
All-trans-retinoic acid and 13-cis-retinoic acid: pharmacokinetics and biological activity in different cell culture models of human keratinocytes.
Palmitic Acid Induces Production of Proinflammatory Cytokines Interleukin-6, Interleukin-1?, and Tumor Necrosis Factor-? via a NF-?B-Dependent Mechanism in HaCaT Keratinocytes.
Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris.
[The influence of AMPs from HaCaT keratinocytes on some bacteria strains derived from skin changes]
Acute Coronary Syndrome
Cholesteryl esters associated with acyl-CoA:cholesterol acyltransferase predict coronary artery disease in patients with symptoms of acute coronary syndrome.
Adenocarcinoma
Anti-cancer effects of cerium oxide nanoparticles and its intracellular redox activity.
Chemopreventive Activity of Polyphenolics from Black Jamapa Bean (Phaseolus vulgaris L.) on HeLa and HaCaT Cells.
Selected Compounds Structurally Related to Acyclic Sesquiterpenoids and Their Antibacterial and Cytotoxic Activity.
Shedding of epidermal growth factor receptor is a regulated process that occurs with overexpression in malignant cells.
Synthesis, structural characterization, docking simulation and in vitro antiproliferative activity of the new gold(III) complex with 2-pyridineethanol.
Targeted HAI-2 deletion causes excessive proteolysis with prolonged active prostasin and depletion of HAI-1 monomer in intestinal but not epidermal epithelial cells.
Adenocarcinoma of Lung
A comparative study of using free radical generators in the testing of chosen oxidative stress parameters in the different types of cells.
AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response.
Cytotoxic and ACAT-inhibitory sesquiterpene lactones from the root of Ixeris dentata forma albiflora.
Gefitinib-induced epidermal growth factor receptor (EGFR)-independent keratinocyte apoptosis is mediated by the JNK-activation pathway.
Mechanistic investigations of antitumor activity of a Rhodamine B?oleanolic acid derivative bioconjugate.
Novel N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives: Synthesis and anticancer activity evaluation.
Synthesis, structural characterization, docking simulation and in vitro antiproliferative activity of the new gold(III) complex with 2-pyridineethanol.
Adrenal Hyperplasia, Congenital
ATR-101, a selective ACAT1 inhibitor, decreases ACTH-stimulated cortisol concentrations in dogs with naturally occurring Cushing's syndrome.
Structure of nevanimibe-bound tetrameric human ACAT1.
Adrenal Insufficiency
Sterol O-Acyltransferase 1 (SOAT1, ACAT) Is a Novel Target of Steroidogenic Factor-1 (SF-1, NR5A1, Ad4BP) in the Human Adrenal.
Adrenocortical Carcinoma
A phase 1 study of nevanimibe HCl, a novel adrenal-specific sterol O-acyltransferase 1 (SOAT1) inhibitor, in adrenocortical carcinoma.
ATR-101, a selective ACAT1 inhibitor, decreases ACTH-stimulated cortisol concentrations in dogs with naturally occurring Cushing's syndrome.
ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs.
Expression of SOAT1 in Adrenocortical Carcinoma and Response to Mitotane Monotherapy: An ENSAT Multicenter Study.
The GRP78/BiP inhibitor HA15 synergizes with mitotane action against adrenocortical carcinoma cells through convergent activation of ER stress pathways.
Albuminuria
Regression of Atherosclerosis in Apolipoprotein E-Deficient Mice is Feasible Using High-Dose Angiotensin Receptor Blocker, Candesartan.
Sterol-O-acyltransferase-1 has a role in kidney disease associated with diabetes and Alport Syndrome.
Alopecia
Minoxidil Acts as an Antiandrogen: A Study of 5?-reductase Type 2 Gene Expression in a Human Keratinocyte Cell Line.
Minoxidil Downregulates Interleukin-1 Alpha Gene Expression in HaCaT Cells.
Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression.
Proprietary Herbal Extract Downregulates the Gene Expression of IL-1? in HaCaT Cells: Possible Implications Against Nonscarring Alopecia.
Alzheimer Disease
A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease.
ACAT1 as a therapeutic target and its genetic relationship with Alzheimer's disease.
ACAT1 is not associated with Alzheimer's disease in two independent family-based samples.
Acat1 knockdown gene therapy decreases amyloid-? in a mouse model of Alzheimer's disease.
Accumulation of neutral lipids in peripheral blood mononuclear cells as a distinctive trait of Alzheimer patients and asymptomatic subjects at risk of disease.
Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage.
Association between acyl-coenzyme A: cholesterol acyltransferase gene and risk for Alzheimer's disease in Chinese.
Dysregulation of Neuronal Cholesterol Homeostasis upon Exposure to HIV-1 Tat and Cocaine Revealed by RNA-Sequencing.
Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease.
Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases A?1-42 clearance.
Neuronal cholesterol esterification by ACAT1 in Alzheimer's disease.
Relationship Between Genetic Variants of ACAT1 and APOE with the Susceptibility to Dementia (SADEM Study).
Silencing the ACAT1 Gene in Human SH-SY5Y Neuroblastoma Cells Inhibits the Expression of Cyclo-Oxygenase 2 (COX2) and Reduces ?-Amyloid-Induced Toxicity Due to Activation of Protein Kinase C (PKC) and ERK.
Study on the association between SOAT1 polymorphisms, Alzheimer's disease risk and the level of CSF biomarkers.
Anemia
[LCAT deficiency: a nephrological diagnosis].
Arteriosclerosis Obliterans
Lipid composition and enzyme activities of human arteriosclerotic femoral and iliac arteries.
Asthma
Magnolol stimulates steroidogenesis in rat adrenal cells.
Ataxia
Biological and molecular mechanisms of sulfur mustard analogue-induced toxicity in JB6 and HaCaT cells: possible role of ataxia telangiectasia-mutated/ataxia telangiectasia-Rad3-related cell cycle checkpoint pathway.
Ataxia Telangiectasia
Knock-down of human MutY homolog (hMYH) decreases phosphorylation of checkpoint kinase 1 (Chk1) induced by hydroxyurea and UV treatment.
Tetrandrine Enhances H2O2-Induced Apoptotic Cell Death Through Caspase-dependent Pathway in Human Keratinocytes.
Atherosclerosis
A glucagon-like peptide-1 analog liraglutide suppresses macrophage foam cell formation and atherosclerosis.
A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels.
Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia.
ACAT inhibitor F-1394 prevents intimal hyperplasia induced by balloon injury in rabbits.
ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver.
Acyl coenzyme A: cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis.
Acyl-CoA:cholesterol acyltransferase inhibition reduces atherosclerosis in apolipoprotein E-deficient mice.
Acyl-CoA:cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-Leiden mice.
Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) is induced in monocyte-derived macrophages: in vivo and in vitro studies.
Acyl-coenzyme A:cholesterol acyltransferase inhibitors for controlling hypercholesterolemia and atherosclerosis.
Anti-atherosclerotic molecules targeting oxidative stress and inflammation.
Association Between LOX-1, LAL, and ACAT1 Gene Single Nucleotide Polymorphisms and Carotid Plaque in a Northern Chinese Population.
Avasimibe Pfizer.
Chemical modification of acyl-CoA:cholesterol O-acyltransferase. 2. Identification of a coenzyme A regulatory site by p-mercuribenzoate modification.
Cholesterol esters (CE) derived from hepatic sterol O-acyltransferase 2 (SOAT2) are associated with more atherosclerosis than CE from intestinal SOAT2.
Decreased microsomal membrane fluidity in the development of cholesterol-induced atherosclerosis in the rabbit.
Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice.
Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only, LDLr-/- mice.
Direct effect of an acyl-CoA:cholesterol acyltransferase inhibitor, F-1394, on atherosclerosis in apolipoprotein E and low density lipoprotein receptor double knockout mice.
Effect of exogenous cholesterol and dithiothreitol on the activity of human liver microsomal acyl-coenzyme A:cholesterol acyltransferase (ACAT).
Effect of F-1394, an acyl-CoA:cholesterol acyltransferase inhibitor, on atherosclerosis induced by high cholesterol diet in rabbits.
Effect of the acyl-CoA:cholesterol acyltransferase inhibitor, E5324, on experimental atherosclerosis in rabbits.
Effects of diazepam (Valium) on aortic atherogenesis and plasma lecithin: cholesterol acyltransferase activity in cockerels fed an atherogenic diet.
Effects of leptin on expression of acyl-coenzymea: cholesterol acyltransferases-1 in cultured human monocyte-macrophages.
Effects of Porphyromonas gingivalis lipopolysaccharide on the expression of key genes involved in cholesterol metabolism in macrophages.
Enhancement of human ACAT1 gene expression to promote the macrophage-derived foam cell formation by dexamethasone.
Estrogen decreases atherosclerosis in part by reducing hepatic acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in monkeys.
Expression of ACAT-1 protein in human atherosclerotic lesions and cultured human monocytes-macrophages.
Genetic depletion of Soat2 diminishes hepatic steatosis via genes regulating de novo lipogenesis and by GLUT2 protein in female mice.
HL-004, the ACAT inhibitor, prevents the progression of atherosclerosis in cholesterol-fed rabbits.
Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells.
Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus TURCZ.
Human ACAT1 gene expression and its involvement in the development of atherosclerosis.
Human Acyl-CoA:cholesterol Acyltransferase (ACAT) and its Potential as a Target for Pharmaceutical Intervention against Atherosclerosis.
Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains.
Human acyl-CoA:cholesterol acyltransferase-1 is a homotetrameric enzyme in intact cells and in vitro.
Human urotensin II accelerates foam cell formation in human monocyte-derived macrophages.
Identification of potential ACAT-2 selective inhibitors using pharmacophore, SVM and SVR from Chinese herbs.
Identification of the Interaction Site within Acyl-CoA:Cholesterol Acyltransferase 2 for the Isoform-specific Inhibitor Pyripyropene A.
Imidazolylbenzopyrane derivatives: a new class of acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors.
Impact of salusin-alpha and -beta on human macrophage foam cell formation and coronary atherosclerosis.
Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages.
Inflammasome Activation Aggravates Cutaneous Xanthomatosis and Atherosclerosis in ACAT1 (Acyl-CoA Cholesterol Acyltransferase 1) Deficiency in Bone Marrow.
Inhibitory effect of acyl-CoA:cholesterol acyltransferase inhibitor-low density lipoprotein complex on experimental atherosclerosis.
Insulin induces human acyl-coenzyme A: cholesterol acyltransferase1 gene expression via MAP kinases and CCAAT/enhancer-binding protein ?.
Intravascular ultrasound assessment of novel antiatherosclerotic therapies: rationale and design of the Acyl-CoA:Cholesterol Acyltransferase Intravascular Atherosclerosis Treatment Evaluation (ACTIVATE) Study.
LDL particle core enrichment in cholesteryl oleate increases proteoglycan binding and promotes atherosclerosis.
Lipids-induced apoptosis is aggravated by acyl-coenzyme A: cholesterol acyltransferase inhibitor.
Liver-specific inhibition of acyl-coenzyme a:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/- mice.
Loss of ACAT1 Attenuates Atherosclerosis Aggravated by Loss of NCEH1 in Bone Marrow-Derived Cells.
Macrophages, inflammation, and atherosclerosis.
Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.
Models to study atherosclerosis: a mechanistic insight.
Molecular aspects of intracellular sterol esterification: the acyl coenzyme A: cholesterol acyltransferase reaction.
Molecular structures of human ACAT2 disclose mechanism for selective inhibition.
Mutant acyl-coenzyme A:cholesterol acyltransferase 1 devoid of cysteine residues remains catalytically active.
Myeloid Acat1/Soat1 KO attenuates pro-inflammatory responses in macrophages and protects against atherosclerosis in a model of advanced lesions.
Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression.
New pyripyropene A derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse models.
Newer pharmaceutical agents to treat lipid disorders.
Nonoxidative ethanol metabolism: formation of fatty acid ethyl esters by cholesterol esterase.
Novel molecules targeting dyslipidemia and atherosclerosis.
NTE-122, an acyl-coa:cholesterol acyltransferase inhibitor, prevents the progression of atherogenesis in cholesterol-fed rabbits.
Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential.
Potential therapeutics for obesity and atherosclerosis: inhibitors of neutral lipid metabolism from microorganisms.
Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism.
Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis.
Pyripyropene A, an Acyl-Coenzyme A:Cholesterol Acyltransferase 2-Selective Inhibitor, Attenuates Hypercholesterolemia and Atherosclerosis in Murine Models of Hyperlipidemia.
Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1.
Regression of Atherosclerosis in Apolipoprotein E-Deficient Mice is Feasible Using High-Dose Angiotensin Receptor Blocker, Candesartan.
Rimonabant is a dual inhibitor of acyl CoA:cholesterol acyltransferases 1 and 2.
Role of acyl-coenzyme a: cholesterol acyltransferase activity in the processing of the amyloid precursor protein.
Role of the N-terminal hydrophilic domain of acyl-coenzyme A:cholesterol acyltransferase 1 on the enzyme's quaternary structure and catalytic efficiency.
Sex-specific association of ACAT-1 rs1044925 SNP and serum lipid levels in the hypercholesterolemic subjects.
Short-Term Acyl-CoA:Cholesterol Acyltransferase Inhibition, Combined with Apoprotein A1 Overexpression, Promotes Atherosclerosis Inflammation Resolution in Mice.
SOAT1 deficiency attenuates atherosclerosis by regulating inflammation and cholesterol transportation via HO-1 pathway.
Synthesis and Evaluation of 11C- and 18F-Labeled SOAT1 Inhibitors as Macrophage Foam Cell Imaging Agents.
Targeted Depletion of Hepatic ACAT2-driven Cholesterol Esterification Reveals a Non-biliary Route for Fecal Neutral Sterol Loss.
Targeted Knockdown of Hepatic SOAT2 With Antisense Oligonucleotides Stabilizes Atherosclerotic Plaque in ApoB100-only LDLr-/- Mice.
The hypolipidemic effect of a new ACAT inhibitor, VULM 1457, in diabetic-hypercholesterolaemic rats.
[Construction and identification of recombinant firefly luciferase report vector containing human acyl coenzyme a: cholesterol acyltransferase 1 gene P7 promoter]
[Ghrelin down-regulates ACAT-1 in THP-1 derived foam cells via growth hormone secretagogue receptor-dependent pathway]
[Involvement of phospholipase A2 in the supply of fatty acids required for cholesterol esterification associated with uptake of oxidized low-density lipoprotein in macrophages]
[MTP inhibitors and ACAT inhibitors. An update]
Autoimmune Diseases
Role of tumor necrosis factor-? in the regulation of keratinocyte cell cycle and DNA repair after ultraviolet-B radiation.
Bacterial Infections
Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin.
Leucocyte recruitment and molecular fortification of keratinocytes triggered by streptococcal M1 protein.
Streptococcus pyogenes infection of tonsil explants is associated with a human ?-defensin 1 response from control but not recurrent acute tonsillitis patients.
Blister
Bikunin, a serine protease inhibitor, is present on the cell boundary of epidermis.
Decreased phospholipase D (PLD) activity in ceramide-induced apoptosis of human keratinocyte cell line HaCaT.
Plasmin Plays a Role in the In Vitro Generation of the Linear IgA Dermatosis Antigen LADB97.
The use of doxycycline as a protectant against sulphur mustard in HaCaT cells.
Bowen's Disease
Deletion mapping of chromosome 3p and 13q and preliminary analysis of the FHIT gene in human nonmelanoma skin cancer.
Karyopherin Alpha2 Is Essential for rRNA Transcription and Protein Synthesis in Proliferative Keratinocytes.
Breast Neoplasms
?-hydroxybutyrate does not alter the effects of glucose deprivation on breast cancer cells.
A Comparative Study of Melissa officinalis Leaves and Stems Ethanolic Extracts in terms of Antioxidant, Cytotoxic, and Antiproliferative Potential.
A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17.
Anticarcinogenic activity of blue fluorescent hexagonal boron nitride quantum dots: as an effective enhancer for DNA cleavage activity of anticancer drug doxorubicin.
Antineoplastic potential and chemical evaluation of essential oils from leaves and flowers of Tagetes ostenii Hicken.
Bacillus thuringiensis toxins are cytotoxic to cervical cancer (HeLa) but not to breast cancer (MCF7) cells.
Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells.
Conserved CPEs in the p53 3' untranslated region influence mRNA stability and protein synthesis.
Disrupting cholesterol esterification by bitter melon suppresses triple-negative breast cancer cell growth.
Efficient hydrolytic cleavage of DNA and antiproliferative effect on human cancer cells by two dinuclear Cu(II) complexes containing a carbohydrazone ligand and 1,10-phenanthroline as a coligand.
Gold Nano-Popcorn Attached SWCNT Hybrid Nanomaterial for Targeted Diagnosis and Photothermal Therapy of Human Breast Cancer Cells.
Green synthesis of multifunctional silver and gold nanoparticles from the oriental herbal adaptogen: Siberian ginseng.
High ACAT1 expression in estrogen receptor negative basal-like breast cancer cells is associated with LDL-induced proliferation.
Imaging Nuclei of MDA-MB-231 Breast Cancer Cells by Chiral Ruthenium(II) Complex Coordinated by 2-(4-Phenyacetylenephenyl)-1H-imidazo[4,5f][1,10]phenanthroline.
Induction of 3beta-hydroxysteroid dehydrogenase/isomerase type 1 expression by interleukin-4 in human normal prostate epithelial cells, immortalized keratinocytes, colon, and cervix cancer cell lines.
Leptin promotes the migration and invasion of breast cancer cells by upregulating ACAT2.
Met receptors induce Sam68-dependent cell migration by activation of alternate extracellular signal-regulated kinase family members.
MicroRNA 10b promotes abnormal expression of the protooncogene c-Jun in metastatic breast cancer cells.
Migration of MDA-MB-231 breast cancer cells depends on the availability of exogenous lipids and cholesterol esterification.
Mitoketoscins: Novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs).
Monofunctional BODIPY-Appended Imidazoplatin for Cellular Imaging and Mitochondria-Targeted Photocytotoxicity.
Multifunctional oval-shaped gold-nanoparticle-based selective detection of breast cancer cells using simple colorimetric and highly sensitive two-photon scattering assay.
Novel 2-benzylthio-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamides with anticancer activity: Synthesis, QSAR study, and metabolic stability.
Quantitative assessment of the relative antineoplastic potential of the n-butanolic leaf extract of Annona muricata Linn. in normal and immortalized human cell lines.
Role of breast tumour kinase in the in vitro differentiation of HaCaT cells.
Rottlerin exhibits antiangiogenic effects in vitro.
Synthesis and biological evaluation of 4-biphenylamino-5-halo-2(5H)-furanones as potential anticancer agents.
Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent.
Caliciviridae Infections
Synthesis and anti-norovirus activity of pyranobenzopyrone compounds.
Carcinogenesis
A novel chemopreventive mechanism for a traditional medicine: East Indian sandalwood oil induces autophagy and cell death in proliferating keratinocytes.
Aberrant cytokeratin expression during arsenic-induced acquired malignant phenotype in human HaCaT keratinocytes consistent with epidermal carcinogenesis.
Angiotensin II enhances EGF receptor expression levels via ROS formation in HaCaT cells.
CD44v6 expression in human skin keratinocytes as a possible mechanism for carcinogenesis associated with chronic arsenic exposure.
Characterisation of the novel spontaneously immortalized and invasively growing human skin keratinocyte line HaSKpw.
Defective TPA signalling compromises HaCat cells as a human in vitro skin carcinogenesis model.
Delayed and sustained activation of extracellular signal-regulated kinase in human keratinocytes by UVA: implications in carcinogenesis.
Detecting expression of keratins 8/18 in human HaCaT keratinocytes.
Differential stromal regulation of MMP-1 expression in benign and malignant keratinocytes.
Epigenetic Inactivation of Acetyl-CoA Acetyltransferase 1 Promotes the Proliferation and Metastasis in Nasopharyngeal Carcinoma by Blocking Ketogenesis.
Impact of Bcl-2 and Ha-ras on keratinocytes in organotypic culture.
Linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity.
Mitoketoscins: Novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs).
Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes.
Nemosis of fibroblasts is inhibited by benign HaCaT keratinocytes but promoted by malignant HaCaT cells.
Neoplastic alterations induced in Mammalian skin following mancozeb exposure using in vivo and in vitro models.
Novel Processed Form of Syndecan-1 Shed from SCC-9 Cells Plays a Role in Cell Migration.
Opposite roles of protein kinase C isoforms in proliferation, differentiation, apoptosis, and tumorigenicity of human HaCaT keratinocytes.
Optimization of the comet assay for the sensitive detection of PUVA-induced DNA interstrand cross-links.
Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells.
Proliferation and motility of HaCaT keratinocyte derivatives is enhanced by fibroblast nemosis.
Protective Effect of Inositol Hexaphosphate Against UVB Damage in HaCaT Cells and Skin Carcinogenesis in SKH1 Hairless Mice.
Rac1 is required for oncolytic NDV replication in human cancer cells and establishes a link between tumorigenesis and sensitivity to oncolytic virus.
Role of tumor necrosis factor-? in the regulation of keratinocyte cell cycle and DNA repair after ultraviolet-B radiation.
Selective cytotoxicity of Aniba rosaeodora essential oil towards epidermoid cancer cells through induction of apoptosis.
Subcellular Raman Microspectroscopy Imaging of Nucleic Acids and Tryptophan for Distinction of Normal Human Skin Cells and Tumorigenic Keratinocytes.
TGF-beta isoforms are differentially expressed in increasing malignant grades of HaCaT keratinocytes, suggesting separate roles in skin carcinogenesis.
The acquisition of cancer stem cell-like properties and neoplastic transformation of human keratinocytes induced by arsenite involves epigenetic silencing of let-7c via Ras/NF-?B.
