2.3.1.26: sterol O-acyltransferase

This is an abbreviated version!
For detailed information about sterol O-acyltransferase, go to the full flat file.

Reaction

Synonyms

A2, ACAT, ACAT-1, ACAT-2, ACAT1, ACAT2, acyl coenzyme A-cholesterol-O-acyltransferase, acyl coenzyme A: cholesteryl acyltransferase, acyl-CoA cholesterol acyltransferase, acyl-CoA cholesterol O-acyltransferase, acyl-CoA: cholesterol acyltransferase, acyl-CoA:cholesterol acyltransferase, acyl-CoA:cholesterol acyltransferase 1, acyl-CoA:cholesterol acyltransferase 2, acyl-coA:cholesterol o-acyl transferase 2, acyl-coenzyme A: cholesterol acyltransferase, acyl-coenzyme A:cholesterol acyltransferase, acyl-coenzyme A:cholesterol acyltransferase 1, acyl-coenzyme A:cholesterol acyltransferase 2, acyl-coenzyme A:cholesterol acyltransferase-1, acyl-coenzyme A:cholesterol O-acyltransferase, acyl-coenzymeA cholesterol acyltransferase, acyl-coenzymeA:cholesterol acyl-transferase, acylcoenzyme A:cholesterol O-acyltransferase, acyltransferase, cholesterol, AsAT, cholesterol acyltransferase, cholesterol acyltransferase 2, cholesterol ester synthase, cholesterol ester synthetase, cholesteryl ester synthetase, hACAT, hACAT-1, hACAT-2, hACAT1, SOAT, SOAT!, Soat1, Soat2, sterol O-acyltransferase 2, sterol-ester synthase, sterol-ester synthetase, steroyl O-acyltransferase 1, steroyl O-acyltransferase 2

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.26 sterol O-acyltransferase

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Results	in table
79	Activating Compound
68	AA Sequence
30	Application
1	CAS Registry Number
48	Cloned(Commentary)
6	Cofactor
4079	Disease/ Diagnostics
6	Expression
32	General Information
487	IC50 Value
513	Inhibitors
28	Ki Value [mM]
35	KM Value [mM]
105	Localization
5	Metals/Ions
26	Molecular Weight [Da]
88	Natural Substrates/ Products (Substrates)
3	Organic Solvent Stability
215	Organism
2	Pathway
22	PDB ID
10	pH Optimum
2	pH Range
5	Posttranslational Modification
97	Protein Variants
25	Purification (Commentary)
2	Reaction
32	Reaction Type
184	Reference
13	Renatured (Commentary)
294	Source Tissue
113	Specific Activity [micromol/min/mg]
12	Storage Stability
291	Substrates and Products (Substrate)
13	Subunits
177	Synonyms
1	Systematic Name
49	Temperature Optimum [°C]
5	Temperature Stability [°C]

KI Value

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KI Value on EC 2.3.1.26 - sterol O-acyltransferase

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00006 - 0.00009

(6R,9S,13S)-3-benzyl-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

2 entries

0.001 - 0.04

(6S,9S,13R)-9-(2-chlorobenzyl)-6-methyl-3-[(1S)-1-methylpropyl]-13-pentyl-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

2 entries

0.00025 - 0.02

(6S,9S,13S)-6-methyl-13-[(1S)-1-methylnonyl]-3-[(1S)-1-methylpropyl]-9-(naphthalen-2-ylmethyl)-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

2 entries

0.0001 - 0.004

(6S,9S,13S)-6-methyl-9-(4-methylbenzyl)-13-[(1S)-1-methylbutyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

2 entries

0.00015 - 0.0065

(6S,9S,13S)-9-(3-chlorobenzyl)-6-methyl-13-[(1S)-1-methylbutyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

2 entries

0.0001 - 0.004

(6S,9S,13S)-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-3-[(1R)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

