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2.3.1.26: sterol O-acyltransferase

This is an abbreviated version!
For detailed information about sterol O-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.26

Reaction

a long-chain acyl-CoA
+
a sterol
=
CoA
 +
a long-chain 3-hydroxysterol ester

Synonyms

A2, ACAT, ACAT-1, ACAT-2, ACAT1, ACAT2, acyl coenzyme A-cholesterol-O-acyltransferase, acyl coenzyme A: cholesteryl acyltransferase, acyl-CoA cholesterol acyltransferase, acyl-CoA cholesterol O-acyltransferase, acyl-CoA: cholesterol acyltransferase, acyl-CoA:cholesterol acyltransferase, acyl-CoA:cholesterol acyltransferase 1, acyl-CoA:cholesterol acyltransferase 2, acyl-coA:cholesterol o-acyl transferase 2, acyl-coenzyme A: cholesterol acyltransferase, acyl-coenzyme A:cholesterol acyltransferase, acyl-coenzyme A:cholesterol acyltransferase 1, acyl-coenzyme A:cholesterol acyltransferase 2, acyl-coenzyme A:cholesterol acyltransferase-1, acyl-coenzyme A:cholesterol O-acyltransferase, acyl-coenzymeA cholesterol acyltransferase, acyl-coenzymeA:cholesterol acyl-transferase, acylcoenzyme A:cholesterol O-acyltransferase, acyltransferase, cholesterol, AsAT, cholesterol acyltransferase, cholesterol acyltransferase 2, cholesterol ester synthase, cholesterol ester synthetase, cholesteryl ester synthetase, hACAT, hACAT-1, hACAT-2, hACAT1, SOAT, SOAT!, Soat1, Soat2, sterol O-acyltransferase 2, sterol-ester synthase, sterol-ester synthetase, steroyl O-acyltransferase 1, steroyl O-acyltransferase 2

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.26 sterol O-acyltransferase

Expression

Expression on EC 2.3.1.26 - sterol O-acyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
ACAT2 expression is induced upon androgen agonist R1881 treatment of LNCaP cells. Increase in the in vitro ACAT1 activity in PC-3 cells treated with androgen
-
angiotensin II significantly increases ACAT1 protein expression in a time- or concentration-dependent manner. Application of angiotensin II type 1 receptor agonist L162313, but not angiotensin II type 2 receptor agonist CGP42112A, mimicks the effects of angiotensin II treatment in inducing ACAT1 protein expression. ACAT activity and ACAT1 mRNA levels are also significantly increased by angiotensin II. Two-fold increases in ACAT1 protein expression and ACAT activity with angiotensin II treatment are completely inhibited by angiotensin type I receptor antagonists candesartan, [Sar(1),Ile(8)]-angiotensin II
-
extracellular signal-regulated kinase inhibitor PD98059, p38 mitogen-activated protein kinase inhibitor SB203580, or c-Jun N-terminal kinase inhibitor SP600125 down-regulate the expression of ACAT1 in a dose-dependent manner
-
in PC-3 cells treated with androgen agonist R1881, ACAT1 protein expression and cholesterol ester levels are decreased
-
microRNAs gga-miR-181a-5p and gga-miR-429-3p participate in regulating TGFbeta pathway, and affect downstream SOAT1 expression and function in the yolk sac membrane
-
no effect from androgen treatment on ACAT1 protein expression in LNCaP cells nor from treatment on ACAT2 expression in PC-3 cells
-