The mRNA Expression Signature and Prognostic Analysis of Multiple Fatty Acid Metabolic Enzymes in Clear Cell Renal Cell Carcinoma.
UV-induced skin cancer: similarities--variations.
Carcinoma
A comparative study of using free radical generators in the testing of chosen oxidative stress parameters in the different types of cells.
A dairy bacterium displays in vitro probiotic properties for the pharyngeal mucosa by antagonizing group A streptococci and modulating the immune response.
A New Survival Model Based on Cholesterol Biosynthesis-Related Genes for Prognostic Prediction in Clear Cell Renal Cell Carcinoma.
A nutraceutical extract from Inula viscosa leaves: UHPLC-HR-MS/MS based polyphenol profile, and antioxidant and cytotoxic activities.
A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines.
ACAT1 and Metabolism-Related Pathways Are Essential for the Progression of Clear Cell Renal Cell Carcinoma (ccRCC), as Determined by Co-expression Network Analysis.
Actin isoforms and reorganization of adhesion junctions in epithelial-to-mesenchymal transition of cervical carcinoma cells.
All-trans-retinoic acid-mediated growth inhibition involves inhibition of human kinesin-related protein HsEg5.
Altered biology of adeno-associated virus type 2 and human papillomavirus during dual infection of natural host tissue.
Ambivalent Effects of Tumor Necrosis Factor Alpha on Apoptosis of Malignant and Normal Human Keratinocytes.
Annexin A5 is involved in migration and invasion of oral carcinoma.
Anti-cancer effects of cerium oxide nanoparticles and its intracellular redox activity.
Antiproliferative Effects on Tumour Cells and Promotion of Keratinocyte Wound Healing by Different Lichen Compounds.
Apoptotic mechanism activated by blue light and cisplatinum in cutaneous squamous cell carcinoma cells.
Camptothecin Fails to Induce Apoptosis in Tumor Necrosis Factor-Alpha-Treated HaCaT Cells.
CBP-mediated Wnt3a/?-catenin signaling promotes cervical oncogenesis initiated by Piwil2.
CD151 dynamics in carcinoma-stroma interaction: integrin expression, adhesion strength and proteolytic activity.
CD44 expression in oro-pharyngeal carcinoma tissues and cell lines.
Characterization of corticotropin-releasing hormone (CRH) in human skin.
Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas.
Chemical Characterization and in Vitro Cytotoxicity on Squamous Cell Carcinoma Cells of Carica Papaya Leaf Extracts.
Chromium(III) oxide nanoparticles induced remarkable oxidative stress and apoptosis on culture cells.
Circ_RPL23A acts as a miR-1233 sponge to suppress the progression of clear cell renal cell carcinoma by promoting ACAT2.
Constitutive expression of G-CSF and GM-CSF in human skin carcinoma cells with functional consequence for tumor progression.
Cooperative autocrine and paracrine functions of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in the progression of skin carcinoma cells.
Cyclosporin A induces the unfolded protein response in keratinocytes.
Cytotoxic and ACAT-inhibitory sesquiterpene lactones from the root of Ixeris dentata forma albiflora.
Decreased growth inhibitory responses of squamous carcinoma cells to interferon-gamma involve failure to recruit cki proteins into cdk2 complexes.
Defective TPA signalling compromises HaCat cells as a human in vitro skin carcinogenesis model.
Deletion mapping of chromosome 3p and 13q and preliminary analysis of the FHIT gene in human nonmelanoma skin cancer.
Development and Characterization of a Novel in vitro Progression Model for UVB-Induced Skin Carcinogenesis.
Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts.
Different pathways are involved in arsenic-trioxide-induced cell proliferation and growth inhibition in human keratinocytes.
Dynamic alteration in miRNA and mRNA expression profiles at different stages of chronic arsenic exposure-induced carcinogenesis in a human cell culture model of skin cancer.
Early phase TGF? receptor signalling dynamics stabilised by the deubiquitinase UCH37 promotes cell migratory responses.
Effect of chromodomain helicase/ATPase DNA binding protein 1-like gene on the invasion and metastasis of tongue squamous cell carcinoma CAL27 cells.
Effect of inhibiting ACAT-1 expression on the growth and metastasis of Lewis lung carcinoma.
Effects of demethoxycurcumin on the viability and apoptosis of skin cancer cells.
Egg-Yolk Sphingomyelin and Phosphatidylcholine Attenuate Cholesterol Absorption in Caco-2 Cells.
Enhanced constitutive invasion activity in human nontumorigenic keratinocytes exposed to a low level of barium for a long time.
Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair.
Epstein-Barr virus latent membrane protein 2A mediates transformation through constitutive activation of the Ras/PI3-K/Akt Pathway.
Evaluation of cellular effects of silicon dioxide nanoparticles.
Evaluation of cellular influences caused by calcium carbonate nanoparticles.
Expression and release of IL-18 binding protein in response to IFN-gamma.
Expression of human macrophage metalloelastase (MMP-12) by tumor cells in skin cancer.
Expression of two isozymes of acyl-coenzyme A: cholesterol acyltransferase-1 and -2 in clear cell type renal cell carcinoma.
Gold nanoparticles conjugated with programmed death-ligand 1 antibodies induce apoptosis of SCC-25 oral squamous cell carcinoma cells via programmed death-ligand 1/signal transducer and transcription 3 pathway.
Host plasminogen activator inhibitor-1 promotes human skin carcinoma progression in a stage-dependent manner.
In vitro evaluation of cellular influences induced by stable fullerene C70 medium dispersion: Induction of cellular oxidative stress.
In vitro evaluation of cellular responses induced by stable fullerene C60 medium dispersion.
In vitro sensitivity of human gastric cancer cells (HGC-27) to Helicobacter pylori cytotoxin.
Indocyanine green (ICG) and laser irradiation induce photooxidation.
Influence of activation and differentiation of cells on the effectiveness of photodynamic therapy.
Inhibition of basal cell carcinoma cells by cold atmospheric plasma?activated solution and differential gene expression analysis.
Inhibition of Cholesterol Esterification Enzyme Enhances the Potency of Human Chimeric Antigen Receptor T Cells against Pancreatic Carcinoma.
Insulin promotes progression of colon cancer by upregulation of ACAT1.
Interferon-gamma mediates gene expression of IL-18 binding protein in nonleukocytic cells.
Iodinated chlorin p6 copper complex induces anti-proliferative effect in oral cancer cells through elevation of intracellular reactive oxygen species.
Karyopherin Alpha2 Is Essential for rRNA Transcription and Protein Synthesis in Proliferative Keratinocytes.
Liver kinase B1 (LKB1) in the pathogenesis of UVB-induced murine basal cell carcinoma.
Mammalian cell viability on hydrophobic and superhydrophobic fabrics.
Methylation-associated silencing of S100A4 expression in human epidermal cancers.
Molecular basis of basal cell carcinoma: analysis of differential gene expression by differential display PCR and expression array.
Myricetin and naringenin inhibit human squamous cell carcinoma proliferation and migration in vitro.
Novel N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives: Synthesis and anticancer activity evaluation.
Oscillations of ultra-weak photon emission from cancer and non-cancer cells stressed by culture medium change and TNF-?.
Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis.
Patterns of desmocollin synthesis in human epithelia: immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells.
Phenolic profiling of an extract from Eugenia jambos L. (Alston)--the structure of three flavonoid glycosides--antioxidant and cytotoxic activities.
Photodynamic therapy of tumour cells mediated by the natural anthraquinone parietin and blue light.
Photosensitization of human skin cell lines by ATMPn (9-acetoxy-2,7,12,17-tetrakis-(beta-methoxyethyl)-porphycene) in vitro: mechanism of action.
Photosensitization of skin-derived cell lines by Dimegin [2,4-di-(alpha-methoxyethyl)-deuteroporphyrin IX] in vitro.
Possible Involvement of F1F0-ATP synthase and Intracellular ATP in Keratinocyte Differentiation in normal skin and skin lesions.
Prognostic significance of two lipid metabolism enzymes, HADHA and ACAT2, in clear cell renal cell carcinoma.
Proliferation and motility of HaCaT keratinocyte derivatives is enhanced by fibroblast nemosis.
Protein Adsorption of Ultrafine Metal Oxide and Its Influence on Cytotoxicity toward Cultured Cells.
Reciprocal transactivation of Merkel cell polyomavirus and high-risk human papillomavirus promoter activities and increased expression of their oncoproteins.
Regulation of cholesterol metabolism and low-density lipoprotein binding in human intestinal Caco-2 cells.
Regulatory role for Krüppel-like zinc-finger protein Gli-similar 1 (Glis1) in PMA-treated and psoriatic epidermis.
Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity.
Suppression of epidermal growth factor receptor, mitogen-activated protein kinase, and Pak1 pathways and invasiveness of human cutaneous squamous cancer cells by the tyrosine kinase inhibitor ZD1839 (Iressa).
Suppression of tumor cell growth by syndecan-1 ectodomain.
Surface plasmon resonance-biosensor detects the diversity of responses against epidermal growth factor in various carcinoma cell lines.
Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent.
Synthesis and In?Vitro Evaluation of a Photosensitizer-BODIPY Derivative for Potential Photodynamic Therapy Applications.
Synthesis, structural characterization, docking simulation and in vitro antiproliferative activity of the new gold(III) complex with 2-pyridineethanol.
The biochemical alterations following administration of Kalpaamruthaa and Semecarpus anacardium in mammary carcinoma.
The Comparison of In Vitro Photosensitizing Efficacy of Curcumin-Loaded Liposomes Following Photodynamic Therapy on Melanoma MUG-Mel2, Squamous Cell Carcinoma SCC-25, and Normal Keratinocyte HaCaT Cells.
The epidermal platelet-activating factor receptor augments chemotherapy-induced apoptosis in human carcinoma cell lines.
The expression of desmoglein isoforms in cultured human keratinocytes is regulated by calcium, serum, and protein kinase C.
The molecular effects of aloe-emodin (AE)/liposome-AE on human nonmelanoma skin cancer cells and skin permeation.
The novel synthetic ether lipid inositol-C2-PAF inhibits phosphorylation of the tyrosine kinases Src and FAK independent of integrin activation in transformed skin cells.
The relative abundance of oxygen alkyl-related groups in aliphatic domains is involved in the main pharmacological-pleiotropic effects of humic acids.
Three-Dimensional In Vitro Skin and Skin Cancer Models Based on Human Fibroblast-Derived Matrix.
Transcriptional activation of the human papillomavirus-16 P97 promoter by an 88-nucleotide enhancer containing distinct cell-dependent and AP-1-responsive modules.
Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells.
Ultrafine NiO Particles Induce Cytotoxicity in Vitro by Cellular Uptake and Subsequent Ni(II) Release.
[Differences of Nonsense-Mediated mRNA Degradation Activity in Mammalian Cell Lines Revealed by a Fluorescence Reporter].
[Effects of RAB1A on the proliferation, invasion, and metastasis of tongue squamous cell carcinoma cells].
[Expression of vascular endothelial growth factor and its receptors in laryngeal carcinoma cell and its significance]
[Over-expression of Hsa-miR-23b-3p suppresses proliferation, migration, invasion and epithelial-mesenchymal transition of human cervical cancer CasKi cells].
Carcinoma, Basal Cell
Deletion mapping of chromosome 3p and 13q and preliminary analysis of the FHIT gene in human nonmelanoma skin cancer.
Inhibition of basal cell carcinoma cells by cold atmospheric plasma?activated solution and differential gene expression analysis.
Carcinoma, Hepatocellular
A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines.
ACAT2 Promotes Cell Proliferation and Associates with Malignant Progression in Colorectal Cancer.
Cholesterol regulates ACAT2 gene expression and enzyme activity in human hepatoma cells.
Control of ACAT2 liver expression by HNF1.
Correction: Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma.
Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and secretions of apolipoprotein B-containing lipoprotein and bile acids in HepG2.
Generation of new hepatocyte-like in vitro models better resembling human lipid metabolism.
Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma.
Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma.
Inhibition of acyl-CoA: cholesterol acyltransferase decreases apolipoprotein B-100-containing lipoprotein secretion from HepG2 cells.
Itraconazole cis-diastereoisomers activate aryl hydrocarbon receptor AhR and pregnane X receptor PXR and induce CYP1A1 in human cell lines and human hepatocytes.
Physicochemical, Bacteriostatic, and Biological Properties of Starch/Chitosan Polymer Composites Modified by Graphene Oxide, Designed as New Bionanomaterials.
Proteomic heterogeneity reveals SOAT1 as a potential biomarker for hepatocellular carcinoma.
Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma.
Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis.
Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent.
Use of cyclodextrins for manipulating cellular cholesterol content.
Carcinoma, Lewis Lung
Effect of inhibiting ACAT-1 expression on the growth and metastasis of Lewis lung carcinoma.
The relative abundance of oxygen alkyl-related groups in aliphatic domains is involved in the main pharmacological-pleiotropic effects of humic acids.
[Differences of Nonsense-Mediated mRNA Degradation Activity in Mammalian Cell Lines Revealed by a Fluorescence Reporter].
Carcinoma, Merkel Cell
Karyopherin Alpha2 Is Essential for rRNA Transcription and Protein Synthesis in Proliferative Keratinocytes.
Carcinoma, Non-Small-Cell Lung
Anti-cancer effects of cerium oxide nanoparticles and its intracellular redox activity.
Carcinoma, Renal Cell
ACAT1 and Metabolism-Related Pathways Are Essential for the Progression of Clear Cell Renal Cell Carcinoma (ccRCC), as Determined by Co-expression Network Analysis.
Circ_RPL23A acts as a miR-1233 sponge to suppress the progression of clear cell renal cell carcinoma by promoting ACAT2.
Prognostic significance of two lipid metabolism enzymes, HADHA and ACAT2, in clear cell renal cell carcinoma.
Carcinoma, Squamous Cell
Altered biology of adeno-associated virus type 2 and human papillomavirus during dual infection of natural host tissue.
Ambivalent Effects of Tumor Necrosis Factor Alpha on Apoptosis of Malignant and Normal Human Keratinocytes.
Annexin A5 is involved in migration and invasion of oral carcinoma.
Anti-proliferative and pro-apoptotic effects of Uncaria tomentosa aqueous extract in squamous carcinoma cells.
Apoptotic mechanism activated by blue light and cisplatinum in cutaneous squamous cell carcinoma cells.
Artesunate induces G0/G1 cell cycle arrest and iron-mediated mitochondrial apoptosis in A431 human epidermoid carcinoma cells.
Cell cycle progression data on human skin cancer cells with anticancer synthetic peptide LTX-315 treatment.
Cell-matrix interactions of normal and transformed human keratinocytes in vitro are modulated by the synthetic phospholipid analogue hexadecylphosphocholine.
Characterization of corticotropin-releasing hormone (CRH) in human skin.
Cooperative autocrine and paracrine functions of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in the progression of skin carcinoma cells.
Correlation between FUT4 expression and its promoter methylation in HaCaT cells.
Covalently bound lipids in reconstructed human epithelia.
Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo.
Cyclosporin A induces the unfolded protein response in keratinocytes.
Decreased growth inhibitory responses of squamous carcinoma cells to interferon-gamma involve failure to recruit cki proteins into cdk2 complexes.
Deletion mapping of chromosome 3p and 13q and preliminary analysis of the FHIT gene in human nonmelanoma skin cancer.
Development and Characterization of a Novel in vitro Progression Model for UVB-Induced Skin Carcinogenesis.
Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repair.
Dynamic alteration in miRNA and mRNA expression profiles at different stages of chronic arsenic exposure-induced carcinogenesis in a human cell culture model of skin cancer.
Effect of chromodomain helicase/ATPase DNA binding protein 1-like gene on the invasion and metastasis of tongue squamous cell carcinoma CAL27 cells.
Effects of demethoxycurcumin on the viability and apoptosis of skin cancer cells.
EGFR-Dependent Downregulation of Bim in Epithelial Cells Requires MAPK and PKC-delta Activities.
Enhanced constitutive invasion activity in human nontumorigenic keratinocytes exposed to a low level of barium for a long time.
Expression of human macrophage metalloelastase (MMP-12) by tumor cells in skin cancer.
GPI-specific phospholipase D mRNA expression in tumor cells of different malignancy.
Indocyanine green (ICG) and laser irradiation induce photooxidation.
Influence of activation and differentiation of cells on the effectiveness of photodynamic therapy.
Jasmonic Acid Induces Endoplasmic Reticulum Stress with Different Outcome in Cultured Normal and Tumor Epidermal Cells.
Karyopherin Alpha2 Is Essential for rRNA Transcription and Protein Synthesis in Proliferative Keratinocytes.
Methylation-associated silencing of S100A4 expression in human epidermal cancers.
Mitogen- and stress-activated protein kinase 1 is critical for interleukin-1-induced, CREB-mediated, c-fos gene expression in keratinocytes.
Molecular basis of basal cell carcinoma: analysis of differential gene expression by differential display PCR and expression array.
Patterns of desmocollin synthesis in human epithelia: immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells.
Photosensitization of human skin cell lines by ATMPn (9-acetoxy-2,7,12,17-tetrakis-(beta-methoxyethyl)-porphycene) in vitro: mechanism of action.
Photosensitization of skin-derived cell lines by Dimegin [2,4-di-(alpha-methoxyethyl)-deuteroporphyrin IX] in vitro.
Possible Involvement of F1F0-ATP synthase and Intracellular ATP in Keratinocyte Differentiation in normal skin and skin lesions.
Protein C inhibitor is expressed in keratinocytes of human skin.
Regulatory role for Krüppel-like zinc-finger protein Gli-similar 1 (Glis1) in PMA-treated and psoriatic epidermis.
Resveratrol enhances the effects of ALA-PDT on skin squamous cells A431 through p38/ MAPK signaling pathway.
Retinoids downregulate vascular endothelial growth factor/vascular permeability factor production by normal human keratinocytes.
Roles of heterogeneous nuclear ribonucleoproteins A and B in cell proliferation.
Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery.
Selective cytotoxicity of Aniba rosaeodora essential oil towards epidermoid cancer cells through induction of apoptosis.
Suppression of epidermal growth factor receptor, mitogen-activated protein kinase, and Pak1 pathways and invasiveness of human cutaneous squamous cancer cells by the tyrosine kinase inhibitor ZD1839 (Iressa).
Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent.
Synthesis and Cytostatic Effect of 3'-deoxy-3'-C-Sulfanylmethyl Nucleoside Derivatives with d-xylo Configuration.
The Comparison of In Vitro Photosensitizing Efficacy of Curcumin-Loaded Liposomes Following Photodynamic Therapy on Melanoma MUG-Mel2, Squamous Cell Carcinoma SCC-25, and Normal Keratinocyte HaCaT Cells.
The effect of resveratrol and its methylthio-derivatives on EGFR and Stat3 activation in human HaCaT and A431 cells.
The expression of desmoglein isoforms in cultured human keratinocytes is regulated by calcium, serum, and protein kinase C.
The molecular effects of aloe-emodin (AE)/liposome-AE on human nonmelanoma skin cancer cells and skin permeation.
The novel synthetic ether lipid inositol-C2-PAF inhibits phosphorylation of the tyrosine kinases Src and FAK independent of integrin activation in transformed skin cells.
Three-Dimensional In Vitro Skin and Skin Cancer Models Based on Human Fibroblast-Derived Matrix.
Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells.
Verbascum nigrum: Cytotoxicity Evaluation in A431 Epidermoid Carcinoma Cells and Untargeted LC-HR-MS/MS Metabolite Profiling.
[Effect of plant hormones on the components of secretory pathway in human normal and tumor cells].
[Effects of RAB1A on the proliferation, invasion, and metastasis of tongue squamous cell carcinoma cells].
Cardiovascular Diseases
Isoform-specific inhibitors of ACATs: recent advances and promising developments.
Liver-specific inhibition of acyl-coenzyme a:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/- mice.
Molecular structures of human ACAT2 disclose mechanism for selective inhibition.
Cell Transformation, Neoplastic
Rac1 is required for oncolytic NDV replication in human cancer cells and establishes a link between tumorigenesis and sensitivity to oncolytic virus.
UVA radiation causes DNA strand breaks, chromosomal aberrations and tumorigenic transformation in HaCaT skin keratinocytes.
Chagas Disease
ACAT-1 gene rs1044925 SNP and its relation with different clinical forms of chronic Chagas disease.
Cholangiocarcinoma
A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines.
Cholelithiasis
ACAT2 and human hepatic cholesterol metabolism: Identification of important gender-related differences in normolipidemic, non-obese Chinese patients.
Effect of exogenous cholesterol and dithiothreitol on the activity of human liver microsomal acyl-coenzyme A:cholesterol acyltransferase (ACAT).
The ACAT2 gene encodes a gatekeeper of intestinal cholesterol absorption that regulates cholesterolemia and gallstone disease.
Cholera
Cholesterol-rich plasma membrane domains (lipid rafts) in keratinocytes: importance in the baseline and UVA-induced generation of reactive oxygen species.
Flotillas of lipid rafts in transit amplifying cell-like keratinocytes.
Cholesteatoma
Establishment and characterization of an in vitro model for cholesteatoma.
Modeling the cholesteatoma microenvironment: coculture of HaCaT keratinocytes with WS1 fibroblasts induces MMP-2 activation, invasive phenotype, and proteolysis of the extracellular matrix.
TFIIB-related factor 2 regulates glucose-regulated protein 78 expression in acquired middle ear cholesteatoma.
[Expression and activation of nuclear factor-kappaB in middle ear cholesteatoma]
Cholesteatoma, Middle Ear
TFIIB-related factor 2 regulates glucose-regulated protein 78 expression in acquired middle ear cholesteatoma.
Cockayne Syndrome
Downregulation of Cockayne syndrome B protein reduces human 8-oxoguanine DNA glycosylase-1 expression and repair of UV radiation-induced 8-oxo-7,8-dihydro-2'-deoxyguanine.