2 entries

0.00027 - 0.01

(6S,9S,13S)-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

2 entries

0.000378

2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide

Homo sapiens

-

inhibition is competitive with respect to oleoyl-coenzyme A

684800

0.05

20alpha-hydroxypregn-4-en-3-one

Oryctolagus cuniculus

-

-

486677

0.5 - 5

Acetic anhydride

2 entries

0.026

CI-976

Candida albicans

-

-

660876

0.04 - 1.5

diethyl dicarbonate

2 entries

0.00515

HWY-289

Candida albicans

-

-

660876

0.039

miconazole

Candida albicans

-

-

660876

0.05

progesterone

Oryctolagus cuniculus

-

-

486677

0.00006

(6R,9S,13S)-3-benzyl-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

Chlorocebus aethiops

O77759, O77760

isoform ACAT2, 37°C

703187

0.00009

(6R,9S,13S)-3-benzyl-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

Chlorocebus aethiops

O77759, O77760

isoform ACAT1, 37°C

703187

0.001

(6S,9S,13R)-9-(2-chlorobenzyl)-6-methyl-3-[(1S)-1-methylpropyl]-13-pentyl-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

Chlorocebus aethiops

O77759, O77760

isoform ACAT1, 37°C

703187

0.04

(6S,9S,13R)-9-(2-chlorobenzyl)-6-methyl-3-[(1S)-1-methylpropyl]-13-pentyl-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

Chlorocebus aethiops

O77759, O77760

isoform ACAT2, 37°C

703187

0.00025

(6S,9S,13S)-6-methyl-13-[(1S)-1-methylnonyl]-3-[(1S)-1-methylpropyl]-9-(naphthalen-2-ylmethyl)-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

Chlorocebus aethiops

O77759, O77760

isoform ACAT2, 37°C

703187

0.02

(6S,9S,13S)-6-methyl-13-[(1S)-1-methylnonyl]-3-[(1S)-1-methylpropyl]-9-(naphthalen-2-ylmethyl)-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

Chlorocebus aethiops

O77759, O77760

isoform ACAT1, 37°C

703187

0.0001

(6S,9S,13S)-6-methyl-9-(4-methylbenzyl)-13-[(1S)-1-methylbutyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

Chlorocebus aethiops

O77759, O77760

isoform ACAT1, 37°C

703187

0.004

(6S,9S,13S)-6-methyl-9-(4-methylbenzyl)-13-[(1S)-1-methylbutyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

Chlorocebus aethiops

O77759, O77760

isoform ACAT2, 37°C

703187

0.00015

(6S,9S,13S)-9-(3-chlorobenzyl)-6-methyl-13-[(1S)-1-methylbutyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

Chlorocebus aethiops

O77759, O77760

isoform ACAT1, 37°C

703187

0.0065

(6S,9S,13S)-9-(3-chlorobenzyl)-6-methyl-13-[(1S)-1-methylbutyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

Chlorocebus aethiops

O77759, O77760

isoform ACAT2, 37°C

703187

0.0001

(6S,9S,13S)-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-3-[(1R)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

Chlorocebus aethiops

O77759, O77760

isoform ACAT2, 37°C

703187

0.004

(6S,9S,13S)-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-3-[(1R)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

Chlorocebus aethiops

O77759, O77760

isoform ACAT1, 37°C

703187

0.00027

(6S,9S,13S)-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

Chlorocebus aethiops

O77759, O77760

isoform ACAT2, 37°C

703187

0.01

(6S,9S,13S)-9-(diphenylmethyl)-6-methyl-13-[(1S)-1-methylpentyl]-3-[(1S)-1-methylpropyl]-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetrone

Chlorocebus aethiops

O77759, O77760

isoform ACAT1, 37°C

703187

0.5

Acetic anhydride

Oryctolagus cuniculus

-

less than, aortic enzyme

486683, 486703

5

Acetic anhydride

Oryctolagus cuniculus

-

greater than, liver enzyme

486683, 486703

0.04

diethyl dicarbonate

Oryctolagus cuniculus

-

aortic enzyme

486683, 486703

1.5

diethyl dicarbonate

Oryctolagus cuniculus

-

liver enzyme

486683, 486703