Colonic Neoplasms
Anti-cancer effects of Porphyra haitanensis polysaccharides on human colon cancer cells via cell cycle arrest and apoptosis without causing adverse effects in vitro.
Anti-colon cancer activity of Murraya koenigii leaves is due to constituent murrayazoline and O-methylmurrayamine A induced mTOR/AKT downregulation and mitochondrial apoptosis.
Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer.
Crosstalk between Hippo and TGF?: Subcellular Localization of YAP/TAZ/Smad Complexes.
Crucial role of cytokines in sex steroid formation in normal and tumoral tissues.
Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway.
Fargesin Inhibits EGF-Induced Cell Transformation and Colon Cancer Cell Growth by Suppression of CDK2/Cyclin E Signaling Pathway.
In situ preparation of water-soluble ginsenoside Rh2-entrapped bovine serum albumin nanoparticles: in vitro cytocompatibility studies.
Induction of 3beta-hydroxysteroid dehydrogenase/isomerase type 1 expression by interleukin-4 in human normal prostate epithelial cells, immortalized keratinocytes, colon, and cervix cancer cell lines.
Insulin promotes progression of colon cancer by upregulation of ACAT1.
Matrix metalloproteinase-21 is expressed epithelially during development and in cancer and is up-regulated by transforming growth factor-beta1 in keratinocytes.
Novel 2-benzylthio-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamides with anticancer activity: Synthesis, QSAR study, and metabolic stability.
PAF-receptor in inflammatory versus non inflammatory human epidermis, cell cultures and embryonal cells.
Regulation of cholesterol metabolism and low-density lipoprotein binding in human intestinal Caco-2 cells.
Resveratrol enhances apoptosis induced by the heterocyclic aromatic amines in p53-wt LoVo cells, but not in p53-deficient HaCaT cells.
SNAI1 expression in colon cancer related with CDH1 and VDR downregulation in normal adjacent tissue.
SOAT1 is a new prognostic factor of colorectal cancer.
The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses.
Colorectal Neoplasms
ACAT2 Promotes Cell Proliferation and Associates with Malignant Progression in Colorectal Cancer.
Enhancement of p53-mutant human colorectal cancer cells radiosensitivity by flavonoid fisetin.
Erratum: ACAT2 Promotes Cell Proliferation and Associates with Malignant Progression in Colorectal Cancer [Corrigendum].
Insulin promotes progression of colon cancer by upregulation of ACAT1.
Serum Starvation Sensitizes Anticancer Effect of Anemarrhena asphodeloides via p38/JNK-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells.
SOAT1 is a new prognostic factor of colorectal cancer.
TLR4 siRNA inhibits proliferation and invasion in colorectal cancer cells by downregulating ACAT1 expression.
Condylomata Acuminata
The cytotoxic mechanism of epigallocatechin gallate on proliferative HaCaT keratinocytes.
Corneal Opacity
[LCAT deficiency: a nephrological diagnosis].
Coronary Artery Disease
Acyl-CoA: cholesterol acyltransferases-2 gene polymorphism is associated with increased susceptibility to coronary artery disease in Uygur population in Xinjiang, China.
Cholesteryl esters associated with acyl-CoA:cholesterol acyltransferase predict coronary artery disease in patients with symptoms of acute coronary syndrome.
Functional characterization of two single nucleotide polymorphisms of acyl-coenzyme A:cholesterol acyltransferase 2.
Intravascular ultrasound assessment of novel antiatherosclerotic therapies: rationale and design of the Acyl-CoA:Cholesterol Acyltransferase Intravascular Atherosclerosis Treatment Evaluation (ACTIVATE) Study.
Reduced regulatory capacity of low density lipoproteins from patients with coronary artery disease.
Coronary Disease
ACAT2 and human hepatic cholesterol metabolism: Identification of important gender-related differences in normolipidemic, non-obese Chinese patients.
ACAT2 is a target for treatment of coronary heart disease associated with hypercholesterolemia.
Acyl-coenzyme A:cholesteryl acyltransferase 2.
Guinea pigs as models to study the hypocholesterolemic effects of drugs.
Monounsaturated fatty acyl-coenzyme A is predictive of atherosclerosis in human apoB-100 transgenic, LDLr-/- mice.
Role of multidrug resistance P-glycoproteins in cholesterol esterification.
SOAT1 methylation is associated with coronary heart disease.
Crohn Disease
Interruption of the enterohepatic circulation of bile acids stimulates the esterification rate of cholesterol in human liver.
Cushing Syndrome
ATR-101, a selective ACAT1 inhibitor, decreases ACTH-stimulated cortisol concentrations in dogs with naturally occurring Cushing's syndrome.
Dehydration
Far infrared ray irradiation attenuates apoptosis and cell death of cultured keratinocytes stressed by dehydration.
Dementia
Relationship Between Genetic Variants of ACAT1 and APOE with the Susceptibility to Dementia (SADEM Study).
Dermatitis
An isoflavone extract from soybean cake suppresses 2,4-dinitrochlorobenzene-induced contact dermatitis.
Anti-atopic dermatitis properties of Cordyceps militaris on TNF?/IFN?-stimulated HaCaT cells and experimentally induced atopic dermatitis in mice.
Rosmarinic acid protects mice from imiquimod induced psoriasis-like skin lesions by inhibiting the IL-23/Th17 axis via regulating Jak2/Stat3 signaling pathway.
Salidroside suppresses solar ultraviolet-induced skin inflammation by targeting cyclooxygenase-2.
Saussurea lappa alleviates inflammatory chemokine production in HaCaT cells and house dust mite-induced atopic-like dermatitis in Nc/Nga mice.
Transduced PEP-1-FK506BP Ameliorates Atopic Dermatitis in NC/Nga Mice.
Dermatitis, Allergic Contact
Calycosin alleviates allergic contact dermatitis by repairing epithelial tight junctions via down-regulating HIF-1?.
Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease.
Dermatitis, Atopic
Anti-Atopic Dermatitis Effect of Seaweed Fulvescens Extract via Inhibiting the STAT1 Pathway.
Anti-atopic dermatitis properties of Cordyceps militaris on TNF?/IFN?-stimulated HaCaT cells and experimentally induced atopic dermatitis in mice.
Effect of Bifidobacterium infantis on Interferon- gamma- induced keratinocyte apoptosis: a potential therapeutic approach to skin immune abnormalities.
Effect of Neferine on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice.
Effects of Deacetylasperulosidic Acid on Atopic Dermatitis through Modulating Immune Balance and Skin Barrier Function in HaCaT, HMC-1, and EOL-1 Cells.
Effects of Hovenia dulcis Thunb. extract and methyl vanillate on atopic dermatitis-like skin lesions and TNF-?/IFN-?-induced chemokines production in HaCaT cells.
Expression and modulation of LL-37 in normal human keratinocytes, HaCaT cells, and inflammatory skin diseases.
Fas/FasL pathway and cytokines in keratinocytes in atopic dermatitis - Manipulation by the electromagnetic field.
IL-10 augments the IFN-gamma and TNF-alpha induced TARC production in HaCaT cells: a possible mechanism in the inflammatory reaction of atopic dermatitis.
Inhibitory Effect of Centella asiatica Extract on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice.
Intermedin: a skin peptide that is downregulated in atopic dermatitis.
Oral administration of Lactococcus chungangensis inhibits 2,4-dinitrochlorobenzene-induced atopic-like dermatitis in NC/Nga mice.
Psidium guajava extract inhibits thymus and activation-regulated chemokine (TARC/CCL17) production in human keratinocytes by inducing heme oxygenase-1 and blocking NF-?B and STAT1 activation.
Roles of SEA-expressing Staphylococcus aureus, isolated from an atopic dermatitis patient, on expressions of human beta-defensin-2 and inflammatory cytokines in HaCaT cells.
Rosa davurica Pall. improves DNCB-induced atopic dermatitis in mice and regulated TNF-Alpa/IFN-gamma-induced skin inflammatory responses in HaCaT cells.
Saussurea lappa alleviates inflammatory chemokine production in HaCaT cells and house dust mite-induced atopic-like dermatitis in Nc/Nga mice.
Solanum nigrum Linne improves DNCB?induced atopic dermatitis?like skin disease in BALB/c mice.
TGF-beta/Smad signaling inhibits IFN-gamma and TNF-alpha-induced TARC (CCL17) production in HaCaT cells.
The Role of Oxidation in FSL-1 Induced Signaling Pathways of an Atopic Dermatitis Model in HaCaT Keratinocytes.
Transduced PEP-1-FK506BP Ameliorates Atopic Dermatitis in NC/Nga Mice.
Umbelliferone reduces the expression of inflammatory chemokines in HaCaT cells and DNCB/DFE-induced atopic dermatitis symptoms in mice.
Dermatitis, Contact
An isoflavone extract from soybean cake suppresses 2,4-dinitrochlorobenzene-induced contact dermatitis.
Ethanol Extract of Peanut Sprout Exhibits a Potent Anti-Inflammatory Activity in Both an Oxazolone-Induced Contact Dermatitis Mouse Model and Compound 48/80-Treated HaCaT Cells.
Formononetin attenuated allergic diseases through inhibition of epithelial-derived cytokines by regulating E-cadherin.
Dermatitis, Phototoxic
An evaluation of the effects of photoactivation of bithionol, amiodarone and chlorpromazine on human keratinocytes in vitro.
Applicability of new degradable hypericin-polymer-conjugates as photosensitizers: principal mode of action demonstrated by in vitro models.
Assessment of primary eye and skin irritants by in vitro cytotoxicity and phototoxicity models: an in vitro approach of new arginine-based surfactant-induced irritation.
Controlled Photodynamic Action of Axial Fluorinated DiethoxyP(V)tetrakis(p-methoxyphenyl)porphyrin through Self-Aggregation.
Fucoxanthin for Topical Administration, a Phototoxic vs. Photoprotective Potential in a Tiered Strategy Assessed by In Vitro Methods.
Implementation of an in vitro methodology for phototoxicity evaluation in a human keratinocyte cell line.
Light-induced cytotoxicity of 16 polycyclic aromatic hydrocarbons on the US EPA priority pollutant list in human skin HaCaT keratinocytes: relationship between phototoxicity and excited state properties.
Metabolic activation of pyrrolizidine alkaloids leading to phototoxicity and photogenotoxicity in human HaCaT keratinocytes.
Nabumetone induced photogenotoxicity mechanism mediated by ROS generation under environmental UV radiation in human keratinocytes (HaCaT) cell line.
New cationic nanovesicular systems containing lysine-based surfactants for topical administration: Toxicity assessment using representative skin cell lines.
Phloxine B phototoxicity: a mechanistic study using HaCaT keratinocytes.
Photo-induced reactive oxygen species generation by different water-soluble fullerenes (C) and their cytotoxicity in human keratinocytes.
Photosensitization of human skin cell lines by ATMPn (9-acetoxy-2,7,12,17-tetrakis-(beta-methoxyethyl)-porphycene) in vitro: mechanism of action.
Phototoxicity of nano titanium dioxides in HaCaT keratinocytes-Generation of reactive oxygen species and cell damage.
Phototoxicity of zinc oxide nanoparticles in HaCaT keratinocytes-generation of oxidative DNA damage during UVA and visible light irradiation.
Phototoxicity to diuretics and antidiabetics in the cultured keratinocyte cell line HaCaT: evaluation by clonogenic assay and single cell gel electrophoresis Comet assay).
Pristine (C60) and hydroxylated [C60(OH)24] fullerene phototoxicity towards HaCaT keratinocytes: type I vs type II mechanisms.
Prodrugs for Skin Delivery of Menahydroquinone-4, an Active Form of Vitamin K2(20), Could Overcome the Photoinstability and Phototoxicity of Vitamin K2(20).
Reduction in hypericin-induced phototoxicity by Hypericum perforatum extracts and pure compounds.
Titanium Dioxide Induces Apoptosis under UVA Irradiation via the Generation of Lysosomal Membrane Permeabilization-Dependent Reactive Oxygen Species in HaCat Cells.
Toxicity evaluation of LQFM048, a novel photoprotective compound synthesized through green chemistry approach.
Diabetes Mellitus
The myocardial infarct size-limiting and antiarrhythmic effects of acyl-CoA:Cholesterol acyltransferase inhibitor VULM 1457 protect the hearts of diabetic-hypercholesterolaemic rats against ischaemia/reperfusion injury both in vitro and in vivo.
Diabetes Mellitus, Type 1
A Dipeptidyl Peptidase-4 Inhibitor Inhibits Foam Cell Formation of Macrophages in Type 1 Diabetes via Suppression of CD36 and ACAT-1 Expression.
Diabetes Mellitus, Type 2
Downregulation of the acetyl-CoA metabolic network in adipose tissue of obese diabetic individuals and recovery after weight loss.
Effect of corosolic acid on dietary hypercholesterolemia and hepatic steatosis in KK-Ay diabetic mice.
Diabetic Nephropathies
Sterol-O-acyltransferase-1 has a role in kidney disease associated with diabetes and Alport Syndrome.
Drug-Related Side Effects and Adverse Reactions
Anti-cancer Effect of Luminacin, a Marine Microbial Extract, in Head and Neck Squamous Cell Carcinoma Progression via Autophagic Cell Death.
Dry Eye Syndromes
Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia.
Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression.
Dyslipidemias
Acyl-coenzyme A:cholesterol acyltransferase-2 (ACAT-2) is responsible for elevated intestinal ACAT activity in diabetic rats.
Design and Synthesis of A-Ring Simplified Pyripyropene?A Analogues as Potent and Selective Synthetic SOAT2 Inhibitors.
Pathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation.
Structure of the human acyl-CoA:cholesterol acyltransferase-2 (ACAT-2) gene and its relation to dyslipidemia.
[LCAT deficiency: a nephrological diagnosis].
Ectodermal Dysplasia
Diverse p63 and p73 isoforms regulate ?133p53 expression through modulation of the internal TP53 promoter activity.
Mechanistic effect of the human GJB6 gene and its mutations in HaCaT cell proliferation and apoptosis.
Erythema
Dioxinodehydroeckol protects human keratinocyte cells from UVB-induced apoptosis modulated by related genes Bax/Bcl-2 and caspase pathway.
Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B-dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract.
Eye Diseases
[LCAT deficiency: a nephrological diagnosis].
Fatty Liver
Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization.
Protein acetylation in mitochondria plays critical functions in the pathogenesis of fatty liver disease.
Fibrosarcoma
Biologically Active Sequences in the Mouse Laminin alpha3 Chain G Domain.
Furunculosis
Defined deletion mutants demonstrate that the major secreted toxins are not essential for the virulence of Aeromonas salmonicida.
Gallstones
ACAT2 and human hepatic cholesterol metabolism: Identification of important gender-related differences in normolipidemic, non-obese Chinese patients.
Antibiotic and synergistic effect of Leu-Lys rich peptide against antibiotic resistant microorganisms isolated from patients with cholelithiasis.
Hepatic acyl-CoA:cholesterol acyltransferase. Development of a standard assay and determination in patients with cholesterol gallstones.
Hepatic acyl-coenzyme A:cholesterol acyltransferase activity is decreased in patients with cholesterol gallstones.
Increased NPC1L1 and ACAT2 expression in the jejunal mucosa from Chinese gallstone patients.
Interruption of the enterohepatic circulation of bile acids stimulates the esterification rate of cholesterol in human liver.
Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice.
Gas Gangrene
[The influence of AMPs from HaCaT keratinocytes on some bacteria strains derived from skin changes]
Genetic Diseases, Inborn
A Novel Mutation in ACAT1 Causing Beta-Ketothiolase Deficiency in a 4-Year-Old Sri Lankan Boy with Metabolic Ketoacidosis.
Glaucoma, Open-Angle
Gene expression profiles of human trabecular meshwork cells induced by triamcinolone and dexamethasone.
Glioblastoma
Acyl-CoA cholesterol acyltransferase in cultured glioblastoma cells.
Acyl-coenzyme A: Cholesterol acyltransferase inhibitor avasimibe affect survival and proliferation of glioma tumor cell lines.
Correction: Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis.
IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke.
Induction of intracellular acyl-CoA:cholesterol acyltransferase activity in glioblastoma cells by lidocaine.
Inhibition of SOAT1 suppresses glioblastoma growth via blocking SREBP-1-mediated lipogenesis.
K604, a specific acyl?CoA:cholesterol acyltransferase 1 inhibitor, suppresses proliferation of U251?MG glioblastoma cells.
Glioma
Acyl-coenzyme A: Cholesterol acyltransferase inhibitor avasimibe affect survival and proliferation of glioma tumor cell lines.
An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis.
Inter-Relationship between Low-Dose Hyper-Radiosensitivity and Radiation-Induced Bystander Effects in the Human T98G Glioma and the Epithelial HaCaT Cell Line.
Leucine-rich glioma inactivated 3 promotes HaCaT keratinocyte migration.
Graft vs Host Disease
Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation.
Granuloma
Influence of the acyl-CoA: cholesterol O-acyltransferase inhibitor, CL 277082, on cholesteryl ester accumulation in rabbit macrophage-rich granulomas and hepatic tissue.
Hand-Foot Syndrome
Local Treatment of Hand-Foot Syndrome with Uridine/Thymidine: In Vitro Appraisal on a Human Keratinocyte Cell Line HaCaT.
Head and Neck Neoplasms
Caesalpinia sappan induces cell death by increasing the expression of p53 and p21WAF1/CIP1 in head and neck cancer cells.
Hepatic Encephalopathy
Reveal genes functionally associated with ACADS by a network study.
Hepatoblastoma
A nutraceutical extract from Inula viscosa leaves: UHPLC-HR-MS/MS based polyphenol profile, and antioxidant and cytotoxic activities.
A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines.
Cell Type-specific Target Selection by Combinatorial Binding of Smad2/3 Proteins and Hepatocyte Nuclear Factor 4{alpha} in HepG2 Cells.
Hepatomegaly
Niemann-Pick C1-deficient mice lacking sterol O-acyltransferase 2 have less hepatic cholesterol entrapment and improved liver function.
Herpes Simplex
Herpes simplex virus type 1 infection has two separate modes of spread in three-dimensional keratinocyte culture.
Human antibodies to herpes simplex virus type 1 glycoprotein C are neutralizing and target the heparan sulfate-binding domain.
In vitro antiviral and immunomodulatory activity of arbidol and structurally related derivatives in herpes simplex virus type 1-infected human keratinocytes (HaCat).
Increased effects of topically applied interferon on herpes simplex virus-induced lesions by caffeine.
Hypercholesterolemia
ACAT inhibitor HL-004 accelerates the regression of hypercholesterolemia in stroke-prone spontaneously hypertensive rats (SHRSP): stimulation of bile acid production by HL-004.
ACAT2 is a target for treatment of coronary heart disease associated with hypercholesterolemia.
ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver.
Acyl-coenzyme A:cholesterol acyltransferase inhibitors for controlling hypercholesterolemia and atherosclerosis.
Anti-atherosclerotic properties of the acyl-coenzyme A:cholesterol acyltransferase inhibitor F 12511 in casein-fed New Zealand rabbits.
Burkholderia cenocepacia: a new biocatalyst for efficient bioreduction of ezetimibe intermediate.
Combination of fish oil and fish protein hydrolysate reduces the plasma cholesterol level with a concurrent increase in hepatic cholesterol level in high-fat-fed Wistar rats.
Effects of FR145237, an acyl-CoA:cholesterol acyltransferase inhibitor, on diet-induced hypercholesterolemia in diabetic rats.
Effects of HMG-CoA reductase inhibition on hepatic expression of key cholesterol-regulatory enzymes and receptors in nephrotic syndrome.
Functional characterization of two single nucleotide polymorphisms of acyl-coenzyme A:cholesterol acyltransferase 2.
Gemfibrozil reduces non-high-density lipoprotein cholesterol in exogenously hypercholesterolemic (ExHC) rats fed a high-cholesterol diet.
Genetic depletion of Soat2 diminishes hepatic steatosis via genes regulating de novo lipogenesis and by GLUT2 protein in female mice.
Hepatic acylcoenzyme A: cholesterol acyltransferase activity during diet-induced hypercholesterolemia in cynomolgus monkeys.
Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus TURCZ.
Identification of potential ACAT-2 selective inhibitors using pharmacophore, SVM and SVR from Chinese herbs.
Identification of the Interaction Site within Acyl-CoA:Cholesterol Acyltransferase 2 for the Isoform-specific Inhibitor Pyripyropene A.
Imidazolylbenzopyrane derivatives: a new class of acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors.
Importance of exogenous cholesterol in diabetic rats: effects of treatment with insulin or with an acyl-CoA:cholesterol acyltransferase inhibitor.
Liver-specific inhibition of acyl-coenzyme a:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/- mice.
Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.
Mikania micrantha Extract Inhibits HMG-CoA Reductase and ACAT2 and Ameliorates Hypercholesterolemia and Lipid Peroxidation in High Cholesterol-Fed Rats.
Molecular structures of human ACAT2 disclose mechanism for selective inhibition.
New pyripyropene A derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse models.
Primates highly responsive to dietary cholesterol up-regulate hepatic ACAT2, and less responsive primates do not.
pX gene causes hypercholesterolemia in hypercholesterolemia-resistant BALB/c mice.
Pyripyropene A, an Acyl-Coenzyme A:Cholesterol Acyltransferase 2-Selective Inhibitor, Attenuates Hypercholesterolemia and Atherosclerosis in Murine Models of Hyperlipidemia.
Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1.
Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice.
Sterol Regulatory Element-Binding Proteins, Liver X Receptor, ABCA1 Transporter, CD36, Scavenger Receptors A1 and B1 in Nephrotic Kidney.
Systemic Acyl-CoA:cholesterol acyltransferase inhibition reduces inflammation and improves vascular function in hypercholesterolemia.
The effect of acyl CoA: cholesterol acyltransferase inhibition on the uptake, esterification and secretion of cholesterol by the hamster small intestine.
Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood.
Upregulation of acyl-CoA: cholesterol acyltransferase in chronic renal failure.
Hyperglycemia
Exposure of human keratinocytes to ischemia, hyperglycemia and their combination induces oxidative stress via the enzymes inducible nitric oxide synthase and xanthine oxidase.
Insulin promotes progression of colon cancer by upregulation of ACAT1.
Hyperinsulinism
Comparison of the effect of hyperinsulinemia on acyl-CoA:cholesterol acyltransferase activity in the liver and intestine of the rat.
Insulin induces human acyl-coenzyme A: cholesterol acyltransferase1 gene expression via MAP kinases and CCAAT/enhancer-binding protein ?.
Hyperlipidemias
Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia.
Acyl-Coenzyme A: Cholesterol Acyltransferase-1 is Related to Hyperlipidemia in Children with Nephrotic Syndrome.
Acyl-coenzyme A:cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, lecithin-cholesterol acyltransferase, SRB-1, and low-denisty lipoprotein receptor deficiencies in nephrotic syndrome.
Avasimibe Pfizer.
Effect of SMP-500, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on serum cholesterol level and LDL cholesterol clearance in hamsters with induced hyperlipidemia.
Effects of a new single-nucleotide polymorphism in the Acyl-CoA:cholesterol acyltransferase-2 gene on plasma lipids and apolipoproteins in patients with hyperlipidemia.
Expression levels of ACAT1 and ACAT2 genes in the liver and intestine of baboons with high and low lipemic responses to dietary lipids.
HL-004, the ACAT inhibitor, prevents the progression of atherosclerosis in cholesterol-fed rabbits.
Identification of Soat1 as a quantitative trait locus gene on mouse chromosome 1 contributing to hyperlipidemia.
Improvement of hyperlipidemia by aerobic exercise in mice through a regulatory effect of miR-21a-5p on its target genes.
Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages.
Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.
Oxidized Low-Density Lipoprotein-Deteriorated Psoriasis Is Associated with the Upregulation of Lox-1 Receptor and Il-23 Expression In Vivo and In Vitro.
Polyacetylenic compounds, ACAT inhibitors from the roots of Panax ginseng.
Postprandial hyperlipidemia in Zucker diabetic fatty fa/fa rats, an animal model of type II diabetes, and its amelioration by acyl-CoA:cholesterol acyltransferase inhibition.
Pyripyropene A, an Acyl-Coenzyme A:Cholesterol Acyltransferase 2-Selective Inhibitor, Attenuates Hypercholesterolemia and Atherosclerosis in Murine Models of Hyperlipidemia.
The influence of the acyl-CoA:cholesterol acyltransferase-1 gene (-77G-->A) polymorphisms on plasma lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects.
Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood.
[Effect of leech on lipid metabolism and liver in hyperlipidemia rats].
Hyperlipoproteinemia Type III
The beta very low density lipoprotein present in hepatic lipase deficiency competitively inhibits low density lipoprotein binding to fibroblasts and stimulates fibroblast acyl-CoA:cholesterol acyltransferase.
Hyperlipoproteinemias
The beta very low density lipoprotein present in hepatic lipase deficiency competitively inhibits low density lipoprotein binding to fibroblasts and stimulates fibroblast acyl-CoA:cholesterol acyltransferase.
Hypersensitivity
Cytokine expression in trichloroethylene-induced hypersensitivity dermatitis: an in vivo and in vitro study.
Inter-Relationship between Low-Dose Hyper-Radiosensitivity and Radiation-Induced Bystander Effects in the Human T98G Glioma and the Epithelial HaCaT Cell Line.
Hypertension
Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension.
Human urotensin II accelerates foam cell formation in human monocyte-derived macrophages.
Potential Clinical Implications of the Urotensin II Receptor Antagonists.
Hypertriglyceridemia
Causes of dysregulation of lipid metabolism in chronic renal failure.
Dyslipidemia of chronic renal failure: the nature, mechanisms, and potential consequences.
High-Fructose Diet-Induced Hypertriglyceridemia Is Associated With Enhanced Hepatic Expression of ACAT2 in Rats.
Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization.
Intestine specific MTP deficiency with global ACAT2 gene ablation lowers acute cholesterol absorption with chylomicrons and high density lipoproteins.
Prediction of genetic risk for dyslipidemia.
Upregulation of acyl-CoA: cholesterol acyltransferase in chronic renal failure.
[Analysis of acyl-coenzyme A: cholesterol acyltransferase 1 polymorphism in patients with endogenous hypertriglyceridemia in Chinese population]
Hypoalbuminemia
Acyl-Coenzyme A: Cholesterol Acyltransferase-1 is Related to Hyperlipidemia in Children with Nephrotic Syndrome.
Acyl-coenzyme A:cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, lecithin-cholesterol acyltransferase, SRB-1, and low-denisty lipoprotein receptor deficiencies in nephrotic syndrome.
Hypoalphalipoproteinemias
[Familial alpha lipoprotein deficiency. Tangier disease, familial hypoalphalipoproteinemia and familial deficiency of lecithin cholesterol acyltransferase deficiency]
Hypoproteinemia
Acyl-Coenzyme A: Cholesterol Acyltransferase-1 is Related to Hyperlipidemia in Children with Nephrotic Syndrome.
Hypothyroidism
Effects of hypothyroidism and high-fat feeding on mRNA concentrations for the low-density-lipoprotein receptor and on acyl-CoA:cholesterol acyltransferase activities in rat liver.
Ichthyosis
Activation of vascular endothelial growth factor receptor 2 in a cellular model of loricrin keratoderma.
Infections
3D-Tissue Model for Herpes Simplex Virus-1 Infections.
ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization.
Biphasic influence of Staphylococcus aureus on human epidermal tight junctions.
Characterization of chikungunya virus infection of a human keratinocyte cell line: role of mosquito salivary gland protein in suppressing the host immune response.
Chlamydia pneumoniae disturbs cholesterol homeostasis in human THP-1 macrophages via JNK-PPAR? dependent signal transduction pathways.
Chlamydia pneumoniae induces macrophage-derived foam cell formation by up-regulating acyl-coenzyme A: cholesterol acyltransferase 1.
Differential expression of Candida dubliniensis-secreted aspartyl proteinase genes (CdSAP1-4) under different physiological conditions and during infection of a keratinocyte culture.
Differential gene expression in HaCaT cells may account for the various clinical presentation caused by anthropophilic and geophilic dermatophytes infections.
Endocytic Internalization of Herpes Simplex Virus 1 in Human Keratinocytes at Low Temperature.
Evaluation of a Product Containing Xyloglucan and Pea Protein on Skin Barrier Permeability.
Exploring chitosan nanoparticles as effective inhibitors of antibiotic resistant skin microorganisms - From in vitro to ex vitro testing.
Expression and modulation of LL-37 in normal human keratinocytes, HaCaT cells, and inflammatory skin diseases.
Furin Cleavage of L2 during Papillomavirus Infection: Minimal Dependence on Cyclophilins.
HaCaT epithelial cells as an innovative novel model of rhinovirus infection and impact of clarithromycin treatment on infection kinetics.
Hantaan virus can infect human keratinocytes and activate an interferon response through the nuclear translocation of IRF-3.
Herpes simplex virus type 1 infection has two separate modes of spread in three-dimensional keratinocyte culture.
Human keratinocyte cultures (HaCaT) can be infected by DENV, triggering innate immune responses that include IFN? and LL37.
Human Papillomavirus 11 Early Protein E6 Activates Autophagy by Repressing AKT/mTOR and Erk/mTOR.
Human papillomavirus type 31b infection of human keratinocytes and the onset of early transcription.
Human papillomavirus type 31b infection of human keratinocytes does not require heparan sulfate.
Human papillomavirus-16 E7 interacts with Siva-1 and modulates apoptosis in HaCaT human immortalized keratinocytes.
Identification of TRAPPC8 as a host factor required for human papillomavirus cell entry.
Impact of Rac1 and Cdc42 signaling during early herpes simplex virus type 1 infection of keratinocytes.
In vitro culture conditions to study keratinocyte differentiation using the HaCaT cell line.
Increasing prevalence of hypervirulent ST5 methicillin susceptible Staphylococcus aureus subtype poses a serious clinical threat.
Infection of immortalized human epithelial cell line Hacat with high-concentration Epstein-Barr virus.
Infectious human papillomavirus type 31b: purification and infection of an immortalized human keratinocyte cell line.
Inhibition of Tetraspanin Functions Impairs Human Papillomavirus and Cytomegalovirus Infections.
Innate immune response in human keratinocytes infected by a feline isolate of Malassezia pachydermatis.
Intermediate Heparan Sulfate Binding During HPV-16 Infection in HaCaTs.
Involvement of ABC-transporters and acyltransferase 1 in intracellular cholesterol-mediated autophagy in bovine alveolar macrophages in response to the Bacillus Calmette-Guerin (BCG) infection.
Keratinocyte infection by Actinomadura madurae triggers an inflammatory response.
Keratinocyte proinflammatory responses to adherent and nonadherent group A streptococci.
La Crosse Virus Infection of Human Keratinocytes Leads to Interferon-Dependent Apoptosis of Bystander Non-Infected Cells In Vitro.
Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus.
Neutralization of human papillomavirus with monoclonal antibodies reveals different mechanisms of inhibition.
Role of breast tumour kinase in the in vitro differentiation of HaCaT cells.
STING Is Involved in Antiviral Immune Response against VZV Infection via the Induction of Type I and III IFN Pathways.
Strains of Streptococcus pyogenes from severe invasive infections bind HEp2 and HaCaT cells more avidly than strains from uncomplicated infections.
Streptolysin O and adherence synergistically modulate proinflammatory responses of keratinocytes to group A streptococci.
TgROP18 targets IL20RB for host-defense-related-STAT3 activation during Toxoplasma gondii infection.
The ameliorative effect of hemp seed hexane extracts on the Propionibacterium acnes-induced inflammation and lipogenesis in sebocytes.
The Herpes simplex virus-induced demise of keratinocytes is associated with a dysregulated pattern of p63 expression.
The orthopoxvirus 68k ankyrin-like protein is essential for DNA replication and complete gene expression of modified vaccinia virus Ankara in non-permissive human and murine cells.
The Short Lipopeptides (C10)2-KKKK-NH2 and (C12)2-KKKK-NH2 Protect HaCaT Keratinocytes from Bacterial Damage Caused by Staphylococcus aureus Infection in a Co-Culture Model.
Vesicular stomatitis virus infection triggers apoptosis associated with decreased DeltaNp63alpha and increased Bax levels in the immortalized HaCaT keratinocyte cell line.
Vimentin Modulates Infectious Internalization of Human Papillomavirus 16 Pseudovirions.
Water-based extracts of Zizania latifolia inhibit Staphylococcus aureus infection through the induction of human beta-defensin 2 expression in HaCaT cells.
[Chlamydia pneumoniae induces THP-1-derived foam cell formation by up-regulating the expression of acyl-coenzyme A: cholesterol acyltransferase 1]
Insulin Resistance
Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation.
Multi-Omics Analysis to Examine Gene Expression and Metabolites From Multisite Adipose-Derived Mesenchymal Stem Cells.
Myeloid-specific Acat1 ablation attenuates inflammatory responses in macrophages, improves insulin sensitivity, and suppresses diet-induced obesity.
Pharmacological inhibition of acyl-coenzyme A:cholesterol acyltransferase alleviates obesity and insulin resistance in diet-induced obese mice by regulating food intake.
Potential Clinical Implications of the Urotensin II Receptor Antagonists.
Sterol O-acyltransferase 1 deficiency improves defective insulin signaling in the brains of mice fed a high-fat diet.
Keratosis, Actinic
Deletion mapping of chromosome 3p and 13q and preliminary analysis of the FHIT gene in human nonmelanoma skin cancer.
Karyopherin Alpha2 Is Essential for rRNA Transcription and Protein Synthesis in Proliferative Keratinocytes.
Ketosis
A Novel Mutation in ACAT1 Causing Beta-Ketothiolase Deficiency in a 4-Year-Old Sri Lankan Boy with Metabolic Ketoacidosis.
Clinical presentation and outcome in a series of 32 patients with 2-methylacetoacetyl-coenzyme A thiolase (MAT) deficiency.
Genome-wide association study and functional analyses for clinical and subclinical ketosis in Holstein cattle.
Reveal genes functionally associated with ACADS by a network study.
The recent insights into the function of ACAT1: A possible anti-cancer therapeutic target.
Kidney Failure, Chronic
F(2)-isoprostanes: sensitive biomarkers of oxidative stress in vitro and in vivo: a gas chromatography-mass spectrometric approach.
Upregulation of acyl-CoA: cholesterol acyltransferase in chronic renal failure.
Latent Infection
Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expression.
Lecithin Cholesterol Acyltransferase Deficiency
ACAT inhibition reverses LCAT deficiency and improves plasma HDL in chronic renal failure.
ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice.
Demonstration of intact intracellular cholesterol esterification and normal low-density lipoprotein pathway in fibroblasts from a patient with lecithin:cholesterol acyltransferase deficiency.
Detection of heterozygotes for familial lecithin: cholesterol acyltransferase (LCAT) deficiency.
[Familial alpha lipoprotein deficiency. Tangier disease, familial hypoalphalipoproteinemia and familial deficiency of lecithin cholesterol acyltransferase deficiency]
Leprosy
Interaction of Mycobacterium leprae with the HaCaT human keratinocyte cell line: new frontiers in the cellular immunology of leprosy.
Leukemia
Action of bleomycin is affected by bleomycin hydrolase but not by caveolin-1.
Anti-Allergic and Anti-Inflammatory Effects of Undecane on Mast Cells and Keratinocytes.
Hydrogen peroxide mediates EGCG-induced antioxidant protection in human keratinocytes.
Induction of differentiation-associated changes in established human cells by infection with adeno-associated virus type 2.
Low level laser irradiation stimulates mitochondrial membrane potential and disperses subnuclear promyelocytic leukemia protein.
Oxidative DNA damage induced by visible light in mammalian cells: extent, inhibition by antioxidants and genotoxic effects.
Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane.
Selected Compounds Structurally Related to Acyclic Sesquiterpenoids and Their Antibacterial and Cytotoxic Activity.
Leukemia, Erythroblastic, Acute
Cholesterol esterification during differentiation of mouse erythroleukemia (Friend) cells.
Leukemia, T-Cell
[Differences of Nonsense-Mediated mRNA Degradation Activity in Mammalian Cell Lines Revealed by a Fluorescence Reporter].
Leukocytosis
Acat1 gene ablation in mice increases hematopoietic progenitor cell proliferation in bone marrow and causes leukocytosis.
Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression.
Lichen Planus
Possible treatment for cutaneous lichen planus: An in vitro anti-inflammatory role of Angelica polysaccharide in human keratinocytes HaCaT.
RETRACTION NOTICE: Possible treatment for cutaneous lichen planus: An in vitro anti-inflammatory role of Angelica polysaccharide in human keratinocytes HaCaT.
Liver Cirrhosis
Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells.
Downregulation of Acat1 by miR-21 may participate in liver fibrosis upon chronic DDT exposure.
Liver Diseases
Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization.
Niemann-Pick C1-deficient mice lacking sterol O-acyltransferase 2 have less hepatic cholesterol entrapment and improved liver function.
Protein acetylation in mitochondria plays critical functions in the pathogenesis of fatty liver disease.
Serum cholesterol esterification in liver disease. Combined determinations of lecithin: cholesterol acyltransferase and lipoprotein-X.
Liver Neoplasms
Long non-coding RNA HULC promotes UVB-induced injury by up-regulation of BNIP3 in keratinocytes.
Lung Neoplasms
A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines.
Blocking mutation independent p53 aggregation by emodin modulates autophagic cell death pathway in lung cancer.
Effect of inhibiting ACAT-1 expression on the growth and metastasis of Lewis lung carcinoma.
Efficient hydrolytic cleavage of DNA and antiproliferative effect on human cancer cells by two dinuclear Cu(II) complexes containing a carbohydrazone ligand and 1,10-phenanthroline as a coligand.
Mining the epigenome for methylated genes in lung cancer.
Pharmacological importance, characterization and applications of gold and silver nanoparticles synthesized by Panax ginseng fresh leaves.
Phoyunnanin E inhibits migration of non-small cell lung cancer cells via suppression of epithelial-to-mesenchymal transition and integrin ?v and integrin ?3.
Potentiation of Kras peptide cancer vaccine by avasimibe, a cholesterol modulator.
The wound-healing effect of 7,3',4'-trimethoxyflavone through increased levels of prostaglandin E2 by 15-hydroxyprostaglandin dehydrogenase inhibition.
Lymphatic Metastasis
ACAT2 Promotes Cell Proliferation and Associates with Malignant Progression in Colorectal Cancer.
Knockdown of sterol O-acyltransferase 1 (SOAT1) suppresses SCD1-mediated lipogenesis and cancer procession in prostate cancer.
SOAT1 is a new prognostic factor of colorectal cancer.
Macular Degeneration
Retinal hypercholesterolemia triggers cholesterol accumulation and esterification in photoreceptor cells.
Serum starvation of ARPE-19 changes the cellular distribution of cholesterol and Fibulin3 in patterns reminiscent of age-related macular degeneration.
matriptase deficiency
Matriptase Regulates Proliferation and Early, but Not Terminal, Differentiation of Human Keratinocytes.
Melanoma
A lectin from Bothrops leucurus snake venom raises cytosolic calcium levels and promotes B16-F10 melanoma necrotic cell death via mitochondrial permeability transition.
A Multifunctional and Possible Skin UV Protectant, (3R)-5-Hydroxymellein, Produced by an Endolichenic Fungus Isolated from Parmotrema austrosinense.
Achillea millefolium L. and Achillea biebersteinii Afan. Hydroglycolic Extracts-Bioactive Ingredients for Cosmetic Use.
Adenoviral-mediated herpes simplex virus-thymidine kinase gene transfer in vivo for treatment of experimental human melanoma.
Alpha-melanocyte-stimulating hormone reduces impact of proinflammatory cytokine and peroxide-generated oxidative stress on keratinocyte and melanoma cell lines.
Antitumorigenic effect of insect-derived peptide poecilocorisin-1 in human skin cancer cells through regulation of Sp1 transcription factor.
Apoptosis regulators and responses in human melanocytic and keratinocytic cells.
Assessment of the Antimicrobial, Antioxidant, and Antiproliferative Potential of Sideritisraeseri subps. raeseri Essential Oil.
Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes.
Betulinic acid induces apoptosis in skin cancer cells and differentiation in normal human keratinocytes.
Biological Evaluation of Black Chokeberry Extract Free and Embedded in Two Mesoporous Silica-Type Matrices.
Cell cycle progression data on human skin cancer cells with anticancer synthetic peptide LTX-315 treatment.
Cell Trivision of Hyperploid Cells.
Characterization of corticotropin-releasing hormone (CRH) in human skin.
Combination of PDT and inhibitor treatment affects melanoma cells and spares keratinocytes.
Cytoprotective effects of the lipoidic-liquiform pro-vitamin C tetra-isopalmitoyl-ascorbate (VC-IP) against ultraviolet-A ray-induced injuries in human skin cells together with collagen retention, MMP inhibition and p53 gene repression.
Cytotoxic constituents of the lichen Diploicia canescens.
Cytotoxic effects of Argentinean plant extracts on tumour and normal cell lines.
Efficacy of Concanavalin-A conjugated nanotransfersomal gel of apigenin for enhanced targeted delivery of UV induced skin malignant melanoma.
Enzymatic metabolism of ergosterol by cytochrome p450scc to biologically active 17alpha,24-dihydroxyergosterol.
Epirubicin-Loaded Superparamagnetic Iron-Oxide Nanoparticles for Transdermal Delivery: Cancer Therapy by Circumventing the Skin Barrier.
Ethanol extract of asiasari radix preferentially induces apoptosis in G361 human melanoma cells by differential regulation of p53.
Expression of the circadian clock genes clock and period1 in human skin.
Fabrication, in-vitro characterization, and enhanced in-vivo evaluation of carbopol-based nanoemulsion gel of apigenin for UV-induced skin carcinoma.
Free-Radical-Scavenging, Antityrosinase, and Cellular Melanogenesis Inhibitory Activities of Synthetic Isoflavones.
Hantaan virus can infect human keratinocytes and activate an interferon response through the nuclear translocation of IRF-3.
Hypericin photodynamic activity in DPPC liposomes - part II: stability and application in melanoma B16-F10 cancer cells.
Identification of functional platelet-activating factor receptors on human keratinocytes.
Imaging and detection of cell apoptosis byIn vitrophotodynamic therapy applications of zinc (II) phthalocyanine on human melanoma cancer.
Insights into ZIKV-Mediated Innate Immune Responses in Human Dermal Fibroblasts and Epidermal Keratinocytes.
Intracellular calcium measurements of single human skin cells after stimulation with corticotropin-releasing factor and urocortin using confocal laser scanning microscopy.
Keratinocyte-derived Laminin-332 Promotes Adhesion and Migration in Melanocytes and Melanoma.
Keratinocytes negatively regulate the N-cadherin levels of melanoma cells via contact-mediated calcium regulation.
KGF Promotes Paracrine Activation of the SCF/c-KIT Axis from Human Keratinocytes to Melanoma Cells.
Label-free and non-invasive discrimination of HaCaT and melanoma cells in a co-culture model by hyperspectral confocal reflectance microscopy.
Lobarin from the Sumatran lichen, Stereocaulon halei.
Mechanism of miR-137 regulating migration and invasion of melanoma cells by targeting PIK3R3 gene.
Mechanisms of Tanshinone II a inhibits malignant melanoma development through blocking autophagy signal transduction in A375 cell.
Mechanistic investigations of antitumor activity of a Rhodamine B?oleanolic acid derivative bioconjugate.
Melanoma cell surface-expressed phosphatidylserine as a therapeutic target for cationic anticancer peptide, temporin-1CEa.
MicroRNA-9 inhibits the proliferation and migration of malignant melanoma cells via targeting sirituin 1.
Mitochondrial expression of the two-pore domain TASK-3 channels in malignantly transformed and non-malignant human cells.
Neurotensin receptor1 antagonist SR48692 reduces proliferation by inducing apoptosis and cell cycle arrest in melanoma cells.
Non-covalent inhibitors of human 20S and 26S proteasome based on trypsin inhibitor SFTI-1.
Nootkatol prevents ultraviolet radiation-induced photoaging via ORAI1 and TRPV1 inhibition in melanocytes and keratinocytes.
Ov-16 [4-(3,4-dihydroxybenzoyloxymethyl)phenyl-O-?-D-glucopyranoside] inhibits melanin synthesis by regulating expressions of melanogenesis-regulated gene and protein.
PCTAIRE1 regulates p27 stability, apoptosis and tumor growth in malignant melanoma.
Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes.
Photogenotoxicity of folic acid.
Potent USP10/13 antagonist spautin-1 suppresses melanoma growth via ROS-mediated DNA damage and exhibits synergy with cisplatin.
Preparation, Drug Treatment, and Immunohistological Analysis of Tri-Culture Spheroid 3D Melanoma-Like Models.
Relative In Vitro Potentials of Parthenolide to Induce Apoptosis and Cell Cycle Arrest in Skin Cancer Cells.
Rosa platyacantha Schrenk from Kazakhstan-Natural Source of Bioactive Compounds with Cosmetic Significance.
RSK2 as a key regulator in human skin cancer.
Sanggenol L promotes apoptotic cell death in melanoma skin cancer cells through activation of caspase cascades and apoptosis-inducing factor.
Sebocytes are the key regulators of androgen homeostasis in human skin.
Selected Compounds Structurally Related to Acyclic Sesquiterpenoids and Their Antibacterial and Cytotoxic Activity.
SiO2-PVA-Fe(acac)3 Hybrid Based Superparamagnetic Nanocomposites for Nanomedicine: Morpho-textural Evaluation and In Vitro Cytotoxicity Assay.
Surface acoustic wave actuated cell sorting (SAWACS).
Synthesis and photochemical transformation of 3?,21-dihydroxypregna-5,7-dien-20-one to novel secosteroids that show anti-melanoma activity.
Synthetic Peptide ?M4-Induced Cell Death Associated with Cytoplasmic Membrane Disruption, Mitochondrial Dysfunction and Cell Cycle Arrest in Human Melanoma Cells.
Targeting Angiogenesis by Blocking the ATM-SerRS-VEGFA Pathway for UV-Induced Skin Photodamage and Melanoma Growth.
tert-Butylphenolic Derivatives from Paenibacillus odorifer-A Case of Bioconversion.
Testing Lab-on-a-Chip Technology for Culturing Human Melanoma Cells under Simulated Microgravity.
The anti-melanogenic effects of ellagic acid through induction of autophagy in melanocytes and suppression of UVA-activated ?-MSH pathways via Nrf2 activation in keratinocytes.
The antimicrobial peptide human cationic antimicrobial protein-18/cathelicidin LL-37 as a putative growth factor for malignant melanoma.
The Comparison of In Vitro Photosensitizing Efficacy of Curcumin-Loaded Liposomes Following Photodynamic Therapy on Melanoma MUG-Mel2, Squamous Cell Carcinoma SCC-25, and Normal Keratinocyte HaCaT Cells.
The enhanced IL-18 production by UVB irradiation requires ROI and AP-1 signaling in human keratinocyte cell line (HaCaT).
The mechanism of melanocytes-specific cytotoxicity induced by phenol compounds having a prooxidant effect, relating to the appearance of leukoderma.
The Phytochemical Analysis of Vinca L. Species Leaf Extracts Is Correlated with the Antioxidant, Antibacterial, and Antitumor Effects.
The Protective Effects of EMF-LTE against DNA Double-Strand Break Damage In Vitro and In Vivo.
The Quinone Methide Aurin Is a Heat Shock Response Inducer That Causes Proteotoxic Stress and Noxa-dependent Apoptosis in Malignant Melanoma Cells.
The Skin-Whitening Effects of Ectoine via the Suppression of ?-MSH-Stimulated Melanogenesis and the Activation of Antioxidant Nrf2 Pathways in UVA-Irradiated Keratinocytes.
Transcutaneous delivery of leflunomide nanoemulgel: Mechanistic investigation into physicomechanical characteristics, in vitro anti-psoriatic and anti-melanoma activity.
UV-B-activated B16 melanoma cells or HaCaT keratinocytes accelerate signaling pathways associated with melanogenesis via ANGPTL 2 induction, an activity antagonized by Chrysanthemum extract.
Well Defined Poly(Methyl Methacrylate)-Fe3O4/Poly(Vinyl Pivalate) Core-Shell Superparamagnetic Nanoparticles: Design and Evaluation of In Vitro Cytotoxicity Activity Against Cancer Cells.
Melanoma, Amelanotic
Photothermal sensitisation as a novel therapeutic approach for tumours: studies at the cellular and animal level.
Melanoma, Experimental
Effect of heterocyclic pyrimidine compounds on UVB-induced cell damage in human keratinocytes and on melanogenesis in mouse B16 cells.
N-acetylglucosamine microemulsions: Assessment of skin penetration, cytotoxicity, and anti-melanogenesis.
UV-B-activated B16 melanoma cells or HaCaT keratinocytes accelerate signaling pathways associated with melanogenesis via ANGPTL 2 induction, an activity antagonized by Chrysanthemum extract.
Mesothelioma, Malignant
Antiproliferative Effects on Tumour Cells and Promotion of Keratinocyte Wound Healing by Different Lichen Compounds.
HPLC-FLD determination of NBD-cholesterol, its ester and other metabolites in cellular lipid extracts.
Metabolic Diseases
Sterol O-acyltransferase 1 deficiency improves defective insulin signaling in the brains of mice fed a high-fat diet.
Mouth Neoplasms
Luteolin Impacts on the DNA Damage Pathway in Oral Squamous Cell Carcinoma.
Muscular Diseases
Reveal genes functionally associated with ACADS by a network study.
Myocardial Infarction
The myocardial infarct size-limiting and antiarrhythmic effects of acyl-CoA:Cholesterol acyltransferase inhibitor VULM 1457 protect the hearts of diabetic-hypercholesterolaemic rats against ischaemia/reperfusion injury both in vitro and in vivo.
Nasal Polyps
Expression of human beta-defensin-1 promotes differentiation of keratinocytes.
Nasopharyngeal Carcinoma
Photogenotoxicity of folic acid.
Neoplasm Metastasis
Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer.
ACAT2 Promotes Cell Proliferation and Associates with Malignant Progression in Colorectal Cancer.
AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response.
Cell death induced by N-(4-hydroxyphenyl)retinamide in human epidermal keratinocytes is modulated by TGF-beta and diminishes during the progression of squamous cell carcinoma.
Circ_0061012 contributes to IL-22-induced proliferation, migration and invasion in keratinocytes through miR-194-5p/GAB1 axis in psoriasis.
Effect of inhibiting ACAT-1 expression on the growth and metastasis of Lewis lung carcinoma.
Insulin promotes progression of colon cancer by upregulation of ACAT1.
Knockdown of sterol O-acyltransferase 1 (SOAT1) suppresses SCD1-mediated lipogenesis and cancer procession in prostate cancer.
MicroRNA-17-3p promotes keratinocyte cells growth and metastasis via targeting MYOT and regulating Notch1/NF-?B pathways.
Mitoketoscins: Novel mitochondrial inhibitors for targeting ketone metabolism in cancer stem cells (CSCs).
Multiple interference of the human papillomavirus-16 E7 oncoprotein with the functional role of the metastasis suppressor Nm23-H1 protein.
Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor ? Superfamily Type 1 Receptors.
Prognostic significance of two lipid metabolism enzymes, HADHA and ACAT2, in clear cell renal cell carcinoma.
SOAT1 is a new prognostic factor of colorectal cancer.
Neoplasms
"Trans-differentiation" from epidermal to mesenchymal/myogenic phenotype is associated with a drastic change in cell-cell and cell-matrix adhesion molecules.
(+)-Nootkatone inhibits tumor necrosis factor ?/interferon ?-induced production of chemokines in HaCaT cells.
(2S)-2?-methoxykurarinone from Sophora flavescens suppresses cutaneous T cell-attracting chemokine/CCL27 expression induced by interleukin-ß/tumor necrosis factor-? via heme oxygenase-1 in human keratinocytes.
1alpha,25-dihydroxyvitamin D3 induces sphingomyelin hydrolysis in HaCaT cells via tumor necrosis factor alpha.
2,3-Dimethoxy-2'-hydroxychalcone ameliorates TNF-?-induced ICAM-1 expression and subsequent monocyte adhesiveness via NF-kappaB inhibition and HO-1 induction in HaCaT cells.
A GPR40 agonist GW9508 suppresses CCL5, CCL17, and CXCL10 induction in keratinocytes and attenuates cutaneous immune inflammation.
A Novel Near-infrared Fluorescent Probe TMTP1-PEG4-ICG for in vivo Tumor Imaging.
A specific cholesterol metabolic pathway is established in a subset of HCCs for tumor growth.
A synthetic peptide blocking TRPV1 activation inhibits UV-induced skin responses.
A Th2 chemokine, TARC, produced by keratinocytes may recruit CLA+CCR4+ lymphocytes into lesional atopic dermatitis skin.
Aberrantly Expressed Genes in HaCaT Keratinocytes Chronically Exposed to Arsenic Trioxide.
Abnormal cholesterol metabolism in renal clear cell carcinoma.
Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.
Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer.
ACAT2 Promotes Cell Proliferation and Associates with Malignant Progression in Colorectal Cancer.
Achillea millefolium L. and Achillea biebersteinii Afan. Hydroglycolic Extracts-Bioactive Ingredients for Cosmetic Use.
Acinar cell carcinoma of rat pancreas: regulation of cholesterol esterification.
Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines.
Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibition in Cancer Treatment.
Acyl-coenzyme A: Cholesterol acyltransferase inhibitor avasimibe affect survival and proliferation of glioma tumor cell lines.
Alantolactone from Saussurea lappa Exerts Antiinflammatory Effects by Inhibiting Chemokine Production and STAT1 Phosphorylation in TNF-? and IFN-?-induced in HaCaT cells.
Allopurinol suppresses expression of the regulatory T-cell migration factors TARC/CCL17 and MDC/CCL22 in HaCaT keratinocytes via restriction of nuclear factor-?B activation.
Alloreactive microenvironment after human hematopoietic cell transplantation induces genomic alterations in epithelium through an ROS-mediated mechanism: in vivo and in vitro study and implications to secondary neoplasia.
Alpha-melanocyte-stimulating hormone reduces impact of proinflammatory cytokine and peroxide-generated oxidative stress on keratinocyte and melanoma cell lines.
An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis.
Anti-Allergic and Anti-Inflammatory Effects of Kuwanon G and Morusin on MC/9 Mast Cells and HaCaT Keratinocytes.
Anti-allergic effects of sesquiterpene lactones from the root of Aucklandia lappa Decne.
Anti-Apoptotic NF-?B and "Gain of Function" mutp53 in Concert Act Pro-Apoptotic in Response to UVB+IL-1 via Enhanced TNF Production.
Anti-apoptotic role of EGF in HaCaT keratinocytes via a PPARbeta-dependent mechanism.
Anti-Atopic Dermatitis Effect of Seaweed Fulvescens Extract via Inhibiting the STAT1 Pathway.
Anti-cancer effects of cerium oxide nanoparticles and its intracellular redox activity.
Anti-glycative effects of asiatic acid in human keratinocyte cells.
Anti-inflammatory Actions of Herbal Formula Gyejibokryeong-Hwan Regulated by Inhibiting Chemokine Production and STAT1 Activation in HaCaT Cells.
Anti-Inflammatory Effect of Chloroform Fraction of Pyrus Ussuriensis Maxim. Leaf Extract on 2, 4-Dinitrochlorobenzene-Induced Atopic Dermatitis in nc/nga Mice.
Anti-inflammatory Effects of Achillea millefolium on Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice.
Anti-Inflammatory Effects of Compounds from Cudrania tricuspidata in HaCaT Human Keratinocytes.
Anti-inflammatory effects of ethanol extract from the leaves and shoots of Cedrela odorata L. in cytokine-stimulated keratinocytes.
Anti-inflammatory effects of Perillae Herba ethanolic extract against TNF-?/IFN-?-stimulated human keratinocyte HaCaT cells.
Anti-inflammatory effects of Sanguisorbae Radix water extract on the suppression of mast cell degranulation and STAT-1/Jak-2 activation in BMMCs and HaCaT keratinocytes.
Anti-inflammatory Properties of Cannabidiol, a Nonpsychotropic Cannabinoid, in Experimental Allergic Contact Dermatitis.
Anti-Inflammatory, Barrier-Protective, and Antiwrinkle Properties of Agastache rugosa Kuntze in Human Epidermal Keratinocytes.
Anti-MRSA-acting carbamidocyclophanes H-L from the Vietnamese cyanobacterium Nostoc sp. CAVN2.
Anti?inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF??B pathway.
Anticancer effects of alloxanthoxyletin and fatty acids esters - In vitro study on cancer HTB-140 and A549 cells.
Anticancer properties of low molecular weight oat beta-glucan – An in vitro study.
Antioxidative, anti-inflammatory, and matrix metalloproteinase inhibitory activities of 20(S)-ginsenoside Rg3 in cultured mammalian cell lines.
Antiproliferative, cytotoxic and apoptotic activity of the bentonite transformation of sesquiterpene lactone glaucolide B to 5?-hydroxy-hirsutinolide on tumor cell lines.
Antipsoriatic effects of avarol-3'-thiosalicylate are mediated by inhibition of TNF-alpha generation and NF-kappaB activation in mouse skin.
Apoptosis and cytokine release induced by ionizing or ultraviolet B radiation in primary and immortalized human keratinocytes.
Applicability of new degradable hypericin-polymer-conjugates as photosensitizers: principal mode of action demonstrated by in vitro models.
Applying Quality by Design Principles in the Development and Preparation of a New Radiopharmaceutical: Technetium-99m-Imatinib Mesylate.
Arazyme inhibits cytokine expression and upregulates skin barrier protein expression.
Aromadendrene oxide 2, induces apoptosis in skin epidermoid cancer cells through ROS mediated mitochondrial pathway.
Artemisia anomala Herba Alleviates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions in Mice and the Production of Pro-Inflammatory Mediators in Tumor Necrosis Factor Alpha-/Interferon Gamma-Induced HaCaT Cells.
Aschantin targeting on the kinase domain of mammalian target of rapamycin suppresses epidermal growth factor-induced neoplastic cell transformation.
Ashwagandha root extract exerts anti?inflammatory effects in HaCaT cells by inhibiting the MAPK/NF??B pathways and by regulating cytokines.
Assessment of acyl-CoA cholesterol acyltransferase (ACAT-1) role in ovarian cancer progression-An in vitro study.
Assessment of the Antimicrobial, Antioxidant, and Antiproliferative Potential of Sideritisraeseri subps. raeseri Essential Oil.
Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3.
Association of chromosomal alterations with arsenite-induced tumorigenicity of human HaCaT keratinocytes in nude mice.
Aster glehni Extract Containing Caffeoylquinic Compounds Protects Human Keratinocytes through the TRPV4-PPAR?-AMPK Pathway.
Avasimibe Encapsulated in Human Serum Albumin Blocks Cholesterol Esterification for Selective Cancer Treatment.
Avasimibe inhibits the proliferation, migration and invasion of glioma cells by suppressing linc00339.
Bacillus thuringiensis toxins are cytotoxic to cervical cancer (HeLa) but not to breast cancer (MCF7) cells.
Baicalin Inhibits Cell Proliferation and Inflammatory Cytokines Induced by Tumor Necrosis Factor ? (TNF-?) in Human Immortalized Keratinocytes (HaCaT) Human Keratinocytes by Inhibiting the STAT3/Nuclear Factor kappa B (NF-?B) Signaling Pathway.
Bcl-2 transfected HaCaT keratinocytes resist apoptotic signals of ceramides, tumor necrosis factor alpha and 1 alpha, 25-dihydroxyvitamin D(3).
Bifunctional alkylating agent-induced p53 and nonclassical nuclear factor kappaB responses and cell death are altered by caffeic acid phenethyl ester: a potential role for antioxidant/electrophilic response-element signaling.
Biological Evaluation of Black Chokeberry Extract Free and Embedded in Two Mesoporous Silica-Type Matrices.
Biotinylated PAMAM G3 dendrimer conjugated with celecoxib and/or Fmoc-l-Leucine and its cytotoxicity for normal and cancer human cell lines.
Biseokeaniamides A, B, and C, Sterol O-Acyltransferase Inhibitors from an Okeania sp. Marine Cyanobacterium.
Blocking ACAT-1 Activity for Tumor Therapy with Fluorescent Hyperstar Polymer-Encapsulated Avasimible.
Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways.
Camptothecin Fails to Induce Apoptosis in Tumor Necrosis Factor-Alpha-Treated HaCaT Cells.
CCHCR1 is up-regulated in skin cancer and associated with EGFR expression.
CCL28 production in HaCaT cells was mediated by different signal pathways from CCL27.
CCR10 and CCL27 are overexpressed in cutaneous squamous cell carcinoma.
CD44-expressing undifferentiated carcinoma with rhabdoid features of the pancreas: Molecular analysis of aggressive invasion and metastasis.
CD44v6 expression in human skin keratinocytes as a possible mechanism for carcinogenesis associated with chronic arsenic exposure.
Cell death induced by N-(4-hydroxyphenyl)retinamide in human epidermal keratinocytes is modulated by TGF-beta and diminishes during the progression of squamous cell carcinoma.
Changes in the Anti-Allergic Activities of Sesame by Bioconversion.
Characterization and differentiation-dependent regulation of secreted phospholipases A in human keratinocytes and in healthy and psoriatic human skin.
Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds.
Chemical composition of the essential oil from the leaves of Anaxagorea brevipes (Annonaceae) and evaluation of its bioactivity.
Chemopreventive Activity of Polyphenolics from Black Jamapa Bean (Phaseolus vulgaris L.) on HeLa and HaCaT Cells.
Chijabyukpi-Tang Inhibits Pro-Inflammatory Cytokines and Chemokines via the Nrf2/HO-1 Signaling Pathway in TNF-?/IFN-?-Stimulated HaCaT Cells and Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions in Mice.
Chlorin-PEI-labeled cellulose nanocrystals: synthesis, characterization and potential application in PDT.
Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer.
Cholesterol metabolism: New functions and therapeutic approaches in cancer.
Cholesterol uptake and regulation in high-grade and lethal prostate cancers.
Chungsimyeonja-eum inhibits inflammatory responses in RAW 264.7 macrophages and HaCaT keratinocytes.
CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network.
Cold atmospheric plasma ameliorates imiquimod-induced psoriasiform dermatitis in mice by mediating antiproliferative effects.
Collagenase 3 (matrix metalloproteinase 13) gene expression by HaCaT keratinocytes is enhanced by tumor necrosis factor alpha and transforming growth factor beta.
Combination cisplatin and sulforaphane treatment reduces proliferation, invasion, and tumor formation in epidermal squamous cell carcinoma.
Comparative effects of UV A and UV B on clonogenic survival and delayed cell death in skin cell lines from humans and fish.
Comparative sensitivity of tumor and non-tumor cell lines as a reliable approach for in vitro cytotoxicity screening of lysine-based surfactants with potential pharmaceutical applications.
Complementation of human papillomavirus type 16 E6 and E7 by Jagged1-specific Notch1-phosphatidylinositol 3-kinase signaling involves pleiotropic oncogenic functions independent of CBF1;Su(H);Lag-1 activation.
Constitutive expression of G-CSF and GM-CSF in human skin carcinoma cells with functional consequence for tumor progression.
Cooperative autocrine and paracrine functions of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in the progression of skin carcinoma cells.
Corn silk extract improves cholesterol metabolism in C57BL/6J mouse fed high-fat diets.
Curcumin induces apoptosis in tumor necrosis factor-alpha-treated HaCaT cells.
Cytotoxic Activity of Bioactive Compound 1, 2- Benzene Dicarboxylic Acid, Mono 2- Ethylhexyl Ester Extracted from a Marine Derived Streptomyces sp. VITSJK8.
Cytotoxic Effect of the Genus Sinularia Extracts on Human SCC25 and HaCaT Cells.
Cytotoxic effects of Argentinean plant extracts on tumour and normal cell lines.
Cytotoxic, tubulin-interfering and proapoptotic activities of 4'-methylthio-trans-stilbene derivatives, analogues of trans-resveratrol.
Cytotoxicity of citral against melanoma cells: The involvement of oxidative stress generation and cell growth protein reduction.
Cytotoxicity profiling of deep eutectic solvents to human skin cells.
Cytotoxicity studies of quantum dots with the electroporation method.
Deep Eutectic Solvents and Nonconventional Technologies for Blueberry-Peel Extraction: Kinetics, Anthocyanin Stability, and Antiproliferative Activity.
Defects of basement membrane and hemidesmosome structure correlate with malignant phenotype and stromal interactions in HaCaT-Ras xenografts.
Dehydroxymethylepoxyquinomicin suppresses atopic dermatitis-like lesions in a stratum corneum-removed murine model through NF-?B inhibition.
Deletion mapping of chromosome 3p and 13q and preliminary analysis of the FHIT gene in human nonmelanoma skin cancer.
Density-dependent modulation of synthesis of keratins 1 and 10 in the human keratinocyte line HACAT and in ras-transfected tumorigenic clones.
Deoxynivalenol induced mouse skin tumor initiation: Elucidation of molecular mechanisms in human HaCaT keratinocytes.
Development of lipoprotein-drug conjugates for targeted drug delivery.
Development of Parvifloron D-loaded Smart Nanoparticles to Target Pancreatic Cancer.
Dictamnine delivered by PLGA nanocarriers ameliorated inflammation in an oxazolone-induced dermatitis mouse model.
Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers.
Differential regulation of IL-1 and IL-1 receptor antagonist in HaCaT keratinocytes by tumor necrosis factor-alpha and transforming growth factor-beta 1.
Differential regulation of surface receptor expression, proliferation, and apoptosis in HaCaT cells stimulated with interferon-?, interleukin-4, tumor necrosis factor-?, or muramyl dipeptide.
Differential regulation of thymus- and activation-regulated chemokine induced by IL-4, IL-13, TNF-alpha and IFN-gamma in human keratinocyte and fibroblast.
Dihydroartemisinin Alleviates Imiquimod-Induced Psoriasis-like Skin Lesion in Mice Involving Modulation of IL-23/Th17 Axis.
Direct monitoring of UV-induced free radical generation in HaCaT keratinocytes.
Discovering pH triggered charge rebound surface modulated topical nanotherapy against aggressive skin papilloma.
Disentangling the Complexity of a Hexa-Herbal Chinese Medicine Used for Inflammatory Skin Conditions-Predicting the Active Components by Combining LC-MS-Based Metabolite Profiles and in vitro Pharmacology.
Disrupting cholesterol esterification by bitter melon suppresses triple-negative breast cancer cell growth.
Distinct progression-associated expression of tumor and stromal MMPs in HaCaT skin SCCs correlates with onset of invasion.
DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation.
Double-Stranded RNA Induces MMP-9 Gene Expression in HaCaT Keratinocytes by Tumor Necrosis Factor-?
Drugging ACAT1 for Cancer Therapy.
Dysregulation of Ketone Body Metabolism Is Associated With Poor Prognosis for Clear Cell Renal Cell Carcinoma Patients.
E3 Ligase Trim21 Ubiquitylates and Stabilizes Keratin 17 to Induce STAT3 Activation in Psoriasis.
Eckol from Ecklonia cava ameliorates TNF-?/IFN-?-induced inflammatory responses via regulating MAPKs and NF-?B signaling pathway in HaCaT cells.
Effect of heterocyclic pyrimidine compounds on UVB-induced cell damage in human keratinocytes and on melanogenesis in mouse B16 cells.
Effect of inhibiting ACAT-1 expression on the growth and metastasis of Lewis lung carcinoma.
Effect of tumor necrosis factor-alpha on acyl coenzyme A: cholesteryl acyltransferase activity and ACAT1 gene expression in THP-1 macrophages.
Effect of yerba mate (Ilex paraguariensis) tea on topoisomerase inhibition and oral carcinoma cell proliferation.
Effects of Ambient Fine Particles PM2.5 on Human HaCaT Cells.
Effects of photodynamic therapy mediated by emodin in cervical carcinoma cells.
Effects of the 24 N-terminal amino acids of p55PIK on endotoxinstimulated release of inflammatory cytokines by hacat cells.
Effects of topical application of a tri-herb formula on inflammatory dry-skin condition in mice with oxazolone-induced atopic dermatitis.
Eicosapentaenoic acid inhibits UV-induced MMP-1 expression in human dermal fibroblasts.
Emodin, Physcion, and Crude Extract of Rhamnus sphaerosperma var. pubescens Induce Mixed Cell Death, Increase in Oxidative Stress, DNA Damage, and Inhibition of AKT in Cervical and Oral Squamous Carcinoma Cell Lines.
Enhanced Antipsoriatic Activity of Mycophenolic Acid Against the TNF-?-Induced HaCaT Cell Proliferation by Conjugated Poloxamer Micelles.
Enhanced constitutive invasion activity in human nontumorigenic keratinocytes exposed to a low level of barium for a long time.
Enhanced expression of cyclooxygenase (COX)-2 in human skin epidermal cancer cells: evidence for growth suppression by inhibiting COX-2 expression.
Enhanced serum interferon-lambda 1 interleukin-29 levels in patients with psoriasis vulgaris.
Epigenetic Inactivation of Acetyl-CoA Acetyltransferase 1 Promotes the Proliferation and Metastasis in Nasopharyngeal Carcinoma by Blocking Ketogenesis.
Epstein-Barr virus LMP2A transforms epithelial cells, inhibits cell differentiation, and activates Akt.
Eupatilin with PPAR? agonistic effects inhibits TNF?-induced MMP signaling in HaCaT cells.
Evaluation of Antiproliferative Effect of N-(alkyladamantyl)phthalimides In vitro.
Expression of human macrophage metalloelastase (MMP-12) by tumor cells in skin cancer.
Expression of laminin 5 by parental and c-Ha-ras-transformed HaCaT keratinocytes in organotypic cultures.
Expression of MHC Class II, CD70, CD80, CD86 and pro-inflammatory cytokines is differentially regulated in oral epithelial cells following bacterial challenge.
Expression of SOAT1 in Adrenocortical Carcinoma and Response to Mitotane Monotherapy: An ENSAT Multicenter Study.
Extracellular synthesis of gold nanoparticles using the marine bacterium Paracoccus haeundaensis BC74171T and evaluation of their antioxidant activity and antiproliferative effect on normal and cancer cell lines.
FasL and TRAIL induce epidermal apoptosis and skin ulceration upon exposure to Leishmania major.
FGF-7 facilitates the process of psoriasis by inducing TNF-? expression in HaCaT cells.
FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes.
Fibroblast growth factor-binding protein expression changes with disease progression in clinical and experimental human squamous epithelium.
Fractionated Coptis chinensis Extract and Its Bioactive Component Suppress Propionibacterium acnes-Stimulated Inflammation in Human Keratinocytes.
Furylhydroquinones and miscellaneous compounds from the roots of Lithospermum erythrorhizon and their anti-inflammatory effect in HaCaT cells.
G-protein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation.
Gain-of-function p53 mutants have widespread genomic locations partially overlapping with p63.
Gardenia jasminoides Extract Attenuates the UVB-Induced Expressions of Cytokines in Keratinocytes and Indirectly Inhibits Matrix Metalloproteinase-1 Expression in Human Dermal Fibroblasts.
Glycophthalocyanines as photosensitizers for triggering mitotic catastrophe and apoptosis in cancer cells.
Glycyrrhizic acid prevents Ultraviolet- B induced photodamage: A role for mitogen-activated protein kinases, nuclear factor kappa B and mitochondrial apoptotic pathway.
Gold nanocage assemblies for selective second harmonic generation imaging of cancer cell.
Hepatocyte growth factor reduces CXCL10 expression in keratinocytes.
High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer.
High sensitivity of human epidermal keratinocytes (HaCaT) to topoisomerase inhibitors.
Highly functionalized piperidines: Free radical scavenging, anticancer activity, DNA interaction and correlation with biological activity.
Histamine differentially regulates the production of Th1 and Th2 chemokines by keratinocytes through histamine H1 receptor.
Host plasminogen activator inhibitor-1 promotes human skin carcinoma progression in a stage-dependent manner.
hTERT/re-caspase-3 system induce apoptosis in hTERT-positive cancer cells.
Human papillomavirus-16 E7 interacts with glutathione S-transferase P1 and enhances its role in cell survival.
Icariin inhibits inflammation via immunomodulation of the cutaneous hypothalamus-pituitary-adrenal axis in vitro.
IL-33 and ST2 in Atopic Dermatitis: Expression Profiles and Modulation by Triggering Factors.
Imaging and detection of cell apoptosis byIn vitrophotodynamic therapy applications of zinc (II) phthalocyanine on human melanoma cancer.
Imatinib mesylate elicits extracellular signal-related kinase (ERK) activation and enhances the survival of ?-irradiated epithelial cells.
Imiquimod-induced psoriasis-like inflammation in differentiated Human keratinocytes: Its evaluation using curcumin.
Immortalized Human hTert/KER-CT Keratinocytes a Model System for Research on Desmosomal Adhesion and Pathogenesis of Pemphigus Vulgaris.
Immunomodulatory and Anti-inflammatory Effects of Asiatic Acid in a DNCB-Induced Atopic Dermatitis Animal Model.
Immunomodulatory potential of Nisin A with application in wound healing.
Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma.
Implication of KRT16, FAM129A and HKDC1 genes as ATF4 regulated components of the integrated stress response.
In vitro and in vivo downregulation of C3 by lipoteichoic acid isolated from Lactobacillus plantarum K8 suppressed cytokine-mediated complement system activation.
In Vitro Anti-Inflammatory, Anti-Oxidant, and Cytotoxic Activities of Four Curcuma Species and the Isolation of Compounds from Curcuma aromatica Rhizome.
In vitro antiproliferative activity of uncommon xanthones from branches of Garcinia achachairu.
In vivo synthesis of selenium nanoparticles by Halococcus salifodinae BK18 and their anti-proliferative properties against HeLa cell line.
Increased release of the tumour necrosis factor receptor p75 by immortalized human keratinocytes results from an activated shedding mechanism and is not related to augmented steady-state levels of p75 mRNA.
Individual Comparison of Cholesterol Metabolism in Normal and Tumour Areas in Radical Prostatectomy Specimens from Patients with Prostate Cancer: Results of the CHOMECAP Study.
Induction of apoptosis in human HaCaT keratinocytes.
Induction of Interleukin-22 (IL-22) production in CD4
Inflammatory cytokine tumor necrosis factor-alpha enhances nerve growth factor production in human keratinocytes, HaCaT cells.
Inhibition of calcium-activated chloride channel ANO1 suppresses proliferation and induces apoptosis of epithelium originated cancer cells.
Inhibition of cytosolic and mitochondrial creatine kinase by siRNA in HaCaT- and HeLaS3-cells affects cell viability and mitochondrial morphology.
Inhibition of Dermatitis Development by Sopungsan in Nc/Nga Mice.
Inhibition of lipopolysaccharide-induced interleukin-1beta and tumor necrosis factor-alpha production by menthone through nuclear factor-kappaB signaling pathway in HaCat cells.
Inhibition of SOAT1 suppresses glioblastoma growth via blocking SREBP-1-mediated lipogenesis.
Inhibition of tumor necrosis factor-alpha stimulated NFkappaB/p65 in human keratinocytes by alpha-melanocyte stimulating hormone and adrenocorticotropic hormone peptides.
Inhibitory Effect of Centella asiatica Extract on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice.
Inhibitory effect of strawberry geranium (Saxifraga stolonifera) on Toll-like receptor 2-mediated inflammatory response in human skin keratinocytes.
Inhibitory effects of heartwood extracts of Broussonetia kazinoki Sieb on the development of atopic dermatitis in NC/Nga mice.
Inhibitory Effects of Helianthus tuberosus Ethanol Extract on Dermatophagoides farina body-induced Atopic Dermatitis Mouse Model and Human Keratinocytes.
Innovative bola-surfactant niosomes as topical delivery systems of 5-fluorouracil for the treatment of skin cancer.
Integration of the activation of the human hyaluronan synthase 2 gene promoter by common cofactors of the transcription factors retinoic acid receptor and nuclear factor kappaB.
Interferon-gamma mediates gene expression of IL-18 binding protein in nonleukocytic cells.
Intracellular mechanisms underlying lipid accumulation (white opaque substance) in gastric epithelial neoplasms: A pilot study of expression profiles of lipid-metabolism-associated genes.
Investigation of the corticotropin-releasing hormone-proopiomelanocortin axis in various skin tumours.
Iodinated chlorin p6 copper complex induces anti-proliferative effect in oral cancer cells through elevation of intracellular reactive oxygen species.
Jasmonic Acid Induces Endoplasmic Reticulum Stress with Different Outcome in Cultured Normal and Tumor Epidermal Cells.
Keratinocyte proinflammatory responses to adherent and nonadherent group A streptococci.
Knockdown of sterol O-acyltransferase 1 (SOAT1) suppresses SCD1-mediated lipogenesis and cancer procession in prostate cancer.
Lack of androgen receptor transcriptional activity in human keratinocytes.
Laminaria japonica Suppresses the Atopic Dermatitis-Like Responses in NC/Nga Mice and Inflamed HaCaT Keratinocytes via the Downregulation of STAT1.
LC-MS profiling highlights hazelnut (Nocciola di Giffoni PGI) shells as a byproduct rich in antioxidant phenolics.
Leptin promotes the migration and invasion of breast cancer cells by upregulating ACAT2.
Low-concentration vemurafenib induces the proliferation and invasion of human HaCaT keratinocytes through mitogen-activated protein kinase pathway activation.
Malignant transformation of immortalized HaCaT keratinocytes through deregulated nuclear factor kappaB signaling.
Matrilysin-2 (matrix metalloproteinase-26) is upregulated in keratinocytes during wound repair and early skin carcinogenesis.
Matrix metalloproteinase-19 expression in normal and diseased skin: dysregulation by epidermal proliferation.
Matrix metalloproteinase-19 is expressed by proliferating epithelium but disappears with neoplastic dedifferentiation.
Matrix metalloproteinase-21 expression is associated with keratinocyte differentiation and upregulated by retinoic acid in HaCaT cells.
MCM5 Expression Is Associated With the Grade of Malignancy and Ki-67 Antigen in LSCC.
Mechanism of Macrophage-Derived Chemokine/CCL22 Production by HaCaT Keratinocytes.
Mechanism of thymus- and activation-regulated chemokine (TARC)/CCL17 production and its modulation by roxithromycin.
Mechanisms by which the N-terminal 24 amino acids of the p55 regulatory subunit of phosphatidylinositol 3-kinase affect endotoxin-induced cytokine release in human keratinocytes.
Mechanistic investigations of antitumor activity of a Rhodamine B?oleanolic acid derivative bioconjugate.
Methyl 5-Chloro-4,5-didehydrojasmonate (J7) Inhibits Macrophage-Derived Chemokine Production via Down-Regulation of the Signal Transducers and Activators of Transcription 1 Pathway in HaCaT Human Keratinocytes.
MG-132 treatment promotes TRAIL-mediated apoptosis in SEB-1 sebocytes.
Modification of gene expression by melatonin in UVB-irradiated HaCaT keratinocyte cell lines using a cDNA microarray.
Modulation of the IL-1 cytokine network in keratinocytes by intracellular IL-1 alpha and IL-1 receptor antagonist.
Multi-Omics Analysis to Examine Gene Expression and Metabolites From Multisite Adipose-Derived Mesenchymal Stem Cells.
Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes.
Myrcia splendens (Sw.) DC. (syn. M. fallax (Rich.) DC.) (Myrtaceae) Essential Oil from Amazonian Ecuador: A Chemical Characterization and Bioactivity Profile.
Myricetin and naringenin inhibit human squamous cell carcinoma proliferation and migration in vitro.
Nicotinamide downregulates gene expression of interleukin-6, interleukin-10, monocyte chemoattractant protein-1, and tumour necrosis factor-? gene expression in HaCaT keratinocytes after ultraviolet B irradiation.
Non-covalent inhibitors of human 20S and 26S proteasome based on trypsin inhibitor SFTI-1.
Novel 2-(2-alkylthiobenzenesulfonyl)-3-(phenylprop-2-ynylideneamino)guanidine derivatives as potent anticancer agents - Synthesis, molecular structure, QSAR studies and metabolic stability.
Novel 2-benzylthio-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamides with anticancer activity: Synthesis, QSAR study, and metabolic stability.
Novel Processed Form of Syndecan-1 Shed from SCC-9 Cells Plays a Role in Cell Migration.
Oxidized Low-Density Lipoprotein-Deteriorated Psoriasis Is Associated with the Upregulation of Lox-1 Receptor and Il-23 Expression In Vivo and In Vitro.
Oxymatrine Sensitizes the HaCaT Cells to the IFN-? Pathway and Downregulates MDC, ICAM-1, and SOCS1 by Activating p38, JNK, and Akt.
PAF-receptor in inflammatory versus non inflammatory human epidermis, cell cultures and embryonal cells.
Palmitic Acid Induces Production of Proinflammatory Cytokines Interleukin-6, Interleukin-1?, and Tumor Necrosis Factor-? via a NF-?B-Dependent Mechanism in HaCaT Keratinocytes.
Pancreatic carcinoma cell lines with SMAD4 inactivation show distinct expression responses to TGFB1.
Pannexin-3 Deficiency Delays Skin Wound Healing in Mice due to Defects in Channel Functionality.
Peptoid-Substituted Hybrid Antimicrobial Peptide Derived from Papiliocin and Magainin 2 with Enhanced Bacterial Selectivity and Anti-inflammatory Activity.
Pharmacological importance, characterization and applications of gold and silver nanoparticles synthesized by Panax ginseng fresh leaves.
Photodynamic therapy of tumour cells mediated by the natural anthraquinone parietin and blue light.
Physical Plasma-Treated Skin Cancer Cells Amplify Tumor Cytotoxicity of Human Natural Killer (NK) Cells.
Physiological status of silver carp (Hypophthalmichthys molitrix) in the Illinois River: An assessment of fish at the leading edge of the invasion front.
Plasminogen activator inhibitor-2: a molecular biomarker for head and neck cancer progression.
Platelet-derived growth factor-B normalizes micromorphology and vessel function in vascular endothelial growth factor-A-induced squamous cell carcinomas.
Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells.
Pleiotropic effects of human papillomavirus type 16 E6 oncogene expression in human epithelial cell lines.
Polyamine-stimulation of arsenic-transformed keratinocytes.
Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism.
Potentiation of Kras peptide cancer vaccine by avasimibe, a cholesterol modulator.
Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor ? Superfamily Type 1 Receptors.
Prognostic significance of two lipid metabolism enzymes, HADHA and ACAT2, in clear cell renal cell carcinoma.
Proliferation and motility of HaCaT keratinocyte derivatives is enhanced by fibroblast nemosis.
Protective effect of Codium fragile against UVB-induced pro-inflammatory and oxidative damages in HaCaT cells and BALB/c mice.
Protective Effect of Inositol Hexaphosphate Against UVB Damage in HaCaT Cells and Skin Carcinogenesis in SKH1 Hairless Mice.
Protective Effect of Processed Panax ginseng, Sun Ginseng on UVB-irradiated Human Skin Keratinocyte and Human Dermal Fibroblast.
Protective role of copper, zinc superoxide dismutase against UVB-induced injury of the human keratinocyte cell line HaCaT.
Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma.
Purification of a polysaccharide from Gynostemma pentaphyllum Makino and its therapeutic advantages for psoriasis
Purification of a polysaccharide from Gynostemma pentaphyllum Makino and its therapeutic advantages for psoriasis.
Pyropia yezoensis Extract Suppresses IFN-Gamma- and TNF-Alpha-Induced Proinflammatory Chemokine Production in HaCaT Cells via the Down-Regulation of NF-?B.
Pyrus ussuriensis Maxim. leaves extract ameliorates DNCB-induced atopic dermatitis-like symptoms in NC/Nga mice.
Quantitative analysis and anti-inflammatory effects of Gleditsia sinensis thorns in RAW 264.7 macrophages and HaCaT keratinocytes.
Radiolabeling and in vitro evaluation of a new 5-Fluorouracil derivative with cell culture studies.
Real-time monitoring system for evaluating the acid-producing activity of oral squamous cell carcinoma cells at different environmental pH.
Regulation of cholesterol metabolism in a slow-growing hepatoma in vivo.
Regulation of interleukin-18 (IL-18) expression in keratinocytes (HaCaT): implications for early wound healing.
Rhodiola crenulata Attenuates ?-Ray Induced Cellular Injury via Modulation of Oxidative Stress in Human Skin Cells.
Role of chemokines and the corresponding receptors in vitiligo: A pilot study.
Role of Cutaneous Aquaporins in the Development of Xeroderma in Type 2 Diabetes.
Role of iron in tumor cell protection from the pro-apoptotic effect of nitric oxide.
Role of p53 in UVB-induced apoptosis in human HaCaT keratinocytes.
Rosa davurica Pall. improves DNCB-induced atopic dermatitis in mice and regulated TNF-Alpa/IFN-gamma-induced skin inflammatory responses in HaCaT cells.
Rottlerin induces a transformed phenotype in human keratinocytes.
Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity.
Sargahydroquinoic acid inhibits TNF?-induced AP-1 and NF-?B signaling in HaCaT cells through PPAR? activation.
Sargassum fulvellum Protects HaCaT Cells and BALB/c Mice from UVB-Induced Proinflammatory Responses.
Saussurea lappa alleviates inflammatory chemokine production in HaCaT cells and house dust mite-induced atopic-like dermatitis in Nc/Nga mice.
SB203580, a pharmacological inhibitor of p38 MAP kinase transduction pathway activates ERK and JNK MAP kinases in primary cultures of human hepatocytes.
Self-assembled nanostructures of phosphomolybdate, nucleobase and metal ions synthesis and their in vitro cytotoxicity studies on cancer cell lines.
Sera/Organ Lysates of Selected Animals Living in Polluted Environments Exhibit Cytotoxicity against Cancer Cell Lines.
Shikonin inhibits CEBPD downregulation in IL?17?treated HaCaT cells and in an imiquimod?induced psoriasis model.
Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion.
SiO2-PVA-Fe(acac)3 Hybrid Based Superparamagnetic Nanocomposites for Nanomedicine: Morpho-textural Evaluation and In Vitro Cytotoxicity Assay.
Skin Barrier Recovery by Protease-Activated Receptor-2 Antagonist Lobaric Acid.
Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses.
SOAT1 is a new prognostic factor of colorectal cancer.
SOAT1 promotes mevalonate pathway dependency in pancreatic cancer.
Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice.
Spilanthol inhibits TNF???induced ICAM?1 expression and pro?inflammatory responses by inducing heme oxygenase?1 expression and suppressing pJNK in HaCaT keratinocytes.
Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis.
Stable over-expression of PPAR?/? and PPAR? to examine receptor signaling in human HaCaT keratinocytes.
Sterol O-Acyl Transferase 1 as a Prognostic Marker of Adrenocortical Carcinoma.
Stratification of patients with clear cell renal cell carcinoma to facilitate drug repositioning.
Sulforaphane suppresses TARC/CCL17 and MDC/CCL22 expression through heme oxygenase-1 and NF-?B in human keratinocytes.
Surface-Modified Industrial Acrylonitrile Butadiene Styrene 3D Scaffold Fabrication by Gold Nanoparticle for Drug Screening.
Sustained nontumorigenic phenotype correlates with a largely stable chromosome content during long-term culture of the human keratinocyte line HaCaT.
Synergistic Inhibition of Tumor Necrosis Factor-Alpha-Stimulated Pro-Inflammatory Cytokine Expression in HaCaT Cells by a Combination of Rapamycin and Mycophenolic Acid.
Synergy of Dendritic Cell Vaccines and Avasimibe in Treatment of Head and Neck Cancer in Mice.
Synthesis and cytotoxicity assay of four ganglioside GM3 analogues.
Synthesis of (Z)-1-(1,3-diphenyl-1H-pyrazol-4-yl)-3-(phenylamino)prop-2-en-1-one derivatives as potential anticancer and apoptosis inducing agents.
Synthesis of a Tyr-Tyr Dipeptide Library and Evaluation Against Tumor Cells.
Synthesis of fluorescent molybdenum nanoclusters at ambient temperature and their application in biological imaging.
Synthesis of stable benzimidazole derivatives bearing pyrazole as anticancer and EGFR receptor inhibitors.
Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard's T and P reagents.
Telmisartan Influences the Antiproliferative Activity of Linoleic Acid in Human Colon Cancer Cells.
Testing Lab-on-a-Chip Technology for Culturing Human Melanoma Cells under Simulated Microgravity.
Tetrahedral framework nucleic acids promote scarless healing of cutaneous wounds via the AKT-signaling pathway.
Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth.
Tetrandrine inhibits the proliferation and cytokine production induced by IL-22 in HaCaT cells.
TGF-beta1 + EGF-initiated invasive potential in transformed human keratinocytes is coupled to a plasmin/MMP-10/MMP-1-dependent collagen remodeling axis: role for PAI-1.
The acquisition of cancer stem cell-like properties and neoplastic transformation of human keratinocytes induced by arsenite involves epigenetic silencing of let-7c via Ras/NF-?B.
The crucial role of IL-22 and its receptor on TARC production and T cell migration by HDM extract.
The Effects of Costaria costata Extracts on Atopic Dermatitis in an In Vitro Model.
The enhanced IL-18 production by UVB irradiation requires ROI and AP-1 signaling in human keratinocyte cell line (HaCaT).
The Expressions of TGF-?(1) and IL-10 in Cultured Fibroblasts after ALA-IPL Photodynamic Treatment.
The Extract of D. dasycarpus Ameliorates Oxazolone-Induced Skin Damage in Mice by Anti-Inflammatory and Antioxidant Mechanisms.
The molecular effects of aloe-emodin (AE)/liposome-AE on human nonmelanoma skin cancer cells and skin permeation.
The platelet-activating factor receptor protects epidermal cells from tumor necrosis factor (TNF) alpha and TNF-related apoptosis-inducing ligand-induced apoptosis through an NF-kappa B-dependent process.
The prevention of TNF-?/IFN-? mixture-induced inflammation in human keratinocyte and atopic dermatitis-like skin lesions in Nc/Nga mice by mineral-balanced deep sea water.
The proapoptotic tumor suppressor protein kinase C-delta is lost in human squamous cell carcinomas.
The recent insights into the function of ACAT1: A possible anti-cancer therapeutic target.
The relative abundance of oxygen alkyl-related groups in aliphatic domains is involved in the main pharmacological-pleiotropic effects of humic acids.
The secretome of skin cancer cells activates the mTOR/MYC pathway in healthy keratinocytes and induces tumorigenic properties.
The space of enzyme regulation in HeLa cells can be inferred from its intracellular metabolome.
The vitamin D receptor inhibits the respiratory chain, contributing to the metabolic switch that is essential for cancer cell proliferation.
Therapeutic Effect of Rumex japonicus Houtt. on DNCB-Induced Atopic Dermatitis-Like Skin Lesions in Balb/c Mice and Human Keratinocyte HaCaT Cells.
Three-Dimensional In Vitro Skin and Skin Cancer Models Based on Human Fibroblast-Derived Matrix.
TLR4 as a negative regulator of keratinocyte proliferation.
TNIP1 reduction sensitizes keratinocytes to post-receptor signalling following exposure to TLR agonists.
Tonggyu-tang, a traditional Korean medicine, suppresses pro-inflammatory cytokine production through inhibition of MAPK and NF-?B activation in human mast cells and keratinocytes.
Traditional Aboriginal Preparation Alters the Chemical Profile of Carica papaya Leaves and Impacts on Cytotoxicity towards Human Squamous Cell Carcinoma.
Traditional Herbal Formula Banhasasim-tang Exerts Anti-Inflammatory Effects in RAW 264.7 Macrophages and HaCaT Keratinocytes.
Traditional herbal formula Jakyakgamcho-tang (Paeonia lactiflora and Glycyrrhiza uralensis) impairs inflammatory chemokine production by inhibiting activation of STAT1 and NF-?B in HaCaT cells.
Transcriptional regulation of the elafin gene in human keratinocytes.
Transduced PEP-1-FK506BP Ameliorates Atopic Dermatitis in NC/Nga Mice.
Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway.
Trifloxystrobin induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in HaCaT, human keratinocyte cells.
Tumor-specific gene expression using regulatory elements of the glucose transporter isoform 1 gene.
Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells.
Tumorigenic conversion of immortal human skin keratinocytes (HaCaT) by elevated temperature.
Two new hydronaphthoquinones from Sinningia aggregata (Gesneriaceae) and cytotoxic activity of aggregatin D.
Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex.
Ultraviolet B irradiation-induced G2 cell cycle arrest in human keratinocytes by inhibitory phosphorylation of the cdc2 cell cycle kinase.
Ultraviolet-A-induced transactivation of the vascular endothelial growth factor gene in HaCaT keratinocytes is conveyed by activator protein-2 transcription factor.
Umbelliferone reduces the expression of inflammatory chemokines in HaCaT cells and DNCB/DFE-induced atopic dermatitis symptoms in mice.
UV erythema reducing capacity of mizolastine compared to acetylsalicylic acid or both combined in comparison to indomethacin.
UVA-induced epigenetic regulation of P16(INK4a) in human epidermal keratinocytes and skin tumor derived cells.
UVB-induced interleukin-18 production is downregulated by tannic acids in human HaCaT keratinocytes.
Vascular Endothelial Growth Factor Induced Skin Carcinogenesis depends on Recruitment and Alternative Activation of Macrophages.
Vesicular stomatitis virus infection triggers apoptosis associated with decreased DeltaNp63alpha and increased Bax levels in the immortalized HaCaT keratinocyte cell line.
Vitamin D inhibits the activation of stress-activated protein kinases by physiological and environmental stresses in keratinocytes.
Water Extract of Rubus coreanus Prevents Inflammatory Skin Diseases In Vitro Models.
Well Defined Poly(Methyl Methacrylate)-Fe3O4/Poly(Vinyl Pivalate) Core-Shell Superparamagnetic Nanoparticles: Design and Evaluation of In Vitro Cytotoxicity Activity Against Cancer Cells.
Xanthii fructus extract inhibits TNF-?/IFN-?-induced Th2-chemokines production via blockade of NF-?B, STAT1 and p38-MAPK activation in human epidermal keratinocytes.
Xanthone suppresses allergic contact dermatitis in vitro and in vivo.
Zinc oxide nanoparticles synthesized from Allium cepa prevents UVB radiation mediated inflammation in human epidermal keratinocytes (HaCaT cells).
[Effects of calcipotriol on the expression of S100A8 in human keratinocytes].
[Effects of phytoestrogens on gap junctional intercellular communication.]
Nephritis, Hereditary
Sterol-O-acyltransferase-1 has a role in kidney disease associated with diabetes and Alport Syndrome.
The ins-and-outs of podocyte lipid metabolism.
Nephrosis
Lipid metabolism in the aorta of daunomycin-induced nephrotic rats.
Nephrotic Syndrome
Acyl-Coenzyme A: Cholesterol Acyltransferase-1 is Related to Hyperlipidemia in Children with Nephrotic Syndrome.
Acyl-coenzyme A:cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, lecithin-cholesterol acyltransferase, SRB-1, and low-denisty lipoprotein receptor deficiencies in nephrotic syndrome.
Up-regulation of acyl-coenzyme A:cholesterol acyltransferase (ACAT) in nephrotic syndrome.
Neural Tube Defects
The association and significance of H3K27me3 and a folate metabolic gene ACat2 in neural tube defects.
Neuralgia
Thymus algeriensis and Thymus fontanesii exert neuroprotective effect against chronic constriction injury-induced neuropathic pain in rats.
Neuroblastoma
A nutraceutical extract from Inula viscosa leaves: UHPLC-HR-MS/MS based polyphenol profile, and antioxidant and cytotoxic activities.
ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-?-processing alteration.
NBPF7 promotes the proliferation of ?-catenin-knockdown HaCaT cells via functional interaction with the NF-?B pathway.
Silencing the ACAT1 Gene in Human SH-SY5Y Neuroblastoma Cells Inhibits the Expression of Cyclo-Oxygenase 2 (COX2) and Reduces ?-Amyloid-Induced Toxicity Due to Activation of Protein Kinase C (PKC) and ERK.
Synthesis of Bioactive Chlorogenic Acid-Silica Hybrid Materials via the Sol-Gel Route and Evaluation of Their Biocompatibility.
Transcription of human neuronal nitric oxide synthase mRNAs derived from different first exons is partly controlled by exon 1-specific promoter sequences.
Neurodegenerative Diseases
Increased expression of acyl-coenzyme A: cholesterol acyltransferase-1 and elevated cholesteryl esters in the hippocampus after excitotoxic injury.
Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases A?1-42 clearance.
Non-alcoholic Fatty Liver Disease
Impact of cholesterol metabolism and the LXRalpha-SREBP-1c pathway on nonalcoholic fatty liver disease.
Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization.
Protein acetylation in mitochondria plays critical functions in the pathogenesis of fatty liver disease.
[Effect of leech on lipid metabolism and liver in hyperlipidemia rats].
Obesity
Extracting time-dependent obese-diabetic specific networks in hepatic proteome analysis.
Leptin promotes the migration and invasion of breast cancer cells by upregulating ACAT2.
Myeloid-specific Acat1 ablation attenuates inflammatory responses in macrophages, improves insulin sensitivity, and suppresses diet-induced obesity.
Pharmacological inhibition of acyl-coenzyme A:cholesterol acyltransferase alleviates obesity and insulin resistance in diet-induced obese mice by regulating food intake.
Potential therapeutics for obesity and atherosclerosis: inhibitors of neutral lipid metabolism from microorganisms.
Osteosarcoma
Determination of Immediate vs. Kinetic Growth Retardation in Physically Plasma-treated Cells by Experimental and Modelling Data.
Ovarian Neoplasms
Assessment of acyl-CoA cholesterol acyltransferase (ACAT-1) role in ovarian cancer progression-An in vitro study.
Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts.
Photodynamic therapy of tumour cells mediated by the natural anthraquinone parietin and blue light.
Transplatin is cytotoxic when photoactivated: enhanced formation of DNA cross-links.
Pancreatic Neoplasms
Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer.
Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana.
SOAT1 promotes mevalonate pathway dependency in pancreatic cancer.
Papilloma
Dehydrocostus lactone suppresses cell growth and induces apoptosis in recombinant human papilloma virus?18 HaCaT cells via the PI3K/Akt signaling pathway.
Papillomavirus Infections
DNAJA4 deficiency enhances NF-kappa B-related growth arrest induced by hyperthermia in human keratinocytes.
Human Keratinocyte Cultures in the Investigation of Early Steps of Human Papillomavirus Infection.
Identification of TRAPPC8 as a host factor required for human papillomavirus cell entry.
Integrative analyses reveal novel strategies in HPV11,-16 and -45 early infection.
The cytotoxic mechanism of epigallocatechin gallate on proliferative HaCaT keratinocytes.
The Role of DCT in HPV16 Infection of HaCaTs.
Pemphigoid, Bullous
Decreased expression levels of complement regulator CD55 contribute to the development of bullous pemphigoid.
Pemphigus
Immortalized Human hTert/KER-CT Keratinocytes a Model System for Research on Desmosomal Adhesion and Pathogenesis of Pemphigus Vulgaris.
Pemphigus vulgaris autoantibodies induce apoptosis in HaCaT keratinocytes.
phosphatidylcholine-sterol o-acyltransferase deficiency
Demonstration of intact intracellular cholesterol esterification and normal low-density lipoprotein pathway in fibroblasts from a patient with lecithin:cholesterol acyltransferase deficiency.
[Familial alpha lipoprotein deficiency. Tangier disease, familial hypoalphalipoproteinemia and familial deficiency of lecithin cholesterol acyltransferase deficiency]
Photosensitivity Disorders
A comparative study on the enhancement efficacy of specific and non-specific iron chelators for protoporphyrin IX production and photosensitization in HaCat cells.
Rapid induction of apoptosis in human keratinocytes with the photosensitizer QLT0074 via a direct mitochondrial action.
Porcine Reproductive and Respiratory Syndrome
Exposure to heat-inactivated Trichophyton rubrum resulting in a limited immune response of human keratinocytes.
Pressure Ulcer
Anti-antioxidant impacts of circZNF609 silence in HaCaT cells through regulating miR-145.
Therapeutic Effect of External Application of Ligustrazine Combined with Holistic Nursing on Pressure Sores.
Prostatic Neoplasms
Bioconjugated graphene oxide-based Raman probe for selective identification of SKBR3 breast cancer cells.
Cytotoxic ellagitannins from Reaumuria vermiculata.
Evaluation and prognostic significance of ACAT1 as a marker of prostate cancer progression.
Identification of Genes Required for Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cells In Vitro.
Knockdown of sterol O-acyltransferase 1 (SOAT1) suppresses SCD1-mediated lipogenesis and cancer procession in prostate cancer.
Positive regulation of prostate cancer cell growth by lipid droplet forming and processing enzymes DGAT1 and ABHD5.
Quantitative Proteomics Reveals that Enzymes of the Ketogenic Pathway are Associated with Prostate Cancer Progression.
Sirtuin 5 regulates the proliferation, invasion and migration of prostate cancer cells through acetyl-CoA acetyltransferase 1.
Transcriptional regulation of the small GTPase RhoB gene by TGF{beta}-induced signaling pathways.
Proteinuria
Acyl-coenzyme A:cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, lecithin-cholesterol acyltransferase, SRB-1, and low-denisty lipoprotein receptor deficiencies in nephrotic syndrome.
Sterol Regulatory Element-Binding Proteins, Liver X Receptor, ABCA1 Transporter, CD36, Scavenger Receptors A1 and B1 in Nephrotic Kidney.
Psoriasis
A Preliminary Study of the Effect of Semaphorin 3A and Acitretin on the Proliferation, Migration, and Apoptosis of HaCaT Cells.
A Randomized, Double-Blind, Controlled Clinical Study on the Curative Effect of Huaier on Mild-to-Moderate Psoriasis and an Experimental Study on the Proliferation of Hacat Cells.
Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7.
Acitretin modulates HaCaT cells proliferation through STAT1- and STAT3-dependent signaling.
All-trans-retinoic acid and 13-cis-retinoic acid: pharmacokinetics and biological activity in different cell culture models of human keratinocytes.
Altered expression of prohibitin in psoriatic lesions and its cellular implication.
Amentoflavone protects against psoriasis-like skin lesion through suppression of NF-?B-mediated inflammation and keratinocyte proliferation.
Antiproliferation of keratinocytes and alleviation of psoriasis by the ethanol extract of Artemisia capillaris.
Antiproliferative potential of zidovudine in human keratinocyte cultures.
Ar-Turmerone Exerts Anti-proliferative and Anti-inflammatory Activities in HaCaT Keratinocytes by Inactivating Hedgehog Pathway.
Baicalin Inhibits Cell Proliferation and Inflammatory Cytokines Induced by Tumor Necrosis Factor ? (TNF-?) in Human Immortalized Keratinocytes (HaCaT) Human Keratinocytes by Inhibiting the STAT3/Nuclear Factor kappa B (NF-?B) Signaling Pathway.
Calcipotriol inhibits proliferation of human keratinocytes by downregulating STAT1 and STAT3 signaling.
Circ_0061012 contributes to IL-22-induced proliferation, migration and invasion in keratinocytes through miR-194-5p/GAB1 axis in psoriasis.
Co-localization of COX-2, CYP4F8, and mPGES-1 in epidermis with prominent expression of CYP4F8 mRNA in psoriatic lesions.
Combination of retinoids and narrow-band ultraviolet B inhibits matrix metalloproteinase 13 expression in HaCaT keratinocytes and a mouse model of psoriasis.
Comparison of stress-induced PRINS gene expression in normal human keratinocytes and HaCaT cells.
Convallatoxin induces HaCaT cell necroptosis and ameliorates skin lesions in psoriasis-like mouse models.
Correction: Boche?ska, K. et al. Lysosome Alterations in the Human Epithelial Cell Line HaCaT and Skin Specimens: Relevance to Psoriasis. Int. J. Mol. Sci. 2019, 20, 2255.
Curcumin induces apoptosis in tumor necrosis factor-alpha-treated HaCaT cells.
Cutaneous delivery of [1-(4-chloro-3-nitrobenzenesulfonyl)-1H-indol-3-yl]-methanol, an indole-3-carbinol derivative, mitigates psoriasiform lesion by blocking MAPK/NF-?B/AP-1 activation.
Dermal Mesenchymal Stem Cells from Psoriatic Lesions Stimulate HaCaT Cell Proliferation, Differentiation, and Migration via Activating the PI3K/AKT Signaling Pathway.
Differential expression of D-type cyclins in HaCaT keratinocytes and in psoriasis.
Dithranol upregulates IL-10 receptors on the cultured human keratinocyte cell line HaCaT.
DUSP1/MKP-1 regulates proliferation and apoptosis in keratinocytes through the ERK/Elk-1/Egr-1 signaling pathway.
E3 Ligase Trim21 Ubiquitylates and Stabilizes Keratin 17 to Induce STAT3 Activation in Psoriasis.
Effects of aloe polysaccharide, a polysaccharide extracted from Aloe vera, on TNF???induced HaCaT cell proliferation and the underlying mechanism in psoriasis.
Effects of luteolin on treatment of psoriasis by repressing HSP90.
Enhanced Antipsoriatic Activity of Mycophenolic Acid Against the TNF-?-Induced HaCaT Cell Proliferation by Conjugated Poloxamer Micelles.
Ethanol and acetone stimulate the proliferation of HaCaT keratinocytes: the possible role of alcohol in exacerbating psoriasis.
Evaluation of the anti-proliferative properties of selected psoriasis-treating Chinese medicines on cultured HaCaT cells.
Exploring the mode of action of dithranol therapy for psoriasis: a metabolomic analysis using HaCaT cells.
Expression and modulation of LL-37 in normal human keratinocytes, HaCaT cells, and inflammatory skin diseases.
EZH2 is involved in psoriasis progression by impairing miR-125a-5p inhibition of SFMBT1 and leading to inhibition of the TGF?/SMAD pathway.
F(2)-isoprostanes: sensitive biomarkers of oxidative stress in vitro and in vivo: a gas chromatography-mass spectrometric approach.
FGF-7 facilitates the process of psoriasis by inducing TNF-? expression in HaCaT cells.
Fluorescent Imaging for Assessment of the Effect of Combined Application of Electroporation and Rifampicin on HaCaT Cells as a New Therapeutic Approach for Psoriasis.
FOS-like antigen 1 is highly expressed in human psoriasis tissues and promotes the growth of HaCaT cells in vitro.
FOXM1 regulates the proliferation, apoptosis and inflammatory response of keratinocytes through the NF-?B signaling pathway.
Fuzhenghefuzhiyang Formula (FZHFZY) Improves Epidermal Differentiation via Suppression of the Akt/mTORC1/S6K1 Signalling Pathway in Psoriatic Models.
Gardiquimod inhibits the expression of calcium-induced differentiation markers in HaCaT cells.
Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis.
Green synthesis, characterization and anti-inflammatory activity of silver nanoparticles using European black elderberry fruits extract.
HIF-1? may promote glycolysis in psoriasis vulgaris via upregulation of CD147 and GLUT1.
hsa-miR-4516 Mediated Downregulation of STAT3/CDK6/UBE2N Plays a Role in PUVA Induced Apoptosis in Keratinocytes.
Hyperforin Ameliorates Imiquimod-Induced Psoriasis-Like Murine Skin Inflammation by Modulating IL-17A-Producing ?? T Cells.
Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes.
IL-33 is secreted by psoriatic keratinocytes and induces pro-inflammatory cytokines via keratinocyte and mast cell activation.
Imiquimod-induced psoriasis-like inflammation in differentiated Human keratinocytes: Its evaluation using curcumin.
Inhibiting Interleukin-18 Production Through the Mitogen-Activated Protein Kinase Pathway, A Potential Role of Corticotropin-Releasing Hormone in Chronic Plaque Psoriasis.
Isoliquiritigenin prevents the progression of psoriasis-like symptoms by inhibiting NF-?B and proinflammatory cytokines.
Karyopherin Alpha2 Is Essential for rRNA Transcription and Protein Synthesis in Proliferative Keratinocytes.
LncRNA MEG3 influences the proliferation and apoptosis of psoriasis epidermal cells by targeting miR-21/caspase-8.
Lysosome Alterations in the Human Epithelial Cell Line HaCaT and Skin Specimens: Relevance to Psoriasis.
MicroRNA-125a Correlates with Decreased Psoriasis Severity and Inflammation and Represses Keratinocyte Proliferation.
MicroRNA-215-5p inhibits the proliferation of keratinocytes and alleviates psoriasis-like inflammation by negatively regulating DYRK1A and its downstream signalling pathways.
MicroRNA-520a suppresses the proliferation and mitosis of HaCaT cells by inactivating protein kinase B.
MicroRNA138 regulates keratin 17 protein expression to affect HaCaT cell proliferation and apoptosis by targeting hTERT in psoriasis vulgaris.
MiR-155 promotes cell proliferation and inhibits apoptosis by PTEN signaling pathway in the psoriasis.
miR-183-3p suppresses proliferation and migration of keratinocyte in psoriasis by inhibiting GAB1.
MiR-20a-3p regulates TGF-?1/Survivin pathway to affect keratinocytes proliferation and apoptosis by targeting SFMBT1 in vitro.
MiR-221-3p as a Potential Biomarker for Patients with Psoriasis and Its Role in Inflammatory Responses in Keratinocytes.
MiR-330 inhibits IL-22-induced keratinocyte proliferation through targeting CTNNB1.
MiR-99a inhibits keratinocyte proliferation by targeting Frizzled-5 (FZD5) / FZD8 through ?-catenin signaling in psoriasis.
miR124-3p/FGFR2 axis inhibits human keratinocyte proliferation and migration and improve the inflammatory microenvironment in psoriasis.
Neutrophil elastase promotes proliferation of HaCaT cell line and transwell psoriasis organ culture model.
Nitidine chloride induces S phase cell cycle arrest and mitochondria-dependent apoptosis in HaCaT cells and ameliorates skin lesions in psoriasis-like mouse models.
Overexpression and potential roles of NRIP1 in psoriasis.
Paeoniflorin inhibits proliferation and migration of psoriatic keratinocytes via the lncRNA NEAT1/miR-3194-5p/Galectin-7 axis.
PGRN Suppresses Inflammation and Promotes Autophagy in Keratinocytes Through the Wnt/?-Catenin Signaling Pathway.
Pro-oxidant status and Nrf2 levels in psoriasis vulgaris skin tissues and dimethyl fumarate-treated HaCaT cells.
Proinflammatory cytokine production in HaCaT cells treated by eosin: implications for the topical treatment of psoriasis.
PSORI-CM02 ameliorates psoriasis in vivo and in vitro by inducing autophagy via inhibition of the PI3K/Akt/mTOR pathway.
PSORI-CM02 Formula Increases CD4+ Foxp3+ Regulatory T Cell Frequency and Ameliorates Imiquimod-Induced Psoriasis in Mice.
Purification of a polysaccharide from Gynostemma pentaphyllum Makino and its therapeutic advantages for psoriasis
Purification of a polysaccharide from Gynostemma pentaphyllum Makino and its therapeutic advantages for psoriasis.
Quercetin enhancement of arsenic-induced apoptosis via stimulating ROS-dependent p53 protein ubiquitination in human HaCaT keratinocytes.
Rapamycin ameliorates psoriasis by regulating the expression and methylation levels of tropomyosin via ERK1/2 and mTOR pathways in vitro and in vivo.
Realgar-mediated growth inhibition on HaCaT human keratinocytes is associated with induction of apoptosis.
Research Note Mesenchymal stem cells from skin lesions of psoriasis patients promote proliferation and inhibit apoptosis of HaCaT cells.
RNA-seq reveal RNA binding protein GNL3 as a key mediator in the development of psoriasis vulgaris by regulating the IL23/IL17 axis.
Rosmarinic acid protects mice from imiquimod induced psoriasis-like skin lesions by inhibiting the IL-23/Th17 axis via regulating Jak2/Stat3 signaling pathway.
Shikonin inhibits CEBPD downregulation in IL?17?treated HaCaT cells and in an imiquimod?induced psoriasis model.
Silencing of miR?155 suppresses inflammatory responses in psoriasis through inflammasome NLRP3 regulation.
Sortilin regulates keratinocyte proliferation and apoptosis through the PI3K-AKT signaling pathway.
Taxifolin attenuates IMQ-induced murine psoriasis-like dermatitis by regulating T helper cell responses via Notch1 and JAK2/STAT3 signal pathways.
The alpha-defensins HNP-1 and HNP-2 are dominant self-peptides presented by HLA class-II molecules in lesional psoriatic skin.
The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model.
The Psoriasis Therapeutic Potential of a Novel Short Laminin Peptide C16.
Topical Sunitinib ointment alleviates Psoriasis-like inflammation by inhibiting the proliferation and apoptosis of keratinocytes.
TRB3 is elevated in psoriasis vulgaris lesions and mediates HaCaT cells proliferation in vitro.
Triptolide Inhibits the Proliferation of HaCaT Cells Induced by IL22 via Upregulating miR-181b-5p.
[Effect of shikonin on proliferation of keratinocytes induced by interleukin-17 and expression of chemokines].
[Effects of drugs known to trigger psoriasis on HaCaT keratinocytes]
[Genetically predetermined limitation in the use of HaCaT cells that affects their ability to serve as an experimental model of psoriasis].
[Mechanism about therapeutic effect of meisoindigo on psoriasis via down-regulation of the TLR4-TAK-NF-kappaB pathways].
[Molecular Mechanism of KLF4 Up-regulating Keratin 17 Expression in Keratinocytes].
Pyoderma Gangrenosum
Gene Therapy for Pyoderma Gangrenosum: Optimal Transfection Conditions and Effect of Drugs on Gene Delivery in the HaCaT Cell Line Using Cationic Liposomes.
Renal Insufficiency
Atorvastatin Improves Hepatic Lipid Metabolism and Protects Renal Damage in Adenine-Induced Chronic Kidney Disease in Sprague-Dawley Rats.
Retinoblastoma
Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression.
Cell-cycle regulation of human B-myb transcription.
Modulation of cell proliferation by cytokeratins K10 and K16.
Perillyl alcohol causes G1 arrest through p15(INK4b) and p21(WAF1/Cip1) induction.
Role of p12(CDK2-AP1) in transforming growth factor-beta1-mediated growth suppression.
ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway.
Reye Syndrome
Reveal genes functionally associated with ACADS by a network study.
Rosacea
Increased expression of IL-33 in rosacea skin and UVB-irradiated and LL-37-treated HaCaT cells.
Long non-coding RNA NEAT1 functions as a competing endogenous RNA to regulate S100A9 expression by sponging miR-196a-5p in rosacea.
The therapeutic effect of artesunate on rosacea through the inhibition of the JAK/STAT signaling pathway.
Tranexamic acid ameliorates rosacea symptoms through regulating immune response and angiogenesis.
Seizures
Expression profiles of hippocampal regenerative sprouting-related genes and their regulation by E-64d in a developmental rat model of penicillin-induced recurrent epilepticus.
F(2)-isoprostanes: sensitive biomarkers of oxidative stress in vitro and in vivo: a gas chromatography-mass spectrometric approach.
Neurobehavioral Deficits in a Rat Model of Recurrent Neonatal Seizures Are Prevented by a Ketogenic Diet and Correlate with Hippocampal Zinc/Lipid Transporter Signals.
Sepsis
Phenotypic and genotypic characteristics of Candida albicans isolates from bloodstream and mucosal infections.
Shock, Septic
Staphylococcal toxins and protein A differentially induce cytotoxicity and release of tumor necrosis factor-alpha from human keratinocytes.
Skin Diseases
Bakuchicin attenuates atopic skin inflammation.
Down-regulation of IL-6, IL-8, TNF-? and IL-1? by glucosamine in HaCaT cells, but not in the presence of TNF-?
Effects of Hovenia dulcis Thunb. extract and methyl vanillate on atopic dermatitis-like skin lesions and TNF-?/IFN-?-induced chemokines production in HaCaT cells.
Expression and modulation of LL-37 in normal human keratinocytes, HaCaT cells, and inflammatory skin diseases.
Identification of sn-2 acetyl glycerophosphocholines in human keratinocytes.
PAMs ameliorates the imiquimod-induced psoriasis-like skin disease in mice by inhibition of translocation of NF-?B and production of inflammatory cytokines.
Protein indicators for HaCaT cell damage induced by UVB irradiation.
Skin Neoplasms
Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis.
Arsenite Regulates Prolongation of Glycan Residues of Membrane Glycoprotein: A Pivotal Study via Wax Physisorption Kinetics and FTIR Imaging.
Caffeic acid directly targets ERK1/2 to attenuate solar UV-induced skin carcinogenesis.
Cell cycle progression data on human skin cancer cells with anticancer synthetic peptide LTX-315 treatment.
Characterisation of the novel spontaneously immortalized and invasively growing human skin keratinocyte line HaSKpw.
Deletion mapping of chromosome 3p and 13q and preliminary analysis of the FHIT gene in human nonmelanoma skin cancer.
Effect of Shenqin biochemical extract on hypoxia-inducible factor-1? expression in ultraviolet B-irradiated HaCaT cells.
Erratum to: Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer.
Ese-3 Inhibits the Proliferation, Migration, and Invasion of HaCaT Cells by Downregulating PSIP1 and NUCKS1.
Identification of novel ?Np63?-regulated miRNAs using an optimized small RNA-Seq analysis pipeline.
Innovative bola-surfactant niosomes as topical delivery systems of 5-fluorouracil for the treatment of skin cancer.
Linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity.
Physical Plasma-Treated Skin Cancer Cells Amplify Tumor Cytotoxicity of Human Natural Killer (NK) Cells.
Proteomic analysis and the antimetastatic effect of N-(4-methyl)phenyl-O-(4-methoxy) phenyl-thionocarbamate-induced apoptosis in human melanoma SK-MEL-28 cells.
RSK2 as a key regulator in human skin cancer.
Sanggenol L promotes apoptotic cell death in melanoma skin cancer cells through activation of caspase cascades and apoptosis-inducing factor.
Subcellular Raman Microspectroscopy Imaging of Nucleic Acids and Tryptophan for Distinction of Normal Human Skin Cells and Tumorigenic Keratinocytes.
TGF-beta1 causes epithelial-mesenchymal transition in HaCaT derivatives, but induces expression of COX-2 and migration only in benign, not in malignant keratinocytes.
The enhanced IL-18 production by UVB irradiation requires ROI and AP-1 signaling in human keratinocyte cell line (HaCaT).
The Flavonol Isoquercitrin Promotes Mitochondrial-Dependent Apoptosis in SK-Mel-2 Melanoma Cell via the PI3K/AKT/mTOR Pathway.
Three-Dimensional In Vitro Skin and Skin Cancer Models Based on Human Fibroblast-Derived Matrix.
UV-induced skin cancer: similarities--variations.
Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer.
Squamous Cell Carcinoma of Head and Neck
Chemical Characterization and in Vitro Cytotoxicity on Squamous Cell Carcinoma Cells of Carica Papaya Leaf Extracts.
Copy number gain and oncogenic activity of YWHAZ/14-3-3zeta in head and neck squamous cell carcinoma.
E-cigarette vapour is not inert and exposure can lead to cell damage.
Gold nanoparticles conjugated with programmed death-ligand 1 antibodies induce apoptosis of SCC-25 oral squamous cell carcinoma cells via programmed death-ligand 1/signal transducer and transcription 3 pathway.
Model examinatio-n of chemoprevention with retinoids in squamous cell carcinomas of the head and neck region and suitable biomarkers for chemoprevention.
Myricetin and naringenin inhibit human squamous cell carcinoma proliferation and migration in vitro.
Reciprocal transactivation of Merkel cell polyomavirus and high-risk human papillomavirus promoter activities and increased expression of their oncoproteins.
Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity.
Silencing novel long non-coding RNA FKBP9P1 represses malignant progression and inhibits PI3K/AKT signaling of head and neck squamous cell carcinoma in vitro.
Small Extracellular Vesicles from Head and Neck Squamous Cell Carcinoma Cells Carry a Proteomic Signature for Tumor Hypoxia.
Synergy of Dendritic Cell Vaccines and Avasimibe in Treatment of Head and Neck Cancer in Mice.
The molecular effects of aloe-emodin (AE)/liposome-AE on human nonmelanoma skin cancer cells and skin permeation.
The Selection of NF?B Inhibitors to Block Inflammation and Induce Sensitisation to FasL-Induced Apoptosis in HNSCC Cell Lines Is Critical for Their Use as a Prospective Cancer Therapy.
Staphylococcal Infections
Biphasic influence of Staphylococcus aureus on human epidermal tight junctions.
The Short Lipopeptides (C10)2-KKKK-NH2 and (C12)2-KKKK-NH2 Protect HaCaT Keratinocytes from Bacterial Damage Caused by Staphylococcus aureus Infection in a Co-Culture Model.
Water-based extracts of Zizania latifolia inhibit Staphylococcus aureus infection through the induction of human beta-defensin 2 expression in HaCaT cells.
Starvation
Chemically Induced Cell Cycle Arrest in Perfusion Cell Culture.
Comparison of stress-induced PRINS gene expression in normal human keratinocytes and HaCaT cells.
Differential expression of classical nuclear transport factors during cellular proliferation and differentiation.
Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A.
Karyopherin Alpha2 Is Essential for rRNA Transcription and Protein Synthesis in Proliferative Keratinocytes.
Monomeric C-mannosyl tryptophan is a degradation product of autophagy in cultured cells.
Serum Starvation Sensitizes Anticancer Effect of Anemarrhena asphodeloides via p38/JNK-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells.
sterol o-acyltransferase deficiency
ACAT1 deficiency disrupts cholesterol efflux and alters cellular morphology in macrophages.
ACAT1 deficiency increases cholesterol synthesis in mouse peritoneal macrophages.
ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice.
ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis.
Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice.
Inflammasome Activation Aggravates Cutaneous Xanthomatosis and Atherosclerosis in ACAT1 (Acyl-CoA Cholesterol Acyltransferase 1) Deficiency in Bone Marrow.
Intestine specific MTP deficiency with global ACAT2 gene ablation lowers acute cholesterol absorption with chylomicrons and high density lipoproteins.
Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.
Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1.
Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression.
Ophthalmological findings in three patients with cholesterol acyltransferase deficiency syndrome before and after kidney transplantation.
Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1.
Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice.
SOAT1 deficiency attenuates atherosclerosis by regulating inflammation and cholesterol transportation via HO-1 pathway.
TLR4-mediated inflammation promotes foam cell formation of vascular smooth muscle cell by upregulating ACAT1 expression.
[Familial alpha lipoprotein deficiency. Tangier disease, familial hypoalphalipoproteinemia and familial deficiency of lecithin cholesterol acyltransferase deficiency]
Stomach Neoplasms
Usnic acid induces apoptosis in human gastric cancer cells through ROS generation and DNA damage and causes up-regulation of DNA-PKcs and ?-H2A.X phosphorylation.
Sunburn
Photoprotection by Cichorum endivia extracts: prevention of UVB-induced erythema, pyrimidine dimer formation and IL-6 expression.
Tangier Disease
[Familial alpha lipoprotein deficiency. Tangier disease, familial hypoalphalipoproteinemia and familial deficiency of lecithin cholesterol acyltransferase deficiency]
Tauopathies
Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage.
triacylglycerol lipase deficiency
The beta very low density lipoprotein present in hepatic lipase deficiency competitively inhibits low density lipoprotein binding to fibroblasts and stimulates fibroblast acyl-CoA:cholesterol acyltransferase.
[Familial alpha lipoprotein deficiency. Tangier disease, familial hypoalphalipoproteinemia and familial deficiency of lecithin cholesterol acyltransferase deficiency]
[LCAT deficiency: a nephrological diagnosis].
Tuberculosis
Formulation of Natural Oil Nano-Emulsions for the Topical Delivery of Clofazimine, Artemisone and Decoquinate.
Uterine Cervical Neoplasms
A comparative study of digital PCR and real-time qPCR for the detection and quantification of HPV mRNA in sentinel lymph nodes of cervical cancer patients.
Action of bleomycin is affected by bleomycin hydrolase but not by caveolin-1.
Anti-neoplastic selenium nanoparticles from Idiomarina sp. PR58-8.
Antineoplastic potential and chemical evaluation of essential oils from leaves and flowers of Tagetes ostenii Hicken.
Bacillus thuringiensis toxins are cytotoxic to cervical cancer (HeLa) but not to breast cancer (MCF7) cells.
Biotin Decorated Gold Nanoparticles for Targeted Delivery of a Smart-Linked Anticancer Active Copper Complex: In Vitro and In Vivo Studies.
Crucial role of cytokines in sex steroid formation in normal and tumoral tissues.
Cudrania tricuspidata Stem Extract Induces Apoptosis via the Extrinsic Pathway in SiHa Cervical Cancer Cells.
Cytotoxicity of Ficus Crocata Extract on Cervical Cancer Cells and Protective Effect against Hydrogen Peroxide-Induced Oxidative Stress in HaCaT Non-Tumor Cells.
Differential Expression and Enzymatic Activity of DPPIV/CD26 Affects Migration Ability of Cervical Carcinoma Cells.
Down modulation of IL-18 expression by human papillomavirus type 16 E6 oncogene via binding to IL-18.
Ectonucleotidase expression profile and activity in human cervical cancer cell lines.
Epigenetic activation of WHSC1 functions as an oncogene and is associated with poor prognosis in cervical cancer.
Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells.
Induction of 3beta-hydroxysteroid dehydrogenase/isomerase type 1 expression by interleukin-4 in human normal prostate epithelial cells, immortalized keratinocytes, colon, and cervix cancer cell lines.
Let?7a suppresses cell proliferation via the TGF??/SMAD signaling pathway in cervical cancer.
Long non-coding RNA cancer susceptibility candidate 2 inhibits the cell proliferation, invasion and angiogenesis of cervical cancer through the MAPK pathway.
Mechanism of hydrogen on cervical cancer suppression revealed by high?throughput RNA sequencing.
Novel 2-benzylthio-5-(1,3,4-oxadiazol-2-yl)benzenesulfonamides with anticancer activity: Synthesis, QSAR study, and metabolic stability.
Oscillations of ultra-weak photon emission from cancer and non-cancer cells stressed by culture medium change and TNF-?.
Oxidative Stress Triggered by Apigenin Induces Apoptosis in a Comprehensive Panel of Human Cervical Cancer-Derived Cell Lines.
Pentoxifylline sensitizes human cervical tumor cells to cisplatin-induced apoptosis by suppressing NF-kappa B and decreased cell senescence.
Proteomic analysis of progressive factors in uterine cervical cancer.
Reciprocal transactivation of Merkel cell polyomavirus and high-risk human papillomavirus promoter activities and increased expression of their oncoproteins.
Selective photodynamic effects on cervical cancer cells provided by P123 Pluronic®-based nanoparticles modulating hypericin delivery.
Sensitization of cervix cancer cells to Adriamycin by Pentoxifylline induces an increase in apoptosis and decrease senescence.
The new-generation proteasome inhibitor oprozomib increases the sensitivity of cervical cancer cells to cisplatin-induced apoptosis.
Ultrasound irradiation inhibits proliferation of cervical cancer cells by initiating endoplasmic reticulum stress-mediated apoptosis and triggering phosphorylation of JNK.
Uterine Neoplasms
Mitochondrial proteomics with siRNA knockdown to reveal ACAT1 and MDH2 in the development of doxorubicin-resistant uterine cancer.
Vaccinia
Glycosylation of human papillomavirus type 16 L1 protein.
Human papillomavirus type 16 (HPV 16) E7 and major histocompatibility complex (MHC) class I and II expression in human keratinocytes in culture.
Vaginitis
Phenotypic and genotypic characteristics of Candida albicans isolates from bloodstream and mucosal infections.
Vascular Diseases
Multi-Omics Analysis to Examine Gene Expression and Metabolites From Multisite Adipose-Derived Mesenchymal Stem Cells.
Vesicular Stomatitis
Vesicular stomatitis virus infection triggers apoptosis associated with decreased DeltaNp63alpha and increased Bax levels in the immortalized HaCaT keratinocyte cell line.
Virus Diseases
Comparison of stress-induced PRINS gene expression in normal human keratinocytes and HaCaT cells.
HaCaT epithelial cells as an innovative novel model of rhinovirus infection and impact of clarithromycin treatment on infection kinetics.
Vesicular stomatitis virus infection triggers apoptosis associated with decreased DeltaNp63alpha and increased Bax levels in the immortalized HaCaT keratinocyte cell line.
Vitiligo
Decreased SUMOylation of the retinoblastoma protein in keratinocytes during the pathogenesis of vitiligo.
miR-9 regulates melanocytes adhesion and migration during vitiligo repigmentation induced by UVB treatment.
Wiskott-Aldrich Syndrome
Potential implications of interleukin-7 in chronic wound healing.
Wound Infection
Cationic-bilayered nanoemulsion of fusidic acid: an investigation on eradication of methicillin-resistant Staphylococcus aureus 33591 infection in burn wound.
Xanthomatosis
Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia.
Inflammasome Activation Aggravates Cutaneous Xanthomatosis and Atherosclerosis in ACAT1 (Acyl-CoA Cholesterol Acyltransferase 1) Deficiency in Bone Marrow.
Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.
Xeroderma Pigmentosum
Phloroglucinol enhances the repair of UVB radiation-induced DNA damage via promotion of the nucleotide excision repair system in vitro and in vivo.
Zika Virus Infection
Insights into ZIKV-Mediated Innate Immune Responses in Human Dermal Fibroblasts and Epidermal Keratinocytes.